Department of Pathology and Laboratory Medicine
J. CHARLES JENNETTE, Chair
Thomas W. Bouldin, Vice Chair for Faculty and Trainee Development
William K. Funkhouser, Director of Anatomic Pathology and Associate Director of McLendon Clinical Laboratories
David G. Kaufman, Vice Chair for Research Development
Herbert C. Whinna, Director of McLendon Clinical Laboratories and Vice Chair for Clinical Services
Professors
Dwight A. Bellinger (89) Laboratory Animal Medicine, Comparative Pathology
Thomas W. Bouldin (72) Neuropathology, Ocular Pathology, Neurotoxicology
Frank C. Church (107) Thrombosis and Hemostasis, Macromolecular Protein Structure-Function, Molecular Pathology
William B. Coleman (139) Breast Cancer Epigenetics, Biology of Liver Stem Cells, Hepatocarcinogenesis, Cancer Molecular Diagnostics
Marila Cordeiro-Stone (96) DNA Replication, DNA Repair, Cell Cycle Checkpoints in Human Cells, Mechanisms of Mutagenesis and Carcinogenesis
Ronald J. Falk (172) Glomerular Disease, Lupus, Vasculitis, Dialysis
Rosann A. Farber (118) Genetic Instability in Cancer, Human Molecular Genetics, Microsatellite Instability
Susan A. Fiscus (173) Retrovirology
William K. Funkhouser Jr. (152) Surgical Pathology, Molecular Pathology, Immunology
Peter H. Gilligan (174) Diagnostic Bacteriology, Pulmonary Disease in Cystic Fibrosis, Toxin Mediated Diarrheal Disease
Margaret L. Gulley (196) Molecular Diagnostics, Oncology, Epstein-Barr Virus
Thomas R. Griggs (50) Blood Coagulation, Atherosclerosis
Catherine A. Hammett-Stabler (171) Clinical Chemistry, Toxicology, Clinical Pharmacology
J. Charles Jennette (61) Renal Pathology, Immunopathology
David G. Kaufman (34) Human Origins of DNA Replication; Interactions between Human Endometrial Epithelial and Stromal Cells
William K. Kaufmann (95) Human DNA Metabolism and Cancer
Nigel Mackman (239) Thrombosis and Hemostasis
Nobuyo Maeda (116) Molecular Genetics of Atherosclerosis, Transgenic Laboratory Animals as Model Systems, Molecular Evolution
Susan J. Maygarden (131) General Surgical Pathology, Cytopathology, Prostate Carcinogenesis
Timothy C. Nichols (156) General Cardiology, Cardiac Catheterization, Per-Cutaneous Transluminal Coronary Angioplasty
Volker Nickeleit (190) Renal Pathology, Fibronectins
Charles M. Perou (209) Breast Cancer, Genomics, Microarrays, Tumor Classification; Drug Resistance
Howard M. Reisner (38) Immunogenetics of Blood Coagulation, Immunochemistry
John L. Schmitz (168) Flow Cytometry, HIV, Diagnostic Immunology, Sexually Transmitted Diseases
Harsharan K. Singh (186) Cytopathology, Fine Needle Aspiration Biopsy, Renal Pathology
Oliver Smithies (115) Molecular Pathology, Genetically Engineered Animal Models of Human Disease, Targeted Mutagenesis
Darrel W. Stafford (127) Molecular Biology
James A. Swenberg (66) Chemical Carcinogenesis, Toxicology, Mass Spectroscopy, DNA Damage and Repair, Endogenous DNA Damage
Richard R. Tidwell (42) Medicinal Chemistry, Antiviral and Antimicrobial Agents, Protease Inhibitors
Michael D. Topal (41) Genomic Instability and Disease
Bernard E. Weissman (119) Tumor Suppressor Genes
Elizabeth M. Wilson (235) Steroid Hormone Regulation of Gene Expression
John T. Woosley (133) Dermatopathology, Hepatobiliary and Gastrointestinal Pathology, Histopathologic Assessment of Prognosis
Associate Professors
Georgette A. Dent (117) Hematopathology, Medical Education
Christopher P. Mack (188) Transcriptional Regulation in the Cardiovascular System, Smooth Muscle Cell Biology
