MICHAEL T. CRIMMINS, Chair
Tomas Baer, Max L. Berkowitz, Maurice S. Brookhart, Michael T. Crimmins, Joseph DeSimone, Malcolm D. E. Forbes, Gary L. Glish, Eugene A. Irene, Donald C. Jicha, James W. Jorgenson, Paul J. Kropp, Thomas J. Meyer, Royce W. Murray, Gary J. Pielak, J. Michael Ramsey, Matthew R. Redinbo, Michael Rubinstein, Edward T. Samulski, Linda L. Spremulli, Joseph L. Templeton, Nancy L. Thompson, H. Holden Thorp, Kevin M. Weeks, R. Mark Wightman.
Valerie S. Ashby, Dorothy A. Erie, Michel R. Gagné, Jeffrey S. Johnson, Wenbin Lin, John M. Papanikolas, Cindy K. Schauer, Mark H. Schoenfisch, Sergey S. Sheyko, Marcey L. Waters.
Christopher J. Fecko, Andrew M. Moran, Garegin A. Papoian, Wei You, Muhammad N. Yousaf.
Todd L. Austell, Brian P. Hogan, Bessie N. Mbadugha, Domenic J. Tiani.
Carribeth L. Bliem, Stacy I. Chamberlin, Carolyn J. Morse.
Chemists often claim that theirs is "the central science," for it sits between physics, of which it is one of the most complex and useful outgrowths, and the biological and geological sciences, which find their basis in it. By a common definition, chemistry is the scientific study of the composition and properties of matter and the investigation of the laws that govern them.
Classically, chemistry is divided into several subdisciplines. Organic chemistry deals primarily with carbon compounds; inorganic chemistry, with compounds of the other elements. Physical chemistry seeks to describe relationships between the chemical and physical properties of all substances. Analytical chemistry studies the analysis of the chemical composition of all substances. Biological chemistry pursues the chemistry of living organisms; at UNC-Chapel Hill biological chemistry is divided between the Department of Chemistry and the Department of Biochemistry and Nutrition. At the borders of these sub-disciplines are many hybrid areas of study: physical organic, organometallic, bioinorganic and others; and at the interface of chemistry with other sciences there are active fields fueled by insights gained from two ways of thinking about things; for example, chemical physics, pharmaceutical chemistry, organic geochemistry and the extensive chemical problems in biotechnology. In all of these areas the chemist's approach may be theoretical, experimental or both.
All chemists have a common core of knowledge, learned through a highly structured sequence of undergraduate courses in which the content is divided into the classical subdisciplines. Toward the end of students' progress through their four years of undergraduate study, they may choose to gain additional concentration in one or more areas of chemistry through the courses selected to fulfill the chemistry elective requirement and undergraduate research.
The degrees offered are bachelor of arts in chemistry, bachelor of science in chemistry, bachelor of science in chemistry (biochemistry track) and bachelor of science in chemistry (polymer track). A minor is offered in chemistry.
The following courses are required1:
First Year
Foundations, quantitative reasoning: MATH 231, MATH 232
Foundations, English composition and rhetoric: ENGL 101 and 102
Foundations, foreign language: 1 course, 3 hours
Foundations, lifetime fitness: 1 hour
Approaches, physical and life sciences: CHEM 101, 101L, 102 or 102H2, CHEM 102L
Other Approaches: 3 courses, 9 hours
Sophomore Year
CHEM 241 or 241H, 241L or 245L, 251, 261 or 261H, 262 or 262H, 262L or 263L
PHYS 105 or 1173
Other Approaches: 3 courses, 9 hours
Junior and Senior Years
CHEM 480 or 481
Choice of two courses9: CHEM 421, 430, 441, 450, 451, 482, or 560L4
Approaches: 2 courses, 6 hours
Connections, communications intensive: CHEM 550L
Other Connections, distributive or integrative option: 3 courses, 9 hours.
