Department of Pathology and Laboratory Medicine


Herbert C. Whinna, Vice Chair for Clinical Services and Director of McLendon Clinical Laboratories

Monte S. Willis, Vice Chair for Academic Affairs

Joan M. Taylor, Vice Chair for Research


Dwight A. Bellinger (89) Laboratory Animal Medicine, Comparative Pathology

Frank C. Church (107) Thrombosis and Hemostasis, Macromolecular Protein Structure-Function, Molecular Pathology

William B. Coleman (139) Breast Cancer Epigenetics, Biology of Liver Stem Cells, Hepatocarcinogenesis, Cancer Molecular Diagnostics

Leslie G. Dodd, Surgical Pathology Cytopathology

Ronald J. Falk (172) Glomerular Disease, Lupus, Vasculitis, Dialysis

Rosann A. Farber (118) Genetic Instability in Cancer, Human Molecular Genetics, Microsatellite Instability

William K. Funkhouser Jr. (152) Surgical Pathology, Molecular Pathology, Immunology

Peter H. Gilligan (174) Diagnostic Bacteriology, Pulmonary Disease in Cystic Fibrosis, Toxin Mediated Diarrheal Disease

Margaret L. Gulley (196) Molecular Diagnostics, Oncology, Epstein-Barr Virus

Catherine A. Hammett-Stabler (171) Clinical Chemistry, Toxicology, Clinical Pharmacology

J. Charles Jennette (61) Renal Pathology, Immunopathology

David G. Kaufman (34) Human Origins of DNA Replication; Interactions between Human Endometrial Epithelial and Stromal Cells

Nigel Mackman (239) Thrombosis and Hemostasis

Nobuyo Maeda (116) Molecular Genetics of Atherosclerosis, Transgenic Laboratory Animals as Model Systems, Molecular Evolution

Susan J. Maygarden (131) General Surgical Pathology, Cytopathology, Prostate Carcinogenesis

Timothy C. Nichols (156) General Cardiology, Cardiac Catheterization, Per-Cutaneous Transluminal Coronary Angioplasty

Volker Nickeleit (190) Renal Pathology, Fibronectins

Charles M. Perou (209) Breast Cancer, Genomics, Microarrays, Tumor Classification; Drug Resistance

Howard M. Reisner (38) Immunogenetics of Blood Coagulation, Immunochemistry

John L. Schmitz (168) Flow Cytometry, HIV, Diagnostic Immunology, Sexually Transmitted Diseases

Harsharan K. Singh (186) Cytopathology, Fine Needle Aspiration Biopsy, Renal Pathology

Oliver Smithies (115) Molecular Pathology, Genetically Engineered Animal Models of Human Disease, Targeted Mutagenesis

Darrel W. Stafford (127) Molecular Biology

James A. Swenberg (66) Chemical Carcinogenesis, Toxicology, Mass Spectroscopy, DNA Damage and Repair, Endogenous DNA Damage

Joan M. Taylor (187) Adhesion Signaling, Cardiovascular Disease

Michael D. Topal (41) Genomic Instability and Disease

Cyrus Vaziri (249) Regulation of DNA Replication, S-Phase Checkpoints, and Post-Replication DNA Repair on Mammalian CellsBernard E. Weissman (119) Tumor Suppressor Genes

Elizabeth M. Wilson (235) Steroid Hormone Regulation of Gene Expression

John T. Woosley (133) Dermatopathology, Hepatobiliary and Gastrointestinal Pathology, Histopathologic Assessment of Prognosis

Associate Professors

Georgette A. Dent (117) Hematopathology, Medical Education

George Fedoriw (242) Hematopathology; Applications of Flow CytometryMehmet Kesimer Mucin Glycobiology and Airway Epithelial Pathobiology

Christopher P. Mack (188) Transcriptional Regulation in the Cardiovascular System, Smooth Muscle Cell Biology

C. Ryan Miller (231) Neuropathology, Genetics of Gliomagenesis and Experimental Therapeutics

Melissa B. Miller (211) Molecular Diagnostics, Antimicrobial Resistance, Molecular Epidemiology of MRSA

Young E. Whang, (236) Androgen Receptor, Prostate Cancer

David C. Williams Jr. Hematopathology, NMR Spectrophotometry and Structural Biology

Monte S. Willis (223) Molecular Mechanisms of Cardiac Disease and Ubiquitin-Proteasome Biology