Melissa B. Miller (211) Molecular Diagnostics, Antimicrobial Resistance, Molecular Epidemiology of MRSA
Joan M. Taylor (187) Adhesion Signaling, Cardiovascular Disease
Cyrus Vaziri (249) Regulation of DNA Replication, S-Phase Checkpoints, and Post-Replication DNA Repair on Mammalian Cells
Young E. Whang, (236) Androgen Receptor, Prostate Cancer
Monte S. Willis (223) Molecular Mechanisms of Cardiac Disease and Ubiquitin-Proteasome Biology
Alisa S. Wolberg (198) Cellular and Molecular Mechanisms in Hemostasis and Thrombosis
Assistant Professors
George Fedoriw (242) Hematopathology; Applications of Flow Cytometry
C. Ryan Miller (231) Neuropathology, Genetics of Gliomagenesis and Experimental Therapeutics
Yara A. Park (246) Transfusion Medicine
Arlin B. Rogers (244) Liver Carcinogenesis; Comparative Pathology
Dimitri G. Trembath (250) Surgical Pathology and Neuropathology
Clinical Professors
Debra A. Budwit (132) Surgical Pathology, Cytopathology, Diagnostic and Prognostic Markers in Gynecologic Neoplasms
M. David Goodman (216) Autopsy Pathology
Pamela M. Groben (157) Dermatopathology
H. Michael Jones (241) Medical Education at Medical Student and Resident Level; Medical History, Autopsy Pathology, Research Support
Kathleen A. Kaiser-Rogers (212) Clinical Cytogenetics
Clay Nichols (266) Forensic Pathology
Deborah L. Radisch (213) Forensic Pathology
Harold R. Roberts (15) Thrombosis and Hemorrhage Research and Therapy, Hematology
Scott V. Smith (164) Surgical Pathology, Cardiovascular Pathology, Pediatric Pathology
Karen E. Weck (210) Molecular Genetic Pathology
Clinical Associate Professors
Jessica K. Booker (199) Genetics, Breast Cancer
Susan C. Hadler (194) Oral Diagnosis
Jonathon W. Homeister (226) Molecular Mechanisms of Leukocyte Trafficking and Homing; Inflammatory Vascular Disease; Thrombosis and Hemostasis; Cardiovascular Pathology; Autopsy Pathology
Ruth A. Lininger (166) Surgical Pathology, Breast Pathology
Leigh B. Thorne (207) Molecular Pathology, Autopsy Pathology
Herbert C. Whinna (167) Mechanisms of Hemostasis and Thrombosis, Biochemistry and Vascular Biology of Blood Coagulation, Protein Structure-Function
Clinical Assistant Professors
Claudia M. Brady (230) Surgical Pathology
Megan J. DiFurio (260) Cytopathology, GYN/Breast Pathology
Kevin Greene (255) Surgical Pathology of the Liver and Gastrointestinal Tract
Rommel P. Lu (267) Clinical Transfusion Practices, Coagulopathy in Trauma and Burn Injury, Cancer-Associated Thrombosis
Stephanie P. Mathews (262) Hematopathology
Siobhan M. O’Connor (257) Breast Pathology, GYN Pathology, Cytopathology
Jonathan D. Privette (268) Forensic Pathology
Lori R. Scanga (256) Surgical Pathology, Cytopathology
Samuel Simmons (263) Forensic Pathology
Ruth E. Winecker (165) Forensic Pathology
Daniel Zedek (269) Dermatopathology
Clinical Instructors
Steve Holmes (254) Examination of Simple and Complex Specimens, Surgical Pathology
April E. Kemper (259) Autopsy Pathology, Surgical Pathology
Vincent J. Moylan Jr. (218) Cardiac Pathology and Autopsy Pathology
Tracie Wagner (247) Tissue Procurement; Surgical Pathology
Research Professors
C. Robert Bagnell Jr. (109) Application of Advanced Light and Electron Microscopy to Research in Basic Medical Sciences
Virginia L. Godfrey (148) Veterinary Pathology, Animal Models of Genetic Disease, Autoimmunity
Hyung-Suk Kim (137) Gene Targeting and Animal Models for Human Diseases, Hypertension and Hereditary Cerebral Hemorrhage with Amyloidosis and Molecular Evolution
