Department of Biomedical Engineering
H. TROY NAGLE, Founding Chair (38) Medical Devices, Microsensors
Faculty at the University of North Carolina at Chapel Hill
Professors
*Albert J. Banes (49) Cytomechanics
*Henry S. Hsiao (3) Medical Instrumentation
*Stephen Knisley (1) Biomedical Systems, Medical Devices, Medical Instrumentation, Mathematical Modeling, Cardiac Electrophysiology
Weili Lin, Medical Imaging
Terry Magnuson, Genomics, Genetics
Harold Pillsbury, Neurobiology, Cochlear Implants
Etta Pisano, Medical Imaging, Breast Cancer Research
J. Michael Ramsey, Medical Instrumentation
Barry Whitsel, Neurobiology
Adjunct Professors
Edward Chaney, Biomedical Imaging
Greg Forest, Transport Processes in the Lung, Flow and Structure of Nanomaterials and Macromolecular Fluids
Henry Fuchs, Virtual Reality
Anthony Hickey, Pharmacy
Timothy A. Johnson, Cardiac Electrophysiology
Keith Kocis, Quantifying Diaphragm Function in Children Using Ultrasonography; Femoral Artery Injury in Children; Clinical Drug Trials in Critically Ill Children.
Stephen M. Pizer, Medical Image Processing, Three-Dimensional Display Techniques
Lola M. Reid, Functional Tissue Engineering
Richard Superfine, Condensed Matter Physics, Biophysics and Microscopy
Alexander Tropsha, Computer Assisted Drug Delivery
Bradley Vaughn, Sleep Monitoring
Sean Washburn, Medical Instrumentation
Research Associate Professor
Jan Wooten
Associate Professors
*Robert Dennis (21) Tissue Mechanics, Biomechanics, Functional Tissue Engineering
*Jeffrey Macdonald (30) Metabolomics
*Roger Narayan (17) Biomedical Sensors, Medical Devices, Biomaterials, Nanometer Systems
*Mark Tommerdahl (48) Neurobiology, Image Processing and Analysis, Physiological Systems
Adjunct Associate Professors
Thomas O'Connell
Anna Spagnoli
Jeffery Y. Thompson, Biomaterials
Bing Yu, Biomechanics, Rehabilitation, Movement Analysis
Research Associate Professors
*Oleg Favorov (31) Digital Signal Processing/Multidimensional Signal Processing, Biomedical Systems, Neural Networks, Bioinformatics, Neurobiology
*Stephen R. Quint (29) Digital Signal Processing/Multidimensional Signal Processing, Biomedical Systems, Computer Applications/Software Engineering
Adjunct Research Associate Professors
*Charles C. Finley (44) Digital Signal Processing/Multidimensional Signal Processing, Medical Devices, Medical Instrumentation, Cochlear Implants
Paul Weinhold (39) Orthopaedics, Biomechanics and Biomaterials
Assistant Professors
Andrei Aleksandrov
*Gallippi, Caterina (16) Biomedical Imaging, Medical Imaging, Image Processing and Analysis
Morgan Giddings , Bioinformatics
*Sean Gomez (12) Bioinformatics, Mathematical Modeling, Genomics, Systems Biology
