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Papers (2004-2007) 


Eletr ZM, Kuhlman B. "Sequence Determinants of E2-E6AP Binding Affinity and Specificity".
J Mol Biol. 2007 Jun 1;369(2):419-28. Epub 2007 Mar 19.
PMID: 17433363 [PubMed - in process]

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Pham Y, Li L, Kim A, Erdogan O, Weinreb V, Butterfoss GL, Kuhlman B, Carter CW Jr. "A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases."
Mol Cell. 2007 Mar 23;25(6):851-62. PMID: 17386262 [PubMed - indexed for MEDLINE]

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Leaver-Fay A, Butterfoss GL, Snoeyink J, Kuhlman B."Maintaining solvent accessible surface area under rotamer substitution for protein design."
J Comput Chem. 2007 Jun;28(8):1336-41. PMID: 17285560 [PubMed - indexed for MEDLINE]

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Dantas G, Watters AL, Lunde BM, Eletr ZM, Isern NG, Roseman T, Lipfert J, Doniach S, Tompa M, Kuhlman B, Stoddard BL, Varani G, Baker D. "Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution."
J Mol Biol. 2006 Oct 6;362(5):1004-24. Epub 2006 Aug 4. PMID: 16949611 [PubMed - indexed for MEDLINE]
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Ambroggio XI, Kuhlman B."Design of protein conformational switches." 
Curr Opin Struct Biol. 2006 Aug;16(4):525-30. Epub 2006 Jun 12. PMID: 16765587 [PubMed - indexed for MEDLINE]
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Hu X, Kuhlman B. "Protein design simulations suggest that side-chain conformational entropy is not a strong determinant of amino acid environmental preferences."
Proteins. 2006 Mar 15;62(3):739-48.PMID: 16317667 [PubMed - - indexed for MEDLINE]
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Liu Y, Kuhlman B."RosettaDesign server for protein design."
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W235-8.PMID: 16845000 [PubMed - indexed for MEDLINE]
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Ambroggio XI, Kuhlman B. "Computational design of a single amino acid sequence that can switch between two distinct protein folds. "
J Am Chem Soc. 2006 Feb 1;128(4):1154-61. PMID: 16433531 [PubMed - - indexed for MEDLINE]
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Jiang L, Kuhlman B, Kortemme T, Baker D "A "solvated rotamer" approach to modeling water-mediated hydrogen bonds at protein-protein interfaces."
Proteins. 2005 Mar 1;58(4):893-904. PMID: 15651050 [PubMed
- indexed for MEDLINE]
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Eletr ZM, Huang DT, Duda DM, Schulman BA, Kuhlman B "E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer. "
Nat Struct Mol Biol. 2005 Oct;12(10):933-4. Epub 2005 Sep 4. PMID: 16142244 [PubMed - indexed for MEDLINE]
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Leaver-Fay A, Kuhlman B, Snoeyink J. "An adaptive dynamic programming algorithm for the side chain placement problem "
Pac Symp Biocomput.2005;:16-27. PMID: 15759610 [PubMed - indexed for MEDLINE]
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Butterfoss GL, Kuhlman B. "Computer-Based Design of Novel Protein Structures."
Annu Rev Biophys Biomol Struct. 2005 Dec 7; [Epub ahead of print] PMID: 16336082 [PubMed - as supplied by publisher]
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Kuhlman B, Baker D. "Exploring folding free energy landscapes using computational protein design."
Curr Opin Struct Biol. 2004 Feb;14(1):89-95. Review. PMID: 15102454 [PubMed - indexed for MEDLINE]
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Papers (2001-2003)

Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, "Design of a novel globular protein fold with atomic-level accuracy."
Science. 2003 Nov 21;302(5649):1364-8.PMID: 14631033 PMID: 14631033 [PubMed - indexed for MEDLINE]
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Dantas G, Kuhlman B, Callender D, Wong M, Baker D., "A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins."
J Mol Biol. 2003 Sep 12;332(2):449-60. PMID: 12948494 [PubMed - indexed for MEDLINE]
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Tsai J, Bonneau R, Morozov AV, Kuhlman B, Rohl CA, Baker D, "An improved protein decoy set for testing energy functions for protein structure prediction."
Proteins. 2003 Oct 1;53(1):76-87.PMID: 12945051 [PubMed - indexed for MEDLINE]>
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Gray JJ, Moughon S, Wang C, Schueler-Furman O, Kuhlman B, Rohl CA, Baker D., "Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations."
J Mol Biol. 2003 Aug 1;331(1):281-99.PMID: 12875852 [PubMed - indexed for MEDLINE]
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Nauli S, Kuhlman B, Le Trong I, Stenkamp RE, Teller D, Baker D, "Crystal structures and increased stabilization of the protein G variants with switched folding pathways NuG1 and NuG2."
Protein Sci. 2002 Dec;11(12):2924-31.PMID: 12441390 [PubMed - indexed for MEDLINE]
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Kuhlman B, O'Neill JW, Kim DE, Zhang KY, Baker D., "Accurate computer-based design of a new backbone conformation in the second turn of protein L."
J Mol Biol. 2002 Jan 18;315(3):471-7.PMID: 11786026 [PubMed - indexed for MEDLINE]
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Kuhlman B, O'Neill JW, Kim DE, Zhang KY, Baker D., "Conversion of monomeric protein L to an obligate dimer by computational protein design."
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10687-91. Epub 2001 Aug 28. Erratum in: Proc Natl Acad Sci U S A 2002 May 28;99(11):7809. PMID: 11526208 [PubMed - indexed for MEDLINE]
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Nauli S, Kuhlman B, Baker D., "Computer-based redesign of a protein folding pathway."
Nat Struct Biol. 2001 Jul;8(7):602-5.PMID: 11427890 [PubMed - indexed for MEDLINE]
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Kuhlman B, Baker D., "Native protein sequences are close to optimal for their structures."
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10383-8. Erratum in: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13460.PMID: 10984534 [PubMed - indexed for MEDLINE]
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Papers (1997 - 1999)

Luisi DL, Kuhlman B, Sideras K, Evans PA, Raleigh DP., "Effects of varying the local propensity to form secondary structure on the stability and folding kinetics of a rapid folding mixed alpha/beta protein: characterization of a truncation mutant of the N-terminal domain of the ribosomal protein L9."
J Mol Biol. 1999 May 28;289(1):167-74.PMID: 10339414 [PubMed - indexed for MEDLINE]
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Sato S, Kuhlman B, Wu WJ, Raleigh DP., "Folding of the multidomain ribosomal protein L9: the two domains fold independently with remarkably different rates."
Biochemistry. 1999 Apr 27;38(17):5643-50.PMID: 10220353 [PubMed - indexed for MEDLINE]
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Kuhlman B, Luisi DL, Young P, Raleigh DP., "pKa values and the pH dependent stability of the N-terminal domain of L9 as probes of electrostatic interactions in the denatured state. Differentiation between local and nonlocal interactions."
Biochemistry. 1999 Apr 13;38(15):4896-903.PMID: 10200179 [PubMed - indexed for MEDLINE]
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Kuhlman B, Luisi DL, Evans PA, Raleigh DP., "Global analysis of the effects of temperature and denaturant on the folding and unfolding kinetics of the N-terminal domain of the protein L9."
J Mol Biol. 1998 Dec 18;284(5):1661-70.PMID: 9878377 [PubMed - indexed for MEDLINE]
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Kuhlman B, Raleigh DP., "Global analysis of the thermal and chemical denaturation of the N-terminal domain of the ribosomal protein L9 in H2O and D2O. Determination of the thermodynamic parameters, deltaH(o), deltaS(o), and deltaC(o)p and evaluation of solvent isotope effects."
Protein Sci. 1998 Nov;7(11):2405-12.PMID: 9828007 [PubMed - indexed for MEDLINE]
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Vugmeyster L, Kuhlman B, Raleigh DP., "Amide proton exchange measurements as a probe of the stability and dynamics of the N-terminal domain of the ribosomal protein L9: comparison with the intact protein."
Protein Sci. 1998 Sep;7(9):1994-7.PMID: 9761480 [PubMed - indexed for MEDLINE]
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Spector S, Kuhlman B, Fairman R, Wong E, Boice JA, Raleigh DP., "Cooperative folding of a protein mini domain: the peripheral subunit-binding domain of the pyruvate dehydrogenase multienzyme complex."
J Mol Biol. 1998 Feb 20;276(2):479-89.PMID: 9512717 [PubMed - indexed for MEDLINE]
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Kuhlman B, Boice JA, Fairman R, Raleigh DP., "Structure and stability of the N-terminal domain of the ribosomal protein L9: evidence for rapid two-state folding."
Biochemistry. 1998 Jan 27;37(4):1025-32.PMID: 9454593 [PubMed - indexed for MEDLINE]
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Kuhlman B, Yang HY, Boice JA, Fairman R, Raleigh DP., "An exceptionally stable helix from the ribosomal protein L9: implications for protein folding and stability."
J Mol Biol. 1997 Aug 1;270(5):640-7.PMID: 9245593 [PubMed - indexed for MEDLINE]
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Kuhlman B, Boice JA, Wu WJ, Fairman R, Raleigh DP., "Calcium binding peptides from alpha-lactalbumin: implications for protein folding and stability."
Biochemistry. 1997 Apr 15;36(15):4607-15.PMID: 9109670 [PubMed - indexed for MEDLINE]
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