Alisa S. Wolberg (198) Cellular and Molecular Mechanisms in Hemostasis and Thrombosis

Assistant Professors

Johann D. Hertel Cytopathology

Nicole L. Korpi-Steiner Clinical Chemistry

Jiandong Liu Cardiovascular Biology

Marshall A. Mazepa Transfusion Medicine

Yara A. Park (246) Transfusion Medicine

Li Qian Cardiovascular and Stem Cell Biology

Jay S. Raval Transfusion Medicine

Dimitri G. Trembath (250) Surgical Pathology and Neuropathology

Scott Williams Stem Cell and Developmental Biology

Qing Zhang Cancer Cell Biology

Clinical Professors

Thomas W. Bouldin (72) Neuropathology, Ocular Pathology, Neurotoxicology

Pamela M. Groben (157) Dermatopathology

H. Michael Jones (241) Medical Education at Medical Student and Resident Level; Medical History, Autopsy Pathology, Research Support

Kathleen A. Kaiser-Rogers (212) Clinical Cytogenetics

Thomas J. Lawton, Breast Pathology, Gynecological Pathology

Deborah L. Radisch (213) Forensic Pathology

Harold R. Roberts (15) Thrombosis and Hemorrhage Research and Therapy, Hematology

Scott V. Smith (164) Surgical Pathology, Cardiovascular Pathology, Pediatric Pathology

Karen E. Weck (210) Molecular Genetic Pathology

Clinical Associate Professors

Jessica K. Booker (199) Genetics, Breast Cancer

Susan C. Hadler (194) Oral Diagnosis

Jonathon W. Homeister (226) Molecular Mechanisms of Leukocyte Trafficking and Homing; Inflammatory Vascular Disease; Thrombosis and Hemostasis; Cardiovascular Pathology; Autopsy Pathology

Daniel J. Kenan Nephropathology

Ruth A. Lininger (166) Surgical Pathology, Breast Pathology

Eizaburo Sasatomi Gastro Intestinal and Liver Pathology

Leigh B. Thorne (207) Molecular Pathology, Autopsy Pathology

Herbert C. Whinna (167) Mechanisms of Hemostasis and Thrombosis, Biochemistry and Vascular Biology of Blood Coagulation, Protein Structure-Function

Clinical Assistant Professors

Claudia M. Brady (230) Surgical Pathology

Kevin Greene (255) Surgical Pathology of the Liver and Gastrointestinal Tract

Stephanie P. Mathews (262) Hematopathology

Vincent J. Moylan Jr. (218) Cardiac Pathology and Autopsy Pathology

Siobhan M. O'Connor (257) Breast Pathology, GYN Pathology, Cytopathology

Nirali M. Patel, Molecular Pathology Anatomic and Clinical Pathology

Marian Rollins-Raval Hematopathology, Flow Cytometry and Coagulation

Lori R. Scanga (256) Surgical Pathology, Cytopathology

Eric T. Weimer Histocompatibility, Flow Cytometry and Clinical Microbiology/Immunology

Ruth E. Winecker (165) Forensic Pathology

Daniel Zedek (269) Dermatopathology

Clinical Instructors

Steve Holmes (254) Examination of Simple and Complex Specimens, Surgical Pathology

April E. Kemper (259) Autopsy Pathology, Surgical Pathology

Tracie W. Massey (247) Tissue Procurement; Surgical Pathology

Research Professors

C. Robert Bagnell Jr. (109) Application of Advanced Light and Electron Microscopy to Research in Basic Medical Sciences

Virginia L. Godfrey (148) Veterinary Pathology, Animal Models of Genetic Disease, Autoimmunity

William K. Kaufmann (95) Human DNA Metabolism and Cancer

Hyung-Suk Kim (137) Gene Targeting and Animal Models for Human Diseases, Hypertension and Hereditary Cerebral Hemorrhage with Amyloidosis and Molecular Evolution

Judith N. Nielsen (222) Animal Health Maintenance, Diagnosis and Eradication

Richard R. Tidwell (42) Medicinal Chemistry, Antiviral and Antimicrobial Agents, Protease Inhibitors

Research Associate Professors

Brian Cooley, Thrombosis, Vascular Injury, Microsurgery

David A. Eberhard (253) Pathology, Scientific and Business Support for Clinical Trials