Adjunct Assistant Professors
Timothy Crowder, Drug Inhalation
Ekhson Holmuhamedov
Darin Padua, Sports Medicine
Research Assistant Professor
*Richard Goldberg (5) Medical Instrumentation
Professors Emeriti
N. A. Coulter Jr.
Richard N. Johnson
Carol L. Lucas
Lloyd R. Yonce
Faculty at North Carolina State University
Core Faculty
Lianne Cartee, Mathematical Modeling, Bioelectric Stimulation
Paul Dayton (19) Medical Devices, Medical Instrumentation, Biomedical Imaging, Medical Imaging
Michael Gamcsik, Biomedical Imaging, Functional Tissue Engineering, Metabolomics, Pharmacy
Edward Grant, Robotics, Biomedical Systems, Neural Networks, Biomedical Sensors, Medical Devices
David Lalush, Image Analysis, Biomedical Imaging, Medical Imaging, Bioinformatics, Image Processing and Analysis
Elizabeth Loboa, Tissue Mechanics, Cytomechanics, Modeling in Mechanobiology, Musculoskeletal Biomechanics, Biomechanics
Greg McCarty, Nanometer Systems, BioMEMS, Bioelectric Stimulation, Biochemical Engineering
Marian McCord, Medical Textiles
Peter Mente, Tissue Mechanics, Cytomechanics, Modeling in Mechanobiology, Musculoskeletal Biomechanics, Biomechanics
Hatice O. Ozturk, Digital Signal Processing/Multidimensional Signal Processing, Biomedical Image Processing and Analysis
Brooke N. Steele, Medical Imaging, Biomechanics, Physiology Systems, Mathematical Modeling, Biofluids Modeling, Simulation Based Medical Planning
Glenn Walker, BioMEMS
Associate Faculty
Nina Allen, Microscopy
Donald L. Bitzer, Bioinformatics
Mohamed Bourham, Biomedical Imaging, Medical Imaging, Fluid Dynamics, Mathematical Modeling
James J. Brickley Jr.
Gregory D. Buckner, Robotics
John Cavanaugh, Biomedical Sensors
Mo-Yuen Chow, Intelligent Systems, Bioengineering
Laura I. Clarke, Nanoscale Science and the Study of Molecular Rotors, Torsional Molecular Dynamics and Artifical Molecular Dielectrics
Stuart L. Cooper, Biomaterials
Denis Cormier, Medical Devices, Medical Instrumentation, Biomaterials, Implant Design
Paul Dayton, Medical Devices, Medical Instrumentation, Biomedical Imaging, Medical Imaging
Dan Feldheim, Nanometer Systems
Michael Gamcsik, Biomedical Imaging, Functional Tissue Engineering, Metabolomics, Pharmacy
Robin P. Gardner, Biomedical Imaging
Russell E. Gorga, Biomaterials, Functional Tissue Engineering, Medical Textiles, Microscopy
Robert Grossfeld, Neurobiology, Physiological Systems
Mansoor A. Haider, Tissue Mechanics, Biomechanics, Mathematical Modeling
S. Andrew Hale, Medical Instrumentation
Ola L. A. Harrysson, Biomedical Imaging, Biomaterials, Functional Tissue Engineering
William C. Holton, Device Simulation and Modeling, Microelectronics, Biomedical Systems, Biomedical Sensors, Medical Devices, Biomedical Imaging
Clement Kleinstreuer, Medical Instrumentation, Biomechanics, Nanometer Systems, BioMEMS, Fluid Dynamics, Physiological Systems, Mathematical Modeling
Hamid Krim, Digital Systems and Signal Processing, Medical Imaging
Andrey Kuznetsov, Medical Devices, Tissue Mechanics, Biomaterials, Biomechanics, Fluid Dynamics, Biofluids Modeling, Biochemical Engineering
Gianluca Lazzi, Computer-Aided Design, Modeling, Electromagnetic Fields, Antenna Analysis, Microwave Devices and Circuits
Sharon R. Lubkin, Tissue Mechanics, Cytomechanics, Modeling in Mechanobiology, Biomaterials, Biomechanics, Image Processing and Analysis
Nancy A. Monteiro-Riviere, Functional Tissue Engineering
John F. Muth, Optical Materials and Devices
Bruce Oberhardt, Medical Devices
Mette S. Olufsen, Biomedical Systems, Large-Scale Nonlinear Systems, Distribution Systems, Biomechanics
Behnam Pourdeyhimi, Medical Textiles
Jie Qi, Tissue Mechanics
Afsaneh Rabiei, Biomechanics
M.K. Ramasubramanian, Biomechanics
Simon C. Roe, Tissue Mechanics, Musculoskeletal Biomechanics, Biomaterials, Biomechanics
Stefan Seelecke, Biomechanics, Fluid Dynamics
Charles E. Smith, Neurobiology, Physiological Systems, Mathematical Modeling, Bioelectrical Stimulation
Wesley E. Snyder, Digital Signal Processing, Multidimensional Signal Processing, Adaptive Signal Processing, Image Analysis, Computer Vision, Robotics
Larry F. Stikeleather, Biomechanics
Anne Stomp, Genomics
Michael K. Stoskopf, Veterinary Medicine
Donald E. Thrall, Veterinary Medicine
Alan E. Tonelli, Biomedical Systems, Biomedical Sensors, Medical Devices, Nanometer Systems, Functional Tissue Engineering
Anka N. Veleva, Biomaterials, Biochemical Engineering
Mladen A. Vouk, Digital Signal Processing, Multidimensional Signal Processing, Reliability Computer Applications, Software Engineering, Large Programs
Donald J. Woodward
Professors Emeriti
C. Frank Abrams, Tissue Mechanics, Biomechanics
* basic teaching faculty
Biomedical engineering is a dynamic field stressing the application of engineering techniques and mathematical analysis to biomedical problems. Faculty research programs are key to the program, and they include digital systems and signal processing, instrumentation, telemedicine, microelectronics, medical imaging, biofluids and biomechanics, biomaterials and tissue engineering, biosystems analysis and biomedical informatics. Facilities include a biomedical sensors laboratory, a tissue engineering laboratory, tissue and cell mechanics laboratories and an array of cell culturing and computing resources. The department offers graduate education in biomedical engineering leading to the master of science and doctor of philosophy degrees. Also, a new joint graduate certificate in medical devices is to be offered.
