Department of Pathology and Laboratory Medicine
J. CHARLES JENNETTE, Chair
Mark E. Brecher, Vice Chair for Clinical Services
Thomas W. Bouldin, Vice Chair for Faculty and Trainee Development
David G. Kaufman, Vice Chair for Research Development
Professors
Nadia Malouf Anderson (26) Muscle Diseases, Plasticity of Adult-Derived Stem Cells
Dwight A. Bellinger (89) Laboratory Animal Medicine, Comparative Pathology
Thomas W. Bouldin (72) Neuropathology, Ocular Pathology, Neurotoxicology
Mark E. Brecher (128) Blood Component Processing and Storage, Transfusion Strategies, Transfusion Transmitted Diseases
John F. Chapman Jr. (79) Laboratory Practice, Clinical Chemistry
Frank C. Church (107) Molecular Pathology, Thrombosis and Hemostasis, Breast and Prostate Carcinogenesis, Macromolecular Structure-Function
William B. Coleman (139) Biology of Liver Stem Cells, Hepatocarcinogenesis, Lung and Breast Carcinogenesis, Epigenetics and Cancer
Marila Cordeiro-Stone (96) DNA Replication, DNA Repair, Cell Cycle Checkpoints in Human Cells, Mechanisms of Mutagenesis and Carcinogenesis
Cherie H. Dunphy (189) Hematopathology
Ronald J. Falk (172) Glomerular Disease, Lupus, Vasculitis, Dialysis
Rosann A. Farber (118) Genetic Instability in Cancer, Human Molecular Genetics, Microsatellite Instability, Fragile X Mental Retardation
Susan A. Fiscus (173) Retrovirology
Peter H. Gilligan (174) Diagnostic Bacteriology, Pulmonary Disease in Cystic Fibrosis, Toxin Mediated Diarrheal Disease
Margaret L. Gulley (196) Molecular Diagnostics, Oncology, Epstein-Barr Virus
Thomas R. Griggs (50) Blood Coagulation, Atherosclerosis
Catherine A. Hammett-Stabler (171) Clinical Chemistry, Toxicology, Clinical Pharmacology
J. Charles Jennette (61) Renal Pathology, Immunopathology
David G. Kaufman (34) Human Origins of DNA Replication; Interactions between Human Endometrial Epithelial and Stromal Cells
William K. Kaufmann (95) Human DNA Metabolism and Cancer
Joe N. Kornegay (232) Duchenne Muscular Dystrophy; Canine Model, Translational Studies, Muscle Hypertrophy
Susan T. Lord (94) Macromolecular Structure/Function of Fibrinogen, Molecular Genetics, Cardiovascular Disease
Nobuyo Maeda (116) Molecular Genetics of Atherosclerosis, Transgenic Laboratory Animals as Model Systems, Molecular Evolution
Susan J. Maygarden (131) General Surgical Pathology, Cytopathology, Prostate Carcinogenesis
Timothy C. Nichols (156) General Cardiology, Cardiac Catheterization, Per-Cutaneous Transluminal Coronary Angioplasty
Howard M. Reisner (38) Immunogenetics of Blood Coagulation, Immunochemistry
Oliver Smithies (115) Molecular Pathology, Genetically Engineered Animal Models of Human Disease, Targeted Mutagenesis
Darrel W. Stafford (127) Molecular Biology
James A. Swenberg (66) Chemical Carcinogenesis, Toxicology
Richard R. Tidwell (42) Medicinal Chemistry, Antiviral and Antimicrobial Agents, Protease Inhibitors
Michael D. Topal (41) Genomic Instability and Disease
Bernard E. Weissman (119) Tumor Suppressor Genes
Elizabeth M. Wilson (235) Steroid Hormone Regualation of Gene Expression
John T. Woosley (133) Dermatopathology, Hepatobiliary and Gastrointestinal Pathology, Histopathologic Assessment of Prognosis
Associate Professors
Georgette A. Dent (117) Hematopathology, Medical Education
