Department of Chemistry

www.chem.unc.edu

VALERIE S. ASHBY, Chair

Professors

Nancy L. Allbritton (50) Analytical Chemistry

Valerie S. Ashby (61) Polymer and Materials Chemistry

Max L. Berkowitz (30) Physical Chemistry

Maurice S. Brookhart (2) Organic and Organometallic Chemistry

Michael T. Crimmins (39) Organic Chemistry

Joseph M. DeSimone (49) Synthetic Polymer Chemistry

Dorothy A. Erie (11) Physical and Biological Chemistry

Malcolm D. E. Forbes (48) Organic and Physical Chemistry

Michel R. Gagné (22) Inorganic, Organic and Polymer Chemistry

Gary L. Glish (40) Analytical Chemistry

Jeffrey S. Johnson (58) Organic Chemistry

James W. Jorgenson (36) Analytical Chemistry

Wenbin Lin (60) Inorganic Chemistry

Thomas J. Meyer (23) Inorganic Chemistry

Royce W. Murray (25) Analytical Chemistry

John M. Papanikolas (52) Physical Chemistry

Gary J. Pielak (46) Biological Chemistry

J. Michael Ramsey (62) Analytical Chemistry

Matthew Redinbo (55) Biological Chemistry

Michael Rubinstein (43) Polymer Physical Chemistry

Edward T. Samulski (44) Polymer Physical Chemistry

Mark H. Schoenfisch (57) Analytical and Materials Chemistry

Sergei S. Sheyko (59) Polymer and Materials Chemistry

Linda L. Spremulli (28) Biological Chemistry

Joseph L. Templeton (31) Inorganic Chemistry

Nancy L. Thompson (41) Physical and Biological Chemistry

Marcey Waters (56) Organic Chemistry

Kevin M. Weeks (53) Biological Chemistry

R. Mark Wightman (47) Analytical and Neurochemistry

Richard V. Wolfenden (65) Biological Chemistry

Associate Professors

Andrew M. Moran (6) Physical Chemistry

Cynthia K. Schauer (45) Inorganic Chemistry

Wei You (42) Polymer and Materials Chemistry

Assistant Professors

Erik J. Alexanian (77) Organic Chemistry

Todd L. Austell (70) Chemistry Education, Academic Advising, Lab Curriculum Development

Jillian Dempsey (3) Inorganic Chemistry

Christopher J. Fecko (5) Physical Chemistry

Brian P. Hogan (72), Chemistry Education, Academic Advising, Lab Curriculum Development

Leslie Hicks () Analytical Chemistry

Yosuke Kanai (81) Physical Chemistry

Jennifer Krumper, Chemistry Education

Matthew Lockett () Analytical Chemistry

Simon Meek (79) Organic Chemistry

Alexander J. Miller (4) Inorganic Chemistry

David A. Nicewicz (78) Organic Chemistry

Domenic Tiani (71) Chemistry Education, Academic Advising, Lab Curriculum Development

Professors Emeriti

Tomas Baer

Maurice M. Bursey

James L. Coke

Richard G. Hiskey

Eugene A. Irene

Richard C. Jarnagin

Donald C. Jicha

Charles S. Johnson Jr.

Paul J. Kropp

Robert G. Parr

Lee G. Pedersen

The Department of Chemistry offers graduate programs leading to the degrees of master of arts, master of science (non-thesis), and doctor of philosophy in the fields of analytical, biological, inorganic, organic, physical, and polymer and materials chemistry. Reinforcing the broad nature of our graduate program, we have close interactions with various departments including Physics, Biochemistry, Biological and Biomedical Sciences, and Environmental Science and Engineering.

Doctor of Philosophy

The Ph.D. degree in chemistry is a research degree and students normally begin research during the first year in graduate school. As soon as the entering student has selected a research advisor, an advisory committee is established to develop an appropriate course of study designed to meet individual needs. The Ph.D. degree consists of completion of a suitable program of study, a preliminary doctoral oral examination, a written comprehensive examination that is satisfied by cumulative examinations, an original research project culminating in a dissertation, and a final oral examination.

Master of Arts

The Master of Arts degree requires a minimum of 30 semester hours of credit. The student's advisory committee determines courses. A written comprehensive examination (which may be satisfied by cumulative examinations), a thesis, and a final oral examination are also required. Admission to the Ph.D. program after completion of the M.A. degree in the department requires approval by the Chemistry Graduate Studies Committee.

