www.med.unc.edu/wrkunits/2depts/biochem
HENRIK DOHLMAN, Interim Chair
Sharon Campbell (18) NMR Spectroscopy, Structure and Regulation of Proteins Involved in Ras-Mediated Cell Signaling
Michael Caplow (16) Chemistry of the Microtubule Cytoskeleton
Charles W. Carter Jr. (19) Structural Molecular Biology, Protein Structure-Function, X-ray Crystallography of Proteins Including Aminoacyl tRNA Synthetases, Deaminases, Phasing Methods and Crystal Growth
Stephen G. Chaney (25) Chemistry and Action Mechanism of Platinum Anticancer Agents, DNA Repair, Effects of DNA-Damaging Agents on DNA Replication
David Clemmons (15) Receptor Signaling
Stephen Crews (24) Molecular Genetics of Nervous System Development, Transcriptional Control, Evolution of Regulatory Mechanisms
Marshall Edgell (143) Use of Biophysical and Genetic Techniques Using Combinatorial Libraries and High Throughput Robotics to Assess Determinants of Protein Structure
Beverly Errede (144) Function and Regulation of MAP-Kinase Activation Pathways in Saccharomyces cerevisiae
Jack Griffith (41) Architecture of DNA-Protein Complexes Involved in Replication, Repair, and Telomere Maintenance, Electron Microscopy
Hengming Ke (50) X-ray Crystallography, Structure and Function of Biologically Important Proteins such as Phosphodiesterase and Molecular Chaperone System
Barry R. Lentz (62) Biomembrane Structure and its Relationship to Function, Platelet Membranes in Blood Coagulation, Membrane Fusion, Liposomes
Patricia F. Maness (68) Mechanisms of Cell Signaling and Adhesion, Axon Guidance and Synaptic Plasticity
William F. Marzluff (69) Control of Gene Activity, Cell-Cycle Regulation in Early Embryos, Control of Expression of Histone mRNA
Gerhard W. Meissner (79) Intracellular Ca2+ Signaling and Regulation of Ion Channels in Striated Muscle
Gary Pielak (99) Protein Structure/Function Using 2-D NMR
Aziz Sancar (105) DNA Repair and Cancer, Structure and Function of DNA Repair Enzymes, Molecular Neurobiology, Reaction Mechanism of Human Blue-Light Photoreceptor
Gwendolyn B. Sancar (104) Cellular Responses to Genotoxic Stress, DNA Repair, Transcriptional Regulation of Stress Response Genes
John Sheehan (111) Understanding the Role of Glycoconjugates in Biology
Ronald I. Swanstrom (123) Molecular Biology of HIV, Resistance to HIV Protease Inhibitors
Michael D. Topal (126) Protein-DNA Recognition, Genomic Instability
Thomas W. Traut (128) Enzyme Structure and Regulation, Allosteric Dissociating Enzymes
Terry Van Dyke (132) Molecular Regulation of Cell Growth Control, Cell Specificity of Tumor Suppression Function, Gene Regulation
Elizabeth M. Wilson (134) Mechanisms of Steroid Hormone Action, Androgen Regulation of Gene Transcription
Richard V. Wolfenden (139) Enzyme Mechanisms, Water Affinities of Biological Compounds
Yue Xiong (140) Molecular Mechanisms of Cell Cycle Control, Tumor Suppression and Development
Ed Collins (23) Use of Biophysical Tools to Study Immunological Problems Focusing on Immune Recognition of Cancer
Henrik Dohlman (17) Regulators of G Protein Signaling, Mechanisms of Drug Desensitization
Ann Erickson (33) Cellular Protein Targeting, Lysosomal Enzyme Biosynthesis, Secretion of Lysosomal Proteases by Transformed Cells
Howard M. Fried (39) Cell and Molecular Biology, Mechanisms of Nuclear-Cytoplasmic Transport, Mechanisms of RNA-Protein Recognition
Dale Ramsden (108) Mechanism of V(D)J Recombination, End-Joining Pathway for Repair of DNA Double Strand Breaks
John Sondek (117) Protein Crystallography and Signal Transduction
Yi Zhang (138) Chromatin Dynamics, Gene Expression, Cellular Proliferation
Christoph Borchers (12) Protein-Protein and Protein-Ligand Interaction, Protein Tertiary Structure, Quaternary Structure of Multi-Protein Complexes, Structure-Function Relationship of Proteins, Functional Proteomics
Jean Cook (150) Regulation of DNA Replication in Mammalian Cells
Lyndon Cooper (21) Osteoblast Responses to Physiological Stress: Characterization of the Heat Shock Response and Mechanochemical Deformation and Stimulation
Nikolay Dokholyan (47) Computational Structural Biology
Brian Kuhlman (72) Computational Protein Design, Protein-Protein Interactions, Structural Biology
Andrew Lee (71) Protein, Structure and Dynamics, NMR Spectroscopy
Matthew Redinbo (110) Structural Biology of Proteins and Protein-nucleic Acid Complexes
Brian Strahl (120) Mechanisms of Chromatin-Mediated Gene Transcription
David G. Kaufman (53) Cellular and Molecular Mechanisms of Cancer Development, Epithelial Cell-Stromal Cell Interactions, Cell-Cycle Influences on Carcinogenesis
Arrel D. Toews (125) Neurochemistry, Neurotoxicology: Metabolism and Gene Expression during Demyelination and Remyelination, Molecular Biology of Cholesterol Metabolism and Trafficking
Michael K. Berkut
Edward B. Glassman
Dr. Jan Hermans
David J. Holbrook Jr.