The following courses are required:
First and Sophomore Years
Foundations, English composition and rhetoric: ENGL 101 and 102
Foundations, foreign language13: 1 course, 3 hours
Foundations, lifetime fitness: 1 hour
Foundations, quantitative reasoning: MATH 231
MATH 232, 233, 383; PHYS 117
Approaches, physical and life sciences: CHEM 101, 101L; BIOL 101
CHEM 1022, 102L; or 102H
CHEM 241 or 241H, 241L or 245L, 251, 261 or 261H, 262 or 262H, 262L or 263L
Other Approaches: 6 courses, 18 hours
Connections, quantitative intensive: PHYS 116
Other Connections
Junior and Senior Years
CHEM 430 and 450
CHEM 481, 481L, 482, and 482L
CHEM 441 and 441L
Advanced chemistry electives (10 hours, one must be a laboratory)
Approaches: 3 courses, 9 hours
Connections, communications intensive: CHEM 550L
Other Connections
The following courses are required:
First and Sophomore Years
BIOL 202 and 205
CHEM 1022, 102L; or 102H
CHEM 241 or 241H, 241L or 245L, 251, 261 or 261H, 262 or 262H, 262L or 263L
MATH 232, 233, and 383
PHYS 117
Foundations, quantitative reasoning: MATH 231
Foundations, English composition and rhetoric: ENGL 101 and 102
Foundations, foreign language: 1 course, 3 hours
Approaches, physical and life sciences: CHEM 101 and 101L; BIOL 101 and 101L
Foundations, lifetime fitness: 1 hour
Other Approaches: 6 courses, 18 hours
Connections, quantitative intensive: PHYS 116
Other Connections
Junior and Senior Years
CHEM 430, 481, 481L, 482, and 530L
CHEM 431 and 432
Advanced chemistry elective: 3 hours6,7
Connections, communications intensive: CHEM 550L
Other Connections
The following courses are required:
CHEM 1022, 102L; or 102H
CHEM 241 or 241H, 241L or 245L, 251, 261 or 261H, 262 or 262H, 262L or 263L
MATH 232, 233, and 383
PHYS 117
Foundations, quantitative reasoning: MATH 231
Foundations, English composition and rhetoric: ENGL 101 and 102
Foundations, foreign language: 1 course, 3 hours
Approaches, physical and life sciences: CHEM 101 and 101L, BIOL 101 and 101L
Foundations, lifetime fitness: 1 hour
Other Approaches: 6 courses, 18 hours
Connections, quantitative intensive: PHYS 116
Other Connections
Junior and Senior Years
CHEM 430, 481, 481L, 482, 482L, 530L, and 550L
APPL 150 or CHEM 470
Polymer electives: 3 courses10
Advanced chemistry elective: 3 hours11
Connections, communications intensive: CHEM 550L
Other Connections
The undergraduate minor in chemistry consists of the following seven courses:8
CHEM 102 (note 2) or 102H, CHEM 241 or 241H, CHEM 261 OR 261H, CHEM 262 OR 262H, CHEM 102L, CHEM 241L OR 245L, CHEM 262L OR 263L
Note: Careful attention should be paid to prerequisites and course timing when planning a long-term schedule. In particular, CHEM 101/101L are prerequisites for CHEM 102/102L. A C- or better grade in CHEM 101 is required to continue in CHEM 102/102L. CHEM 102 is a prerequisite for CHEM 241/241L and 261. CHEM 261 is required for CHEM 262, and CHEM 241L is recommended (although not absolutely required) before CHEM 262L. Note that CHEM 262 and 262L are only offered in the spring and summer. Students intending to take pregraduate or preprofessional exams (such as the GRE or MCAT) should plan accordingly.
Upon the recommendation of the Department of Chemistry the B.A. or B.S. degree may be awarded by the University with honors in chemistry or highest honors in chemistry.
Highest honors in chemistry is a distinction bestowed on a truly exceptional student who has excelled in course work and who has completed a research project of considerable depth and significance. To attain this distinction the candidate must have nominally satisfied the following guidelines:
B.A. candidates must have achieved a grade point average of 3.85 or higher; B.S. candidates, a grade point average of 3.75 or higher;
have completed at least five courses in chemistry numbered 420 or above. For B.A. candidates one of these may be a laboratory course; for B.S. candidates they must all be lecture courses;
have completed or be about to complete a research project certified to be of publishable quality by the research advisor and two faculty members appointed by the vice chair for undergraduate studies.
Honors in chemistry is a distinction bestowed on an outstanding student who has demonstrated marked competence in the course work and who has completed a research project of considerable merit. To attain this distinction the candidate must have nominally satisfied the following guidelines:
have achieved a grade point average of 3.40 or higher;
have received no grade below B- in junior-senior level chemistry courses.
have completed at least three lecture courses in chemistry numbered 420 or above;
have completed or be about to complete a research project certified to be of honors quality by the research advisor and two faculty members appointed by the vice chair for undergraduate studies.
