PUBLICATIONS
Click on a publication to download the PDF file.
Note: You must have Adobe Acrobat Reader installed to open the PDF Files.  
Adobe



81) Hilton IB, Simon JM, Lieb JD, Davis IJ, Damania B, Dittmer DP. The Open Chromatin Landscape of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2013 Nov;87(21):11831-11842.
80) Chugh PE, Sin SH, Ozgur S, Henry DH, Menezes P, Griffith J, Eron JJ, Damania B, Dittmer DP. Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.PLoS Pathog. 2013 Jul;9(7):e1003484. doi: 10.1371/journal.ppat.1003484
79) Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.Modulation of B-cell exosome proteins by gamma herpesvirus infection.Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2925-33. doi: 10.1073/pnas.1303906110.
78) Dittmer DP, Damania B.Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.Curr Opin Virol. 2013 Jun;3(3):238-44. doi: 10.1016/j.coviro.2013.05.012.
77) Yanik EL, Tamburro K, Eron JJ, Damania B, Napravnik S, Dittmer DP.Recent cancer incidence trends in an observational clinical cohort of HIV-infected patients in the US, 2000 to 2011.Infect Agent Cancer. 2013 May 24;8(1):18. doi: 10.1186/1750-9378-8-18.
76) Dillon PJ, Gregory SM, Tamburro K, Sanders MK, Johnson GL, Raab-Traub N, Dittmer DP, Damania B. Tousled-like Kinases Modulate Reactivation of Gammaherpesviruses from Latency.
Cell Host Microbe. 2013 Feb 13;13(2):204-14. doi: 10.1016/j.chom.2012.12.005.
-This article was highlighted by F1000 Biology.   http://f1000.com/prime/717982020
75) Roy D, Sin SH, Lucas AS, Venkataramanan R, Wang L, Eason A, Chavakula V, Tamburro KM, Hilton IB, Damania B, Dittmer DP. mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis. Cancer Res. 2013 Feb 4.(In press)
74) Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.J. Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749.
73) Bhatt AP, Damania B. AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV. Front Immunol. 2012;3:401. doi: 10.3389/fimmu.2012.00401. Epub 2013 Jan 7.
72) Chen W, Sin SH, Wen KW, Damania B, Dittmer DP.  Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
PLoS Pathog. 2012 Nov;8(11):e1003048. doi: 10.1371/journal.ppat.1003048.
71) Jacobs SR, Gregory SM, West JA, Wollish AC, Bennett CL, Blackbourn DJ, Heise MT, Damania B.  The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.
J Virol. 2013 Jan;87(2):798-806. doi: 10.1128/JVI.01851-12. Epub 2012 Oct 31.
-J. Virology Spotlight Feature article
70) West JA, Gregory SM, Damania B.Toll-like receptor sensing of human herpesvirus infection. Front Cell Infect Microbiol. 2012;2:122. doi: 10.3389/fcimb.2012.00122.
69)  Tamburro KM, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, Sin SH, Malouf N, Moylan V, Damania B, Moll S, van der Horst C, Dittmer DP. Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.Virology. 2012 Nov 10;433(1):220-5. doi: 10.1016/j.virol.2012.08.014.
68) Bhatt, AP., Jacobs, SR., Freemerman, AJ, Makowski L, Rathmell, JC, Dittmer, DP,  and B. Damania. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. 2012.
Proceedings of the National Academy of Sciences (PNAS). Jul 17;109(29):11818-23.
67)  Damania B, Blackbourn DJ. Innate barriers to viral infection. Future Microbiol. 2012 Jul;7:815-22.
66) Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy.Immunity. 2012. 36(6):933-46.
65) Jacobs SR, Damania B.  NLRs, inflammasomes, and viral infection.  J Leukoc Biol. 2012 May 10.
64) Dittmer DP, Richards KL, Damania B. Treatment of kaposi sarcoma-associated herpesvirus-associated cancers.  Front Microbiol. 2012;3:141. Epub 2012 Apr 18.
63) Dittmer DP, Bhatt AP, Damania B.Rapalogs in viral cancers. Expert Opin Investig Drugs. 2012 Feb;21(2):135-8.
62) Gregory SM, Wang L, West JA, Dittmer DP, Damania B. Latent Kaposi's sarcoma-associated herpesvirus infection of monocytes downregulates expression of adaptive immune response costimulatory receptors and proinflammatory cytokines.
J Virol. 2012 Apr;86(7):3916-23. Epub 2012 Jan 25.
61) Dittmer DP, Bhatt AP, Damania B.Rapalogs in viral cancers. Expert Opin Investig Drugs. 2012 Feb;21(2):135-8. Epub 2012 Jan 4.
