Yen Pham

Yen Pham recently returned to Hanoi, where she is now Instructor in Enzyme and Protein Biotechnology. Her dissertation research opened up the new field of Urzymology by demonstrating that the most highly conserved disjoint fragments of the Class I tryptophanyl-tRNA synthetase, TrpRS, could be fused to produce a 130-residue polypeptide capable of accelerating the rate of Tryptophan activation by 109-fold.


1.Pham, Y., Kuhlman, B., Butterfoss, G. L., Hu, H., Weinreb, V. & Carter, C. W., Jr (2010) Tryptophanyl-tRNA synthetase Urzyme:  a model to recapitulate molecular evolution and investigate intramolecular complementation Journal of Biological Chemistry 285.

2.Pham, Y., Li, L., Kim, A., Weinreb, V., Butterfoss, G., Kuhlman, B. & Carter, C. W., Jr (2007) A Minimal TrpRS Catalytic Domain Supports Sense/Antisense Ancestry of Class I and II Aminoacyl-tRNA Synthetases Mol. Cell 25, 851-862.