Maile Publications

  Recent Publications
Maile LA, Clemmons DR Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs. Mol Endocrinol. 2005

Ling Y, Maile LA, Clemmons DR DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells.J Biol Chem. 2004 Nov 16;

Maile LA, Clemmons DR. Integrin-associated protein binding domain of thrombospondin-1 enhances insulin-like growth factor-I receptor signaling in vascular smooth muscle cells. Circulation Research. 93(10): 925-931, 14 Nov 2003

Maile LA Badley-Clarke J Clemmons DR. The Association between Integrin-associated Protein and SHPS-1 Regulates Insulin-like Growth Factor-I Receptor Signaling in Vascular Smooth Muscle Cells. Molecular Biology of The Cell. 14(9): 3519-28, 14 Sep 2003

Ling Y, Maile LA, Clemmons DR. Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for membrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor. Mol Endocrinol. 17(9): 1824-33. Sep 2003.

Clemmons DR, Maile LA. Minireview: Integral membrane proteins that function coordinately with the insulin-like growth factor I receptor to regulate intracellular signaling. Endocrinology. 144(5): 1664-70, May 2003

Maile LA, Clemmons DR. The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor. Endocrinology. 143(11): 4259-64, Nov 2002

Maile LA, Clemmons DR. Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2. The Journal of Biological Chemistry. 277(11): 8955-60, Mar 2002

Maile LA, Imai Y, Clarke JB, Clemmons DR. Insulin-like growth factor I increases alpha Vbeta 3 affinity by increasing the amount of integrin-associated protein that is associated with non-raft domains of the cellular membrane. The Journal of Biological Chemistry. 277(3): 1800-5, Jan 2002

Maile LA, Badley-Clarke J, Clemmons DR. Structural analysis of the role of the beta 3 subunit of the alpha V beta 3 integrin in IGF-I signaling. Journal of Cell Science. 114(Pt 7): 1417-25, Apr 2001

Maile LA, Whellams EJ and Holly, JMP. Endogenous IGFBP-3 is protected from inducible IGFBP-3 protease activity in normal adult serum. Growth Horm IGF Research. 10(2): 71-77, Apr 2000.

Whellams EJ, Maile LA, Fernihough JK, Billingham ME, Holly JM. Alterations in insulin-like growth factor binding protein-3 proteolysis and complex formation in the arthritic joint. J. Endocrinol. 165(3): 545-556 Jun 2000.

Maile LA, Gill ZP, Perks CM, Holly JM. The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. Endocrinology. 140(9): 4040-5 Sep 1999.

Maile LA, Holly JM. Insulin-like growth factor binding protein (IGFBP) proteolysis: occurrence, identification, role and regulation. Growth Horm IGF Res. 9(2): 85-95. Apr 1999.

Maile LA, Xu S, Cwyfan-Hughes SC, Fernihough JK, Pell JM, Holly JM. Active and inhibitory components of the insulin-like growth factor binding protein-3 protease system in adult serum, interstitial, and synovial fluid. Endocrinology. 139(12): 4772-81. Dec 1998.
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