60)  Gregory SM, Damania B. Inhibition of the inflammasome response by a viral protein that interacts with NLRs. Commun Integr Biol. 2011 Jul;4(4):416-8.
59) Guilluy C, Zhang Z, Bhende PM, Sharek L, Wang L, Burridge K, Damania B.  Latent KSHV infection increases the vascular permeability of human endothelial cells. Blood. 2011 Aug 31.
58)  Roy D, Sin SH, Damania B, Dittmer DP. Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.  Blood. 2011 Aug 18;118(7):e32-9.
57) Gregory,SM, Davis,BK., West, JA., Taxman, D., Matsuzawa, S., Reed, J., Ting. JP, and B. Damania.  Discovery of a Viral NLR Homolog that Inhibits the Inflammasome.  Science. 2011.
This article was featured in:
-Da Silva, K. Editors’ Choice: Evasion through evolution. Nature Medicine 2011
-Sanchez, C. Research Highlight: Viral immune evasion: NLR identity theft. Nature Reviews Microbiology 2011
-Dempsey, L. Research Highlight: Viral inflammasome inhibitor. Nature Immunology 2011.
-Mueller, K. Editors’ Choice: Immune Evasion tactic. Science Signaling. 2011
-F1000 Biology (F1000.com/8136972) and (F1000.com/8136972)
56) Ozgur S, Damania B, Griffith J.  The Kaposi's sarcoma-associated herpesvirus ORF6 DNA binding protein forms long DNA-free helical protein filaments. J Struct Biol. 2011
55)  West JA, Gregory SM, Sivaraman V, Su L, Damania B. Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2011. 85(2):895-904.
54) Bhende PM, Park SI, Lim MS, Dittmer DP, Damania B. The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma. Leukemia. 2010. 24(10):1781-4.
53) Moyo TK, Richards KL, Damania B. Use of cidofovir for the treatment of HIV-negative human herpes virus-8-associated primary effusion lymphoma. Clin Adv Hematol Oncol. 2010. (5):372-4.
52) Bhatt, AP, Bhende, PM, Sin, SH, Roy, D, Dittmer, DP and B. Damania.  Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.  Blood. 2010. 115(22):4455-63.
51) Wen, K and B. Damania.  HSP90 and HSP40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1.  Oncogene. 2010. 29(24):3532-44.
50) West JA, Damania B.  Kaposi's sarcoma-associated herpesvirus and innate immunity.Future Virol. 2010 Mar 1;5(2):185-196.
49) Gregory SM, Damania  B.   KSHV and the toll of innate immune activation.  Cell Cycle. 2009 Oct 15;8(20):3246-7.
48) González CM, Wang L, Damania B. KSHV Encodes a Viral Deubiquitinase. J Virol. 2009 Oct;83(19):10224-33.
47) Wen KW, Damania B. Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis. Cancer Lett. 2009.
46) Wen, KW, Dittmer, DP and B. Damania.  Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus. J Virol. 2009 Oct;83(19):9786-802.
45) Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP, Damania B.  Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci U S A. 2009 Jun 29.
This article was highlighted in Science Signaling: L. Bryan Ray. For Whom the Toll-Like Receptor Signals.  Sci. Signal.,Vol. 2, Issue 80, p. ec242
44)  O'Hara AJ, Chugh P, Wang L, Netto EM, Luz E, Harrington WJ, Dezube BJ, Damania B, Dittmer DP. Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma. PLoS Pathog. 2009 Apr;5(4). Website: http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000389
43) O'Hara AJ, Wang L, Dezube BJ, Harrington WJ Jr, Damania B, Dittmer DP.  Tumor suppressor micro RNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma. Blood. 2009 Feb 27.
42) Wang, L. and B. Damania.  KSHV confers a cell survival advantage to endothelial cells.  Cancer Research. 2008. 68(12):4640-8.
This article was highlighted in Nature Reviews Cancer: Angiogenesis: Survival of the Infected.  Vol.8, page 569 (August 2008).
This article was also featured in the August 2008 Signaling Gateway Highlights section: http://www.signaling-gateway.org/update/updates/200808/index.html
41) Tomlinson, CC and B. Damania.A critical role for endocytosis in the regulation of signaling by the KSHV K1 protein. J. Virology. 2008. 82(13):6514-23.
40) West, J. and B. Damania. Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection.  J. Virology. 2008. 82(11):5440-9
39) Nun, T.K., Kroll D.J.,Oberlies,N.H., Soejarto, DD, Case, RJ, Piskaut, P.,Matainaho, T., Hilscher, C., Wang, L., Dittmer, DP., Gao, SJ and B. Damania. Development of a Novel, High Throughput Assay to Screen Anti-Viral Drugs against Kaposi’s Sarcoma-Associated Herpesvirus. Molecular Cancer Therapeutics. 2007.  Aug;6(8):2360-70.
