H. HOLDEN THORP, Chair
Tomas Baer (1) Physical Chemistry
Max L. Berkowitz (30) Physical Chemistry
Maurice S. Brookhart (2) Organic and Organometallic Chemistry
Michael T. Crimmins (39) Organic Chemistry
Joseph M. DeSimone (49) Synthetic Polymer Chemistry
Malcolm D. E. Forbes (48) Organic and Physical Chemistry
Gary L. Glish (40) Analytical Chemistry
Eugene A. Irene (38) Electronic Materials, Solid State Chemistry
Charles S. Johnson Jr. (18) Physical Chemistry
James W. Jorgenson (36) Analytical Chemistry
Paul J. Kropp (20) Organic Chemistry
Susan T. Lord (50) Biological Chemistry
Thomas J. Meyer (23) Inorganic Chemistry
Royce W. Murray (25) Analytical Chemistry
Lee G. Pedersen (26) Physical Chemistry
Gary J. Pielak (46) Biological Chemistry
J. Michael Ramsey (62) Analytical Chemistry
Michael Rubinstein (43) Polymer Physical Chemistry
Edward T. Samulski (44) Polymer Physical Chemistry
Thomas N. Sorrell (35) Organic Chemistry
Linda L. Spremulli (28) Biological Chemistry
Joseph L. Templeton (31) Inorganic Chemistry
Nancy L. Thompson (41) Physical and Biological Chemistry
H. Holden Thorp (51) Inorganic Chemistry
R. Mark Wightman (47) Analytical and Neurochemistry
Richard V. Wolfenden (65) Biological Chemistry
Valerie Sheares Ashby (61) Polymer and Materials Chemistry
Dorothy A. Erie (11) Physical and Biological Chemistry
Michel R. Gagné (22) Inorganic, Organic, and Polymer Chemistry
Wenbin Lin (60) Inorganic Chemistry
John M. Papanikolas (52) Physical Chemistry
Matthew Redinbo (55) Biological Chemistry
Cynthia K. Schauer (45) Inorganic Chemistry
Mark H. Schoenfisch (57) Analytical and Materials Chemistry
Sergei S. Sheyko (59) Polymer and Materials Chemistry
Marcey Waters (56) Organic Chemistry
Kevin M. Weeks (53) Biological Chemistry
Todd L. Austell (70) Chemistry Education, Academic Advising, Lab Curriculum Development
Brian P. Hogan, Chemistry Education, Lab Curriculum Development
Jeffrey S. Johnson (58) Organic Chemistry
Garegin A. Papoian (63) Physical Chemistry
Domenic Tiani (71) Chemistry Education, Academic Advising, Lab Curriculum Development
Muhammad N. Yousaf (64) Biological Chemistry
Richard P. Buck
Maurice M. Bursey
Francis N. Collier
James L. Coke
Henry H. Dearman
Ernest L. Eliel
Richard G. Hiskey
Richard C. Jarnagin
Donald C. Jicha
William F. Little
Robert G. Parr
The Department of Chemistry offers graduate programs leading to the degrees of master of arts, master of science (nonthesis), and doctor of philosophy in the fields of analytical, biological, inorganic, organic, physical, and polymer and materials chemistry. Close interaction between the departments of Chemistry, Physics, Biochemistry, and Environmental Sciences and Engineering reinforces the broad nature of the graduate research program.
The PhD degree in chemistry is a research degree and students normally begin research during the first year in graduate school. As soon as the entering student has selected a research advisor, an advisory committee is established to develop an appropriate course of study designed to meet individual needs. The PhD degree consists of completion of a suitable program of study, a preliminary doctoral oral examination, a written comprehensive examination that is satisfied by cumulative examinations, an original research project culminating in a dissertation, and a final oral examination.
The master of arts degree requires a minimum of thirty semester hours of credit. Courses are determined by the student's advisory committee. A written comprehensive examination (which may be satisfied by cumulative examinations), a thesis, and a final oral examination are also required. Admission to the PhD program after completion of the MA degree in the department requires approval by the Chemistry Graduate Studies Committee.
The master of science (nonthesis) degree requires a minimum of thirty semester hours. The candidate must earn at least twenty-four hours of graduate credit in chemistry and allied subjects, which may include graduate seminars numbered 700 or higher but may not include CHEM 921, 931, 941, 951, 961, and 981 (referred to collectively as "9X1"). As a substitute for the thesis the candidate must earn a minimum of three hours of CHEM 992 (master's nonthesis option). The student's program of study is determined by the student's advisory committee. A written report submitted to the student's research director describing work done while registered for CHEM 992 and a written examination (which may be satisfied by cumulative examinations) are also required. Admission to the PhD program after completing the MS degree in the department requires approval by the Chemistry Graduate Studies Committee.
