Gene Regulation

single-mindedOne major focus of our research concerns studying how gene regulation drives developmental decisions. The lab has a long-standing interest in the bHLH-PAS family of transcription factors, including the single-minded bHLH-PAS gene that acts as a master regulator of midline development. We have identified 80 transcription factor genes expressed in the CNS midline cells, and are studying how they function in regulatory networks to control midline glial and neuronal fate and differentiation.