Fall
Semester 2007
| Course Director | Dr. James A. Swenberg |
| Time | MWF - 9:00-9:50AM |
| Location | 235
Rosenau Hall |
| Phone | 966-6139 |
| Fax | 966-6123 |
| e-mail |
james_swenberg@unc.edu |
| Website
trouble |
keesee@email.unc.edu |
| Date | Topic | Lecturer |
| AUGUST | Overview/Regulatory Toxicology (Course Director: Dr. James Swenberg) |
|
| 22 (W) | Course overview and Regulatory Toxicology | James Swenberg |
| 24 (F) | Risk Assessment | James Swenberg |
| 27 (M) | Risk Assessment Journal articles to read: PMID 17118728 Boobis 2006EJ click on view article pdf icon; PMID 11603957 Sonich-Mullin EJ (click on pdf 61K tab); and PMID 14727733 Meek et al EJ (63 pages) |
James Swenberg |
| Clinical
Pathology (Team Leader: Dr. Greg Travlos ) |
||
| 29 (W) | Hematology
in Toxicity Studies Powerpoint slides: Bare Bones, Blood (203 slides) Hemo tiss Table 1 Hemo factors Tbl 2 MCV-MCHC Table 3 Hematopoiesis - Fig 1 |
Greg Travlos |
| 31 (F) |
Hematology
in Toxicity Studies Powerpoint slides: Hemostasis/Coagulation (66 slides) |
Greg Travlos |
| SEPTEMBER | ||
| 3 (M) | Labor
Day –
No Class |
|
| 5 (W) | Coagulation
Evaluations in Toxicity Studies Powerpoint slides (Continue with set from 8/31) |
Greg Travlos |
| 7 (F) | Clinical
Chemistry Evaluations in Toxicity
Studies Powerpoint slides (75 slides) |
Greg Travlos |
| 10 (M) |
Clinical Chemistry
Evaluations in Toxicity Studies Case Studies (33 slides) |
Greg Travlos |
| Neurotoxicology (Team Leader: Dr. Richard Mailman ) |
||
| 12 (W) | Introduction Powerpoint (45) slides |
Richard Mailman |
| 14 (F) | Practical Problems PMID 15081274 Vidair (click on PDF 236K tab to access 16 pages) |
Richard
Mailman |
| 17(M) | Pesticides |
Stephanie Padilla |
| 19 (W) |
Toxins Powerpoint presentation ( 24 slides) Journal articles:PMID 15809446 Cox et al PNAS and Correction (see Ecology), PMID 10698729 EHP Van Dolah , PMID 17035666 MI Vortherms&Roth , PMID 12490687 NEJM Herbal Remedies (go to PubMed to link to Comments), and PMID 16075378 Nicotinic receptor agents |
Robert MacPhail |
| 21 (F) |
Solvents Replacement PPT Slides Journal articles: PMID 8909612 Grosch , PMID 12480295 Ridgway et al (35 pages), and PMID 9130958 White and Proctor *** End of material for
questions on Exam 1 ***
|
William Boyes |
| Molecular
Mech. Of Radiation Toxicology (Team Leader: Dr. Elaine Zeman) |
||
| 24 (M) | Physico-Chemical Basis of
Radiation Action Part 1 (pages 1-30, 6+ MB pdf) Part 2 (pages 31-60, 6+ MB pdf) |
Elaine Zeman |
| 26 (W) | Radiation-Induced Mutagenesis
and
Carcinogenesis EXAM I handed out |
Elaine Zeman |
| 28 (F) | Consequences of Radiation-Induced Cell Killing | Elaine Zeman Eval Form |
| OCTOBER | ||
| Pulmonary
Toxicology (Team Leader: Dr. Milan Hazucha) |
||
| 1 (M) | Basic physiology and function of
the
respiratory system PowerPoint Slides (17+MB) |
Milan Hazucha Eval Form |
| 3 (W) | Pulmonary
Toxicology Markers EXAM I due |
Gary Hatch Eval Form |
| 5 (F) |
Metabolism and Enzyme Kinetics
in the Lung Powerpoint 40 slides |
Anthony
Hickey Eval Form |
| 8 (M) |
Animal Models: Their Utility in
the Assessment of Toxic Inhalants Lecture in PDF (56 pages) 6.42 MB |
Dan Costa Eval Form |
| 10 (W) |
Uptake and Disposition of Gases
and Vapors in the Respiratory System Powerpoint 46 slides |
Paul
Schlosser Eval Form |
| Hepatic Toxicology (Team Leader: Dr. David Malarkey) |
||
| 12 (F) | Introduction to the liver Powerpoint 56 slides Malarkey et al (PMID 15805053) Toxicol Pathol 2005 33(1) 27-34 |
Dave Malarkey Eval Form |
| 15 (M) | Acute responses to hepatic injury Powerpoint 55 slides; Reference List |