William Henry Pearlman
Ralph Penniall
Howard A. Schneider
George K. Summer
Robert H. Wagner
James R. White
John E. Wilson
The Department of Biochemistry and Biophysics is an administrative division of the School of Medicine and a member of The Graduate School. The graduate program offers instruction and research opportunities leading to the PhD degree. Although the department offers the MS degree, the graduate program is not designed as a terminal master's curriculum. Applicants are offered admission with the expectation that they will complete their doctorate.
Modern research in biochemistry and biophysics is designed to address mechanism and function; it utilizes the paradigms of molecular biology, but is influenced by chemistry, physics, and genetics. The philosophy of the department and its graduate program is to provide students with broad training in modern approaches to the field and unique opportunities for multidisciplinary training.
Students admitted to the graduate program take any two of the following six courses: BIOC 601, 631, 632, 643, 644, 655, or any three of the physical biochemistry modules (BIOC 650-653, 660-678). In addition, all students take a special seminar course (BIOC 701) and select a minimum of three laboratory rotations (BIOC 702). These four core courses can be completed during the first year when a student has all prerequisites. A scientific writing course, BIOC 712, is required during the second year. This course is designed to prepare students for the Comprehensive Examination, which is in the format of an NIH grant proposal. Students are also required to take a minimum of twelve semester hours of electives, including at least three three-hour lecture courses. The remainder of the electives can be either seminar or lecture courses. The electives may be courses offered either by the Department of Biochemistry and Biophysics or by other departments. Further information on course requirements may be found in the Guidelines for Students in the Graduate Program in Biochemistry and Biophysics at The University of North Carolina at Chapel Hill.
Students in the combined MD/PhD program are required to complete two of the following courses (six credit hours): BIOC 601, 631, 632, 643, 644, 655, or any three of the physical biochemistry modules (BIOC 650-653, 660-678), as well as BIOC 701 (three credit hours), two rotations in BIOC 702 (four credit hours), and BIOC 712 (two credit hours). School of Medicine courses can serve in lieu of electives.
A faculty committee advises entering students about course selection until the student chooses a research sponsor. Students select research sponsors from the department's primary and joint faculty members following the three laboratory rotations. After a research sponsor has been selected, a dissertation committee is formed to review the student's yearly progress. The examinations required for admission to candidacy for the PhD are administered as a comprehensive exam and a written research proposal. The comprehensive exam will cover major topics in the areas of biochemistry/biophysics and cell/molecular biology. The written research proposal will be on the student's chosen research project and will be defended in an oral examination. The most important requirement for the PhD degree is a dissertation of original research carried out independently by the candidate. The PhD candidate is required to conduct a final oral defense of a dissertation.
Funds available from the University, the department, and individual research grants provide stipends for students. All applicants are considered for special fellowships and teaching or research assistantships. In 2005 students received a stipend of $22,000 plus in-state tuition and fees. Major medical insurance was also provided. Nonresidents with predoctoral fellowships or assistantships are recommended for special tuition rates. Applications are considered from prospective graduate students who present evidence of superior scholarship in biology, chemistry, or biochemistry. The department recommends that students prepare themselves by taking general and organic chemistry, biochemistry, biology, physics, and calculus. It is anticipated that students who have not had these courses will take them, as appropriate, after their arrival. Departmental information may be obtained through the department's Web site: www.med.unc.edu/wrkunits/2depts/biochem. Applicants should apply online at gradschool.unc.edu.
