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    The 3D Human Genome

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    Genome Editing

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    Monocyte Differentiation

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    Software Development

Research Interests

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    3D Chromatin Structure

    We study how DNA loops regulate gene transcription and human development.

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    Genome editing

    We are developing and applying new techniques to manipulate non-coding regulatory DNA and 3D chromatin structure.

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    Cellular Differentiation

    We are interested in the complex network of molecular events that drive lineage specification and the maintenance of cellular identity.

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    Software Development

    We are developing novel software to analyze and visualize data from genomic and proteomic data sets.

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Latest News

02|11|18   Welcome Eliza and Maya

We are excited to welcome two new lab members this week. Eliza Thulson joins the groups as a BBSP rotation student to work on transcription factor-mediated DNA loop formation during macrophage development. Mayura Patwardhan is an undergraduate researcher developing a new R package for genomic data analysis.

01|25|18   Katie receives a travel grant

Congratulations to Katie Metz who was awarded a UNC Graduate Student Transportation Grant to help offset costs for her travel to the a Keystone Symposia. She will be traveling to Whistler, British Columbia, Canada next month to present her research at the 'Chromatin Architecture and Chromosome Organization' meeting.

01|10|18   Welcome Robert

Robert Fisher joins the group as an undergraduate researcher. He will employ CRISPR/Cas9 technology to study the role of AP-1 in enhancer-mediated gene regulation.

12|07|17   Doug receives a JFD Award

Doug has received a Junior Faculty Development Award to develop high-throughput CRISPR screens of chromatin loops involved in macrophage development.