Analytical. . Chemical separations: Development of instrumentation for ultra-high pressure capillary liquid chromatography, capillary electrophoresis, and combined two-dimensional separations. Applications include proteomics and measurement of peptide hormones in biological tissues. Mass spectrometry: of biological, environmental, organic, and polymeric compounds; tandem MS, ion activation, ion molecule reactions; instrument development. Electrochemistry: new methods for study of biological media, neurotransmitters small spaces, redox solids, chemically modified surfaces, nanoparticle chemistry, and quantum size effects including the analytical chemistry of nanoparticles. Chemical microsystems: Microfabricated fluidics technologies, or lab-on-a-chip devices, are being developed to address biological measurement problems such as protein expression, cell signaling and cancer diagnostics. Miniaturized mass spectrometers, in addition to microfluidics, are being developed for environmental monitoring. Nanoscale fluidics devices are being developed for single molecule DNA sequencing and chemical sensing. Biomaterials: synthesis and characterization of in vivo sensor membranes, medical device coatings, nanoparticle therapeutics, and their physiological impact; analysis of proteins and cells at surfaces.
Biological. Kinetics and mechanisms of complex biochemical processes; mechanism of protein biosynthesis; metabolic regulation; gene organization and regulation of gene expression; structural studies of macromolecules; protein structure and function using nuclear magnetic resonance spectroscopy, protein folding and site-directed mutagenesis; in-cell NMR; the thermodynamics of protein-protein interactions; characterization of protein/DNA complexes using scanning force microscopy and rapid mixing techniques; RNA structure in vivo, assembly of complex RNA-protein architectures, protein-facilitation of RNA catalysis; nucleic acid-based biosensors; chemical synthesis of peptides and proteins; protein engineering through chemical synthesis; biochemical studies of the serum complement and clotting cascades; molecular immunology; computer graphics and molecular modeling of biomolecules; mathematical methods for comparison of genetic sequences; cell surface biophysics; fluorescence microscopy and spectroscopy; cell migration on tailored surfaces; small molecule and protein microarray development; live cell fluorescence microscopy.
Inorganic. Physical inorganic chemistry: electronic structure of transition metal complexes; photochemistry and electrochemistry of metal complexes; molecular orbital theory, nuclear magnetic resonance and electron paramagnetic resonance spectroscopies; X-ray crystallography; infrared and Raman spectroscopies. Chemistry of transition metal complexes: synthesis of transition metal compounds, organometallic chemistry including metal-catalyzed organic reactions; reactions of coordinated ligands; kinetics and mechanisms of inorganic reactions; metal cluster chemistry; chiral supramolecular chemistry. Materials chemistry: molecular precursors to materials; solid state lattice design; metal-ion containing thin films; metal-polymer complexes; functional coordination polymers; chiral porous solids. Bioinorganic chemistry: reactivity of oxidized metal complexes with nucleic acids, photo-induced DNA cleavage, synthesis and characterization of model complexes for metalloenzymes.
Organic. Synthesis and biological reactions of natural products; peptide synthesis; protein engineering; structure-function studies on polypeptides and proteins; mechanistic and synthetic studies in organometallic chemistry; catalysis using organometallic complexes; nuclear magnetic resonance; kinetics; organosulfur and organophosphorus chemistry; surface effects in chemical behavior; chemistry of reactive intermediates including carbocations, carbanions, carbenes and radical pairs; new synthetic methods including asymmetric synthesis; stereochemistry and conformational analysis; design and synthesis of models for metalloenzymes; epr investigations of electronic couplings in high-spin organic molecules; spectroscopic studies of free radicals; synthesis and characterization of well-defined polymeric materials; synthesis of materials for use in microelectronics; homogeneous and heterogeneous polymerizations in supercritical fluids; synthesis of engineering polymers; molecular recognition.
Physical Chemistry. Surface science: electron and optical spectroscopies of surface complexes, thermal desorption and isotopic tracer measurement on species of submonolayer coverage, surface etching and deposition initiated by electric discharges, ion beams and laser beams, mechanisms of reactive etching. Gas-surface energy transfer and catalytic reactivity probed by laser spectroscopies. Molecular dynamics: photoionization and multi-photonionization mass spectroscopy, state-to-state ion molecule reactions, crossed molecular beam scattering, molecular motion and reaction rates in solutions examined by photon correlation spectroscopy and holographic relaxation spectroscopy, laser-induced vibrational dynamics. Biophysical chemistry: membrane phenomena, physical chemistry of DNA complexes, nonlinear kinetics and cell differentiation, phospholipid Langmuir-Blodgett films, time-resolved fluorescence microscopy, laser light scattering applied to protein aggregation and the determination of mechanical properties of biological gels, dynamics in liquids. Photochemistry: photoelectron spectroscopy of molecules, photolytic charge separation and transport in organic solids and liquids, multi-photonionization and fragmentation, state-to-state dynamics.