Master of Science (non-thesis)

The Master of Science (non-thesis) degree requires a minimum of thirty semester hours. The candidate must earn at least 24 hours of graduate credit in chemistry and allied subjects, which may include graduate seminars numbered 700 or higher but may not include CHEM 921, 931, 941, 951, 961, and 981 (referred to collectively as "9X1"). As a substitute for the thesis, the candidate must earn a minimum of three hours of CHEM 992 (master's non-thesis option). The student's advisory committee determines the student's program of study. A written report submitted to the student's research director describing work done while registered for CHEM 992 and a written examination (which may be satisfied by cumulative examinations) are also required. Admission to the Ph.D. program after completing the M.S. degree in the department requires approval by the Chemistry Graduate Studies Committee.

Research Interests

Analytical. Development of instrumentation for ultra-high pressure capillary liquid chromatography, capillary electrophoresis, and combined two-dimensional separations. Applications include proteomics and measurement of peptide hormones in biological tissues. Mass spectrometry of biological, environmental, organic, and polymeric compounds; tandem MS, ion activation, ion molecule reactions; instrument development. Electrochemistry: New methods for study of biological media, neurotransmitters small spaces, redox solids, chemically modified surfaces, nanoparticle chemistry, and quantum size effects including the analytical chemistry of nanoparticles. Chemical microsystems: Microfabricated fluidics technologies (i.e., lab-on-a-chip devices) to address biological measurement problems such as protein expression, cell signaling, and clinical diagnostics. Miniaturized mass spectrometers for environmental monitoring. Nanoscale fluidics devices for single molecule DNA sequencing and chemical sensing. Polymeric membranes to improve the analytical performance of in vivo sensors and enable accurate measurement of analytes in challenging milieu.

Biological. Structure-function relationships of complex biochemical processes; the molecular basis of disease; chemical biology; biophysics; mechanism of protein biosynthesis; metabolic regulation; gene organization and regulation of gene expression; biomolecular structure; protein folding; protein and RNA chemistry under physiologically relevant conditions, in-cell NMR; thermodynamics of protein-protein interactions; characterization of protein-protein and protein-DNA complexes by atomic force microscopy and single molecule fluorescence; in vitro and in vivo studies of DNA repair; RNA structure in vivo, RNA and viral genomics, transcriptome structure, assembly of biomedically important RNA-protein complexes; chemical synthesis of peptides and proteins; protein engineering through chemical synthesis and directed evolution; unnatural amino acid mutagenesis; molecular modeling of biomolecules; cell surface biophysics; fluorescence microscopy and spectroscopy; small molecule and protein microarray development; live cell fluorescence microscopy; genomics-driven natural product discovery; natural product biosynthesis and pathway engineering and design; synthetic biology; antibiotic mechanism of action; bioinformatics; metabolomics; small molecules involved in inter- and intra- species signaling.

Inorganic. Physical inorganic chemistry: Electronic structure of transition metal complexes; photochemistry and electrochemistry of metal complexes; use of coordination complexes and inorganic materials for solar energy harvesting and conversion; molecular orbital theory, nuclear magnetic resonance and electron paramagnetic resonance spectroscopies; X-ray crystallography; infrared and Raman spectroscopies. Chemistry of transition metal complexes: Synthesis of transition metal compounds, organometallic chemistry including metal-catalyzed organic reactions; reactions of coordinated ligands; kinetics and mechanisms of inorganic reactions; metal cluster chemistry; chiral supramolecular chemistry. Materials chemistry: Molecular precursors to materials; solid state lattice design; metal-ion containing thin films; metal-polymer complexes; functional coordination polymers and metal-organic frameworks; chiral porous solids. Bioinorganic and medicinal inorganic chemistry: Nanomaterials for biomedical imaging and anticancer drug delivery; reactivity of oxidized metal complexes with nucleic acids, photo-induced DNA cleavage, synthesis and characterization of model complexes for metalloenzymes.

Organic. Synthesis and biological reactions of natural products; peptide synthesis; protein engineering; structure-function studies on polypeptides and proteins; mechanistic and synthetic studies in organometallic chemistry; catalysis using organometallic complexes; nuclear magnetic resonance; kinetics; organosulfur and organophosphorus chemistry; surface effects in chemical behavior; chemistry of reactive intermediates including carbocations, carbanions, carbenes radical ions and radical pairs; photochemistry; light-driven organic catalysis; fluorescent sensors; enzyme inhibitors; new synthetic methods including asymmetric catalysis; stereochemistry and conformational analysis; design and synthesis of models for metalloenzymes; epr investigations of electronic couplings in high-spin organic molecules; spectroscopic studies of free radicals; synthesis and characterization of well-defined polymeric materials; synthesis of materials for use in microelectronics; homogeneous and heterogeneous polymerizations in supercritical fluids; synthesis of engineering polymers; molecular recognition.