38) Mark, L. Spiller, Okroj, Chanas, Aitken, Wong,S.,  Damania,B., Blom,H and D. Blackbourn.  Molecular characterization of the Rhesus Rhadinovirus (RRV)  ORF4 gene and the RRV complement control protein (RCP) it encodes. J Virol. 2007 Apr;81(8):4166-76.
37) Hoon-Sin,S., Roy,D., Wang,L., Staudt M.R., Fakhari,FD., Patel,DD. Koon,H., Damania, B. and D.P. Dittmer. Rapamycin is efficacious against primary effusion lymphoma (PEL). Blood. 2007 Mar 1;109(5):2165-73.
36) Damania B.  DNA tumor viruses and human cancer. Trends in Microbiology. 2007.
35) Wang, L., Dittmer, D. P., Tomlinson, C.C., Fakhari, F.D. and B. Damania.  “Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV). 2006. Cancer Research.  66(7):3658-66.
34) Bowser, B.S., Song, M.J., Sun, R., Morris, S. and B. Damania.  “Identification of Multiple Rta Responsive Elements in the KSHV K1 promoter.”  2006. Virology. 348(2):309-27.
33) Gonzalez, C.M., Wong, E.L., Bowser, B.S., Hong, G, Kenney S. and B. Damania. Identification and Characterization of the KSHV Orf49 Protein. 2006. J. Virology. 80(6):3062-70.
32) Wong, E.L. and B. Damania.  Transcriptional Regulation of the Kaposi’s Sarcoma-Associated Herpesvirus K15 Gene. 2006. J. Virology;80 1385-1392.
31) Bilelo, J., Morgan, J. Damania, B., Lang, S, and RC Desrosiers.  A Genetic System for Rhesus Monkey Rhadinovirus: Use of Recombinant Virus to Quantitate Antibody-Mediated Neutralization.  2006. J. Virology;80 1549-1562.
30) Hong, G., Kumar, P., Wang, L., Damania, B., Gulley, M.L., Delecluse H-J., Polverini, P., and S. Kenney. Epstein-Barr Virus Lytic Infection is Required for Efficient Production of the Angiogenesis Factor VEGF in Lymphoblastoid Cell Lines.  J Virol. 2005 79(22):13984-92.
29) Wong, E.L. and B. Damania.  Linking KSHV to Human Cancer.2005. Current Oncology Reports (5):349-356.
28) Dittmer, D.P., Gonzalez C.M., Vahrson, W., DeWire, S.M., and B. Damania.  “Whole-Genome Transcription Profiling of Rhesus Monkey Rhadinovirus.” 2005. Journal of Virology 79: 8637-8650.
27) Cai, W., Lu, S., Zhang, Z., Gonzalez, C.M., Damania B., and B. Cullen.  Kaposi’s sarcoma associated herpesvirus expresses an array of novel viral microRNAs in latently infected cells. 2005. Proc. Natl. Acad. Sciences. 2005. 102(15):5570-5.
26) DeWire, S. and B. Damania. “The Latency-Associated Nuclear Antigen of Rhesus Monkey Rhadinovirus (RRV) Inhibits Viral Replication through Repression of Orf50/Rta Transcriptional Activation.”  J. Virol. 2005. 79; 3127-3138.
25) Payton ME, d'Offay JM, Prado ME, Black DH, Damania B, White GL, Eberle R.  Comparative transmission of multiple herpesviruses and simian virus 40 in a baboon breeding colony. Comp Med. 2004. 54(6):695-704. 
24) Pagano, J.S. Blaser, M. Buendia, M.A., Damania, B., Khalili, K. Raab-Traub, N., Roizman, B. Validation Of A Causal Relationship: Criteria To Establish Etiology of Viral Cancers. Seminars in Cancer Biology. Semin Cancer Biol. 2004. 14(6):453-71.
23) Damania, B.  Oncogenic Gammaherpesviruses: Comparison of Viral Proteins involved in Tumorigenesis. Nature Reviews Microbiology, 2004. Vol. 2, pp.656-668.
22) Damania, B. Modulation of cell signaling pathways by Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8). Cell Biochemistry & Biophysics, 2004.Vol. 40, pp. 305-322
21) Wang, L., Wakisaka N., Tomlinson, C., DeWire S., Krall, S., Pagano, J. and B. Damania. "The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) K1 Protein Induces Expression of Angiogenic and Invasion Factors."  Cancer Research.2004. 64. pp.2774-2781.
20) Damania B., J. H. Jeong, B. S. Bowser, S. M. DeWire and D. P. Dittmer. “A Functional Comparison of Rta Transactivator Proteins of Gamma-2 Herpesviruses.” J.Virol. 2004. 78. p.5491-5499.
