Fall
Semester 2006
| Course Director | Dr. James A. Swenberg |
| Time | MWF - 9:00-9:50AM |
| Location | 2304 McGavran Greenberg |
| Phone | 966-6139 |
| Fax | 966-6123 |
| e-mail |
james_swenberg@unc.edu |
| Website
trouble |
dmgatti@email.unc.edu |
| Date | Topic | Lecturer |
| AUGUST | Overview/Regulatory Toxicology (Course Director: Dr. James Swenberg) |
|
| 23 (W) | Course overview and Regulatory Toxicology | James
Swenberg |
| 25 (F) | Risk Assessment | James Swenberg |
| 28 (M) | Risk Assessment | James Swenberg |
| Clinical
Pathology (Team Leader: Dr. Greg Travlos ) |
||
| 30 (W) | Hematology
in Toxicity Studies Powerpoint slides |
Greg Travlos |
| SEPTEMBER | ||
| 1 (F) | Coagulation
Evaluations in Toxicity Studies Powerpiont slides |
Greg Travlos |
| 4 (M) | Labor Day – No Class | |
| 6 (W) | Coagulation Evaluations in Toxicity Studies | Greg Travlos |
| 8 (F) | Clinical
Chemistry Evaluations in Toxicity
Studies Powerpoint slides |
Greg Travlos |
| 11 (M) | Clinical Chemistry Evaluations in Toxicity Studies | Greg Travlos |
| Immunotoxicology
(Team Leader: Dr. Ralph Smialowicz ) |
||
| 13 (W) | Structure and function of the immune system | Ralph Smialowicz |
| 15 (F) | Assessment and Examples of Chemical- Induced Immunosuppression & Autoimmunity | Ralph Smialowicz |
| 18 (M) | Contribution
of Chemicals to Allergic
Disease Assessment, Examples and Mechanisms Supplemental Reading List Basketter Gilmour 1 Gilmour 2 Sailstad Sarlo 1 Sarlo 2 Selgrade |
MaryJane Selgrade |
| Molecular
Mech. Of Radiation Toxicology (Team Leader: Dr. Elaine Zeman) |
||
| 20 (W) | Physico-Chemical Basis of Radiation Action | Elaine Zeman |
| 22 (F) | Radiation-Induced Mutagenesis
and
Carcinogenesis EXAM I handed out |
Elaine Zeman |
| 25 (M) | Consequences of Radiation-Induced Cell Killing | Elaine Zeman |
| Cardiovascular
Toxicology (Team Leader: Dr. Abraham Nyska) |
||
| 27 (W) | Cardiotoxicology | James Swenberg |
| 29 (F) | Vascular
Toxicology EXAM I due |
Mitchell Troutman |
| OCTOBER | ||
| Respiratory Toxicology (Team Leader: Milan Hazucha) |
||
| 2 (M) | Basic physiology and function or the respiratory system | Milan Hazucha |
| 4 (W) | Pulmonary Toxicology Markers | Gary Hatch |
| 6 (F) | Metabolism and Enzyme Kinetics in the Lung | Anthony Hickey |
| 9 (M) | Animal Models: Their Utility in the Assessment of Toxic Inhalants | Dan Costa |
| 11 (W) | Uptake and disposition of gases
and vapors
in the respiratory system EXAM II handed out |
Paul Schlosser |
| Neurotoxicology
(Team Leader: |
||
| 13 (F) | Unique
aspects of
nervous system structure and function Intro. Bioch. Tox. Reading |
Richard Mailman |
| 16 (M) | CNS diseases
and the
environment |
Richard Mailman |
| 18 (W) | Neurotoxicity of
Pesticides EXAM II due |
Stephanie
Padilla |
| 20 (F) | Fall Break – No Class | |
| 23 (M) | Neurotoxicity of Solvents
Neurotoxicity of
Solvents (PDF) |
William Boyes |
| 25 (W) | Neurotoxicity of Natural Toxins | Robert MacPhail |
| Renal Toxicology (Drs. Douglas Wolf and James Swenberg) |
||
| 27 (F) | Toxicologic Pathology of the Kidney | Douglas Wolf |
| 29 (M) | Toxicologic Pathology of the Kidney | Douglas Wolf |
| NOVEMBER | ||
| 1 (M) | alpha2u Globulin-Nephropathy | James Swenberg |
| Hepatic
Toxicology (Team Leader: Dr. Gary Boorman) |
||
| 3 (F) | Introduction to Liver | Gary Boorman |
| 6 (M) | Aspects of Hepatic Injury | Robert Sills |
| 8 (W) | Biochemistry of Liver Injury Molecular | Edward LeCluyse |
| 10 (F) | Acute Liver Injury Reference list EXAM III handed out |
Rich Miller |
| 13 (M) | Chronic Liver Injury and Carcinogenesis | Amy Brix |
| Clinical
Toxicology & Drug
Interactions (Team Leader: Dr. Paul Watkins) |
||
| 15 (W) | Drug Induced Liver Injury (DILI) | Paul Watkins |
| 17 (F) | Nutrition and Xenobiotics: The story of grapefruit juice EXAM III due |
Paul Watkins |
| Reproductive Toxicology (Team Leader: Dr. John Rogers) | ||
| 20 (M) | Developmental Toxicology I | John Rogers |
| 22 - 24 (W & F) | No Class - Thanksgiving | |
| 27 (M) | Female Reproductive Toxicology | Jerome Goldman |
| 29(W) | Male Reproductive Toxicology | Gary Klinefelter |
| DECEMBER | ||
| 1 (F) | Developmental Toxicology II Wells review Teratogen induced cell death |
Sid Hunter |
| 4 (M) | Regulatory Aspects of Developmental & Reproductive Toxicology | Rochelle Tyl |
| 6 (W) | Course Review EXAM IV handed out |
James Swenberg |
| 13(W) |
EXAM IV due at 10:00 AM |
EXAM SCHEDULE |
||
| Exam I | Regulatory Toxicology, Clinical Pathology and Immunotoxicology | Out: 9/22/06 In: 9/29/06 |
| Exam II | Radiation Toxicology,
Cardiovascular
Toxicology and Pulmonary Toxicology Mode of Action example |
Out: 10/11/06 In: 10/18/06 |
| Exam III | Neurotoxicology and Renal Toxicology | Out: 11/10/06 In: 11/17/06 |
| Exam IV | Hepatic Toxicology, Clinical Toxicology and Reproductive and Developmental Toxicology | Out: 12/6/06 In: 12/13/06* |
University Holidays/Breaks:
Oct. 19th (Th), 20th (F) - Fall Break;
Nov. 22nd
(W), 23th (Th) and 24th (F) – Thanksgiving (No
classes)