Students enter this program with backgrounds in engineering, physical science, mathematics or biological science. Curricula are tailored to fit the needs and develop the potential of individual students. In addition, courses in statistics, mathematics, life sciences and engineering sciences provide a well-rounded background of knowledge and skills.
The Joint Biomedical Engineering Graduate Program is administered by the combined biomedical engineering graduate faculty from both North Carolina State University and the University of North Carolina at Chapel Hill. The joint program also has close working relations with the Research Triangle Institute and industries in the Research Triangle area. These associations enable students to obtain research training in a wide variety of fields and facilitate the selection and performance of dissertation research. Students in the joint program may study under faculty members based at the University of North Carolina at Chapel Hill or at North Carolina State University. The department, thus, provides students with excellent opportunities to realize the goal of enhancing medical care through the application of modern technology.
Admission Requirements
Students must satisfy all entrance requirements for The Graduate School of the University of North Carolina at Chapel Hill or the Graduate School at North Carolina State University, and must demonstrate interest and capability commensurate with the quality of the biomedical engineering program. Prospective students may apply to the graduate school at either UNC-Chapel Hill or NC State. All applicants are considered together as a group. Generally, applications should be submitted by January 15 for consideration for admission in the coming fall semester. Applicants are expected to present Graduate Record Examination (GRE) scores; scores for verbal and quantitative should be at or above the 50th percentile to be competitive. The program requires that a one-to-three page personal statement about research interest and background be submitted.
Students should have a good working knowledge of mathematics at least through differential equations, plus two years of physical or engineering science and basic courses in biological science. Deficiencies in preparation can be made up in the first year of graduate training.
Requirements for Degrees
Candidates for the UNC-Chapel Hill/NC State jointly issued degrees in biomedical engineering must have met the general requirements of The Graduate School of the University of North Carolina at Chapel Hill or the North Carolina State University Graduate School. Master's students are required to take a comprehensive examination, encompassing coursework and thesis research. The master's comprehensive exam may be either written or oral, and is administered by the students advisory committee. Doctoral students qualify for the Ph.D. degree by meeting grade requirements in their core courses, and then advance on to written and oral preliminary exams before admission to candidacy. Details can be found on the department Web site at www.bme.ncsu.edu/academics/graduate/Exams.html. Degree candidates in this program are expected to obtain experience working in a research laboratory during their residence and to demonstrate proficiency in both teaching and research. The Ph.D. dissertation should be judged by the graduate committee to be of publishable quality.
UNC-Chapel Hill Biomedical Engineering Courses
Courses for Graduates and Advanced Undergraduates
* core curriculum courses
*400 [100] INTRODUCTION TO BIOMEDICAL ENGINEERING (1). Seminar introducing students to biomedical engineering research, including literature search, faculty presentation of ongoing research and student discussion of research papers. Fall. Staff.
*430 [121] DIGITAL SIGNAL PROCESSING I (APPL 430) (3). Prerequisite, COMP 110 or 116 or equivalent. This is an introduction to methods of automatic computation of specific relevance to biomedical problems. Sampling theory, analog-to-digital conversion, digital filtering will be explored in depth. Spring. Lucas.
*450 [132] LINEAR CONTROL THEORY (APPL 450) (4). Prerequisite, MATH 528 or equivalent. Linear control system analysis and design are presented. Frequency and time domain characteristics and stability are studied. These techniques are applied in an included laboratory. Fall. Quint.