The faculty research interests are diverse and include research in the following areas: cell signaling and growth control, DNA repair and replication, membrane biophysics and function, molecular regulation including transcriptional control, nervous system development and function, and protein structure/function, including enzymology. Model systems used by the faculty range from bacteria to mammals; techniques span molecular biology to physical biochemistry. A brochure describing the department and more detailed faculty research interests can be obtained by writing to the director of graduate studies of the Department of Biochemistry and Biophysics, or by visiting the department's Web site: www.med.unc.edu/wrkunits/2depts/biochem.
The departmental research facilities are centered in the Mary Ellen Jones Building, which is within walking distance of the Cancer Research Center and the departments of Biology, Chemistry, and Physics. The building is equipped with instruments for molecular biological, biochemical, structural, and biophysical research. Animal-care facilities are available to support the department's research endeavors. The computer facilities are networked within the department, to the Research Triangle area, and to national and international databases. Color graphics workstations (including an Evans & Sutherland PS350) and high speed minisupercomputers are available within the department.
402 [102] UNDERGRADUATE RESEARCH IN BIOCHEMISTRY (1-3). Prerequisites, an overall G.P.A. of 3.0 and permission of the course director. For juniors and seniors who wish to carry out an independent, mutually-arranged research project in the laboratory of a biochemistry faculty sponsor. Restricted to on-campus work. Minimum three hours per week for each unit of credit per semester. May be repeated. May not substitute for honors, advanced elective, or other course requirements of another department. A written report is required in each term. Fall and spring. Fried, staff.
442 [142] BIOCHEMICAL TOXICOLOGY (ENVR 442) (TOXC 442) (3). Prerequisites, CHEM 430 or equivalent, and one additional biochemistry course (or permission of the course director). Biochemical actions of toxicants, and assessment of cellular damage by biochemical measurements. Course intended primarily for graduate students. Spring. Harper (course director).
505 [105] MOLECULAR BIOLOGY (GNET 505) (3). Prerequisites, undergraduate biochemistry or genetics, and organic chemistry. Techniques in molecular biology, mechanisms of DNA replication, transcription, and translation of genetic material in prokaryotic and eukaryotic systems; genomics, gene organization; regulatory and signaling mechanisms; and molecular biology of cancer. Fall. Crews, Fried, Van Dyke, Xiong.
601 [104] ENZYME PROPERTIES, MECHANISMS, AND REGULATION (3). Prerequisite, CHEM 430 or equivalent. Focuses on enzyme architecture to illustrate how the shapes of enzymes are designed to optimize the catalytic step and become allosterically modified to regulate the rate of catalysis. Fall. Traut, Wolfenden.
631 [110] ADVANCED MOLECULAR BIOLOGY I (BIOL 631) (GNET 631) (MCRO 631) (PHCO 631) (3). Prerequisites, at least one undergraduate course in both biochemistry and genetics and permission of the instructor. DNA structure, function, and interactions in prokaryotic and eukaryotic systems, including chromosome structure, replication, recombination, repair, and genome fluidity. Fall. Griffith, Matson, A. Sancar.
632 [111] ADVANCED MOLECULAR BIOLOGY II (BIOL 632) (GNET 632) (MCRO 632) (PHCO 632) (3). Prerequisites, at least one undergraduate course in both biochemistry and genetics and permission of the instructor. RNA structure, function, and processing in biological systems including transcription, gene regulation, translation, protein and RNA transport. Spring. Baldwin, Marzluff, Strahl.
643 [117] CELL STRUCTURE, FUNCTION, AND GROWTH CONTROL I (BIOL 642) (MCRO 643) (PHCO 643) (2 or more). Prerequisites, undergraduate cell biology or biochemistry or permission of the instructor. Comprehensive introduction to cell structure and function. Fall. Meissner, staff.
644 [118] CELL STRUCTURE, FUNCTION, AND GROWTH CONTROL II (BIOL 644) (MCRO 644) (PHCO 644) (2 or more). Prerequisites, undergraduate cell biology or biochemistry or permission of the instructor. Comprehensive introduction to cell structure, function, and transformation. Spring. Cox, staff.