Students who wish to qualify for either of these awards should begin planning their course programs and research activities in the junior year so that ample time and effort may be devoted to attainment in upper level courses and research.
Departmental Involvement
Majors are encouraged to participate in AXE (chemistry fraternity) and the undergraduate advisory board.
Laboratory Teaching Internships and Assistantships
Undergraduates have the opportunity to serve as lab assistants for entry level undergraduate laboratory courses.
Special Topics
Special topics not offered through the normal course sequence may be pursued through directed reading and registration in CHEM 396, with the approval of the supervising faculty member, advisor and vice chair for undergraduate studies.
Undergraduate Awards
Excellent performances by undergraduates in chemistry are recognized by the department through the following awards.
Francis P. Venable Medal: A medallion and cash award are presented to the two most outstanding graduating seniors majoring in chemistry in honor of Dr. Francis P. Venable, who was chairman of the department, president of the University from 1900 to 1914 and president of the American Chemical Society.
Emmett Gladstone Rand Premedical Scholarship: A scholarship is presented to an exceptionally talented graduating senior intending to pursue a career in medicine.
Jason D. Altom Memorial Award for Undergraduate Research: This cash award recognizes research potential of an undergraduate chemistry major.
J. Thurman Freeze Scholarship: This scholarship serves to fund summer research between a student's junior and senior years.
E.C. Markham Summer Research Fund: The recipient of this award is chosen by the department chair and will use the salary to perform research between the junior and senior years.
David L. Stern Scholar: Top students from upper division lab courses are chosen for this cash award.
Undergraduate Award for Excellence in Physical Chemistry: This cash award is given to the top student in physical chemistry courses.
James H. Maguire Memorial Award: This award goes to an outstanding and academically gifted junior honors student majoring in chemistry.
Tanya R. Ellison Scholarship: A female, junior or senior, B.S. chemistry major is selected for this cash award on the basis of character and academic commitment.
American Institute of Chemists Student Award: An annual membership is presented to an outstanding graduating senior majoring in chemistry who has shown potential for advancement of the chemical profession.
Merck Index Awards: A copy of the Merck Index is presented annually to outstanding graduating seniors majoring in chemistry.
Hypercube Scholar Award: An outstanding senior majoring in chemistry is given this chemical software package.
Undergraduate Research
Almost every undergraduate chemistry major who has undertaken a research project has found it to be an exciting and rewarding experience. The reasons are many. One certainly is that it affords an opportunity to make pioneering discoveries at the forefront of science, using instrumentation and techniques far more sophisticated than those usually encountered in standard laboratory courses.
More than 80 students are involved in undergraduate research projects in chemistry each year. Although successful completion of an undergraduate research project is a requirement for graduation with honors or highest honors (see below), it is not necessary to be a participant in the Honors Program to undertake a research project.
The usual mechanism for getting involved in a research project is to register for CHEM 395. This process begins well in advance of a preregistration or registration period with a visit to the Chemistry Student Services office, where a student may obtain a list of undergraduate research opportunities and a form titled Request for Registration in CHEM 395.
Most students begin research during the spring semester of their junior year and continue throughout their senior year. CHEM 395 and CHEM 396 (Special Problems in Chemistry) together may be taken for credit as many times as desired but may be counted for no more than nine hours total credit toward graduation in either the B.A. or B.S. traditional and polymer tracks and for no more than six hours in the B.S. biochemistry track. In the B.S. curriculum, it may be counted no more than once as an advanced chemistry elective.
An undergraduate degree tailored according to the student's interests can open doors to graduate programs in many academic disciplines: chemistry itself, environmental science, materials science, polymer science, chemical engineering, geochemistry, chemical physics and several disciplines at the interface between biology and chemistry. A technically oriented administrator in the chemical industry might choose to obtain a master's degree in business administration. More than 100 schools in the United States offer graduate programs in chemistry and related areas, and it is the usual practice to take graduate education at a different institution from the undergraduate institution. It is necessary to specialize in graduate study, either within one of the branches previously mentioned or at the interface between two of them. A student admitted to a graduate program in chemistry in the United States is usually offered a teaching assistantship or fellowship, so that family support is not necessary.