Physical Chemistry. Ultrafast spectroscopy: Femtosecond laser techniques to study photochemistry (e.g., energy transfer, proton coupled electron transfer) in systems including carbon nanotubes, light harvesting proteins, and several materials relevant to the production of solar fuels. Nonlinear Optics: Lasers pulses with widely tunable bandwidths and frequencies with new nonlinear optical methods. Molecular interactions and dynamics in cells using optical Kerr effect and phase contrast methods. Spatial and temporal resolution of energy and charge transport within individual metal oxide nanoparticles using pump-probe microscopies. Biophysics: Movements and interactions of regulatory proteins in cell nuclei using optical microscopies (e.g., FRET, FCS). Coherent quantum effects in photosynthesis using new laser spectroscopies analogous to multidimensional NMR techniques. Theoretical Chemistry: Molecular dynamics simulations to study the structures and dynamics of biological membranes in addition to the properties of aqueous solutions next to such membranes. Laser spectroscopy in cooled molecular beams of transient species, ions and molecular complexes, subdoppler infrared spectroscopy, ion photodissociation studies, development of spectroscopic techniques, double resonance spectroscopy, pulsed field gradient NMR and NMR imaging. Application of optical and mass spectroscopies to study atmospheric chemistry. Quantum chemistry, density functional theory, quantum biology of neurotransmitters and pharmacological agents, energy minimization, protein dynamics, cooperativity, molecular graphics, mutagenesis, statistical mechanics of a liquid phase, structure and dynamics of aqueous solutions, kinetics in condensed phases, mechanical properties of polymers, state-to-state chemistry, reactions and energy transfer at solid surfaces. Polymer properties: Preparation of and nonlinear optical effects in polymeric systems, self-organized polymers, and liquid crystalline materials.

Polymer and Materials Chemistry. Synthesis, properties, and utilization of novel functional materials for various applications ranging from medicine and microelectronics to oil recovery and climate change. The many-pronged approach includes synthesis and molecular characterization of multifunctional monomers and polymers, computer modeling and intelligent design of molecular architectures that are able to sense, process, and response to impacts from the surrounding environment, and preparation of new engineering thermoplastics and liquid crystalline materials. Recent efforts funded by the National Cancer Institute, National Institute of Health, Advanced Energy Consortium, and Army Research Office are focused on lithographic design of organic nanoparticles for the detection, diagnosis, and treatment of diseases (especially cancer), self-healing, shape-memory, mechanocatalysis, organic solar cells, and imaging contrast agents for oil exploration. A broad variety of expertise includes imaging and probing of submicrometer surface structures by scanning probe microscopy, dynamic mechanical analysis, characterization of polymer dynamics by NMR techniques and light scattering, microfluidics and drug delivery control, measurement of molecular conductivity and energy conversion efficiency, and analytical as well as computational and numerical studies of soft materials, such as polymers, colloids, and liquid crystals.

Facilities and Equipment

Research is carried out in the William Rand Kenan Jr. Laboratories; a facility of 130,000 square feet completed in 1971 the W. Lowry and Susan S. Caudill Laboratories, a facility of 71,000 square feet completed in 2006. The undergraduate laboratories are housed in the modern John Motley Morehead Laboratories, completed in 1986. Included in the department are some major facilities managed by Ph.D.-level staff scientists. The NMR laboratory includes five high-resolution FT-NMR spectrometers ranging from 300 to 600 MHz for liquids: two 400 MHz, 500 MHz and 600 MHz Bruker spectrometers, and a 600 MHz Agilent/Varian spectrometer. The Bruker 600MHz spectrometer is equipped with two cryoprobes for ultra-high sensitivity and a sample changer.  There is also a Bruker 360 MHz wide bore FT-NMR spectrometer suitable for solid polymeric samples with magic angle spinning. The MS laboratory houses a Bruker BioTOF II Reflectron Time of Flight Mass Spectrometer (ESI/nESI), an Agilent HPLC Quadrupole Mass Spectrometer (ESI, APCI), A Bruker 820 ICP-MS for elemental analysis, a Thermo LTqFT with 7.0 Tesla magnet primary used for accurate mass measurements, a Photon Machines 192 Eximer Laser integrated onto a Thermo Element XR ICP-MS for elemental analysis of both solution and solid material and a Micromass Quattro II Triple Quadrupole Mass Spectrometer. An IonSpec 9.4 Telsa FT-ICR is also available for conducting high-resolution electrospray and MALDI experiments. The X-ray laboratory is equipped with a Bruker AXS SMART APEX2 single crystal diffractometer and Rigaku Multiflex powder diffractometer.

