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Ajit Joglekar |
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Curriculum vitae |
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EDUCATION
University of Michigan, Ann Arbor Ph.D. Biomedical Engineering May 2004 Thesis: “A study of directional instability during mitotic chromosome movement” Advisor: Prof. Alan Hunt, Co-advisor: Prof. Edgar Meyhfer
Pune University, Pune, India B.E. Mechanical Engineering May 1999 Final year project: “Fabrication of small capacity wind-turbine blades”
RESEARCH EXPERIENCE
University of North Carolina, Chapel Hill Post-doctoral research associate July 2004-Present “In vivo protein architecture of a kinetochore-microtubule attachment”
University of Michigan, Ann Arbor Doctoral student 1999 - 2004 “A study of the directional instability during mitotic chromosome movement”
TEACHING EXPERIENCE
University of Michigan, Ann Arbor Teaching assistant, Quantitative Physiology Fall 2001
HONOURS
Research Excellence Award from the Office of Post-doctoral Affairs, UNC 2008
Career Award at the Scientific Interface - Burroughs-Wellcome Fund 2007-2011
Summer Research fellowship - Jawaharlal Nehru Institute for Advanced Scientific Research, Bangalore, India 1998
PUBLICATIONS
Johnson, K., Joglekar A. P., Fukagawa, T., Salmon E. D. (manuscript under preparation) “Protein composition of the kinetochore in DT40 chicken cells determined by live-cell fluorescence microscopy”
Joglekar A. P., Bloom K., Salmon E. D. “Mechanisms of force generation with end-on kinetochore-microtubule attachments” review submitted to Curr Op Cell Biol.
Joglekar A. P. and Bloom K. “Resolving kinetochore architecture with quantitative biology” review submitted to Curr Biol.
Joglekar A. P. and DeLuca J. G. “Chromosome Segregation: Ndc80 Can Carry the Load” Curr Biol. 19(10):R404-7.
Joglekar A. P., Bloom K., Salmon E. D. (2009) “In vivo protein architecture of the eukaryotic kinetochore with nanometer accuracy” Curr Biol. 19(8):694-99.
Wan X., O’Quinn R.P., Pierce H. L., Joglekar A. P., DeLuca J. G., Desai A., Yen T. J., Salmon E. D. “Protein architecture of the core microtubule attachment site in human kinetochores measured by KSHREC” Cell 137(4):672-84.
Ribeiro S., Gatlin J. C., Dong Y., Joglekar A. P., Cameron L., Hudson D. F., McEwen B. F., Salmon E. D., Earnshaw W. C., Vagnarelli P. (2009) “Condensin regulates the stiffness of vertebrate centromeres” Mol Biol Cell 20(9):2371-80.
Gardner M. K., Bouck D. C., Paliulis L. V., Meehl J. B., O’Toole E. T., Haase J., Soubry A., Joglekar A. P., Winey M., Salmon E. D., Bloom K., and Odde D. J. (2008) “Kinesin-5 motors mediate chromosome congression by promoting disassembly of longer microtubules” Cell 135(5): 894-906.
Joglekar A. P., Bouck D., Finley K., Liu X., Wan Y., Berman J., He X., Salmon E.D., Bloom K. (2008) “Molecular architecture of kinetochore-microtubule attachment sites is conserved in point and regional centromeres” J Cell Biol. 181(4): 587-94.
Bouck D., Joglekar A. P., Bloom K. (2008) “Design Features of a Mitotic Spindle: Balancing tension and compression at a single microtubule kinetochore interface in budding yeast” Ann. Rev. Genet. 42:335-59.
Joglekar A. P., Salmon E. D., Bloom K. (2008) “Counting kinetochore proteins in budding yeast using genetically encoded fluorescent proteins” Methods Cell Biol. 85:127-51.
Yeh E., Haase J., Paliulis L. V., Joglekar A. P., Bond L., Bouck D., Salmon E. D., Bloom K. S. (2008) “Pericentric chromatin is organized into an intramolecular loop in mitosis.” Curr. Biol. 18(2):81-90.
Gardner M. K., Haase J., Mythreye K., Molk J. N., Anderson M., Joglekar A. P., O'Toole E. T., Winey M., Salmon E. D., Odde D. J., Bloom K. (2008) “The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle.” J. Cell Biol. 180(1):91-100.
Kudryashov S. I., Joglekar A. P., Mourou G., Herbstman J. F., Hunt A. J. (2007) “Nanochannels fabricated by high-intensity femtosecond laser pulses on dielectric surfaces” Appl. Phys. Lett. 91:141111.
Joglekar A. P., Bouck D., Molk J., Bloom K., Salmon E. D. (2006) “Molecular architecture of a kinetochore-microtubule attachment site” Nature Cell Biol. 8:581-85.
Joglekar A. P., Liu, H. H., Meyhofer E., Mourou G., Hunt, A. J. (2004) Optics at Critical Intensity: Applications to Nanomorphing. PNAS USA 101(16): 5856-61.
Joglekar A. P., Liu H. H., Meyhofer E., Mourou G., Hunt, A. J. (2003) A Study of the Deterministic Character of Optical Damage by Femtosecond Laser Pulses and Applications to Nanomachining. Appl. Phys. B - Lasers 77 (1): 25-30.
Joglekar A. P., Hunt, A. J. (2002). A Simple, Mechanistic Model for Directional Instability during Mitotic Chromosome Movement. Biophys. J. 83(1): 42-58.
Kunte, K., Joglekar, A.P., Ghate, U., Pramod, P. (1999) Patterns of Butterfly, Bird and Tree Diversity in the Western Ghats. Current Science 77 (4): 577-86.
CONFERENCE POSTER PRESENTATIONS
Motile and Contractile systems, Gordon Research Conference, 2009 Annual Meeting of the American Society for Cell Biology, 2008 Annual Meeting of the Biophysical Society, 2007 Annual Meeting of the America Society for Cell Biology, 2007 Annual Meeting of the America Society for Cell Biology, 2006 Annual Meeting of the Biophysical Society, 2006 Annual Meeting of the America Society for Cell Biology, 2005 Annual Meeting of the America Society for Cell Biology, 2004 Annual Meeting of the Biophysical Society, 2003 Annual Meeting of the Biophysical Society, 2002 Annual Meeting of the Biophysical Society, 2001
INVITED SEMINARS
“Some assembly required: Protein architecture of the eukaryotic kinetochore” – Yeast Cell Biology meeting at Cold Spring Harbor Laboratories (August 2009) Department of Biological Sciences at Virginia Tech (2009) Biomedical Engineering at Vanderbilt Institute of Cell and Molecular Biology at the University of Utah, Salt Lake City Biochemistry Department at Dartmouth Institute of Cell and Molecular Biology/Biomedical Engineering at Cornell Institute of Cell and Molecular Biology at the University of Texas, Austin Department of Cell Biology at Yale Institute of Cell and Molecular Biology at the University of Colorado, Boulder Department of Molecular Physiology and Biophysics at the University of Vermont National Heart, Lung, and Blood Institute (NHLBI) Annual Meeting of the Biophysical Society (2004)
PATENTS
US Patent # 6,995,336 ‘Method for forming nanoscale features’ Hunt, Alan J.; Mourou, Gerard; Joglekar, Ajit P.; Meyhofer, Edgar; Nees, John A.; Spooner, Greg.
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