Chemists have a wide choice of academic, governmental or industrial positions. By far the greatest percentage accept industrial positions, mostly in the chemical manufacturing or the petroleum, food and pharmaceutical industries, where they may be developing new products to benefit humanity or assessing the level of risk in the processes for some proposed production methods, for example. Most government chemists are employed in agriculture, health, energy, environmental and defense-related areas. In the academic field, with such a broad spectrum of colleges and universities in this country, academic chemists can set career goals with varying levels of emphasis on training students in research and teaching in the classroom and instructional laboratory.
Chemistry Department Web site: www.chem.unc.edu.
Student Services Manager and Assistant, Department of Chemistry, CB# 3290, (919) 843-7827, (919) 843-7826, chemus@unc.edu.
Dr. Valerie Ashby, Associate Professor and Vice Chair for Undergraduate Studies, Department of Chemistry, CB# 3290, 239 Caudill Labs, (919) 962-3663, ashby@email.unc.edu.
Footnotes:
1 At least 18 semester hours of credit in chemistry courses above CHEM 101 and 101L with individual grades of C or higher are required. (Grades of C- do not satisfy this requirement.) Courses in chemistry and other courses specifically required (and designated by number) may not be taken pass/fail.
2 CHEM 102 has a CHEM 101 prerequisite. Students must receive a grade of C- or higher in CHEM 101 to take CHEM 102.
3 PHYS 116 and 117 are encouraged for those students considering careers as professional chemists or those students that want the option to switch from the B.A. program to the B.S. program.
4 CHEM 460L is strongly recommended for students planning professional work in chemical laboratories.
5 This program meets the requirements of the American Chemical Society for the training of professional chemists.
6 CHEM 395 and CHEM 396 may be taken for credit as many times as desired but may be counted for no more than nine hours of total credit toward fulfillment of graduation requirements. Additionally, CHEM 395 may not be counted more than once as an advanced chemistry elective in the B.S. chemistry degree, B.S. chemistry degree (biochemistry track) and B.S. chemistry degree (polymer track). CHEM 395 can be counted for no more than six hours in the B.S. chemistry (polymer track).
7 One course must be taken from the following: CHEM 395, BIOC 601, BIOC 650, BIOL 422, or any chemistry lecture course numbered 420 or above that is not already required.
8 CHEM 241 or 241H are pre- or corequisites of CHEM 241L or 245L. CHEM 261 or 261H is a prerequisite to CHEM 262L or 263L, and CHEM 262 or 262H is a pre- or corequisite to CHEM 262L or 263L. However, CHEM 241L or 245L and 262L or 263L can be taken in either order as long as all pre- and corequisites are satisfied.
9 With the permission of the course instructor, CHEM 420 or other chemistry courses numbered above 420 may be substituted for the listed courses.
10 Three courses must be taken from the following: CHEM 420, 421, 422, and 423.
11 Students may take CHEM 395 once to fulfill an advanced chemistry elective.
CHEM
070 [006D] First-Year Seminar: You Don't Have to be a Rocket Scientist (3). The underlying theme of this first-year seminar is the development of the basic tools for extracting information from, or finding flaws in, news reports and popular science writing. Students will work in groups on such issues as biomass fuels, the hydrogen economy and other alternative energy sources to develop an understanding of their economic and environmental impact.
071 [006D] First-Year Seminar: Foundations of Chemistry: A Historical and Modern Perspective (3). Students in the class will learn about the ways in which scientists think. We will explore the process by which new knowledge is generated and examine the impact of science on society. Topics to be considered include: (1) the nature of gases; (2) atomic structure and radioactivity; (3) molecules and the development of new materials.
072 [006D] First-Year Seminar: From Imagination to Reality: Idea Entrepreneurism in Science, Business and the Arts (3). Bringing ideas to fruition is a multistep process. In the present knowledge economy, high value is placed on individuals who both formulate new concepts and bring them to reality. This process requires a number of important skills that will be explored in this course.
101 [11] Special General Descriptive Chemistry I (3). Prerequisite, MATH 110. The course is the first member of a two-semester sequence. See also CHEM 102. Atomic and molecular structure, stoichiometry and conservation of mass, thermochemical changes and conservation of energy.
101L [11L] Quantitative Chemistry Laboratory I (1). Pre- or corequisite, CHEM 101. One four-hour laboratory a week.
102 [21] General Descriptive Chemistry II (3). Prerequisites, CHEM 101, 101L, with a C- or better in CHEM 101. The course is the second member of a two-semester sequence. See also CHEM 101. Chemical equilibrium, reaction rates, representative chemical structures and reactions.