650 [144] MACROMOLECULAR THERMODYNAMICS (1). Prerequisites, CHEM 430 and two semesters of physical chemistry or permission of the instructor. Basic molecular models and their use in developing statistical descriptions of macromolecular function. Fall. Lentz.
651 [145] MACROMOLECULAR STRUCTURE AND DYNAMICS (1). Prerequisites, CHEM 430 and two semesters of physical chemistry or permission of the instructor. Macromolecules as viewed with modern computational methods. Fall. Sondek (course director), Temple, Lentz.
652 [146] MACROMOLECULAR EQUILIBRIA (1). Prerequisites, CHEM 430 and two semesters of physical chemistry or permission of the instructor. Stability of macromolecules and their complexes with other molecules. Fall. Hermans.
653 [147] MACROMOLECULAR SPECTROSCOPY (1). Prerequisites, CHEM 430 and two semesters of physical chemistry or permission of the instructor. Principles of UV, IR, Raman, fluorescence, and spin resonance spectroscopies; applications to the study of macromolecules and membranes. Spring. Lentz.
655 [134] CASE STUDIES IN STRUCTURAL MOLECULAR BIOLOGY (3). Prerequisite, CHEM 430 or equivalent. Principles of macromolecular structure and function with emphasis on proteins, molecular assemblies, enzyme mechanisms, and ATP enzymology. Spring. Carter.
660 [150a] INTRODUCTION TO LIGHT MICROSCOPY (1). Prerequisites, BIOC 650-653 or permission of the course director. Fundamentals of optics and light microscope design for the novice student. Spring (even-numbered years). Salmon (course director).
661 [150b] ADVANCED TOPICS IN IMAGING (2). Prerequisites, BIOC 650-653 or permission of the course director. Optical imaging including fluorescence and confocal techniques. Scanning and transmission electron microscopy and image interpretation. Mechanical imaging and scanning probe microscopy. Spring (even-numbered years). Costello (course director), Erie, Jacobson, Salmon, Superfine.
662 [151] MACROMOLECULAR INTERACTIONS (1). Prerequisites, BIOC 650-653 or permission of the course director. Theory and practice of biophysical methods used in the study of interactions between macromolecules and their ligands including surface plasmon resonance, analytical ultracentrifugation, and calorimetry. Spring. Pielak (course director), Tripathy.
663A [152] MACROMOLECULAR NMR THEORY (1). Prerequisite, BIOC 650-653 or permission of the course director. This is the lecture component of a combined lecture/laboratory course that provides a practical introduction to the use of macromolecular NMR spectroscopy. The lecture may be taken independently of the lab (BIOC 152L). Spring. Campbell (course director), Pielak, Young.
663B [152L] MACROMOLECULAR NMR PRACTICE (1). Prerequisite, BIOC 653 or permission of the course director. Lab section for BIOC 152. Spring. Campbell (course director), Pielak, Young.
666 [153] X-RAY CRYSTALLOGRAPHY OF MACROMOLECULES(1). Prerequisite, BIOC 650 or permission of the course director. Principles of protein crystallography; characterization of crystals; theory of diffraction; phasing of macromolecular crystals and structure refinement. Spring. Ke.
667 [157] MACROMOLECULAR CRYSTALLOGRAPHIC METHODS (CHEM 233) (2). Prerequisite, BIOC 666 or permission of the course director. A combined lecture/laboratory workshop for serious students of protein crystallography. Spring (odd-numbered years). Collins (course director), Redinbo, Carter, Sondek.
668 [154] PRINCIPLES OF AND SIMULATION OF MACROMOLECULAR DYNAMICS (1). Prerequisites, BIOC 650-653 or permission of the instructor. A combined lecture/computer lab treatment of the principles of macromolecular dynamics and structure as approached using the tools of molecular dynamics simulations. Spring (odd-numbered years). Hermans (course director), Tropsha.
670 [156] BIOMOLECULAR INFORMATICS (1). Prerequisites, BIOC 650-653 or permission of the instructor. A combined workshop/distance learning course introducing the methods and principles of biological data management as this relates to macromolecular sequence analysis. Spring. Vaisman.
673 [158] PROTEOMICS, PROTEIN IDENTIFICATION AND CHARACTERIZATION BY MASS SPECTROMETRY (1). Prerequisite, BIOC 650-653 or one semester of physical chemistry or permission of the instructor. A lecture module that introduces students to the basics of mass spectrometry as applied to protein science. Spring. Borchers (course director).
