Welcome to the Clemmons/Maile Laboratories!

 
Overview:

The activity of a small protein found in both the circulation and in the fluid that surrounds the cells and tissues called insulin-like growth factor -I (IGF-I)has been implicated in the progression of a number of diseases including atherosclerosis, cancer and retinopathy. These diseases are characterized by aberrant proliferation and migration of various cell types. We are particularly interested in the ability of IGF-I to stimulate smooth muscle and endothelial cell migration and proliferation contributing to the progression of these diseases. Our recent studies have shown that the responsiveness of these cells to IGF-I is determined, not only by the activation of the IGF-I receptor itself but also by three other transmembrane proteins, including the alphaVbeta3 integrin and two cell to cell adhesion molecules, integrin associated protein, and SHPS-1. The overall goal of the research undertaken in our laboratory is to understand the molecular cross talk between the IGF-IR and these three other proteins.

The long term goal of our work is to identify new molecular therapeutic targets that would allow the specific regulation of IGF-I action in smooth muscle and endothelial cells to limit dysregulation of cell growth and proliferation without disrupting its vital action in other parts of the body.

Clemmons Maile Endocrinology

Clemmons Lab
Maile Lab