William K. Funkhouser Jr. (152) Surgical Pathology, Molecular Pathology, Immunology
J. Ed Hall (177) Infectious Diseases, Pathogenic Protozoa, Drug Metabolism
Suzanne L. Kirby (181) General Hematology/Oncology and Bone Marrow Transplantation
Chad A. Livasy (193) Surgical Pathology
Christopher P. Mack (188) Transcriptional Regulation in the Cardiovascular System, Smooth Muscle Cell Biology
Volker Nickeleit (190) Renal Pathology, Fibronectins
Charles M. Perou (209) Breast Cancer, Genomics, Microarrays, Tumor Classification; Drug Resistance
W. Eugene Sanders (176) Difibrillation, Pacing Platelets
John L. Schmitz (168) Flow Cytometry, HIV, Diagnostic Immunology, Sexually Transmitted Diseases
Harsharan K. Singh (186) Cytopathology, Fine Needle Aspiration Biopsy
Joan M. Taylor (187) Adhesion Signaling, Cardiovascular Disease
Young E. Whang, (236) Androgen Receptor, Prostate Cancer
Assistant Professors
Jonathon W. Homeister (226) Defining the Molecular Mechanisms of Leukocyte Trafficking and Homing in Inflammatory and/or Immune Reactions
C. Ryan Miller (231) Neuropathology, Cancer Chemotherapy
Melissa B. Miller (211) Molecular Virology
Tara C. Rubinas 229) Gastrointestinal Pathology and Hepatopathology
Nobuyuki Takahashi (184) Animal Models of Hypertension, Preeclampsia, Diabetic Nephropathy and Obesity
Keith E. Volmar (219) Neoplasia and Developmental Abnormalities of the Pancreas
Monte S. Willis (223) Molecular Mechanisms of Cardiac Disease and Ubiquitin-Proteasome Biology
Alisa Sue Wolberg (198) Thrombosis Research, Coagulation
Clinical Professors
Debra A. Budwit (132) Surgical Pathology, Cytopathology, Diagnostic and Prognostic Markers in Gynecologic Neoplasms
John D. Butts (70) Forensic Pathology, Injury Prevention
M. David Goodman (216) Autopsy Pathology
Harold R. Roberts (15) Thrombosis and Hemorrhage Research and Therapy, Hematology
Clinical Associate Professors
Thomas B. Clark III (134) Forensic Pathology, Computer Applications in Forensic Medicine
Kathleen A. Kaiser-Rogers (212) Clinical Cytogenetics
Ruth A. Lininger (166) Surgical Pathology, Breast Pathology
Deborah L. Radisch (213) Forensic Pathology
Scott V. Smith (164) Vascular Biology, Cardiovascular Pathology, Platelet and von Willebrand Factor Pathophysiology
Karen E. Weck (210) Molecular Genetic Pathology
Herbert C. Whinna (167) Mechanisms of Hemostasis and Thrombosis, Biochemistry and Vascular Biology of Blood Coagulation, Protein Structure-Function
Clinical Assistant Professors
Araba N. Afenyi-Annan (220) Transfusion Medicine
Jessica K. Booker (199) Genetics, Breast Cancer
Maryanne Gaffney-Kraft (225) Forensic Pathology
Cynthia D. Gardner (233) Forensic Pathology
Diana Garside (202) Forensic Toxicology
Susan C. Hadler (194) Oral Diagnosis
Leigh B. Thorne (207) Molecular Pathology, Autopsy Pathology
Lisa J. Weinstein (234) Surgical Pathology, Cytopathology
Ruth E. Winecker (165) Forensic Pathology
Clinical Instructors
Kristen M. Boland (214) Anatomic Pathology and Medical Education
Claudia M. Brady (230) Surgical Pathology
Vincent J. Moylan, Jr. (218) Cardiac Pathology and Autopsy Pathology
Research Professors
C. Robert Bagnell Jr. (109) Application of Advanced Light and Electron Microscopy to Research in Basic Medical Sciences
John F. Bradfield (221) Laboratory Animal Medicine and Pathology
Virginia L. Godfrey (148) Veterinary Pathology, Animal Models of Genetic Disease, Autoimmunity