678 [155] ELECTRICAL SIGNALS FROM MACROMOLECULAR ASSEMBLAGES (NBIO 722A) (2). Prerequisite, BIOC 653 or permission of the course director. An intensive, six-hour-per-week introduction to the fundamentals of ion channel biophysics, including laboratory sessions to demonstrate principles and methods. Fall. Oxford (course director), Cheney, Rosenberg, Pallotta, Stuart.
701 [205] RESEARCH TOPICS IN BIOCHEMISTRY (3). Prerequisites, CHEM 430 or equivalent and permission of the coordinator. Seminar and critical study of modern research topics in biochemistry under the supervision of individual biochemistry faculty. Spring. Caplow and Fried, staff.
702 [207] ADVANCED BIOCHEMISTRY LABORATORY (2 or 4). Prerequisite, CHEM 430 or equivalent. Permission of the department required except for departmental majors. Designed to introduce the student to research methods. Minor investigative problems are conducted with advice and guidance of the staff. May be repeated two or more semesters for credit. Hours and credit to be arranged. Fall. Staff.
703 [207] ADVANCED BIOCHEMISTRY LABORATORY (2 or 4). Prerequisite, CHEM 430 or equivalent. Permission of the department required except for departmental majors. Designed to introduce the student to research methods. Minor investigative problems are conducted with advice and guidance of the staff. May be repeated two or more semesters for credit. Hours and credit to be arranged. Spring. Staff.
704 [260] SEMINARS IN BIOPHYSICS (2). Prerequisite, permission of the instructor. Students present seminars coordinated with the visiting lecturer series of the Program in Molecular and Cellular Biophysics. Fall and spring. Lentz, staff.
705 [208] ADVANCED BIOPHYSICS LABORATORY (2 or 4). Permission of the program required. Designed to introduce students in the Molecular and Cellular Biophysics Program to research methods. Minor investigative projects are conducted with advice and guidance of the staff. May be repeated two or more semesters for credit. Hours and credit to be arranged. Fall and spring. Staff.
711 [211] RESEARCH CONCEPTS IN BIOCHEMISTRY (2). Prerequisite, master's candidate in biochemistry and biophysics. A series of lectures and exercises on formulating a research plan to attack a specific scientific problem, and on presenting the research plan in the form of a grant proposal. Fall. G. Sancar (course director), staff.
712 [212] SCIENTIFIC WRITING (3). Prerequisite, doctoral candidate in biochemistry and biophysics. A course of lectures and workshops on the principles of clear scientific exposition with emphasis on the design and preparation of research grants. Fall. G. Sancar (course director), staff.
715 SCIENTIFIC PRESENTATION (1). Senior graduate students present original research results as a formal seminar. Feedback on presentation effectiveness and style will be provided by faculty instructors and classmates. Fall. Cook (co-director), Strahl (co-director), Kuhlman and Dokholyan.
721 [221] CELL REGULATION BY UBIQUITINATION (PHCO 721B) (2). Prerequisite, two semesters of biochemistry. Lecture and literature-based discussion course on ubiquitin-mediated regulation of hormone receptor signaling, trafficking, and degradation. Spring (even-numbered years). Dohlman.
722A [222A] CELLULAR AND MOLECULAR NEUROBIOLOGY: INTRODUCTION (NBIO 722A) (PHCO 722A) (PHYI 722A) (2). Prerequisite, permission of the course director. Introductory section covers basic neurobiology, including neuronal cell biology, action potentials, synaptic potentials, molecular biology, and neuroanatomy. Course meets for four weeks with six lecture hours per week. Fall. Stuart.
722B [222B] CELLULAR AND MOLECULAR NEUROBIOLOGY: POSTSYNAPTIC MECHANISMS-RECEPTORS (NBIO 722B) (PHCO 722B) (PHYI 722B) (2). Prerequisite, permission of the instructor. Consideration of membrane receptor molecules activated by neurotransmitters in the nervous system with emphasis on ligand binding behavior and molecular and functional properties of different classes of receptors. Course meets for four weeks with six lecture hours per week. Fall. Neurobiology faculty.
722C [222C] CELLULAR AND MOLECULAR NEUROBIOLOGY: ELECTRICAL SIGNALING (NBIO 722C) (PHCO 722C) (PHYI 722C) (2). Prerequisite, permission of the course director. The genesis of electrical impulses in the nervous system is considered with an emphasis on membrane potentials, voltage-gated ion channels, and structural features of neurons that influence coding. Course meets for five weeks with six lecture hours per week. Fall. Stuart.
