Deb Laboratory


Stem Cells and Regeneration


  1. 1.   Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan J, Rojas M, Willis, M, Leask A, Majesky M, Deb A. Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts and is critical for cardiac repair. EMBO J 2011 [Epub]   

  2. 2.    Gherghe C, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A. Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF dependent manner. FASEB J 2011 Feb 14 [Epub]

  3. 3.    Deb A, Patterson C. Closer to fine: Fewer Steps to endothelial stemness. Arterioscler Thromb Vasc Biol 2010 1880-1881

  4. 4.    Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, Mirotsou M, Pratt RE, Dzau VJ. Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium. Circ Res 2010 April 8 [Epub]

  5. 5.    Deb A, Patterson C. Hard Luck Stories: The Reality of Endothelial Progenitor Cells Continues to Fall Short of the Promise. Circulation 2010; 121: 850-52 (Editorial)

  6. 6.    Zhang Z, Deb A, Zhang Z, Pachori A, We H, Guo J, Pratt R, Dzau VJ. Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol. 2009 46(3):370-77

  7. 7.    Deb A, Guo J, Ni A, Davis B, Huang J, Zhang J, Mu H, Dzau V J. SFRP2 regulates myogenic differentiation by inhibiting a positive transcriptional auto-feedback loop of Wnt3a. Stem Cells. 2008; 26(1):35-44

  8. 8.    Mirotsou M, Zhnag Z, Deb A, Zhang L, Gneechi M, Noiseux N, Mu H, Pachori A, Dzau V. Sfrp2 mediates the paracrine survival signal of Akt genetically modified mesenchymal stem cell for myocardial protection and repair. Proc Natl Acad Sci U.S.A 2007 104(5):1643-8

  9. 9.    Noiseux N, MD, Gnecchi M, Lopez-Ilasaca M, Zhang L, Solomon S, Deb A, Dzau V, Pratt R. Mesenchymal stem cells over-expressing Akt dramatically repairs infarcted myocardium and improves cardiac function despite infrequent cellular fusion or differentiation. Molecular Therapy 2006;(6):840-50

  10. 10.    Wolk R, Deb A, Caplice NM, Virend K. Somers. Leptin receptor and functional effects of leptin in ‘late outgrowth’ human endothelial progenitor cells. Atherosclerosis 2005; 183(1):131-139

  11. 11.    Deb A, Wang S, Skelding K, Miller D, Simper D, Caplice N. Bone Marrow derived smooth muscle like cells are present in adult human heart valves. J Heart Valve Dis 2005;14:674-678

  12. 12.    Liu C, Wang S, Deb A et al. Commercial C-reactive protein (CRP) preparation but not dialyzed CRP exhibits pro-apoptotic, anti-migratory, anti-proliferative and anti-angiogenic effects on human endothelial cells and endothelial progenitor cells in vitro. Implications of presence of sodium azide in commercial preparation. Circ Res  2005:97(2) 135-143

  13. 13.    Deb A, Skelding K, Wang S, Reeder M, Simper D, Caplice N. Integrin characteristics and in vivo homing of human smooth muscle progenitor cells. Circulation 2004;110:2673-2677

  14. 14.  Simper D, Wang S, Deb A et al. Endothelial progenitor cells are decreased in blood and endothelial cells of non cardiac origin are enriched in transplant atherosclerosis of cardiac subjects with vasculopathy. Circulation 2003. 107: 143-149

  15. 15.   Deb A, Wang S, Skelding KA, Simper D, Caplice NM. Bone Marrow-Derived Cardiomyocytes Are Present in Adult Human Heart. A study in gender mismatched bone marrow transplantation patients. Circulation. 2003;107(9):1247-49

  16. 16.  Young A.L, Baysal B.E, Deb A, Young W.F. Jr. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. J Clin Endocrinol Metab. 2002;87(9):4101-5

  17. 17.  Caplice N, Deb A. Myocardial Cell Replacement. The Science, the Clinic and the Future. Nature Clinical Practice Cardiovascular Medicine 2004.1(2):90-95

  18. 18.  Deb A, Caplice N. Lipoprotein a: New insights into mechanisms of atherogenesis and thrombosis. Clin Cardiol. 2004;27:258-264

  19. 19.  Deb A, Tefferi A. Systemic Mastocytosis. N Engl J Med. 2003. 349(7); e7

  20. 20.  Deb A, Wang S, Skelding K, Simper D, Caplice N. Quantifying chimeric cardiomyocytes Circulation 2003 108 (8) e60