Computing services are among the most important for modern research. The University computing resources that currently reside in Information Technology Services (ITS) include Emerald (Linux) - Beowulf Red Hat Linux cluster consisting of ~830 Intel Xeon IBM Blade Center processors ranging from 2.0–3.2GHz. (help.unc.edu/6020) Emerald (AIX) - High memory (32+GB) Power5 AIX cluster with 64 processors. Topsail - 520 blade Dell Linux server with 2 quad-core 2.3 GHz Intel EM64T processors for 4160 total processors, and a variety of specialty machines that provide services for statistics, bioinformatics, and database applications. A number of the individual research laboratories in Chemistry own Silicon Graphics- or Linux-based workstations. Numerous software packages of interest to chemical, biochemical, and materials researchers are maintained for use on central systems by the ITS Research Computing group (Accelrys, Gaussian, MolPro, NWChem, CPMD, AMBER, Gromacs, Sybyl, SAS, Stata, Mathematica, ECCE, Gaussview, Schrodinger, etc.). The combined hardware and software resources are tailored to meet the needs of a broad range of chemists working on applications in quantum mechanics, molecular dynamics, NMR, X-RAY, structural biology, and bioinformatics.

To support the research programs, the department provides a number of services. Glass and Electronics facilities are provided to assist in construction and maintenance of specialized equipment. Technicians are also available to run certain specialized instruments. The William Rand Kenan Jr. Chemistry Library is located in Venable/Murray Hall. The majority of the Chemistry Library journal subscriptions and databases are available online for 24-hour access from campus workstations and other workstations that meet licensing requirements. The Chemistry collection also includes many print reference works and monographs that are available for checkout or use in the reading room when the library is open. Reference and instructional services are also available at the library service desk and by arrangement with library staff.

Financial Aid and Admission

The department awards a number of industrial fellowships and predoctoral research and teaching appointments. All outstanding prospective graduate students who apply for admission/support are automatically considered for fellowships.

There are more than 200 graduate students in the department. All are supported either as teaching assistants (27 percent), research assistants (65 percent), or as fellows (8 percent) supported by The Graduate School, industry, or the United States government. The duties of the teaching assistants include the preparation for and supervision of laboratory classes in undergraduate courses and the grading of laboratory reports.

Applications for assistantships and fellowships should be made before the end of January, although applicants for assistantships are considered after that date. All applicants (international and domestic) must take the Graduate Record Examination (GRE). All international students whose native language is not English must take the Test of English as a Foreign Language (TOEFL) examination in addition to the Graduate Record Examination. However, international students who hold a degree from a university in the United States may be exempt. Both the TOEFL and the GRE should be taken as early as possible for fall acceptance, preferably in October.

Application forms for admission can be completed online at the Graduate School's Web site at gradschool.unc.edu/admissions. Financial support as well as information about the department can be obtained from the Chemistry Department Web site, www.chem.unc.edu/grads. Questions about our program may be directed to chemgs@unc.edu.

Courses for Graduate and Advanced Undergraduate Students

CHEM

410 Instructional Methods in the Chemistry Classroom (4). Prerequisites, CHEM 241, 251, 262, and 262L. Permission of the instructor. This course explores secondary school chemical education through current chemical education theory and classroom teaching. Students will develop a comprehensive approach to teaching chemistry content through student-centered activities.

420 Introduction to Polymer Chemistry (APPL 420) (3). Prerequisite, CHEM 261 or 261H; pre- or corequisites, CHEM 262 or 262H, and 262L or 263L. Chemical structure and nomenclature of macromolecules, synthesis of polymers, characteristic polymer properties.

421 Synthesis of Polymers (APPL 421, MTSC 421) (3). Prerequisites, CHEM 251, and 262 or 262H. Synthesis and reactions of polymers; various polymerization techniques.