Research Associate Professors
Thomas H. Fischer (169) Gene Therapy, Blood Coagulation, Atherosclerosis
Tracey M. Heenan (163) Laboratory-, Exotic- and Companion-Animal Medicine
Hyung-Suk Kim (137) Gene Targeting and Animal Models for Human Diseases, Hypertension and Hereditary Cerebral Hemorrhage with Amyloidosis and Molecular Evolution
Judith N. Nielsen (222) Animal Health Maintenance, Diagnosis and Eradication
Gloria A. Preston (237) Pathogenesis of Renal Diseases
Research Assistant Professors
Jayne C. Boyer (200) Human Molecular Genetics, Molecular Mechanisms of Microsatellite Instability
Oleg V. Gorkun (195) Coagulation, Fibrinolysis, Fibrinogen Structure
Seigo Hatada (217) Appling Gene Targeting for Curing Genetic Diseases
Masao Kakoki (224) Prevention of Cardiovascular Diseases
Dennis A. Simpson (204) Cell Biology, Molecular Biology, Virology
Julia W. Whitaker (227) Laboratory Animal Medicine
Hong Xiao (215) Immune-Mediated Glomerular Disease and Vasculitis
Xianwen Yi (228) Alpha Lipoic Acid and Diabetes Mellitus
Maimoona A. Zariwala (205) Genetic Analysis of Patients with Primary Ciliary Dyskinesia (PCD)
Adjunct Professors
Byron Butterworth (67) Genetic Toxicology
Robert R. Maronpot (140) Mechanisms of Carcinogenesis
Gary J. Smith (85) Prostate Cancer, Cancer Cell-Tissue Microenvironmental Interaction, Angiogenesis
Adjunct Associate Professors
Gary A. Boorman (102) Toxicological Pathology, Myelotoxicology
Jeffrey I. Everitt (180) Experimental Pulmonary and Toxicology Pathology
Richard S. Paules (144) Oncogenes Tumor Suppressor Genes and Cell Cycle Control in Neoplastic Transformation of Mammalian Cells
Douglas C. Wolf (185) Mechanisms of Toxicity and Carcinogenesis
Adjunct Assistant Professor
Christopher W. Gregory (201) Prostate Cancer, Androgen Receptor
Professors Emeriti
Walter Benson
Stuart Bentley
Myra L. Collins
Robert E. Cross
Frederic G. Dalldorf
Cora-Jean S. Edgell
James D. Folds
Donald T. Forman
Joe W. Grisham
John E. Hammond
William D. Huffines
William W. McLendon
James R. Pick
Katherine B. Pryzwansky
Marjorie S. Read
Kinuko I. Suzuki
Graduate work in the Department of Pathology is offered to those interested in acquiring more extensive knowledge of diseases and their effects at different levels of molecular and cellular organization. Major emphasis is given to investigation of molecular mechanisms responsible for disease processes. Students are given the opportunity to undertake candidacy for the doctor of philosophy degree. Participation in research activities leading to an original dissertation is required of all advanced degree candidates.
Prospective candidates must hold a bachelor's degree from an accredited college or university.
The department is located in the Brinkhous-Bullitt Building, and offers well-equipped laboratories for research and advanced work in pathology.
Courses for Graduates and Advanced Undergraduates
128 [008] BIOLOGY OF HUMAN DISEASE (BIOL 128) (3). Open to all undergraduates and graduates. No prerequisites. Presents an overview of basic human molecular and cellular biology in the setting of common human diseases. The course emphasizes how an understanding of disease mechanisms provides the knowledge base for an informed use of modern health care. Fall. Reisner, Smith.