Molecular Spectroscopy: laser spectroscopy in cooled molecular beams of transient species, ions and molecular complexes, subdoppler infrared spectroscopy, ion photodissociation studies, development of spectroscopic techniques, double resonance spectroscopy, pulsed field gradient NMR and NMR imaging. Application of optical and mass spectroscopies to the study of atmospheric chemistry.
Theoretical Chemistry: quantum chemistry, density functional theory, quantum biology of neurotransmitters and pharmacological agents, energy minimization, protein dynamics, cooperativity, molecular graphics, mutagenesis, statistical mechanics of a liquid phase, structure and dynamics of aqueous solutions, kinetics in condensed phases, mechanical properties of polymers, state-to-state chemistry, reactions and energy transfer at solid surfaces. Polymer properties: preparation of and nonlinear optical effects in polymeric systems, self-organized polymers, and liquid crystalline materials.
Polymer and Materials Chemistry. Many challenging problems in modern science and technology are related to the preparation, properties, and utilization of novel functional materials. The polymer chemistry, drug delivery, and chemical microelectronics programs represent parts of the multidisciplinary effort in this field. The many-pronged approach includes: synthesis and molecular characterization of well-defined block and graft copolymers; design of multifunctional monomers and polymers, preparation of new engineering thermoplastics and liquid crystalline materials; synthesis, modification and processing of polymers in super-critical carbon dioxide; chemical design of hybrid polymers for catalysis and photoredox activity, polymers for imprint lithography and nano-molding, and defined microstructures. Recent efforts funded by the National Cancer Institute and NIH for employing lithographic techniques from the electronics industry to make organic nano-particles for the detection, diagnosis, and treatment of diseases, especially cancer. Chemical microelectronics is focused on preparation of organic and inorganic electronic materials; microscopic patterning of thin films using novel techniques (plasma, ion beam, laser beam, etc.); kinetics of etching and film formation; characterization of mechanical, electronic, and optical properties; spatially resolved chemical analysis of surfaces, interfaces, and thin films and microstructures. A broad variety of expertise includes visualization and probing of submicrometer surface structures by scanning probe microscopy, characterization of polymer dynamics by NMR techniques and light scattering, measurement of molecular conductivity, and analytical as well as computational and numerical methods in polymers.
Biotechnology. The University has instituted a program in Molecular Biology and Biotechnology. This program is an umbrella covering faculty and their research programs located in various departments including Biochemistry and Biophysics, Microbiology, Pathology, Biology, and Chemistry. Some of the research being carried out in this field includes recombinant DNA technology, molecular genetics, atomic force microscopy, protein biosynthesis, enzymology, protein engineering, monoclonal antibodies, protein molecular dynamics, molecular modeling, and site-directed mutagenesis. Attention is drawn to the possibility of arranging, through consultations with staff of the departments of Chemistry and Physics, a program combining course work in the two departments with thesis research in either department. Such a program would provide training in an area in which methods of theoretical and experimental physics are applied to chemical problems.
Research is carried out in the William Rand Kenan Jr. Laboratories, a facility of 130,000 square feet completed in 1971, and the W. Lowry and Susan S. Caudill Laboratories, an exciting new facility of 71,000 square feet completed in 2006. The undergraduate laboratories are housed in the modern John Motley Morehead Laboratories, completed in 1986. Included in the department are some major facilities managed by PhD-level staff scientists. The NMR laboratory includes 6 high-resolution FT-NMR spectrometers ranging from 300 to 600 MHz for liquids: 300 MHz, two 400 MHz and 500MHz Bruker spectrometers, and 300 MHz and 600 MHz Varian spectrometers. There is also a Bruker 360 MHz wide bore FT-NMR spectrometer suitable for solid polymeric samples with magic angle spinning. The MS laboratory houses a Bruker BioTOF II Reflectron Time of Flight Mass Spectrometer (ESI/nESI), an Agilent HPLC Quadrupole Mass Spectrometer (ESI, APCI), and a Micromass Quattro II Triple Quadrupole Mass Spectrometer. The X-ray laboratory is equipped with a new Bruker AXS SMART APEX2 single crystal diffractometer and Rigaku Multiflex powder diffractometer.
Computing services are among the most important for modern research. The University computing resources that currently reside in Information Technology Services (ITS) include a SGI Altix 3700bx2 system with 128 Intel Itanium2 processors (1600MHz), a Dell cluster with 520 PowerEdge 1855 servers with dual Intel EM64T 3.6 GHZ processors (total 1040 processors), a Beowulf Linux cluster with 135 Dual processor servers, an IBM 690 (32 processors), and a variety of specialty machines that provide services for statistics, bioinformatics, and database applications. A number of the individual research laboratories in Chemistry own Silicon Graphics or Linux based workstations. Numerous software packages of interest to chemical, biochemical and materials researchers are maintained for use on central systems by the ITS Research Computing group (Accelrys, Gaussian, MolPro, NWChem, CPMD, AMBER, Gromacs, Felix, Sybyl, SAS, Stata, Mathematica, ECCE, Gaussview, etc). The combined hardware and software resources are tailored to meet the needs of a broad range of chemists working on applications in quantum mechanics, molecular dynamics, NMR, X-RAY, structural biology, and bioinformatics.