422 Physical Chemistry of Polymers (APPL 422, MTSC 422) (3). Prerequisites, CHEM 420 and 481. Polymerization and characterization of macromolecules in solution.

423 Intermediate Polymer Chemistry (APPL 423, MTSC 423) (3). Prerequisite, CHEM 422. Polymer dynamics, networks and gels.

425 Polymer Materials (3). Prerequisite, CHEM 421 or 422. Solid-state properties of polymers; polymer melts, glasses and crystals.

430 Introduction to Biological Chemistry (BIOL 430) (3). Prerequisites, BIOL 101, CHEM 262 or 262H, and 262L or 263L. The study of cellular processes including catalysts, metabolism, bioenergetics, and biochemical genetics. The structure and function of biological macromolecules involved in these processes is emphasized.

431 Macromolecular Structure and Metabolism (3). Prerequisites, BIOL 202 and CHEM 430. Structure of DNA and methods in biotechnology; DNA replication and repair; RNA structure, synthesis, localization and transcriptional reputation; protein structure/function, biosynthesis, modification, localization, and degradation.

432 Metabolic Chemistry and Cellular Regulatory Networks (3). Prerequisite, CHEM 430. Biological membranes, membrane protein structure, transport phenomena; metabolic pathways, reaction themes, regulatory networks; metabolic transformations with carbohydrates, lipids, amino acids, and nucleotides; regulatory networks, signal transduction.

433 Transport in Biological Systems (1). Prerequisites, CHEM 430 and MATH 383. Permission of the instructor for undergraduates. Diffusion, sedimentation, electrophoresis, flow. Basic principles, theoretical methods, experimental techniques, role in biological function, current topics.

434 Biochemical Kinetics (1). Prerequisites, CHEM 430 and MATH 383. Permission of the instructor for undergraduates. Kinetics of biochemical interactions. Basic principles, theoretical methods, experimental techniques, current topics.

435 Protein Biosynthesis and Its Regulation (1). Prerequisite, CHEM 430; pre- or corequisite, CHEM 431. Permission of the instructor for undergraduates. Protein biosynthesis mechanism in prokaryotes and eukaryotes; emphasis on structures of the macromolecular machinery; translational regulation mechanisms including autogenous regulation, metabolic and developmental signals; viral control of host protein synthesis.

436 The Proteome and Interactome (1). Prerequisite, CHEM 430. Permission of the instructor for undergraduates. Methods for and role of bioinformatics in proteomic analysis; proteomics in the analysis of development, differentiation and disease states; the interactome—definitions, analysis, methods of protein-protein interactions in complex systems.

437 DNA Processes (2). Prerequisites, CHEM 431 and either 480 or 481. Permission of the instructor for undergraduates. Elucidation of the mechanisms of these processes in prokaryotes and eukaryotes from experiments. Experimental results ranging from in vivo studies to structural studies to kinetics.

438 Macromolecular Structure and Human Disease (1). Prerequisite, CHEM 431. Permission of the instructor for undergraduates. Impact of protein and macromolecular structure on the development and treatment of human disease, with emphasis on recent results. Examination of relevant diseases, current treatments, and opportunities for improved therapies.

439 RNA Processing (2). Prerequisite, CHEM 431. Permission of the instructor for undergraduates. RNA processing, structure and therapeutics; in-depth exploration of examples from the contemporary literature. Topics include RNA world hypothesis, RNA structure and catalysis, and nucleic acid-based sensors and drug design.

441 Intermediate Analytical Chemistry (2). Prerequisites, CHEM 241 (or 241H), 241L (or 245L) and 262 (or 262H) and 480 (or 481). Spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis, signal processing.

441L Intermediate Analytical Chemistry Laboratory (2). Corequisite, CHEM 441. Experiments in spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis, and signal processing. One four-hour laboratory and one one-hour lecture each week.

444 Separations (3). Prerequisites, CHEM 441 and either 480 or 481. Theory and applications of equilibrium and nonequilibrium separation techniques. Extraction, countercurrent distribution, gas chromatography, column and plane chromatographic techniques, electrophoresis, ultra-centrifugation, and other separation methods.

445 Electroanalytical Chemistry (3). Prerequisite, CHEM 480 or 481. Basic principles of electrochemical reactions, electroanalytical voltammetry as applied to analysis, the chemistry of heterogeneous electron transfers, and electrochemical instrumentation.