460 [110] SURVEY OF ENGINEERING MATH APPLICATIONS (APPL 460) (1). Computational laboratory that surveys engineering math with emphasis on differential equations, and Laplace and Fourier analysis. Applications in biomedical engineering emphasized through problem set computation using Matlab. This course should be taken concurrently with MATH 528. Fall. Finley.
*465 [111] BIOMEDICAL INSTRUMENTATION I (APPL 465) (4). Prerequisite, PHYS 351. Topics include basic electronic circuit design, analysis of medical instrumentation circuits, physiologic transducers (pressure, flow, bioelectric, temperate, and displacement). This course includes a laboratory where the student builds biomedical devices. Spring. Hsiao.
505 [102] BIOMECHANICS (3). Prerequisites, MATH 383, PHYS 116 and permission of instructor. Fundamental principles of solid and fluid mechanics applied to biological systems. Human gait analysis, joint replacement, testing techniques for biological structures and viscoelastic models are presented. Papers from current biomechanics literature will be discussed.
510 [112] BIOMATERIALS (APPL 510) (3). Prerequisite, BMME 589 or one year of college-level biology. Chemical, physical engineering and biocompatibility aspects of materials, devices or systems for implantation in or interfering with the body cells or tissues. Food and Drug Administration and legal aspects. Fall. Banes/Narayan.
515 [153] BIOMATHEMATICAL MODELING (3). Prerequisite, engineering-level mathematics, e.g., MATH 383, 528. Various approaches to mathematical modeling of biological systems will be considered. The major focus at the cellular level will be expanded to include examples in organs, organisms and populations.
520 [160] FUNDAMENTALS OF MATERIALS ENGINEERING (3). The structure, defects, thermodynamics, kinetics and properties (mechanical, electrical, thermal and magnetic) of matter (metals, ceramics, polymers and composites) will be considered. Spring. Staff.
532 [154] MICROELECTRODE TECHNIQUES (4). Prerequisites, BIOL 101 and PHYS 351 or equivalent. Models for measurement of cellular transmembrane voltages with microelectrodes are introduced. Basic and technical aspects of the measurements are described. Students fabricate microelectrodes and measure action potentials in living cells.
550 [141] MEDICAL IMAGING: ULTRASONIC, OPTICAL AND MAGNETIC RESONANCE SYSTEMS (3). Prerequisites, BIOS 550, BMME 430 and PHYS 128. Physical and mathematical foundations of ultrasonic, optical and magnetic resonance imaging systems in application to medical diagnostics. Each imaging modality is examined on a case-by-case basis, highlighting the following critical system characteristics: 1) underlying physics of the imaging system, including the physical mechanisms of data generation and acquisition; 2) image creation and 3) basic processing methods of high relevance, such as noise reduction. Fall. (Alternate years.) Gallippi.
560 [142] MEDICAL IMAGING: X-RAY, CT AND NUCLEAR MEDICINE SYSTEMS (3). Prerequisites, APPL 410, BIOS 550 and PHYS 128. Overview of medical imaging systems using ionizing radiation. Interaction of radiation with matter. Radiation production and detection. Radiography systems and applications. Tomography. PET and SPECT systems and applications. Fall. (Alternate years.) Lalush.
*570 [151] FROM GENES TO TISSUES: MOLECULAR BIOLOGY AND GENETICS FOR BIOMEDICAL ENGINEERS (4). Prerequisites, undergraduate organic chemistry or biochemistry and undergraduate biology, or permission of the instructor. An introduction to molecular, cell and tissue biology for BMME students covering molecular genetics, gene expression, self-assembling mechanisms, metabolism, bioenergetics, cell organelles, regulation of growth and differentiation and signaling. Fall. Macdonald, Bernacki.
580 [120] MICROCONTROLLER APPLICATIONS I (3). Introduction to digital computers for online, real-time processing and control of signals and systems. Programming analog and digital input and output devices using C and assembly language is stressed. Case studies are used as vehicles to present software design strategies for real-time laboratory systems.
581 [220] MICROCONTROLLER APPLICATIONS II (3). Prerequisites, BMME 465 and 580. Problems of interfacing computers with biomedical and systems are studied. Students collaborate to develop a new biomedical instrument. Projects have included process control, data acquisition, disk systems interfaces and DMW interfaces between interconnected computers.