723A [223A] CELLULAR AND MOLECULAR NEUROBIOLOGY: POSTSYNAPTIC MECHANISMS-INTRACELLULAR SIGNALING (NBIO 723A) (PHCO 723A) (PHYI 723A) (2). Prerequisite, permission of the course director. Explores biochemical signal transduction events following activation of neurotransmitter receptors including G-protein coupling, desensitization, signaling specificity, downstream effectors, calcium signaling and tryosine kinases. Course meets for five weeks with six lecture hours per week. Spring. Neurobiology faculty.
723B [223B] CELLULAR AND MOLECULAR NEUROBIOLOGY: PRESYNAPTIC MECHANISMS AND SYNAPTIC PLASTICITY (NBIO 723B) (PHCO 723B) (PHYI 723B) (2). Prerequisite, permission of the course director. Explores the mechanisms regulating the release of neurotransmitters from nerve terminals, including quantal release, vesicle and terminal membrane proteins, neurotransmitter transporters, and plasticity of synaptic transmission. Course meets for five weeks with six lecture hours per week. Spring. Stuart and faculty.
The following seminar courses are designed for students majoring or minoring in biochemistry who wish to further their knowledge in particular areas. Unless otherwise stated, two semesters of biochemistry are prerequisites for seminar courses. Most of these courses are given in alternate years by interested staff members. Unless otherwise stated, these seminars may not be repeated for credit. Seminar courses provide teaching experience, which is required for a graduate degree in biochemistry and biophysics. In addition, the courses provide experience in giving a critical review of the current literature.
801 [241] SEMINAR ON SPECIAL TOPICS IN BIOCHEMICAL RESEARCH (2). Prerequisites, two semesters of biochemistry. Covers currently active and productive areas of biochemical research. Specific subjects will be announced. May be repeated for credit. (Either semester as announced.) Staff.
802 [244] SEMINAR IN THE PHASE PROBLEM IN X-RAY CRYSTALLOGRAPHY (2). Prerequisite, permission of the instructor. Image formation is treated from a quite general point of view, drawing from Fourier transform methods used in X-ray crystallography. Isomorphous replacement, multiple wavelength anomalous scattering, and Bayesian direct methods are covered. One two-hour seminar a week. Spring (odd-numbered years.) Carter.
803 [245] SEMINAR ON CELL SIGNALING (2). Prerequisite, two semesters of biochemistry. Signal transduction in embryonic development. Spring (odd-numbered years). Maness.
804 [251] SEMINAR IN DNA-PROTEIN INTERACTIONS (2). Prerequisites, two semesters of biochemistry. Review of current literature on structural, thermodynamic, and kinetic aspects of binding to DNA of proteins involved in replication, regulation, recombination, and repair. Spring (odd-numbered years). A. Sancar.
805 [273] MOLECULAR MODELING (MEDC 805) (3). Prerequisites: MATH 231 and 232, CHEM 481. Introduction to computer-assisted molecular design, techniques, and theory with an emphasis on the practical use of molecular mechanics and quantum mechanics programs. Fall. Tropsha (coordinator).
806 [276] MACROMOLECULAR MODELING (MEDC 806) (3). Prerequisites, CHEM 430 or equivalent and permission of instructor. Applications of computational techniques to the study of macromolecular systems (protein and nucleic acid structure, molecular dynamics, free energy simulations, ligand docking). Practical use of macromolecular modeling programs in the laboratory. Two to three lecture hours and three laboratory hours per week. Spring. Tropsha (coordinator), staff.
807 [254] SEMINAR IN CELLULAR RESPONSES TO DNA DAMAGE (2). Prerequisites, graduate-level courses (one each) in molecular biology and biochemistry. A seminar course on the enzymology of DNA repair and damage tolerance and the regulation of genes involved in these processes. Both classic and recent literature are discussed. Spring. G. Sancar.
901, 902 [301, 302] RESEARCH IN BIOCHEMISTRY (3 or more). Prerequisite, permission of the department. Six or more hours a week throughout both semesters. (On demand.) Staff.
993 [393] MASTER'S THESIS (Var.). Staff.
994 [394] DOCTORAL DISSERTATION (Var.). Staff.