Judith N. Nielsen (222) Animal Health Maintenance, Diagnosis and Eradication
Gloria A. Preston (237) Pathogenesis of Renal Diseases
Research Associate Professors
Arlene S. Bridges (248) Molecular Pharmaceutics and Mass Spectrometry
David A. Eberhard (253) Pathology, Scientific and Business Support for Clinical Trials
Craig A. Fletcher (251) Vascular Biology
Tracy M. Heenan (163) Laboratory-, Exotic- and Companion-Animal Medicine
Masao Kakoki (224) Prevention of Cardiovascular Diseases
Maimoona A. Zariwala (205) Genetic Analysis of Patients with Primary Ciliary Dyskinesia (PCD)
Research Assistant Professors
Adil Hussein Gasim (265) Nephropathology
Peiqi Hu (261) Immune-Mediated Kidney Disease
Ashley G. Rivenbark (270) Cancer Biology, Cancer Epigenetics, Breast Cancer, Epigenetic Therapy, and Epigenetic Reprogramming
Dennis A. Simpson (204) Cell Biology, Molecular Biology, Virology
Julia W. Whitaker (227) Laboratory Animal Medicine
Hong Xiao (215) Immune-Mediated Glomerular Disease and Vasculitis
Xianwen Yi (228) Alpha Lipoic Acid and Diabetes Mellitus
Adjunct Professors
Mark E. Brecher (128) Blood Component Processing and Storage, Transfusion Strategies, Transfusion Transmitted Diseases
Cherie H. Dunphy (189) Hematopathology
J. Ed Hall (177) Infectious Diseases, Pathogenic Protozoa, Drug Metabolism
Joe N. Kornegay (232) Duchenne Muscular Dystrophy; Canine Model, Translational Studies, Muscle Hypertrophy
Chad A. Livasy (193) Surgical Pathology
Richard S. Paules (144) Oncogenes Tumor Suppressor Genes and Cell Cycle Control in Neoplastic Transformation of Mammalian Cells
Gary J. Smith (85) Prostate Cancer, Cancer Cell-Tissue Microenvironmental Interaction, Angiogenesis
Adjunct Associate Professors
Gary A. Boorman (102) Toxicological Pathology, Myelotoxicology
Jeffrey I. Everitt (180) Experimental Pulmonary and Toxicology Pathology
Thomas H. Fischer (169) Gene Therapy, Blood Coagulation, Atherosclerosis
Suzanne L. Kirby (181) General Hematology/Oncology and Bone Marrow Transplantation
Tara C. Rubinas 229) Gastrointestinal Pathology and Hepatopathology
Nobuyuki Takahashi (184) Animal Models of Hypertension, Preeclampsia, Diabetic Nephropathy and Obesity
Douglas C. Wolf (185) Mechanisms of Toxicity and Carcinogenesis
Adjunct Assistant Professor
Araba N. Afenyi-Annan (220) Transfusion Medicine
Oleg V. Gorkun (195) Coagulation, Fibrinolysis, Fibrinogen Structure
Christopher W. Gregory (201) Prostate Cancer, Androgen Receptor
Heike Hunt (245) Liver and Gastrointestinal Pathology
John P. Hunt (243) Surgical Pathology and Hematopathology
Professors Emeriti
Nadia Malouf Anderson
Stuart Bentley
John F. Chapman Jr.
Myra L. Collins
Robert E. Cross
Frederic G. Dalldorf
Cora-Jean S. Edgell
James D. Folds
Donald T. Forman
Joe W. Grisham
John E. Hammond
Susan T. Lord
William W. McLendon
James R. Pick
Marjorie S. Read
Kinuko I. Suzuki
Graduate work in the Department of Pathology and Laboratory Medicine is offered through the Molecular and Cellular Pathology program to those interested in acquiring more extensive knowledge of disease pathogenesis. Major emphasis is given to investigation of molecular and cellular mechanisms responsible for disease initiation, progression, and treatment. Students are given the opportunity to undertake candidacy for the doctor of philosophy degree. Participation in research activities leading to an original dissertation is required of all advanced degree candidates.
Prospective candidates must hold a bachelor’s degree from an accredited college or university.