*589 [181] SYSTEMS PHYSIOLOGY FOR BIOMEDICAL ENGINEERS (5). Prerequisites, six hours of undergraduate biology or chemistry and permission of the instructor. A graduate-level introduction to systems and organ physiology. Topics covered will include membrane structure and physiology, muscle physiology, central neural systems, cardiac electrophysiology and endocrinology. Fall. Tommerdahl.
Courses for Graduate Students
705 [260] BIOMATERIALS INSTRUMENTATION (3). Prerequisite, BMME 520 or permission of the instructor. Within a laboratory environment, the fundamental or engineering properties of various biomaterials are evaluated. Scientific methodology, data analysis and technical report writing are stressed. Spring.
730 [223] DIGITAL SIGNAL PROCESSING II (3). Prerequisites, BMME 430, MATH 528 and BMME 450 or equivalent. Advanced techniques for analyzing biomedical systems and signals are presented, including signal characterization, pattern recognition and parameter estimation. Examples from biomedical literature are studied. Spring. Favorov.
740 [212] ADVANCED BIOMATERIALS (MTSC 740) (3). Prerequisite, BMME 510 or permission of the instructor. Medical or dental implants or explants are highlighted from textbooks, scientific literature and personal accounts. Spring. Banes, Narayan.
750 [232] DIGITAL CONTROL THEORY (3). Prerequisite, BMME 450 or equivalent. Discrete time systems performance and stability are represented in the time and frequency domains. Series compensation and state variable design techniques are studied. Student projects include discrete time control designs, simulations and implementation using laboratory devices. Spring. Quint.
760 [235] FINITE ELEMENT ANALYSIS (3). Prerequisites, BMME 405 or equivalent and permission of the instructor. The underlying principles associated with the finite element method are presented along with applications. Topics to be included are the development of the stiffness matrix, node numbering schemes, potential energy and the Rayleigh-Ritz method, and element selection. Fall (odd-numbered years). Weinhold.
765 [201] BIOMEDICAL INSTRUMENTATION II (3). Prerequisite, BMME 465 or permission of the instructor. The fundamentals of interfacing microprocessors and microcomputers with physiological transducers. Practical circuit design problems are presented with biomedical applications. This course includes a laboratory and individual student projects. Fall. Hsiao.
770 [251] PHYSIOLOGY AND METHODS IN GENOMICS (5). Prerequisites, BMME 570 or undergraduate organic chemistry or biochemistry and undergraduate biology or with permission of instructor. Lectures in physiology systems and lab techniques covering various functional genomic methods including DNA sequencing, gene arrays, proteomics, confocal microscopy and imaging modalities. Spring. Macdonald, Bernacki.
775 [259] IMAGE PROCESSING AND ANALYSIS (COMP 775) (3). Prerequisites, COMP 665, MATH 547 and STAT 435. Approaches to analysis of digital images. Scale geometry, statistical pattern recognition, optimization. Segmentation, registration, shape analysis. Applications, software tools.
780 [220] REAL-TIME COMPUTER APPLICATIONS II (3). Prerequisites, BMME 480, 465. Problems of interfacing computers with biomedical and systems are studied. Students collaborate to develop a new biomedical instrument. Projects have included process control, data acquisition, disk systems interfaces, and DMW interfaces between interconnected computers. Spring. Goldberg.
*790 [281] SYSTEMS PHYSIOLOGY FOR BIOMEDICAL ENGINEERS II (3). Prerequisite, BMME 589. This is the second semester of the two-semester series intended to provide graduate students with an introduction to systems and organ physiology. Spring. Tommerdahl.
795 [282] INFORMATION PROCESSING IN THE CENTRAL NERVOUS SYSTEM (3). Prerequisite, BMME 589. Introduction to methodologies used to characterize a) the aggregate behavior of living neural networks and b) the changes in that behavior that occurs as a function of stimulus properties, pharmacological manipulations and other factors that dynamically modify the functional status of the network. Spring. (Alternate years.) Tommerdahl.
810 [252] DIGITAL NUCLEAR IMAGING (3). Prerequisites, BMME 550, 560. Advanced topics of physics and instrumentation in nuclear imaging and magnetic resonance techniques. Fall. (Alternate years.)