446 Analytical Spectroscopy (3). Prerequisites, CHEM 441 and 482. Optical spectroscopic techniques for chemical analysis including conventional and laser-based methods. Absorption, fluorescence, scattering and nonlinear spectroscopies, instrumentation and signal processing.

447 Bioanalytical Chemistry (3). Prerequisite, CHEM 441. Principles and applications of biospecific binding as a tool for performing selective chemical analysis.

448 Mass Spectrometry (3). Prerequisite, CHEM 480 or 481. Fundamental theory of gaseous ion chemistry, instrumentation, combination with separation techniques, spectral interpretation for organic compounds, applications to biological and environmental chemistry.

449 Microfabricated Chemical Measurement Systems (3). Prerequisite, CHEM 441. Introduction to micro and nanofabrication techniques, fluid and molecular transport at the micrometer to nanometer length scales, applications of microtechnology to chemical and biochemical measurements.

450 Intermediate Inorganic Chemistry (3). Prerequisite, CHEM 251. Introduction to symmetry and group theory; bonding, electronic spectra, and reaction mechanisms of coordination complexes; organometallic complexes, reactions, and catalysis; bioinorganic chemistry.

451 Theoretical Inorganic Chemistry (3). Prerequisites, CHEM 251 and 262 or 262H. Chemical applications of symmetry and group theory, crystal field theory, molecular orbital theory. The first third of the course, corresponding to one credit hour, covers point symmetry, group theoretical foundations and character tables.

452 Electronic Structure of Transition Metal Complexes (3). Prerequisite, CHEM 451. A detailed discussion of ligand field theory and the techniques that rely on the theoretical development of ligand field theory, including electronic spectroscopy, electron paramagnetic resonance spectroscopy, and magnetism.

453 Physical Methods in Inorganic Chemistry (3). Prerequisite, CHEM 451. Introduction to the physical techniques used for the characterization and study of inorganic compounds. Topics typically include nuclear magnetic resonance spectroscopy, vibrational spectroscopy, diffraction, Mossbauer spectroscopy, X-ray photoelectron spectroscopy, and inorganic electrochemistry.

460 Intermediate Organic Chemistry (3). Prerequisite, CHEM 262 or 262H. Modern topics in organic chemistry.

465 Mechanisms of Organic and Inorganic Reactions (4). Prerequisite, CHEM 450. Kinetics and thermodynamics, free energy relationships, isotope effects, acidity and basicity, kinetics and mechanisms of substitution reactions, one- and two-electron transfer processes, principles and applications of photochemistry, organometallic reaction mechanisms.

466 Advanced Organic Chemistry I (3). Prerequisite, CHEM 262 or 262H; pre- or corequisites, CHEM 450 and 481. A survey of fundamental organic reactions including substitutions, additions, elimination, and rearrangements; static and dynamic stereochemistry; conformational analysis; molecular orbital concepts and orbital symmetry.

467 Advanced Organic Chemistry II (2). Prerequisite, CHEM 466. Spectroscopic methods of analysis with emphasis on elucidation of the structure of organic molecules: 1H and 13C NMR, infrared, ultraviolet, ORD-CD, mass, and photoelectron spectroscopy. CHEM 446 and 467 may not both be taken for academic credit.

468 Synthetic Aspects of Organic Chemistry (3). Prerequisite, CHEM 466. Modern synthetic methods and their application to the synthesis of complicated molecules.

469 Organometallics and Catalysis Organometallics (3). Pre- or corequisites, CHEM 262 or 262H, and 450. Structure and reactivity of organometallic complexes and their role in modern catalytic reactions.

470 Fundamentals of MTSC (APPL 470) (3). Prerequisite, CHEM 482; or prerequisite, PHYS 128 and pre- or corequisite, PHYS 341. Crystal geometry, diffusion in solids, mechanical properties of solids, electrical conduction in solids, thermal properties of materials, phase equilibria.

471 Mathematical Techniques for Chemists (3). Prerequisite, MATH 383. Permission of the instructor for students lacking the prerequisite. Knowledge of differential and integral calculus. Chemical applications of higher mathematics.

472 Chemistry and Physics of Electronic Materials Processing (APPL 472, MTSC 472, PHYS 472) (3). See PHYS 472 for description.

473 Chemistry and Physics of Surfaces (APPL 473, MTSC 473) (3). Prerequisite, CHEM 470. The structural and energetic nature of surface states and sites, experimental surface measurements, reactions on surfaces including bonding to surfaces and adsorption, interfaces.