102L [21L] Quantitative Chemistry Laboratory II (1). Prerequisite, CHEM 101L; pre- or corequisite, CHEM 102 or 102H. Techniques for quantitative acid-base, redox and complexometric titrimetry. Gravimetric analysis. Total salt ion exchange analysis. Transfer students who have not had quantitative analysis in their previous courses will take this laboratory. One four-hour laboratory a week.
200 [015] Extraordinary Chemistry of Ordinary Things (3). Prerequisite, MATH 110. Co-registration in CHEM 200 and CHEM 101L fulfills the natural science perspective for a General College perspective with laboratory. The goal of the course is to help students understand the chemistry behind important societal issues and the consequences of actions aimed at addressing the issues. (Students who have taken CHEM 200 cannot take CHEM 101 for credit.).
241 [041] Modern Analytical Methods for Separation and Characterization (2). Prerequisite, CHEM 102 or 102H. Analytical separations, chromatographic methods, spectrophotometry, acid-base equilibria and titrations, fundamentals of electrochemistry.
241L [041L] Laboratory in Separations and Analytical Characterization of Organic and Biological Compounds (1). Prerequisite, CHEM 102L or 105L; pre- or corequisite, CHEM 241 or 241H. Applications of separation and spectrophotometric techniques to organic compounds, including some of biological interest. One three-hour laboratory a week.
245L [045L] Honors. Laboratory in Separations and Analytical Characterization of Organic and Biological Compounds (1). Prerequisite, CHEM 102L or 105L; pre- or corequisite, CHEM 241H. Applications of separation and spectrophotometric techniques to organic compounds, including some of biological interest. Honors equivalent of CHEM 241L. One three-hour laboratory a week.
251 [051] Introduction to Inorganic Chemistry (2). Prerequisite, CHEM 102 or 102H. Chemical periodicity, introductory atomic theory and molecular orbital theory, structure and bonding in solids, descriptive nonmetal chemistry, structures and reactions of transition metal complexes, applications of inorganic complexes and materials.
261 [061] Introduction to Organic Chemistry I (3). Prerequisite, CHEM 102 or 102H. Molecular structure and its determination by modern physical methods; correlation between structure and reactivity and the theoretical basis for these relationships; classification of reaction types exhibited by organic molecules using as examples molecules of biological importance.
262 [062] Introduction to Organic Chemistry II (3). Prerequisite, CHEM 261 or 261H. Continuation of CHEM 261, with particular emphasis on the chemical properties of organic molecules of biological importance.
262L [062L] Laboratory in Organic Chemistry (1). Prerequisite, CHEM 102L; pre- or corequisite, CHEM 262 or CHEM 262H. Continuation of CHEM 241L or CHEM 245L, with particular emphasis on applications of modern analytical spectroscopic techniques and separation and identification of organic unknowns. One three-hour laboratory a week.
263L [066L] Honors. Laboratory in Organic Chemistry (1). Prerequisite, CHEM 102L; pre- or corequisite, CHEM 262H or permission of instructor. Continuation of CHEM 245L, with particular emphasis on applications of modern analytical spectroscopic techniques and separation and identification of organic unknowns. Honors equivalent of CHEM 262L. One three-hour laboratory a week.
395 [099] Research in Chemistry for Undergraduates (3). Prerequisites, one chemistry course numbered 120 or higher and permission of instructor and vice chair for undergraduate studies. For advanced majors in chemistry and the applied science curriculum who wish to conduct a research project in collaboration with a faculty supervisor. Restricted to on-campus work. May be taken repeatedly for credit, but CHEM 395 and CHEM 396 together may not be counted for more than nine hours total credit toward B.A. or B.S. degree in chemistry nor more than six hours total credit toward biochemistry track of the B.S. degree, and CHEM 395 may be counted for no more than three hours credit toward the advanced chemistry elective category of the B.S. degree. Work done in CHEM 395 may be counted toward honors in chemistry by petition to the honors committee of the department. More details on CHEM 395 and honors in chemistry are available from the Office of Undergraduate Studies in the Department of Chemistry.
396 [101] Special Problems in Chemistry (1-3). Prerequisite, to be determined by consultation with vice chair for undergraduate studies. Equivalent of one to three hours a week.