820 [253] ADVANCED MEDICAL IMAGE PROCESSING (3). Prerequisites, BMME 550, 560. Theory and digital implementation of image processing and reconstruction techniques applied in medical imaging are discussed. Specific topics include filtering, edge detection and image reconstruction algorithms. Spring. (Alternate years.)
840 [290] REHABILITATION ENGINEERING DESIGN (4). Prerequisites, BMME 465 or permission of the instructor. Students will design an assistive technology device to help individuals with disabilities to become more independent. The project will be used in the community when it is completed. Spring. Goldberg.
860 [230] NUMERICAL METHODS FOR BIOMEDICAL ENGINEERING (3). Prerequisite, MATH 383, BMME 480, or experience in Car Fortran programming. Emphasis on numerical methods for solving inverse problems relevant to biomedical engineering, Matrix inversion, singular value decomposition and parameter estimation are covered with an emphasis on application of the methods. Fall. (Alternate years.) Favorov.
890 [231] SPECIAL TOPICS (Hours to be arranged.) Prerequisite, permission of the instructor. Special library and/or laboratory work on an individual basis on specific problems in biomedical engineering and biomedical mathematics. Direction of students is on a tutorial basis and subject matter is selected on the basis of individual needs and interests. Fall and spring. Staff.
900 [311] RESEARCH IN BIOMEDICAL ENGINEERING AND BIOMATHEMATICS (Hours to be arranged.) Prerequisite, permission of the instructor. Staff.
910L [300] LABORATORY ROTATION IN BIOMEDICAL ENGINEERING (1). Laboratory practicum in a University of North Carolina at Chapel Hill lab. Observational and hands-on experience in state-of-the-art biomedical laboratories with bioengineering faculty/preceptor. Fall and spring. Hsiao.
920L [301] LABORATORY ROTATION IN FUNCTIONAL GENOMICS (1). Prerequisites, BMME 570 and permission of the instructor. Students are required to work in two laboratories that involve 1) the creation and analysis of mouse technologies and 2) developing technologies (biosensors or imaging) for use in functional genomics. Spring. Macdonald.
993 [393] MASTER'S THESIS (Hours to be arranged.) Staff.
994 [394] DOCTORAL DISSERTATION (Hours to be arranged.) Staff.
North Carolina State University Biomedical
Engineering Courses
512 BIOMEDICAL SIGNAL PROCESSING (3) Prerequisites, BME 311, and ST 370 or ST 371; BME or graduate standing only. (Credit is not allowed for both BME 412 and BME 512.) Fundamentals of continuous- and discrete-time signal processing as applied to problems in biomedical instrumentation. Properties of biomedical signals and instruments. Descriptions of random noise and signal processes. Interactions between random biomedical signals and systems. Wiener filtering. Sampling theory. Discrete-time signal analysis. Applications of Z-transform and discrete Fourier transform. Digital filter design methods for biomedical instruments. Spring. Lalush.
522 MEDICAL INSTRUMENTATION (3). Students should have a background in electronics design using operational amplifiers Fundamentals of medical instrumentation systems, sensors, and biomedical signal processing. Example instruments for cardiovascular and respiratory assessment. Clinical laboratory measurements, therapeutic and prosthetic devices, and electrical safety requirements.
525 BIOELECTRICITY (3). Prerequisites, BME 302 or ZO 421 and a course in electrical circuits; senior or graduate standing. (Credit is not given for both BME 425 and BME 525.) Quantitative analysis of excitable membranes and their signals, including plasma membrane characteristics, origin of electrical membrane potentials, action potentials, voltage clamp experiments, the Hodgkin-Huxley equations, propagation, subthreshold stimuli, extracellular fields, membrane biophysics and electrophysiology of the heart. Design and development of an electrocardiogram analysis system. Fall. Cartee.
541 BIOMECHANICS (3). Prerequisites, ZO 160 or BIO 183, BME 342, ST 370. (Credit is not allowed for both BME 441 and BME 541.) Students study human body kinematics, force analysis of joints, and the structure and composition of biological materials. Emphasis is placed on the measurement of mechanical properties and the development and understanding of models of biological material. Fall. Mente.