Craig A. Fletcher (251) Vascular Biology

Tracy M. Heenan (163) Laboratory-, Exotic- and Companion-Animal Medicine

Peiqi Hu (261) Immune-Mediated Kidney Disease

Masao Kakoki (224) Prevention of Cardiovascular Diseases

Julia W. Whitaker (227) Laboratory Animal Medicine

Hong Xiao (215) Immune-Mediated Glomerular Disease and Vasculitis

Maimoona A. Zariwala (205) Genetic Analysis of Patients with Primary Ciliary Dyskinesia (PCD)

Research Assistant Professors

J. Todd Auman, Pharmacogenomics, Cancer Pharmacology

Feng Li Cardiovascular Biology

Stephanie A. Montgomery Comparative Pathology and Animal Histopathology

Adjunct Professors

Mark E. Brecher (128) Blood Component Processing and Storage, Transfusion Strategies, Transfusion Transmitted Diseases

Cherie H. Dunphy (189) Hematopathology

J. Ed Hall (177) Infectious Diseases, Pathogenic Protozoa, Drug Metabolism

Joe N. Kornegay (232) Duchenne Muscular Dystrophy; Canine Model, Translational Studies, Muscle Hypertrophy

Chad A. Livasy (193) Surgical Pathology

Richard S. Paules (144) Oncogenes Tumor Suppressor Genes and Cell Cycle Control in Neoplastic Transformation of Mammalian Cells

Gary J. Smith (85) Prostate Cancer, Cancer Cell-Tissue Microenvironmental Interaction, Angiogenesis

Adjunct Associate Professors

Gary A. Boorman (102) Toxicological Pathology, Myelotoxicology

Jeffrey I. Everitt (180) Experimental Pulmonary and Toxicology Pathology

Thomas H. Fischer (169) Gene Therapy, Blood Coagulation, Atherosclerosis

Suzanne L. Kirby (181) General Hematology/Oncology and Bone Marrow Transplantation

Tara C. Rubinas 229) Gastrointestinal Pathology and Hepatopathology

Nobuyuki Takahashi (184) Animal Models of Hypertension, Preeclampsia, Diabetic Nephropathy and Obesity

Douglas C. Wolf (185) Mechanisms of Toxicity and Carcinogenesis

Adjunct Assistant Professors

Araba N. Afenyi-Annan (220) Transfusion Medicine

Christopher W. Gregory (201) Prostate Cancer, Androgen Receptor

Heike Hunt (245) Liver and Gastrointestinal Pathology

John P. Hunt (243) Surgical Pathology and Hematopathology

Professors Emeriti

Nadia Malouf Anderson

Stuart Bentley

Budwit, Debra A.

Butts, John D.

John F. Chapman Jr.

Myra L. Collins

Marila Cordeiro-Stone

Robert E. Cross

Frederic G. Dalldorf

Cora-Jean S. Edgell

James D. Folds

Donald T. Forman

Joe W. Grisham

John E. Hammond

Susan T. Lord

William W. McLendon

James R. Pick

Marjorie S. Read

Kinuko I. Suzuki

Graduate work in the Department of Pathology and Laboratory Medicine is offered through the Molecular and Cellular Pathology program to those interested in acquiring more extensive knowledge of disease pathogenesis. Major emphasis is given to investigation of molecular and cellular mechanisms responsible for disease initiation, progression, and treatment. Students are given the opportunity to undertake candidacy for the doctor of philosophy degree. Participation in research activities leading to an original dissertation is required of all advanced degree candidates.

Prospective candidates must hold a bachelor's degree from an accredited college or university.

The department is located in the Brinkhous-Bullitt Building, and offers well-equipped laboratories for research and advanced work in pathology.

Please visit for more graduate program information.

Courses for Graduate and Advanced Undergraduate Students


426 Biology of Blood Diseases (BIOL 426) (3). Prerequisite, BIOL 205. Permission of the instructor for students lacking the prerequisite. An introduction to the biology and pathophysiology of blood and the molecular mechanisms of some human diseases: anemias; leukemias; hemorrhagic, thrombotic, and vascular disorders; and HIV disease/AIDS.

462 Experimental Pathology (1–9). Hours, credits, and instructor to be arranged on an individual basis. Hands-on research experience in a predetermined instructor's laboratory. Students learn and apply specific techniques and participate in investigations of molecular mechanisms responsible for disease processes (pathobiology). Contact the director of graduate studies in pathology for information. May be repeated.