420 [120] Introduction to Polymer Chemistry (APPL 420) (3). Prerequisite, CHEM 261 or 261H; pre- or corequisites, CHEM 262 or 262H, CHEM 262L or 263L. Chemical structure and nomenclature of macromolecules, synthesis of polymers, characteristic polymer properties.
421 [121] Synthesis of Polymers (APPL 421, MTSC 421) (3). Prerequisites, CHEM 251, CHEM 262 or 252H. Synthesis and reactions of polymers, various polymerization techniques.
422 [122] Physical Chemistry of Polymers (APPL 422, MTSC 422) (3). Prerequisites, CHEM 420, 481. Polymerization and characterization of macromolecules in solution.
423 [123] Intermediate Polymer Chemistry (APPL 423, MTSC 423) (3). Prerequisite, CHEM 422. Polymer dynamics, networks and gels.
430 [130] Introduction to Biological Chemistry (BIOL 430) (3). Prerequisites, CHEM 262 or 262H; CHEM 262L or 263L; BIOL 101. The study of cellular processes including catalysts, metabolism, bioenergetics and biochemical genetics. The structure and function of biological macromolecules involved in these processes will be emphasized.
431 [131] Macromolecular Structure and Metabolism (3). Prerequisites, CHEM 430; BIOL 202. Structure of DNA and methods in biotechnology; DNA replication and repair; RNA structure, synthesis, localization and transcriptional reputation; protein structure/function, biosynthesis, modification, localization and degradation.
432 [132] Metabolic Chemistry and Cellular Regulatory Networks (3). Prerequisite, CHEM 430. Biological membranes, membrane protein structure, transport phenomena; metabolic pathways, reaction themes, regulatory networks; metabolic transformations with carbohydrates, lipids, amino acids and nucleotides; regulatory networks, signal transduction.
433 [133] Transport in Biological Systems (1). Prerequisites, CHEM 430, MATH 383 and permission of instructor. Diffusion, sedimentation, electrophoresis, flow. Basic principles, theoretical methods, experimental techniques, role in biological function, current topics.
434 [134] Biochemical Kinetics (1). Prerequisites, CHEM 430, MATH 383 and permission of instructor. Kinetics of biochemical interactions. Basic principles, theoretical methods, experimental techniques, current topics.
435 [135] Protein Biosynthesis and Its Regulation (1). Prerequisite, CHEM 430; pre- or corequisite, CHEM 431 and permission of instructor. Protein biosynthesis mechanism in prokaryotes and eukaryotes; emphasis on structures of the macromolecular machinery; translational regulation mechanisms including autogenous regulation, metabolic and developmental signals; viral control of host protein synthesis.
436 [136] The Proteome and Interactome (1). Prerequisites, CHEM 430 and permission of instructor. Methods for and role of bioinformatics in proteomic analysis; proteomics in the analysis of development, differentiation and disease states; the interactome - definitions, analysis methods of protein-protein interactions in complex systems.
437 [137] DNA Processes (2). Prerequisites, CHEM 431, CHEM 480 or 481, and permission of instructor. Elucidation of the mechanisms of these processes in prokaryotes and eukaryotes from experiments. Experimental results ranging from in vivo studies to structural studies to kinetics.
438 [138] Macromolecular Structure and Human Disease (1). Prerequisites, CHEM 431 and permission of instructor. Impact of protein and macromolecular structure on the development and treatment of human disease, with emphasis on recent results. Examination of relevant diseases, current treatments and opportunities for improved therapies.
439 [139] RNA Processing (2). Prerequisites, CHEM 431 and permission of instructor. RNA processing, structure and therapeutics; in-depth exploration of examples from the contemporary literature. Topics include RNA world hypothesis, RNA structure and catalysis, and nucleic acid-based sensors and drug design.
441 [141] Intermediate Analytical Chemistry (2). Prerequisites, CHEM 241 or 241H, CHEM 241L or 245L, CHEM 262 or 262H, and CHEM 480 or 481. Spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis, signal processing.
441L [141L] Intermediate Analytical Chemistry Laboratory (2). Corequisite, CHEM 441. Experiments in spectroscopy, electroanalytical chemistry, chromatography, thermal methods of analysis, and signal processing. One four-hour laboratory a week and one one-hour lecture.
442 [142] Chemical Instrumentation (2). Prerequisite, CHEM 480 or 482; corequisites, CHEM 442L and permission of instructor. Introduction to chemical instrumentation including digital and analog electronics, computers, interfacing and chemometric techniques. Two one-hour lectures a week.