543 CARDIOVASCULAR BIOMECHANICS (3). Prerequisites, BME 302, MAE 308 or CE 382. Engineering principles are applied to the cardiovascular system. Anatomy of cardiovascular system; form and function of blood and blood vessels. Electric analogs; continuum mechanics with derivation of equations of motion; and constitutive models of soft tissue mechanics, with attention to normal, diseased and adaptive processes. Programming project required. Fall. Steele.
550 MEDICAL IMAGING: ULTRASONIC, OPTICAL, AND MAGNETIC RESONANCE SYSTEMS (3). Prerequisites, BME 412, ST 370 or ST 371, and PY 208. Physical and mathematical foundations of ultrasonic, optical and magnetic resonance imaging systems in application to medical diagnostics. Each imaging modality is examined on a case-by-case basis, highlighting the following critical system characteristics: 1) underlying physics of the imaging system, including the physical mechanisms of data generation and acquisition 2) image creation and 3) basic processing methods of high relevance, such as noise reduction. Alternate Fall. Gallippi.
551 MEDICAL DEVICE DESIGN I (3). Prerequisite, graduate standing. Student multidisciplinary teams work with local medical professionals to define specific medical device concepts for implementation. Medical specialty immersion with clinical departments at local medical centers; design input based on stakeholder-needs assessment, market analysis and intellectual property review, new medical devices with broad markets, design output and device specification, product feasibility and risk assessment, design for medical device manufacturing. Fall. Nagle.
552 MEDICAL DEVICE DESIGN II (3). Prerequisite,: BME 551. Student groups build and test prototypes of devices designed in the first course of this series. Good manufacturing practices, process validation, FDA quality system regulations, design verification and validation, regulatory approval planning and intellectual property protection. Students will work with local patent attorneys and/or agents to draft a patent application. The final prototypes will be evaluated by clinicians for potential use with patients. Spring. Nagle.
560 MEDICAL IMAGING: X-RAY, CT AND NUCLEAR MEDICINE SYSTEMS (3). Prerequisites: BME 311, ST 370 or ST 371, and PY 208. Overview of medical imaging systems using ionizing radiation. Interaction of radiation with matter. Radiation production and detection. Radiography systems and applications. Tomography. PET and SPECT systems and applications. Alternate Fall. Lalush.
590 SPECIAL TOPICS (1–4). Prerequisite, senior or graduate standing in engineering or physical or biological sciences. A study of topics in the special fields under the direction of the graduate faculty. Fall, spring and summer. Staff.
590R LABORATORY ROTATION IN BIOMEDICAL ENGINEERING (1). Laboratory practicum in a North Carolina State University lab. Observational and hands-on experience in state-of-the-art biomedical laboratories with bioengineering faculty/preceptor. Fall and spring. Knisley.
601 BIOMEDICAL ENGINEERING SEMINAR (1). Prerequisite, graduate standing. Elaboration of subject areas, techniques and methods important in biomedical engineering through presentations of personal and published works; opportunity to present and critically defend ideas, concepts and inferences. Discussions to identify analytical solutions and analogies between problems in biomedical engineering and other technologies, and to present relationship of biomedical engineering to societal needs. Fall and spring.
620 BIOMEDICAL ENGINEERING: SPECIAL PROBLEMS (1–4). Prerequisite, graduate standing in biomedical engineering. Selection of a subject by each student on which to do research and write a technical report on the results. Subject may pertain to the student's particular interest in any area of study in biomedical engineering. Fall, spring and summer.
650 INTERNSHIP IN BIOMEDICAL ENGINEERING (1–3). Prerequisite, graduate standing in biomedical engineering. Students obtain professional experience through advanced engineering work in industrial and commercial settings under joint supervision of a member of the graduate faculty and an outside professional. Fall, spring and summer.
790 ADVANCED SPECIAL TOPICS (1–4). Prerequisite, graduate standing in engineering, physical or biological sciences. A study of topics in advanced or emerging special areas under the direction of the graduate faculty. Experimental doctoral level courses. Fall, spring and summer.
802 BIOMEDICAL ENGINEERING ADVANCED SEMINAR (1). Elaboration of advanced subject areas, techniques and methods related to professional interest through presentations of personal and published works; opportunity for students to present and critically defend ideas, concepts and inferences; opportunity for distinguished scholars to present results of their work. Discussions to uncover analytical solutions and analogies between problems in biomedical engineering and other technologies, and to present relationship of biomedical engineering to society. Fall and spring.