To support the research programs, the department provides a number of services. Instrument, glass, and electronics shops are provided to assist in construction and maintenance of specialized equipment. Technicians are also available to run certain specialized instruments.
The William Rand Kenan Jr. Chemistry Library is currently being housed in temporary quarters in the Wilson Library annex and is scheduled to move into "New Venable" upon its completion in 2009. During this temporary period the Chemistry Library is sharing space and combining some services with the Zoology Library. The entrance to the combined Chemistry/Zoology Library is on the south side of Wilson Library, across the street from the Bell Tower. Most Chemistry Library journal subscriptions and databases are available online for 24-hour access from campus workstations and other workstations that meet licensing requirements. The Chemistry collection also includes many print reference works and monographs that are available for checkout or use in the reading room when the library is open. Reference and instructional services are also available at the library service desk and by arrangement with library staff.
The department awards a number of industrial fellowships and predoctoral research and teaching appointments. All outstanding prospective graduate students who apply for admission/support are automatically considered for fellowships.
There are over 200 graduate students in the department. All are supported either as teaching assistants (27%), research assistants (65%), or as Fellows (8%) supported by The Graduate School, industry, or the United States government. The duties of the teaching assistants include the preparation for and supervision of laboratory classes in undergraduate courses and the grading of laboratory reports.
Applications for assistantships and fellowships should be made before the end of January, although applicants for assistantships are considered after that date. All applicants (international and domestic) must take the Graduate Record Examination (GRE). All international students whose native language is not English must take the Test of English as a Foreign Language (TOEFL) examination in addition to the Graduate Record Examination. However, international students who hold a degree from a university in the United States may be exempt. Both the TOEFL and the GRE should be taken as early as possible for fall acceptance, preferably in October.
Application forms for admission/support, as well as information about the department, should be obtained from the Chemistry Department Web site, www.chem.unc.edu. Questions may be directed to: chemgs@unc.edu.
396 [101] SPECIAL PROBLEMS IN CHEMISTRY (1-3). Prerequisite, to be determined by consultation with vice-chair of Undergraduate Studies. Equivalent of one to three hours a week. Fall and spring. Chemistry faculty.
420 [120] INTRODUCTION TO POLYMER CHEMISTRY (APPL 420) (3). Prerequisite, CHEM 261 or 261H; prerequisites or corequisites, CHEM 262 or 262H, 262L or 263L. Introduction to polymer chemistry; synthesis and reactions of polymers; thermodynamics and kinetics of polymerization; physical characterization of polymers; industrial uses of polymers. Fall. Organic and Physical Chemistry faculty.
421 [121] SYNTHESIS OF POLYMERS (APPL 421) (MTSC 421) 3). Prerequisites, CHEM 251, 262 or 262H. Synthesis and reactions of polymers. Fall. Organic and Inorganic Chemistry faculty.
422 [122] PHYSICAL CHEMISTRY OF POLYMERS (APPL 422) (MTSC 422) (3). Prerequisites, CHEM 420, 481. Kinetics of polymerization, molecular weight, distribution and molecular weight measurements, solution properties, solid-state properties of macromolecules. Spring. Physical Chemistry faculty.
423 [123] INTERMEDIATE POLYMER CHEMISTRY (APPL 423) (MTSC 423) (3). Prerequisite, CHEM 422. Rheology and mechanical properties of polymers; plastics, fiber, and elastomer technology. Spring. Chemistry faculty.
430 [130] INTRODUCTION TO BIOLOGICAL CHEMISTRY (3). Prerequisites, CHEM 262 or 262H, 262L or 263L; BIOL 101. The study of cellular processes including catalysis, metabolism, bioenergetics, and biochemical genetics. The structure and function of biological macromolecules involved in these processes is emphasized. Fall and spring. Biological Chemistry faculty.
431 [131] NUCLEIC ACID CHEMISTRY (3). Prerequisites, CHEM 430, BIOL 202. Study of reactions and chemical properties basic to nucleic acids; chemical synthesis as well as biosynthesis; nucleic acids in protein biosynthesis. Spring. Biological Chemistry faculty.
432 [132] PROTEIN CHEMISTRY (3). Prerequisite, CHEM 430. Structural properties of proteins; active-site chemistry; chemical modification of proteins; metalloproteins; coenzyme-enzyme interactions; organization of enzyme systems. Fall. Biological Chemistry faculty.
433 [133] ENZYME MECHANISMS AND KINETICS (3). Prerequisite, CHEM 432. A detailed discussion of enzyme catalysis; principles of catalysis; enzyme kinetics; the active site of enzymes; allosteric interactions between subunits; the mechanism of coenzyme-catalyzed reactions. Spring. Biological Chemistry faculty.
