Department of Biochemistry and Biophysics

www.med.unc.edu/biochem

LESLIE V. PARISE, Chair

The Department of Biochemistry and Biophysics offers a number of courses to undergraduate students, though it has no program leading to a B.A. or B.S. degree. Students interested in these areas should take relevant undergraduate courses in the Department of Chemistry and the Department of Physics. The department serves undergraduate students who are interested in biochemistry, particularly students seeking a health-related career. It offers courses, research opportunities, and counseling to students taking premedical, predental, nursing, pharmacy, or public health curricula. Students majoring in other scientific disciplines such as chemistry, biology, or physics also are served by the Department of Biochemistry and Biophysics.

BIOC

107 Introduction to Biochemistry (4). Recommended preparation, one year of high school chemistry. Designed for prenursing, predental hygiene, allied health, and other students who desire a background in biochemistry as it relates to the human body. Brief review of inorganic and organic chemistry, followed by a survey of biochemistry (survey continues in BIOC 108).

108 Introduction to Biochemistry (4). Designed for prenursing, predental hygiene, allied health, and other students who desire a background in biochemistry as it relates to the human body. Continuation of BIOC 107; covers basic and clinically relevant aspects of biochemistry. Three lecture hours and one two-hour laboratory a week.

442 Biochemical Toxicology (ENVR 442, TOXC 442) (3). See ENVR 442 for description.

601 Enzyme Properties, Mechanisms, and Regulation (3). Prerequisite, CHEM 430. Permission of the instructor for students lacking the prerequisite. Focuses on enzyme architecture to illustrate how the shapes of enzymes are designed to optimize the catalytic step and become allosterically modified to regulate the rate of catalysis.

631 Advanced Molecular Biology I (BIOL 631, GNET 631, MCRO 631) (3). See GNET 631 for description.

632 Advanced Molecular Biology II (BIOL 632, GNET 632, MCRO 632) (3). See GNET 632 for description.

643 Cell Structure, Function, and Growth Control I (CBIO 643, MCRO 643, PHCO 643, PHYI 643) (3). See CBIO 643 for description.

644 Cell Structure, Function, and Growth Control II (CBIO 644, MCRO 644, PHCO 644, PHYI 644) (3). See CBIO 644 for description.

650 Basic Principles: From Basic Models to Collections of Macromolecules (1.5). Prerequisite, CHEM 430. Required preparation, two semesters of physical chemistry or permission of the instructor. Basic molecular models and their use in developing statistical descriptions of macromolecular function. Course intended primarily for graduate students.

651 Macromolecular Equilibria: Conformation, Change, and Binding (1.5). Prerequisite, CHEM 430. Required preparation, two semesters of physical chemistry or permission of the instructor. Macromolecules as viewed with modern computational methods. Course intended primarily for graduate students.

652 Macromolecular Equilibria (1.5). Prerequisite, CHEM 430. Required preparation, two semesters of physical chemistry or permission of the instructor. Stability of macromolecules and their complexes with other molecules. Course intended primarily for graduate students.

655 Case Studies in Structural Molecular Biology (3). Prerequisite, CHEM 430. Permission of the instructor for students lacking the prerequisite. Principles of macromolecular structure and function with emphasis on proteins, molecular assemblies, enzyme mechanisms, and ATP enzymology.

660 Introduction to Light Microscopy (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. Fundamentals of optics and light microscope design for the novice student.

662 Macromolecular Interactions (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. Theory and practice of biophysical methods used in the study of interactions between macromolecules and their ligands, including surface plasmon resonance, analytical ultracentrifugation, and calorimetry.

663A Macromolecular NMR (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. Principles and practice of nuclear magnetic resonance spectroscopy: applications to biological macromolecule structure and dynamics in solution. Course intended primarily for graduate students.

663B Macromolecular NMR Practice (1). Prerequisite, BIOC 653. Permission of the instructor for students lacking the prerequisite. Lab section for BIOC 663A. Course intended primarily for graduate students.

664 Macromolecular Spectroscopy (1). Prerequisite, CHEM 430. Required preparation, two semesters of physical chemistry or permission of the instructor. Principles of UV, IR, Raman, fluorescence, and spin resonance spectroscopies; applications to the study of macromolecules and membranes. Course intended primarily for graduate students.

665 Advanced NMR Spectroscopy Course (1). Advanced NMR spectroscopy.

666 X-Ray Crystallography of Macromolecules (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. Principles of protein crystallography, characterization of crystals, theory of diffraction, phasing of macromolecular crystals and structure refinement. Course intended primarily for graduate students.

667 Macromolecular Crystallographic Methods (2). Prerequisite, BIOC 666. Permission of the instructor for students lacking the prerequisite. A combined lecture/laboratory workshop for serious students of protein crystallography. Course intended primarily for graduate students.

668 Principles of and Simulation of Macromolecular Dynamics (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. A combined lecture/computer lab treatment of the principles of macromolecular dynamics and structure as approached using the tools of molecular dynamics simulations. Course intended primarily for graduate students.

670 Biomolecular Informatics (1). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. A combined lecture/computer lab course introducing the methods and principles of biological data management as this relates to macromolecular sequence analysis. Course intended primarily for graduate students.

673 Proteomics, Protein Identification and Characterization by Mass Spectrometry (1). Prerequisites, BIOC 650653. Required preparation, one semester of physical chemistry or permission of the instructor. A lecture module that introduces students to the basics of mass spectrometry as applied to protein science. Course intended primarily for graduate students.

674 Ion Channels Transporters (1). Ion channels transporters.

678 Electrical Signals from Macromolecular Assemblages (2). Prerequisites, BIOC 650653. Permission of the instructor for students lacking the prerequisites. An intensive, six-hour per week introduction to the fundamentals of ion channel biophysics, including laboratory sessions to demonstrate principles and methods. Course intended primarily for graduate students.