442L [142L] Laboratory in Chemical Instrumentation (2). Prerequisite, CHEM 480 or 482; corequisite, CHEM 442. Experiments in digital and analog instrumentation, computers, interfacing and chemometrics, with applications to chemical instrumentation. One four-hour laboratory a week.
444 [144] Separations (3). Prerequisite, CHEM 441, 480, or 481. Theory and applications of equilibrium and nonequilibrium separation techniques. Extraction, countercurrent distribution, gas chromatography, column and plane chromatographic techniques, electrophoresis, ultra-centrifugation and other separation methods.
445 [145] Electroanalytical Chemistry (3). Prerequisite, CHEM 480 or 481. Basic principles of electrochemical reactions, electroanalytical voltammetry as applied to analysis and the chemistry of heterogeneous electron transfers, and electrochemical instrumentation.
446 [146] Analytical Spectroscopy (3). Prerequisites, CHEM 441, 482. Optical spectroscopic techniques for chemical analysis including conventional and laser-based methods. Absorption, fluorescence, scattering and nonlinear spectroscopies, instrumentation and signal processing.
447 [147] Bioanalytical Chemistry (3). Prerequisite, CHEM 441. Principles and applications of biospecific binding as a tool for performing selective chemical analysis.
448 [148] Mass Spectrometry (3). Prerequisite, CHEM 480 or 481. Fundamental theory of gaseous ion chemistry, instrumentation, combination with separation techniques, spectral interpretation for organic compounds, applications to biological and environmental chemistry.
449 [149] Microfabricated Chemical Measurement Systems (3). Prerequisite, CHEM 441. Introduction to micro and nanofabrication techniques, fluid and molecular transport at the micrometer to nanometer length scales, applications of microtechnology to chemical and biochemical measurements.
450 [150] Intermediate Inorganic Chemistry (3). Prerequisite, CHEM 251. Introduction to symmetry and group theory; bonding, electronic spectra and reaction mechanisms of coordination complexes; organometallic complexes, reactions and catalysis; bioinorganic chemistry.
451 [151] Theoretical Inorganic Chemistry (1-21). Prerequisites, CHEM 251, CHEM 262 or 262H. Chemical applications of symmetry and group theory, crystal field theory, molecular orbital theory. The first third of the course, corresponding to one credit hour, covers point symmetry, group theoretical foundations and character tables.
452 [152] Electronic Structure of Transition Metal Complexes (3). Prerequisite, CHEM 451. A detailed discussion of ligand field theory and the techniques that rely on the theoretical development of ligand field theory, including electronic spectroscopy, electron paramagnetic resonance spectroscopy and magnetism.
453 [153] Physical Methods in Inorganic Chemistry (3). Prerequisite, CHEM 451. Introduction to the physical techniques used for the characterization and study of inorganic compounds. Topics typically include nuclear magnetic resonance spectroscopy, vibrational spectroscopy, diffraction, Mossbauer spectroscopy, x ray photoelectron spectroscopy and inorganic electrochemistry.
460 [160] Intermediate Organic Chemistry (3). Prerequisite, CHEM 262 or 262H. Modern topics in organic chemistry.
465 [175] Mechanisms of Organic and Inorganic Reactions (4). Prerequisite, CHEM 450. Kinetics and thermodynamics; free energy relationships; isotope effects; acidity and basicity; kinetics and mechanisms of substitution reactions; one- and two-electron transfer processes; principles and applications of photochemistry; organometallic reaction mechanisms.
466 [166] Advanced Organic Chemistry I (3). Prerequisite, CHEM 262 or 262H; pre- or corequisites, CHEM 450, 481. A survey of fundamental organic reactions including substitutions, additions, eliminations and rearrangements; static and dynamic stereochemistry; conformational analysis; molecular orbital concepts and orbital symmetry.
467 [167] Advanced Organic Chemistry II (2). Prerequisite, CHEM 466. Spectroscopic methods of analysis with emphasis on elucidation of the structure of organic molecules: 1H and 13C NMR, infrared, ultraviolet, ORD-CD, mass and photoelectron spectroscopy. CHEM 446 and 467 may not both be taken for academic credit.
468 [168] Synthetic Aspects of Organic Chemistry (3). Prerequisite, CHEM 466. Modern synthetic methods and their application to the synthesis of complicated molecules.