The department is located in the Brinkhous-Bullitt Building, and offers well-equipped laboratories for research and advanced work in pathology.
Please visit www.med.unc.edu/pathology/mcp for more graduate program information.
Courses for Graduate and Advanced Undergraduate Students
PATH
426 Biology of Blood Diseases (BIOL 426) (3). Prerequisite, BIOL 205. Permission of the instructor for students lacking the prerequisite. An introduction to the biology and pathophysiology of blood and the molecular mechanisms of some human diseases: anemias; leukemias; hemorrhagic, thrombotic, and vascular disorders; and HIV disease/AIDS.
462 Experimental Pathology (1–9). Hours, credits, and instructor to be arranged on an individual basis. Hands-on research experience in a predetermined instructor’s laboratory. Students learn and apply specific techniques and participate in investigations of molecular mechanisms responsible for disease processes (pathobiology). Contact the director of graduate studies in pathology for information. May be repeated.
464 Light Microscopy (3). Permission of the instructor. Course focuses on practical fundamentals of light microscopy including optics, contrast mechanisms, fluorescence, laser scanning confocal microscopy, photography, and digital imaging.
667 Molecular and Cellular Biology of Cardiovascular Diseases (3). This advanced course will explore the pathogenesis of cardiac and vascular disease with the objective of teaching students to understand, investigate, and communicate current concepts of cardiovascular disease.
Courses for Graduate Students
PATH
713 Mechanisms of Disease (3). Corequisite, PATH 714L. A graduate course on cell injury and pathogenesis of disease with emphasis on basic mechanisms at the molecular, cellular, and organismal levels. Three lecture hours (three credits) with a complementary two-and-a-half-hour laboratory (two credits) each week.
714L Molecular and Cellular Pathophysiological Basis of Disease: Laboratory I (2). Pre- or corequisite, PATH 713. A graduate-level laboratory course on basic mechanisms of disease pathogenesis, emphasizing cell and tissue-based examples of major disease mechanisms.
715 Molecular and Cellular Pathophysiological Basis of Disease: Systemic Pathology (3). Corequisite, PATH 716L. A graduate-level course on systemic pathology, emphasizing the molecular and cellular pathogenesis of diseases of major organ systems. A follow-up to PATH 713/714L. Three lecture hours (three credits) with a complementary two-and-a-half-hour laboratory (two credits) each week.
716L Molecular and Cellular Pathophysiological Basis of Disease: Laboratory II (2). Pre- or corequisite, PATH 715. A graduate-level laboratory course on mechanisms of systemic disease pathogenesis, emphasizing cell and tissue-based examples of diseases of the major organ systems.
723 Translational Pathology and Laboratory Medicine (2). Permission of the instructor. A multi-disciplinary course providing students principles involved in translating basic science into clinically applicable diagnostics and therapies to improve human disease outcomes. The course is focused on bioinformatics, bioethics, trial design, FDA approval, and commercialization of laboratory diagnostics.
725 Cancer Pathobiology (3). Permission of the instructor. This course examines pathobiological features of cancer. An interdisciplinary approach draws from epidemiology, genetics, molecular biology, and clinical medicine to investigate cancer etiology, pathogenesis, prevention, and treatment.
792 Seminar in Carcinogenesis (TOXC 792) (2). Permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week.
801 Scientific Critical Thinking (3). A graduate-level course designed to teach the ‘scientific method’ and based on student presentations of primary literature and group discussions. Teaches students the process by which scientists identify problems, formulate testable hypotheses, collect data through experiments, and eventually establish new models describing biological processes.
890 Special Topics in Pathology: Human Environmental Disease (1–3). This course will study human disease processes that are induced or exacerbated by our environment. Environmental disease stressors include solar radiation, air and water pollution, bioreactive substances in foods, pesticides, metals, dusts, particles, and allergens. Lectures will emphasize epidemiology, mechanisms of toxicity, and human disease pathogenesis.
900 Research in Pathology (2–12). Permission of the department. This is a research course in which advanced students in pathology carry on investigations on mechanisms of disease. Six or more laboratory hours a week, to be arranged. May be repeated.
993 Master’s Thesis (3–6). May be repeated.
994 Doctoral Dissertation (3–9). May be repeated.