Rich Miller Eval Form |
| 17 (W) | Chronic and carcinogenic effects
of liver injury (Provided CD to all in class) |
Amy Brix Eval Form |
| 19 (F) | Fall
Break - No Class |
|
| 22 (M) |
Molecular aspects of hepatic
injury Powerpoint (also to be handed out in print) |
Robert Sills Eval Form |
| 24 (W) |
Biochemistry of hepatic injury Powerpoint (48 slides) *** End of material for
questions on Exam 2 ***
|
Ed LeCluyse Eval Form |
| Cardiovascular
Toxicology (Team Leader: |
||
| 26 (F) | Cardiovascular
toxicology Powerpoint (80 slides) |
Brian Berridge |
| 29 (M) | Vascular toxicology |
Brian Berridge Eval Form |
| Immunotoxicology (Team Leader: Dr. MaryJane Selgrade) |
||
| 31 (W) |
Immune system overview &
mechanisms of chemically-induced immunosuppression Powerpoint (45 slides) Luebke et al Association (no PMID found) EXAM II handed out |
Bob Luebke |
| NOVEMBER | ||
| 2 (F) | Immunotoxicity: Contribution of Chemicals to Allergic Disease Assessment, Examples, & Mechanisms Powerpoint (36 slides), Chem characteristics (1 page), Basketter (PMID 11955664), Farraj et al (PMID 17693426), Gilmour et al 06 (PMID 16581557), GilmourSelgradeLambert (no PMID), Sailstad (PMID 12200592), Sarlo 94 (proceedings), Sarlo et al 97 (PMID 9325026) | MaryJane
Selgrade Eval Form |
| 5 (M) | Mechanisms of autoimmunity &
Immunotox risk assessment Powerpoint (42 slides) and Health Effects Test Guidelines Luebke et al Comparative (PMID 16393867) |
Bob Luebke Eval Form |
| Renal Toxicology (Drs. Douglas Wolf and James Swenberg) |
||
| 7 (W) | Renal Toxicology Powerpoint
(79 slides) EXAM II due |
Douglas Wolf |
| 9 (F) | Renal Toxicology |
Douglas Wolf Eval Form |
| 12 (M) | alpha2u
Globulin-Nephropathy Powerpoint (57 slides) *** End of material for
questions on Exam 3 ***
|
James
Swenberg Eval Form |
| Reproductive
Toxicology (Team Leader: Dr. John Rogers) |
||
| 14 (W) | Overview and Developmental
Toxicology I Powerpoint (54 slides) and chapter provided on CD in class Compressed version of slides here |
John Rogers Eval Form |
| 16 (F) | Female Reproductive Toxicology Powerpoint (46 slides) EXAM III handed out |
Jerome
Goldman Eval Form |
| 19 (M) | Male Reproductive Toxicology Powerpoint (40 slides -- adapted for UNC) |
Gary
Klinefelter Eval Form |
| 21 - 23 (W & F) | No Class - Thanksgiving | |
| 26 (M) | Developmental Toxicology II Powerpoint (59 slides).
Lots of supplemental material provided on CD. (Including the following
three items.) NTP-CERHR
monograph and two journal articles: Wobus & Boheler (PMID
15788707) and Boheler
et al (PMID 12169644) which are both free-full text through PubMed. EXAM III due |
Sid Hunter Eval Form |
| 28(W) | Regulatory Aspects of
Developmental & Reproductive Toxicology Presentation notes (23 pages in Word) |
Rochelle Tyl Eval Form |
| Clinical Toxicology & Drug Interactions (Team Leader: Dr. Paul Watkins) |
||
| 30 (F) |
Drug Induced Liver Injury (DILI)
PowerPoint
(61 slides) |
Paul Watkins |
| DECEMBER | ||
| 3 (M) | Diet/xenobiotic interactions PowerPoint (53 slides) |
Paul Watkins Eval Form |
| 5 (W) | Course Review EXAM IV handed out |
James Swenberg |
| 12(W) |
EXAM IV due at 10:00 AM in Rosenau 253c |
EXAM SCHEDULE |
||
| Exam I | Regulatory Toxicology, Clinical Pathology and Neurotoxicology | Out: 9/26/07 In: 10/3/07 |
| Exam II | Radiation Toxicology,
Pulmonary Toxicology and Hepatic Toxicology |
Out: 10/31/07 In: 11/7/07 |
| Exam III | Cardiovascular Toxicology, Immunotoxicology and Renal Toxicology | Out: 11/16/07 In: 11/26/07 |
| Exam IV | Reproductive Toxicology and Clinical Toxicology | Out: 12/5/07 In: 12/12/07* |