470 [190] Fundamentals of MTSC (APPL 470) (3). Prerequisite, CHEM 482; or prerequisite, PHYS 128 and pre- or corequisite, PHYS 341. Crystal geometry; diffusion in solids; mechanical properties of solids; electrical conduction in solids, thermal properties of materials; phase equilibria.
471 [191] Mathematical Techniques for Chemists (3). Prerequisite, knowledge of differential and integral calculus. Chemical applications of higher mathematics.
472 [192] Chemistry and Physics of Electronic Materials Processing (APPL 472, MTSC 472, PHYS 472) (3). Prerequisites, CHEM 482, or PHYS 117 or 321, and permission of instructor. A survey of materials' processing and characterization used in fabricating microelectronics devices. Crystal growth, thin film deposition and etching and microlithography, characterization techniques, electric and dielectric properties of materials.
473 [193] Chemistry and Physics of Surfaces (APPL 473, MTSC 473) (3). Prerequisite, CHEM 470. The structural and energetic nature of surface states and sites; experimental surface measurements; reactions on surfaces including bonding to surfaces and adsorption; interfaces.
480 [180] Introduction to Biophysical Chemistry (3). Prerequisites, CHEM 261 or 261H; PHYS 105; MATH 232. Does not carry credit toward graduate work in chemistry or credit toward any track of the B.S. degree in chemistry. Application of thermodynamics to biochemical processes; enzyme kinetics; properties of biopolymers in solution.
481 [181] Physical Chemistry I (3). Prerequisites, CHEM 102 or 102H, PHYS 116; pre- or corequisites, MATH 383, PHYS 116. Thermodynamics, kinetic theory, chemical kinetics.
481L [181L] Physical Chemistry Laboratory I (2). Prerequisite, CHEM 481; pre- or corequisite, CHEM 482. Experiments in physical chemistry. One three-hour laboratory and a single one-hour lecture a week.
482 [182] Physical Chemistry II (3). Prerequisite, CHEM 481. Introduction to quantum mechanics, atomic and molecular structure, spectroscopy, statistical mechanics.
482L [182L] Physical Chemistry Laboratory II (2). Prerequisites, CHEM 481, 481L, 482. Experiments in physical chemistry. One four-hour laboratory a week.
484 [184] Thermodynamics and Introduction to Statistical Thermodynamics (1-21). Prerequisite, CHEM 482. Thermodynamics, followed by an introduction to the classical and quantum statistical mechanics and their application to simple systems. The section on thermodynamics can be taken separately for one hour credit.
485 [185] Chemical Dynamics (3). Prerequisites, CHEM 481, 482. Experimental and theoretical aspects of atomic and molecular reaction dynamics.
486 [186] Introduction to Quantum Chemistry (3). Prerequisites, CHEM 481, 482. Introduction to the principles of quantum mechanics. Approximation methods; angular momentum; simple atoms and molecules.
487 [187] Introduction to Molecular Spectroscopy (3). Prerequisite, CHEM 486. Interaction of radiation with matter; selection rules; rotational, vibrational and electronic spectra of molecules; laser based spectroscopy and nonlinear optical effects.
488 [188] Quantum Chemistry (3). Prerequisite, CHEM 486. Applications of quantum mechanics to chemistry. Molecular structure; time-dependent perturbation theory; interaction of radiation with matter.
489 [189] Statistical Mechanics (3). Prerequisite, CHEM 484. Applications of statistical mechanics to chemistry. Ensemble formalism; condensed phases; nonequilibrium processes.
520L [124L] Polymer Chemistry Laboratory (APPL 520L) (2). Pre- or corequisite, CHEM 420 or 421. Thermal analysis; solution viscosity; gel permeation chromatography; end group analysis; synthesis; characterization of an unknown polymer. One four-hour laboratory and one one-hour lecture each week.
530L [131L] Laboratory Techniques for Biochemistry (3). Prerequisite, CHEM 430. An introduction to chemical techniques and research procedures of use in the fields of protein and nucleic acid chemistry. Two four-hour laboratories and one one-hour lecture a week.
550L [170L] Synthetic Chemistry Laboratory I (2). Prerequisites, CHEM 241L or 245L, CHEM 251, CHEM 262L or 263L. A laboratory devoted to synthesis and characterization of inorganic complexes and materials. A four-hour synthesis laboratory, a characterization laboratory outside of the regular laboratory period and a one-hour recitation each week.