Axon-Glial Interactions

Midline gliaMost neurons in the CNS send their axons across the midline via two commissures. The midline glia ensheath the commissural axons. The migration of midline glia and axonal ensheathment are mediated by the interaction between Wrapper, which is localized on the surface of midline glia, and Neurexin IV, which is localized on axonal membranes. We are interested in understanding how adhesion proteins, signaling factors, and transcription factors control midline glial migration, ensheathment of commissural axons, and subdivision of the commissures by glial projections.