480 Introduction to Biophysical Chemistry (3). Prerequisites, CHEM 261 or 261H, MATH 232, and PHYS 105. Does not carry credit toward graduate work in chemistry or credit toward any track of the B.S. degree with a major in chemistry. Application of thermodynamics to biochemical processes, enzyme kinetics, properties of biopolymers in solution.

481 Physical Chemistry I (3). Prerequisites, CHEM 102 or 102H, PHYS 116; pre- or corequisites, MATH 383 and PHYS 117. C- or better required in chemistry course prerequisites. Thermodynamics, kinetic theory, chemical kinetics.

481L Physical Chemistry Laboratory I (2). Prerequisite, CHEM 482. Experiments in physical chemistry. Solving thermodynamic and quantum mechanical problems using computer simulations. One three-hour laboratory and a single one-hour lecture each week.

482 Physical Chemistry II (3). Prerequisite, CHEM 481. Introduction to quantum mechanics, atomic and molecular structure, spectroscopy, and statistical mechanics.

482L Physical Chemistry Laboratory II (2). Prerequisite, CHEM 482; pre- or corequisite, CHEM 481L. Experiments in physical chemistry. One four-hour laboratory each week.

484 Thermodynamics and Introduction to Statistical Thermodynamics (1–21). Prerequisite, CHEM 482. Thermodynamics, followed by an introduction to the classical and quantum statistical mechanics and their application to simple systems. The section on thermodynamics can be taken separately for one hour credit.

485 Chemical Dynamics (3). Prerequisites, CHEM 481 and 482. Experimental and theoretical aspects of atomic and molecular reaction dynamics.

486 Introduction to Quantum Chemistry (3). Prerequisites, CHEM 481 and 482. Introduction to the principles of quantum mechanics. Approximation methods, angular momentum, simple atoms and molecules.

487 Introduction to Molecular Spectroscopy (3). Prerequisite, CHEM 486. Interaction of radiation with matter; selection rules; rotational, vibrational, and electronic spectra of molecules; laser based spectroscopy and nonlinear optical effects.

488 Quantum Chemistry (3). Prerequisite, CHEM 486. Applications of quantum mechanics to chemistry. Molecular structure, time-dependent perturbation theory, interaction of radiation with matter.

489 Statistical Mechanics (3). Prerequisite, CHEM 484. Applications of statistical mechanics to chemistry. Ensemble formalism, condensed phases, nonequilibrium processes.

520L Polymer Chemistry Laboratory (APPL 520L) (2). Pre- or corequisite, CHEM 420 or 421 or 425. Various polymerization techniques and characterization methods. One four-hour laboratory each week.

530L Laboratory Techniques for Biochemistry (3). Pre- or corequisite, CHEM 430. An introduction to chemical techniques and research procedures of use in the fields of protein and nucleic acid chemistry. Two four-hour laboratories and one one-hour lecture each week.

541 Analytical Microscopy (3). Introduction to microscopy techniques utilized in the analysis of chemical and biological samples with a focus on light, electron, and atomic force microscopy. Permission of instructor required for those missing prerequisites.

550L Synthetic Chemistry Laboratory I (2). Prerequisites, CHEM 241L (or 245L), 251, and 262L (or 263L). A laboratory devoted to synthesis and characterization of inorganic complexes and materials. A four-hour synthesis laboratory, a characterization laboratory outside of the regular laboratory period, and a one-hour recitation each week.

560L Synthetic Organic Laboratory (2). Prerequisites, CHEM 241L, 245L, 262L, 263L. An advanced synthesis laboratory focused on topics in organic chemistry. A four-hour synthesis laboratory, a characterization laboratory outside of the regular laboratory period, and a one-hour recitation each week.

Courses for Graduate Students

CHEM

721 Seminar in Materials Chemistry (2). Graduate standing required.

730 Chemical Biology (2–4). Prerequisite, CHEM 430. Application of chemical principles and tools to study and manipulate biological systems; in-depth exploration of examples from the contemporary literature. Topics include new designs for the genetic code, drug design, chemical arrays, single molecule experiments, laboratory-based evolution, chemical sensors, and synthetic biology.

731 Seminar in Biological Chemistry (2). Graduate standing required. Literature survey dealing with topics in protein chemistry and nucleic acid chemistry.