434 [134] BIOCHEMICAL KINETICS (1). Prerequisites, CHEM 430, MATH 383, and permission of the instructor. Kinetics of biochemical interactions. Basic principles, theoretical methods, experimental techniques, current topics. Fall. Biological Chemistry faculty.
435 [135] PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES (3). Prerequisites, CHEM 430, 481, and 482. Structure of proteins, nucleic acids and lipids. Structural transitions and intermolecular interactions. Properties of macromolecular assemblies. Techniques for the study of structure and function-optical spectroscopy, magnetic resonance, hydrodynamics, scattering, diffraction. Fall. Physical Chemistry faculty.
436 [136] PROTEOME AND INTERACTOME (1). Prerequisites, CHEM 430 and permission of the instructor. Methods for and role of bioinformatics in proteomic analysis; proteomics in the analysis of development, differentiation and disease states; the interactome - definitions, analysis methods of protein-protein interactions in complex systems. Fall (first five weeks). Biological Chemistry faculty.
437 [137] MEMBRANE CHEMISTRY (3). Prerequisites, BIOL 101, CHEM 430; corequisite or prerequisite, CHEM 480 or 481. The structure and properties of synthetic membranes and of naturally occurring biological membranes. Spring. Biological Chemistry faculty.
438 [138] CHEMISTRY OF METABOLIC REGULATION (3). Prerequisites, CHEM 430, 480 or 481. Energy metabolism and its regulation, nitrogen metabolism, biosynthesis of amino acids, fatty acid metabolism. Fall. Biological Chemistry faculty.
439 [139] RNA PROCESSING (2). Prerequisites, CHEM 431 and permission of the instructor. RNA processing, structure, and therapeutics; in-depth exploration of examples from the contemporary literature. Topics include RNA World hypothesis, RNA structure and catalysis, and nucleic acid-base sensors and drug design. Spring (last ten weeks). Biological Chemistry faculty.
441 [141] INTERMEDIATE ANALYTICAL CHEMISTRY (2). Prerequisites, CHEM 241 or 241H, 241L or 245L, 262 or 262H, and 480 or 481. Spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis and signal processing. Spring. Analytical Chemistry faculty.
441L [141L] INTERMEDIATE ANALYTICAL CHEMISTRY LABORATORY (2). Corequisite, CHEM 441. Experiments in spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis and signal processing. One four-hour laboratory a week and a one-hour lecture each week. Spring. Analytical Chemistry faculty and staff. (Fee required.)
442 [142] ANALYTICAL RESEARCH TECHNIQUES (2). Prerequisite, CHEM 480 or 482. Introduction to chemical instrumentation including digital and analog electronics, computers, interfacing, and chemometric techniques. Two one-hour lectures a week. Fall. Analytical Chemistry faculty.
442L [142L] LABORATORY IN ANALYTICAL RESEARCH TECHNIQUES (3). Prerequisite, CHEM 480 or 482; corequisite, CHEM 442. Experiments in digital and analog instrumentation, computers, interfacing and chemometrics, with applications to chemical instrumentation. One four-hour laboratory a week. Fall. Analytical Chemistry faculty.
444 [144] SEPARATIONS (2). Prerequisites, CHEM 441 and 480 or 481. Theory and applications of equilibrium and nonequilibrium separation techniques. Extraction, countercurrent distribution, gas chromatography, column and plane chromatographic techniques, electrophoresis, ultra-centrifugation, and other separation methods. Fall or spring. Analytical Chemistry faculty.
445 [145] ELECTROANALYTICAL CHEMISTRY (3). Prerequisite, CHEM 480 or 481. Basic principles of electrochemical reactions, electroanalytical voltammetry as applied to analysis and the chemistry of heterogeneous electron transfers, analog electronics, and electrochemical instrumentation. Fall or spring. Analytical Chemistry faculty.
446 [146] ANALYTICAL SPECTROSCOPY I (3). Prerequisite, CHEM 480 or 482. Fundamentals of interactions of electromagnetic radiation with matter, vibrational, electronic, nuclear magnetic, mass spectrometries, scattering-based spectroscopy, instrumentation and signal processing. Fall or spring. Analytical Chemistry faculty.
447 [147] ANALYTICAL SPECTROSCOPY II (2). Prerequisite, CHEM 480 or 482. Principles and applications of X-ray absorption and emission, photoelectron, Raman, gamma-ray, Mossbauer and internal reflection spectroscopy, nuclear quadrupole and electron spin resonance, fluorescence, optical rotatory dispersion and circular dichroism, secondary emission methods. Fall or spring. Analytical Chemistry faculty.
448 [148] MASS SPECTROMETRY (2). Prerequisite, CHEM 480 or 481. Fundamental theory of gaseous ion chemistry, instrumentation, combination with separation techniques, spectral interpretation for organic compounds, applications to biological and environmental chemistry. Fall or spring. Chemistry faculty.
