The Michael T. Crimmins Group Home Page


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Methodology

42. "Addition of Metalated Pyrones to β-Alkoxy Aldehydes: Synthesis of Hydroxylated Spiroketals" Crimmins, M. T.; Washburn, D. G.; Katz, J. D.; Zawacki, F. J. Tetrahedron Lett. 1998, 39, 3439-3442.
| Full Article-PDF | DOI: 10.1016/S0040-4039(98)00566-8 |

34. "Regioselective and Stereoselective Reductive Cleavage of 1,7-dioxaspiro[5.5]undecane Alcohols" Crimmins, M. T.; Rafferty, S. W. Tetrahedron Lett. 1996, 37, 5649-5652.
| Full Article-PDF | DOI: 10.1016/0040-4039(96)01196-3 |

20. "Synthesis of Spiroketals: A General Approach" Crimmins, M. T.; O'Mahony, R. J. Org. Chem. 1990, 55, 5894.
| Full Article-PDF | DOI: 10.1021/jo00310a023 |

2. "Addition of 1-Methoxy-1-buten-3-yne to Lactones: Synthesis of Substituted Spiroketals" Crimmins, M. T.; Bankaitis, D. M. Tetrahedron Lett. 1983, 24, 4551-4554.
| Full Article-PDF | DOI: 10.1016/S0040-4039(00)85952-3 |

Examples in Synthesis

87. "Enantioselective Total Synthesis of FD-891" Crimmins, M. T.; Caussanel, F. J. Am. Chem. Soc. 2006, 128, 3128-3129.
| Full Article-PDF | (Supporting Information) | DOI: 10.1021/ja060018v |

86. "A Hetero-Diels-Alder Approach to Complex Pyrones: An Improved Synthesis of the Spongistatin AB Spiroketal" Crimmins, M. T.; Smith, A. C. Org. Lett. 2006, 8, 1003-1006.
| Full Article-PDF | (Supporting Information) | DOI: 10.1021/ol0601601 |

69. "Asymmetric Total Synthesis of Spongistatins 1 and 2" Crimmins, M. T.; Katz, J. D.; Washburn, D. G.; Allwein, S. P.; McAtee, L. F. J. Am. Chem. Soc. 2002, 124, 5661-5663.
| Full Article-PDF | (Supporting Information) | DOI: 10.1021/ja0262683 |

55. "Synthesis of the AB Spiroketal Subunit of Spongistatin 1 (Altohyrtin A): The Pyrone Approach" Crimmins, M. T.; Washburn, D. G. Tetrahedron Lett. 1998, 39, 7487-7490.
| Full Article-PDF | DOI: 10.1016/S0040-4039(98)01629-3 |

36. "Asymmetric Total Synthesis of (+)-Milbemycin D" Crimmins, M. T.; Al-awar, R. S.; Vallin, I. M.; Hollis, W. G., Jr.; O'Mahony, R.; Lever, J. G.; Bankaitis-Davis, D. M. J. Am. Chem. Soc. 1996, 118, 7513-7528.
| Full Article-PDF | (Supporting Information) | DOI: 10.1021/ja961071u |

18. "A Synthesis of (-)-Talaromycin A" Crimmins, M. T.; O'Mahony, R. J. Org. Chem. 1989, 54, 1157.
| Full Article-PDF | DOI: 10.1021/jo00266a030 |

17. "Synthesis of the Spiroketal Fragment of Avermectin B1b" Crimmins, M. T.; O'Mahony, R. Tetrahedron Lett. 1989, 30, 5993.
| Full Article-PDF | DOI: 10.1016/S0040-4039(01)93836-5 |

13. "Total Synthesis of Milbemycin β3" Crimmins, M. T.; Bankaitis-Davis, D. M.; Hollis, W. G., Jr. J. Org. Chem. 1988, 53, 652-657.
| Full Article-PDF | DOI: 10.1021/jo00238a031 |

12. "Intramolecular Photocycloaddition-Cyclobutane Fragmentation: Total Synthesis of (±)-Laurenene" Crimmins, M. T.; Bredon, L. D. J. Am. Chem Soc. 1987, 109, 6199.
| Full Article-PDF | DOI: 10.1021/ja00254a058 |

8. "Intramolecular Photocycloadditions-Cyclobutane Fragmentation: Total Synthesis of (±)-Pentalenene, (±)-Pentalenic Acid, and (±)-Deoxypentalenic Acid" Crimmins, M. T.; DeLoach, J. A. J. Am. Chem. Soc. 1986, 108, 800.
| Full Article-PDF | DOI: 10.1021/ja00264a037 |