732 Advances in Macromolecular Structure and Function (3). In-depth analysis of the structure-function relationships governing protein-protein and protein-nucleic acid interactions. Topics include replication, DNA repair, transcription, translation, RNA processing, protein complex assembly, and enzyme regulation. Course includes both the current and classic literature that highlight the techniques used to study these processes.

733 Special Topics in Biological Chemistry (0.5–21). Modern topics in biological chemistry.

734 Biomolecular NMR (1–2). Introduction to practical solution NMR of proteins in solution.

735 Macromolecular Interactions (1). This practical course coordinates lectures with experience in the UNC Macromolecular Interactions Facility. Lectures introduce methods for monitoring interactions of macromolecules. Labs offer study teams of fewer than three students hands-on experience with major techniques available in the facility.

736 Macromolecular Crystallographic Methods (2). Data collection, phase determination, and structural refinement. Laboratory component allows students to crystallize protein, collect and process data, determine phases, and refine their structures.

741 Literature Seminar in Analytical Chemistry (2). Graduate standing required. Colloquium of modern analytical chemistry topics presented by graduate students and select invited speakers.

742 Analytical Research Techniques (2). Introduction to chemical instrumentation including digital and analog electronics, computers, interfacing, and chemometric techniques. Two one-hour lectures a week.

742L Laboratory in Analytical Research Techniques (2). Corequisite, CHEM 742. Experiments in digital and analog instrumentation, computers, interfacing and chemometrics, with applications to chemical instrumentation.

744 Special Topics in Analytical Chemistry (0.5–21). Modern topics in analytical chemistry, including advanced electroanalytical chemistry, advanced mass spectrometry, chemical instrumentation, and other subjects of recent significance. Two lecture hours a week.

752 Special Topics in Inorganic Chemistry (0.5–21). Permission of the instructor. Research-level survey of topics in inorganic chemistry and related areas.

754 Literature Seminar in Inorganic Chemistry (2). Graduate standing required.

758 X-Ray Structure Determination (3). Required preparation, knowledge of elementary and differential calculus is assumed. Permission of the instructor. This course is designed to introduce students to the techniques used in solving crystal structures by X-ray diffraction. Three lecture hours a week.

761 Seminar in Organic Chemistry (2). Graduate standing required. One afternoon meeting a week and individual consultation with the instructor.

764 Special Topics in Organic Chemistry (0.5–21). Two lecture hours a week.

767 Organic Chemistry (0.5–21). Permission of the instructor. Three to six hours a week.

781 Seminar in Physical Chemistry (2). Graduate standing required. Two hours a week.

783 Special Topics in Physical Chemistry (0.5–21). Permission of the instructor. Modern topics in physical chemistry, chemical physics, or biophysical chemistry. One to three lecture hours a week.

786 Special Topics in Physical Chemistry (0.5–21). Permission of the instructor. Modern topics in physical chemistry, chemical physics, or biophysical chemistry. One to three lecture hours a week.

788 Principles of Chemical Physics (PHYS 827) (3). See PHYS 827 for
description.

791 Special Topics in Chemistry (1–4). Selected research-level, cross-disciplinary topics in modern chemistry.

921 Research Methodology and Seminar in Polymer/Materials Chemistry (1–21). Seminar and directed study on research methods of polymer/materials chemistry. This course provides a foundation for master's thesis or doctoral dissertation research.

931 Research Methodology and Seminar in Biological Chemistry (1–21). Seminar and directed study on research methods of biological chemistry. This course provides a foundation for master's thesis or doctoral dissertation research.

941 Research Methodology and Seminar in Analytical Chemistry (1–21). Seminar and directed study on research methods of analytical chemistry. The course provides a foundation for master's thesis or doctoral dissertation research.

951 Research Methodology and Seminar in Inorganic Chemistry (1–21). Seminar and directed study on research methods of inorganic chemistry. The course provides a foundation for master's thesis or doctoral dissertation research.

961 Research Methodology and Seminar in Organic Chemistry (1–21). Seminar and directed study on research methods of organic chemistry. The course provides a foundation for master's thesis or doctoral dissertation research.

981 Research Methodology and Seminar in Physical Chemistry (1–21). Seminar and directed study on research methods of physical chemistry. The course provides a foundation for master's thesis or doctoral dissertation research.

992 Master's (Non-Thesis) (3–6).

993 Master's Thesis (3–6). Prerequisite, CHEM 921, 931, 941, 951, 961 or 981.

994 Doctoral Dissertation (3–9). Prerequisite, CHEM 921, 931, 941, 951, 961 or 981.