450 [150] INTERMEDIATE INORGANIC CHEMISTRY (3). Prerequisite, CHEM 251. Electronic states of transition metal ions, symmetry labels, ligand field theory and angular overlap model for coordination complexes, kinetics and mechanisms of transition metal reactions, organometallic chemistry, biomimetic chemistry. Fall. Inorganic Chemistry faculty.
451 [151] THEORETICAL INORGANIC CHEMISTRY (1-3). Prerequisites, CHEM 251, 262 or 262H. Chemical applications of symmetry and group theory, crystal field theory, molecular orbital theory. The first third of the course, corresponding to one credit hour, covers point symmetry, group theoretical foundations, and character tables. Fall. Inorganic Chemistry faculty.
452 [152] ELECTRONIC STRUCTURE OF TRANSITION METAL COMPLEXES (3). Prerequisite, CHEM 451. A detailed discussion of ligand field theory and the techniques that rely on the theoretical development of ligand field theory, including electronic spectroscopy, electron paramagnetic resonance spectroscopy, and magnetism. Spring. Inorganic Chemistry faculty.
453 [153] PHYSICAL METHODS IN INORGANIC CHEMISTRY (3). Prerequisite, CHEM 451. Introduction to the physical techniques used for the characterization and study of inorganic compounds. Topics typically include vibrational spectroscopy, nuclear diffraction, Mossbauer spectroscopy, X-ray photoelectron spectroscopy, and inorganic electrochemistry. Spring. Inorganic Chemistry faculty.
460 [160] INTERMEDIATE ORGANIC CHEMISTRY (3). Prerequisite, CHEM 262 or 262H. Modern topics in organic chemistry, reaction mechanisms and organic synthesis. Fall. Organic Chemistry faculty.
465 [175] MECHANISMS OF ORGANIC AND INORGANIC REACTIONS (4). Prerequisite, CHEM 450. Kinetics and thermodynamics; free energy relationships; isotope effects; acidity and basicity; kinetics and mechanisms of substitution reactions; one- and two-electron transfer processes; principles and applications of photochemistry; organometallic reaction mechanisms. Fall. Inorganic and Organic Chemistry faculty.
466 [166] ADVANCED ORGANIC CHEMISTRY I (3). Prerequisite, CHEM 262 or 262H; prerequisites or corequisites, CHEM 450, 481. A survey of fundamental organic reactions including substitutions, additions, eliminations, and rearrangements; static and dynamic stereochemistry; conformational analysis; molecular orbital concepts and orbital symmetry. Fall. Organic Chemistry faculty.
467 [167] ADVANCED ORGANIC CHEMISTRY II (2). Prerequisite, CHEM 466. Spectroscopic methods of analysis with emphasis on elucidation of the structure of organic molecules: 1H and 13C NMR, infrared, ultraviolet, ORD-CD, mass and photo-electron spectroscopy. CHEM 446 and 467 may not both be taken for academic credit. Spring. Organic Chemistry faculty.
468 [168] SYNTHETIC ASPECTS OF ORGANIC CHEMISTRY (3). Prerequisite, CHEM 466. Modern synthetic methods and their application to the synthesis of complicated molecules. Spring. Organic Chemistry faculty.
470 [190] FUNDAMENTALS OF MATERIALS SCIENCE (APPL 470) (3). Prerequisite, CHEM 482; or prerequisite, PHYS 128 and prerequisite or corequisite, PHYS 341. Crystal geometry; diffusion in solids; mechanical properties of solids; electrical conduction in solids; thermal properties of materials; phase equilibria. Fall. Irene.
471 [191] MATHEMATICAL TECHNIQUES FOR CHEMISTS (3). Prerequisites, knowledge of differential and integral calculus. Chemical applications of higher mathematics. Fall. Chemistry faculty.
472 [192] CHEMISTRY AND PHYSICS OF ELECTRONIC MATERIALS PROCESSING (PHYS 472) (APPL 472) (MTSC 472) (3). Prerequisite, CHEM 482, or PHYS 105 or 117, and permission of the instructor. A survey of materials processing and characterization used in fabricating microelectronics devices. Crystal growth, thin film deposition and etching and microlithography, characterization techniques, electric and dielectric properties of materials. Spring. Chemistry and Physics faculty.
473 [193] CHEMISTRY AND PHYSICS OF SURFACES (APPL 473) (MTSC 473) (3). Prerequisite, CHEM 470. The structural and energetic nature of surface states and sites; experimental surface measurements; reactions on surfaces, including bonding to surfaces and adsorption; interfaces. Spring. Irene.
480 [180] INTRODUCTION TO BIOPHYSICAL CHEMISTRY (3). Prerequisites, CHEM 261 or 261H; PHYS 105, MATH 232. Does not carry credit toward graduate work in Chemistry or credit toward any track of the BS degree in chemistry. Application of thermodynamics to biochemical processes; enzyme kinetics; properties of biolpolymers in solution. Fall. Physical Chemistry faculty.
