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People participating in Systems Biology initiative |
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Dept.
Biochemistry & Biophysics
Henrik Dohlman
Our primary focus is the regulation of G proteins and
downstream MAP kinases. G protein-coupled receptors
detect neurotransmitters, hormones, odors, taste and
light. Genetic defects in G protein signaling pathways
can cause a variety of developmental and metabolic
disorders, including cancer, obesity, narcolepsy, drug
addiction, and resistance to HIV infection.
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Nikolay
Dokholyan Dept.
Biochemistry & Biophysics
We study the physical nature of interactions between atoms,
molecules, cells, and organisms. The underlying question
throughout our research is how these interactions shape the
complex organization, behavior, and evolution of biomolecules and organisms. |
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Dept.
Pharmacology
Timothy C. Elston
The Elston lab is interested in
understanding the dynamics of complex biological systems, and
developing reliable mathematical models that capture the essential
components of these systems. The projects in the lab encompass a wide
variety of biological phenomena including MAPK activation in the
pheromone response pathway of yeast, noise in gene regulatory networks,
airway surface volume regulation, diffusion in viscoelastic fluids,
glycine metabolism, and the motor protein dynein. |
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Morgan
Giddings Dept. of Microbiology & Immunology and
Biomedical Engineering
The Giddings lab focuses on an integrated,
cross-disciplinary approach to studying both microbial and eukaryotic
systems (some might even call it Systems Biology). We start from a
strong basis in bioinformatics, combining that with lab work in
proteomics, metabolomics, and related areas to study and model cellular
systems. |
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Joint
Department of Biomedical Engineering at UNC-Chapel Hill
and NC State University,
Shawn Gomez
Our research is focused on the study of biological
processes from an integrated or systems viewpoint,
commonly referred to as Systems Biology. Currently, we
are especially interested in better understanding the
"wiring" of biological systems and the discovery of
underlying principles in biological organization. For
example, at the molecular level how are interactions
created and maintained between proteins? How does the
topology of an interaction network affect its dynamics
and stability? |
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Ken
Jacobson Dept. Cell & Developmental
Biology Together with Professors Gabriel Weinreb and Tim
Elston, our laboratory has embarked on an effort in systems biology.
Biological processes that occur at the cellular level and consist of
large numbers of interacting elements are highly nonlinear and
generally involve multiple time and spatial scales. The
quantitative description of these complex systems is of great
importance but presents large challenges. |
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Dept. Chemistry,
Garegin A. Papoian
Using tools from diverse areas of physics and
bioinformatics we are building nonequilibrium
statistical mechanics of signal transduction networks.
In particular, we are interested in spatio-temporal
regulation of eukaryotic cell motility. |
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Leslie
Parise
Dept. Biochemistry & Biophysics
The lab is currently mapping signal transduction pathways
that lead to the activation of 2 different integrins, aIIbß3
and a2ß1. The lab is studying the structure and function of
the integrin cytoplasmic domain binding proteins (e.g. CIB1)
as well as small G-proteins (R-Ras and Rap1) to understand
how these proteins relay information to these integrins to
regulate their activation state. |
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Dept. Chemistry,
Michael Rubinstein
The research of our group is in the field of polymer theory
and computer
simulations. The unique properties of polymeric systems are due to the
size,
topology and interactions of the molecules they are made of. Our goal
is
to understand the properties of various polymeric systems and to design
new
systems with even more interesting and useful properties.
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Richard
Superfine
Department of Physics and Astronomy
Dr. Superfine studies the nanoscale properties of molecules, nanotubes,
molecular motors, DNA, viruses and cells. He develops and
applies new techniques for these studies using optical,
scanning probe, electron and magnetic force microscopes.
Current experiments probe the ultimate scales for machinery
and devices in nanotechnology, including atomic scale gears
and devices powered with biological molecular motors. |
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Dept.
Physics & Astronomy
Paul Tiesinga
The primary objective of the Computational Neurophysics Laboratory is
to understand how the brain processes sensory information. The key
question is how the cacophony of neural activity leads to day to day
behavior. We approach this problem using information-theoretical analysis
of experimental data and biophysical model simulations.
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Gabriel
Weinreb Dept. Cell & Developmental Biology
Along with data
quantification and application of traditional
mathematical methods such as chemical kinetics and mechanical dynamics,
we
work on a graphical systems biology approach, the causal mapping
(CMAP),
to analyze biological systems. CMAP is a course-grained biological network tool
that permits description of causal interactions between the
elements of the network and overall system dynamics. |
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