19) Tomlinson, C.C., and B. Damania.  The K1 Protein of Kaposi’s Sarcoma-Associated Herpesvirus Activates the Akt Signaling Pathway.  J. Virol. 2004. 78 (4): 1918-27.
18) O’Connor, C., Damania, B. and Kedes, D.H. Capsid.   De Novo Infection with Rhesus Monkey Rhadinovirus Leads to the Accumulation of Multiple Intranuclear Capsid Species during Lytic Replication but Favors the Release of Genome-Containing Virions.  J Virol. 2003 Dec 15;77(24):13439-13447. 
17) Yu, X.K., O’Connor, C., Atanosov, I., Damania, B., Kedes, D., and Z.H. Zhou.  Three-Dimensional Structures of the A, B, and C Capsids of Rhesus Monkey Rhadinovirus: Insights into Gammaherpesvirus Capsid Assembly, Maturation, and DNA Packaging. J Virol. 2003 Dec 15;77(24):13182-13193.
16) DeWire, S.M., Money, E.S., Krall, S.P., and B. Damania. Rhesus Monkey Rhadinovirus (RRV): Construction of a RRV-GFP Recombinant Virus and the Development of Assays to Assess Viral Replication. 2003. Virology. 312 (1): 122-134.
15) Bowser, B.S., DeWire, S. and B. Damania.  Transcriptional Regulation of the KSHV K1 viral gene of Kaposi’s sarcoma-associated herpesvirus.  2002.Journal of Virology, 76 (24): 12574-12583.
14) DeWire, S., McVoy,, M., and B. Damania.  Kinetics of Expression of Rhesus Monkey Rhadinovirus (RRV)  and the Identification and Characterization of a polycistronic transcript  encoding  the RRV Orf 50/Rta, RRV R8 and R8.1 genes. 2002.Journal of Virology, 76(19): 9819-9831.
13) Damania, B. and R.C. Desrosiers.  Oncogenic gamma-herpesviruses.  Philosophical Transactions of the  Royal Society.2001.
12) Choi JK, Means R, Damania B., and J.U. Jung. Molecular piracy of Kaposi’s sarcoma associated herpesvirus.2001. Cytokine and Growth Factor Rev. 12(2-3):245-257.
11) Damania, B and J.U. Jung.  Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri. 2000. Advances in Cancer Research, 80:51-82.
10) Li, M., Damania, B. Alvarez, X.,  Ogryko, G., Ozato, K., and J.U. Jung.  The Kaposi sarcoma herpesvirus vIRF gene inhibits histone acetyltransferases.   Molecular & Cellular Biology. 20(21):8254-63. 2000.
9) Lee, B.S., Damania, B., and J.U. Jung. The Kaposi's sarcoma-associated herpesvirus K1 and Rhesus Monkey Rhadinovirus R1 proteins. EBV Report. 1999.  Vol. 6 (5), pp. 123-125.
8) Alexander, L., Denekamp, L., Auerbach, M., Knappe, A., Damania, B. and R.C. Desrosiers. Sequence analysis of Rhesus Rhadinovirus Isolate H26-95.Journal of Virology, 2000 76 (8).
7) Damania, B. DeMaria, M., Jung, J.U. and R.C. Desrosiers  Activation of lymphocyte signaling by the R1 protein of Rhesus monkey rhadinovirus.Journal of Virology, 2000 (76)6.
6) Damania, B., Choi, J.K. and Jung J.U.  Gammaherpesviruses: Transforming functions of the first open reading frames. J. Virol. 1999.Journal of Virology, 2000. 76 (4).
5) Damania, B. Lee, H. and Jung, J.U.  Primate herpesviral oncogenes.  Mol. Cells, 1999.  Vol.  9 (4), pp. 20-24.
4)  Damania B, Li M, Choi JK, Alexander L, Jung JU, Desrosiers RC. Identification and characterization of the R1 oncogene and its protein  product  from the rhadinovirus of rhesus monkeys. J. Virol., 1999.  Vol.  73(6), pp. 5123-5133.  
3) Damania B, Lieberman P, Alwine JC. Simian virus 40 large T antigen stabilizes the TATA-binding protein-TFIIA complex on the TATA element. Mol Cell Biol. 1998 Jul;18(7):3926-35.
2) Damania B, Mital R, Alwine JC.  Simian virus 40 large T antigen interacts with human TFIIB-related factor and small nuclear RNA-activating protein complex for transcriptional activation of TATA-containing polymerase III promoters. Mol Cell Biol. 1998 Mar;18(3):1331-8. 
1) Damania B, Alwine JC.  TAF-like function of SV40 large T antigen. Genes Dev. 1996 Jun 1;10(11):1369-81. 


home