481 [181] PHYSICAL CHEMISTRY I (3). Prerequisites, CHEM 102 or 102H; PHYS 116, 117; and pre- or corequisite, MATH 383. Thermodynamics, kinetic theory, chemical kinetics. Fall. Physical Chemistry faculty.
481L [181L] PHYSICAL CHEMISTRY LABORATORY I (2). Prerequisite or corequisite, CHEM 481. Experiments in physical chemistry. One three-hour laboratory and a single one-hour lecture a week. Fall. Physical Chemistry faculty and staff.
482 [182] PHYSICAL CHEMISTRY II (3). Prerequisite, CHEM 481. Introduction to quantum mechanics, atomic and molecular structure, spectroscopy, statistical mechanics. Spring. Physical Chemistry faculty.
482L [182L] PHYSICAL CHEMISTRY LABORATORY II (2). Prerequisites, CHEM 481, 481L; prerequisite or corequisite, CHEM 182. Experiments in physical chemistry. One four-hour laboratory a week. Spring. Physical Chemistry faculty and staff.
484 [184] THERMODYNAMICS AND INTRODUCTION TO STATISTICAL THERMODYNAMICS (1-3). Prerequisite, CHEM 182. Thermodynamics, followed by an introduction to the classical and quantum statistical mechanics and their application to simple systems. The section on thermodynamics can be taken separately for one hour credit. Fall. Physical Chemistry faculty.
485 [185] CHEMICAL DYNAMICS (3). Prerequisites, CHEM 181, 182. Experimental and theoretical aspects of atomic and molecular reaction dynamics. Fall or spring. Physical Chemistry faculty.
486 [186] INTRODUCTION TO QUANTUM CHEMISTRY (3). Prerequisites, CHEM 481, 482. Introduction to the principles of quantum mechanics. Approximation methods; angular momentum; simple atoms and molecules. Fall. Physical Chemistry faculty.
487 [187] INTRODUCTION TO MOLECULAR SPECTROSCOPY (3). Prerequisite, CHEM 486. Interaction of radiation with matter; selection rules; rotational, vibrational, and electronic spectra of molecules; laser-based spectroscopy and nonlinear optical effects. Fall or spring. Physical Chemistry faculty.
488 [188] QUANTUM CHEMISTRY (3). Prerequisite, CHEM 486. Applications of quantum mechanics to chemistry. Molecular structure; time-dependent perturbation theory; interaction of radiation with matter. Spring. Physical Chemistry faculty.
489 [189] STATISTICAL MECHANICS (3). Prerequisite, CHEM 484. Applications of statistical mechanics to chemistry. Ensemble formalism; condensed phases; nonequilibrium processes. Spring. Physical Chemistry faculty.
520L [124L] POLYMER CHEMISTRY LABORATORY (APPL 520L) (2). Prerequisite or corequisite, CHEM 420 or 421. Thermal analysis; solution viscosity; gel permeation chromatography; end group analysis; synthesis; characterization of an unknown polymer. One four-hour laboratory and a one-hour lecture each week. Spring. Chemistry faculty and staff.
530L [131L] LABORATORY TECHNIQUES FOR BIOCHEMISTRY (3). Prerequisite, CHEM 430. An introduction to important chemical techniques and research procedures of use in the fields of protein and nucleic acid chemistry. Two four-hour laboratories a week, and a one-hour lecture each week. Biological Chemistry faculty.
550L [170L] SYNTHETIC CHEMISTRY LABORATORY I (2). Prerequisites, CHEM 241L or 245L, 251, 262L or 263L. A laboratory devoted to synthesis and characterization of inorganic complexes and materials. A four-hour synthesis laboratory, a characterization laboratory outside of the regular laboratory period, and a one-hour recitation each week. Fall. Chemistry faculty and staff.
560L [160L] SYNTHETIC ORGANIC LAB (2). Prerequisites, CHEM 241L, 245L, 262L, 263L. An advanced synthesis laboratory focused on topics in organic chemistry. A four-hour synthesis laboratory, a characterization laboratory outside of the regular laboratory period, and a one-hour recitation each week. Fall. Chemistry faculty and staff.
721 [221] SEMINAR IN MATERIALS CHEMISTRY (2). Prerequisite, graduate standing. Fall and spring. Polymer/Materials Chemistry faculty.
731 [231], [232] SEMINAR IN BIOLOGICAL CHEMISTRY (2 each). Prerequisite, graduate standing. Literature survey dealing with topics in protein chemistry and nucleic acid chemistry. Fall and spring. Biological Chemistry faculty.
733 [233] SPECIAL TOPICS IN BIOLOGICAL CHEMISTRY (1-3). Modern topics in biological chemistry. Fall and spring. Biological Chemistry faculty.
734 [234] SPECIAL TOPICS IN BIOLOGICAL CHEMISTRY: NMR (1-3). Introduction to practical solution NMR of proteins in solution. Fall and spring. Pielak.