464 Light Microscopy (3). Permission of the instructor. Course focuses on practical fundamentals of light microscopy including optics, contrast mechanisms, fluorescence, laser scanning confocal microscopy, photography, and digital imaging.

Courses for Graduate Students


713 Molecular and Cellular Pathophysiological Basis of Disease: Mechanisms of Disease (3). Corequisite, PATH 714L. A graduate course on cell injury and pathogenesis of disease with emphasis on basic mechanisms at the molecular, cellular, and organismal levels. Three lecture hours with a complementary two-and-a-half-hour laboratory each week.

714L Molecular and Cellular Pathophysiological Basis of Disease: Laboratory I (2). Pre- or corequisite, PATH 713. A graduate-level laboratory course on basic mechanisms of disease pathogenesis, emphasizing cell and tissue-based examples of major disease mechanisms.

715 Molecular and Cellular Pathophysiological Basis of Disease: Systemic Pathology (3). Corequisite, PATH 716L. A graduate-level course on systemic pathology, emphasizing the molecular and cellular pathogenesis of diseases of major organ systems. A follow-up to PATH 713/714L. Three lecture hours (three credits) with a complementary two-and-a-half-hour laboratory (two credits) each week.

716L Molecular and Cellular Pathophysiological Basis of Disease: Laboratory II (2). Pre- or corequisite, PATH 715. A graduate-level laboratory course on mechanisms of systemic disease pathogenesis, emphasizing cell and tissue-based examples of diseases of the major organ systems.

723 Practical Considerations for Translational Research (2). Permission of the instructor. A multi-disciplinary course providing students principles involved in translating basic science into clinically applicable diagnostics and therapies to improve human disease outcomes. The course is focused on bioinformatics, bioethics, trial design, FDA approval, and commercialization of laboratory diagnostics.

725 Cancer Pathobiology (3). Permission of the instructor. This course examines pathobiological features of cancer. An interdisciplinary approach draws from epidemiology, genetics, molecular biology, and clinical medicine to investigate cancer etiology, pathogenesis, prevention, and treatment.

726 Human Environmental Disease (1–3). This course will study human disease processes that are induced or exacerbated by our environment. Environmental disease stressors include solar radiation, air and water pollution, bioreactive substances in foods, pesticides, metals, dusts, particles, and allergens. Lectures will emphasize epidemiology, mechanisms of toxicity, and human disease pathogenesis.

766 Current Topics in Cardiovascular Biology (3). Permission of the instructor. Second-year graduate students only. This manuscript-based course will emphasize recent advances in heart and blood vessel development, the molecular mechanisms that regulate cardiovascular cell function, and current methodologies in the cardiovascular field. It will be team taught by members of UNC's McAllister Heart Institute.

767 Molecular and Cellular Biology of Cardiovascular Diseases (3). Second year graduate students or permission of the instructor. Course reviews the molecular, cellular, and organismal pathogenesis of cardiovascular disease. It is team-taught by faculty with topic expertise and stresses primary literature and current methodologies. May be taken as a companion to PATH766 or on its own.

792 Seminar in Carcinogenesis (TOXC 792) (2). Permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week.

801 Cell Cycle Regulation and Cancer (GNET 801) (3). This journal club-style discussion course will focus on molecular events that regulate normal cell cycle progression, and on how deregulation of the cell cycle leads to cancer. Classes will follow the development of the cell cycle field chronologically, learning how current concepts and paradigms have evolved through scientific inquiry.

890 Special Topics in Pathology (1-3). A study in special fields under the direction of the faculty. Offered as needed for presenting material not normally available.

900 Research in Pathology (2–12). Permission of the department. This is a research course in which advanced students in pathology carry on investigations on mechanisms of disease. Six or more laboratory hours a week, to be arranged. May be repeated.

920 Seminar in Interdisciplinary Vascular Biology (1). Permission of the instructor. Participants in the Interdisciplinary Vascular Biology Training Program only. Students will be required to present their thesis work as a formal seminar, give an introductory lecture to introduce their project (in cooperation with their thesis advisor), and to attend and discuss the seminars of other students.

993 Master's Research and Thesis (3). May be repeated.

994 Doctoral Research and Dissertation (3).