426 [134] BIOLOGY OF BLOOD DISEASES (BIOL 426) (3). Prerequisite, BIOL 205 or permission of the instructor. An introduction to the biology and pathophysiology of blood and the molecular mechanisms of some human diseases: anemias; leukemias; hemorrhagic, thrombotic and vascular disorders; and HIV disease/AIDS. Fall. Church.
462 [162] EXPERIMENTAL PATHOLOGY (1-21). Hours, credits, and instructor to be arranged on an individual basis. This course involves hands-on research experience in a predetermined instructor's laboratory. Students have the opportunity to learn and apply specific techniques and to participate in investigations of molecular mechanisms responsible for disease processes (pathobiology). Contact the director of graduate studies in pathology for more information. May be repeated. Staff.
463 [163] ELECTRON MICROSCOPY (3). Permission of the instructor. Theoretical and practical aspects of electron microscopy. Application of transmission and scanning electron microscopy to pathology, with emphasis on ultrastructure of cells and organelles. Two lecture and six laboratory hours a week. Fall. (2007 and alternate years.) Bagnell.
464 [164] LIGHT MICROSCOPY (3). Permission of the instructor. Course focuses on practical fundamentals of light microscopy including optics, contrast mechanisms, fluorescence, laser scanning confocal microscopy, photography and digital imaging. Spring. Bagnell.
678 [178] HUMAN DNA METABOLISM (2). Prerequisite, a basic biochemistry course. This course examines the molecular biology of DNA replication, resorption, recombination and repair as these processes occur in human cells. Two seminar hours per week. Fall. (2006 and alternate years.) Kaufmann.
Courses for Graduates
713 [213] MECHANISMS OF DISEASE (2, 3 or 5). Prerequisite, cell biology, histology or permission of the course director. A graduate course on cell injury and pathogenesis of disease with emphasis on basic mechanisms at the molecular, cellular and organismal levels. Three lecture hours (three credits) and a two-and-a-half-hour laboratory (two credits) each week. Fall. Church.
723 [223] TRANSLATIONAL MEDICINE (2). Prerequisite, permission of the instructor. Conducted on a tutorial basis, with the aim of providing experience with specialized techniques including histochemistry, electron microscopy, fluorescent and phase microscopy, chromatography, electrophoresis and ultracentrifugation. Two seminar hours per week, including clinical experiences. Spring. (2006 and alternate years.) Whinna.
725 [225] CANCER PATHOBIOLOGY (3). Permission of the course director required. This course examines pathobiological features of cancer. An interdisciplinary approach draws from epidemiology, genetics, molecular biology and clinical medicine to investigate cancer etiology, pathogenesis, prevention and treatment. Three lecture hours a week. Spring. Kaufmann.
750 [250] APPLIED BIOSTATISTICS (PHCO 750, TOXC 750) (2). Data analysis for biomedical scientists. This largely self-study course deals with basic statistical and quantitative methods for the analysis and interpretation of biomedical data. This course is required for PHCO/TOXC/PATH graduate students. Permission of the instructor is required for other students. Fall. Graves.
792 [292] SEMINAR IN CARCINOGENESIS (TOXC 792) (2). Prerequisite, permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week. Spring. Coleman.
801 [301] SEMINAR IN PATHOLOGY (2). This course emphasizes the development of written and oral scientific communication skills. It is designed specifically for first and second year graduate students within the department. Fall. Cordeiro-Stone.
900 [302] RESEARCH IN PATHOLOGY (2–12). Prerequisite, permission of the department. This is a research course in which advanced students in pathology carry on investigations on mechanisms of disease. Six or more laboratory hours a week, to be arranged. May be repeated. Fall, spring and summer. Staff.
993 [393] MASTER'S THESIS (Var.). Fall, spring and summer. May be repeated. (Total maximum of six credits.) Staff.
994 [394] DOCTORAL DISSERTATION (Var.). May be repeated. Fall, spring and summer. Staff.