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Research Collaborators of the Siderovski group:
UNC-Chapel
Hill collaborators -
Dr. John
Sondek
Dr. Sondek and his laboratory have been very generous in helping our
structural biology efforts.
Indeed, our two groups have joint lab meetings,
shared resources, and common research interests.
Dr. T. Kendall Harden
Dr. Harden is principal investigator on our NIH-sponsored Program Project
Grant entitled "G-protein signal
integration by multifunctional proteins".
Ken has also been very active in mentoring the graduate students of our
lab, including Randall Kimple, Melinda Hains, and Chris Johnston.
Dr. Klaus Hahn
Klaus has recently brought his expertise in real-time fluorescence-based
biosensor creation to Chapel Hill from
Scripps. Our two labs are committed to developing novel biosensors for
heterotrimeric G-protein subunits in the aid of unravelling the dynamics of G
protein-coupled receptor signaling and the interplay between G-alpha
subunits, tubulin, and their regulatory proteins in establishing and
maintaining the mammalian mitotic spindle.
International collaborators -
Dr. Pierre Gönczy
Pierre's group at ISREC (Lausanne,
Switzerland)
has been working closely with the Siderovski lab in unravelling the nature of
the guanine nucleotide cycle(s) underlying mitotic spindle organization and
force generation in the asymmetric cell division of the C. elegans
zygote.
Dr. S.J. (Tony)
D'Souza
Tony D'Souza and his group up in the wilds of Canada (The University of
Western Ontario in London, Ontario, to be exact) have wrestled with the early
embryonic lethality of our RGS14 knockout mice and, collectively, we have
uncovered an intimate association between RGS14 and microtubules at the
mitotic spindle of mammalian cells, including the one-cell mouse zygote.
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