735 [235] SPECIAL TOPICS IN BIOLOGICAL CHEMISTRY: MACROMOLECULAR INTERACTIONS (1-3). Fall and spring. Pielak.
736 [236] MACROMOLECULAR CRYSTALLOGRAPHIC METHODS (2). Data collection, phase determination, and structural refinement. Laboratory component allows students to crystallize protein, collect and process data, determine phases, and refine their structures. Spring. Redinbo.
741 [242], [243] LITERATURE SEMINAR IN ANALYTICAL CHEMISTRY (2 each). 242 given in fall; 243 given in spring. Analytical Chemistry faculty.
744 [244], [245] SPECIAL TOPICS IN ANALYTICAL CHEMISTRY (1-2). Modern topics in analytical chemistry, including advanced electroanalytical chemistry, advanced mass spectrometry, chemical instrumentation, and other subjects of recent significance. Two lecture hours a week. Fall and spring. Analytical Chemistry faculty.
752 [252] SPECIAL TOPICS IN INORGANIC CHEMISTRY (1-3). Prerequisite, permission of the instructor. Research-level survey of topics in inorganic chemistry and related areas. Fall and spring. Inorganic Chemistry faculty.
754 [254] LITERATURE SEMINAR IN INORGANIC CHEMISTRY (2). Prerequisite, graduate status. Fall and spring. Inorganic Chemistry faculty.
758 [258] X-RAY STRUCTURE DETERMINATION (3). Prerequisites, permission of the instructor; a knowledge of elementary and differential calculus is assumed. This course is designed to introduce students to the techniques used in solving crystal structures by X-ray diffraction. Three lecture hours a week. Fall. Inorganic Chemistry faculty.
761 [261], [262] SEMINAR IN ORGANIC CHEMISTRY (2 each). Prerequisite, graduate standing. One afternoon meeting a week and individual consultation with the professor in charge. Fall and spring. Organic Chemistry faculty.
764 [264], [265] SPECIAL TOPICS IN ORGANIC CHEMISTRY (1-3 each). Two lecture hours a week. Fall and spring. Organic Chemistry faculty.
767 [267] ORGANIC CHEMISTRY (2-6). Prerequisite, to be determined by consultation with professor in charge. Three to six hours a week. Fall and spring. Organic Chemistry faculty.
781 [281], [282] SEMINAR IN PHYSICAL CHEMISTRY (2 each). Prerequisite, graduate standing. Two hours a week. Fall and spring. Physical Chemistry faculty.
783, 786 [283], [286] SPECIAL TOPICS IN PHYSICAL CHEMISTRY (1-3 each). Prerequisite, permission of the instructor. Modern topics in physical chemistry, chemical physics, or biophysical chemistry. One to three lecture hours a week. Fall and spring. Physical Chemistry faculty.
788 [288], [289] PRINCIPLES OF CHEMICAL PHYSICS (PHYS 827) (3 each). Prerequisite, CHEM 281 or PHYS 321 or permission of the instructor. The quantum mechanics of molecules and their aggregates. Atomic orbitals, Hartee-Fock methods for atoms and molecules.
921 [321] RESEARCH METHODOLOGY AND SEMINAR IN POLYMER/MATERIALS CHEMISTRY (1 or more). Seminar and directed study on research methods of polymer/materials chemistry. This course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Polymer/Materials Chemistry faculty.
931 [331] RESEARCH METHODOLOGY AND SEMINAR IN BIOLOGICAL CHEMISTRY (1 or more). Seminar and directed study on research methods of biological chemistry. This course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Biological Chemistry faculty.
941 [341] RESEARCH METHODOLOGY AND SEMINAR IN ANALYTICAL CHEMISTRY (1 or more). Seminar and directed study on research methods of analytical chemistry. The course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Analytical Chemistry faculty.
951 [351] RESEARCH METHODOLOGY AND SEMINAR IN INORGANIC CHEMISTRY (1 or more). Seminar and directed study on research methods of inorganic chemistry. The course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Inorganic Chemistry faculty.
961 [361] RESEARCH METHODOLOGY AND SEMINAR IN ORGANIC CHEMISTRY (1 or more). Seminar and directed study on research methods of organic chemistry. The course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Organic Chemistry faculty.
981 [381] RESEARCH METHODOLOGY AND SEMINAR IN PHYSICAL CHEMISTRY (1 or more). Seminar and directed study on research methods of physical chemistry. The course provides a foundation for master's thesis or doctoral dissertation research. Fall and spring. Physical Chemistry faculty.
992 [392] MASTER'S (NONTHESIS) (Var.).
993 [393] MASTER'S THESIS (Var.). Prerequisites, 921, 931, 941, 951, 961, or 981. Fall and spring. Graduate faculty.
994 [394] DOCTORAL DISSERTATION (Var.). Prerequisites, CHEM 921, 931, 941, 951, 961, or 981. Fall and spring. Graduate faculty.