Charlie Carter’s laboratory page


I’ve been a structural biologist all of my career. Mechanistic enzymology provided a natural trajectory, and recently has morphed into a broader interest in long-range allosteric communication and its role in catalysis. My interest in early molecular evolution has grown and blossomed into a small cottage industry, using what we call Urzymology (Ur = primitive, original + enzyme) to develop experimental models for long-extinct ancestral catalysts.

I graduated from Yale University with the Class of 1967, with whom I remain in close contact via our class listserve. I received my PhD in Biology in 1972 from UCSD for work with the crystallographer Joseph Kraut and spent a year in Cambridge, England with Aaron Klug at the Medical Research Council Lab of Molecular Biology. Sabbatical leaves in 1986-7 with Gérard Bricogne (LURE, Orsay; supported by an NIH Fogarty Fellowship and in 2010 with Marc Delarue (Institut Pasteur; supported by a Fulbright Fellowship)  greatly stimulated my more mathematical and computational interests complementary to my research interests in Chapel Hill. UNC Annual Leave Grants also supported both visits to France, where I have a secondary spiritual home.


Contact Information

Charles W. Carter, Jr

Department of Biochemistry and Biophysics

CB 7260

3092 Genetic Medicine Building

University of North Carolina at Chapel Hill

120 Mason Farm Rd

Chapel Hill, NC 27599-7260


Tel:  (919) 966-3263

Fax:  (919) 966-2842

My family

My Blog

I explore issues of personal growth and the origins and expression of my very progressive political views.

Extrascientific interests




Professor of Biochemistry and Biophysics

UNC Chapel Hill