1994 - present
Postdoctoral Fellow: UNC at Chapel Hill Department of Biology
Faculty Advisor: Dr. Thomas Petes
Project: Control of Initiation of Meiotic Recombination at the HIS4 Locus in Saccharomyces cerevisiae

1987 - 1994
Graduate Student: Massachusetts Institute of Technology, Cambridge, MA
Department of Biology and Center for Cancer Research
Faculty Advisor: Dr. Frank Solomon
Thesis: Suppression of cold-sensitive mutants of yeast alpha-tubulin by overexpression of wild-type genes

1983 - 1987
Undergraduate: Carnegie - Mellon University, Pittsburgh PA
Bachelor of Science in Biology
Faculty advisor: Dr. Elizabeth Jones
Project: Cloning of the PEP3 gene in Saccharomyces cerevisiae

Publications:

Kirkpatrick, D. T. (1998) "Roles of the DNA Mismatch Repair and Nucleotide Excision Repair Proteins During Meiosis in the Yeast Saccharomyces cerevisiae" (review), submitted, Cellular and Molecular Life Sciences.

Kirkpatrick, D. T., Wang, Y.-H., Dominska, M., Griffith, J. D., and T. D. Petes. (1998) "Control of Meiotic Recombination and Gene Expression in Yeast by a Simple Repetitive DNA Sequence that Excludes Nucleosomes" submitted, Molecular Cell.

Kirkpatrick, D. T., Fan, Q.-Q., and T. D. Petes. (1998) "Maximal Stimulation of Meiotic Recombination By a Yeast Transcription Factor Requires the Transcription Activation Domain". submitted, Genetics.

Kirkpatrick, D. T., Dominska, M., and T. D. Petes. (1998) "Conversion-type and restoration-type repair of DNA mismatches formed during meiotic recombination in Saccharomyces cerevisiae". Genetics 149: 1693-1705.

Kirkpatrick, D. T. and T. D. Petes. (1997) "Repair of DNA Loops Involves DNA Mismatch and Nucleotide Excision Repair Proteins" Nature 387: 929-931.

Kirkpatrick, D. T. (1997) "Deletion of Flanking ARS Elements Does Not Affect Meiotic Recombination at the HIS4 Locus in Yeast" Current Genetics 31: 106-111.

Kirkpatrick, D. and F. Solomon. (1994) "Overexpression of Yeast Homologs of the Mammalian Checkpoint Gene RCC1 Suppresses the Class of Alpha-Tubulin Mutations that Arrest with Excess Microtubules" Genetics 137: 381-392.

Solomon, F., Guenette, S., Kirkpatrick, D., Praitis, V., Weinstein, B., and J. Archer. A Genetic Analysis of Microtubule Assembly and Function in Yeast. In "Chromosome Segregation and Aneuploidy", NATO ASI Series H: Cell Biology, Vol. 72 (ed. B. Vig), Springer-Verlag, pp. 199-209, 1993.

Solomon, F., Connell, L., Kirkpatrick, D., Praitis, V., and B. Weinstein. Methods for Studying the Cytoskeleton in Yeast. In "The Cytoskeleton: a Practical Approach", ed. Carraway, K.L., and C.A.C. Carroway, IRL/Oxford University Press, New York, 1992.

Preston, R., Manolson, M., Becherer, K., Weidenhammer, E., Kirkpatrick, D., Wright, R., and E.W. Jones. (1991) "Isolation and Characterization of PEP3, a Gene Required for Vacuolar Biogenesis in Saccharomyces cerevisiae." Mol. Cell. Bio. 11: 5801-5812.

Abstracts/Talks:

Kirkpatrick, D. T. and Petes, T. Repair of DNA Loops During Meiosis Involves DNA Mismatch and Nucleotide Excision Repair Proteins. Talk at the Mid-Atlantic Yeast Meeting, Carnegie Mellon University, June 19-21, 1997.

Kirkpatrick, D. T. and Petes, T. The Transcription Activation Domain of the Yeast RAP1 Protein is Required for the Initiation of Meiotic Recombination at HIS4. Gordon Conference on Meiosis, Holderness School, NH, June, 1996.

Kirkpatrick, D. Identification of the Functional Domain of the Rap1 Protein Required for Meiotic Recombination at HIS4. Talk at the Mid-Atlantic Yeast Meeting, Princeton, NJ June 28 - July 1, 1995.

Kirkpatrick, D. and Petes, T. Does a Delay in Replication of HIS4 Affect the Initiation of Meiotic Recombination? Gordon Conference on Meiosis, Plymouth State College NH, July 3-8, 1994.

Kirkpatrick, D. and Solomon, F. ATS1 Overexpression Suppresses Cold-sensitive Extra-Microtubule Alpha-Tubulin Mutants. Cold Spring Harbor Laboratory Yeast Cell Biology Meeting, Cold Spring Harbor, August 17-22, 1993

Guenette, S., Kirkpatrick, D., Magendantz, M., and Solomon, F. Suppression of Microtubule Assembly Defects by Overexpression of Wild Type Genes. Yeast Genetics and Molecular Biology Meeting, University of Wisconsin-Madison, June 8-13, 1993.

Kirkpatrick, D. and Solomon, F. Suppression of a Cold-Sensitive Alpha-Tubulin Mutant of Saccharomyces cerevisiae by Overexpression. American Society of Cell Biology, Denver, Colorado, November 15-19, 1992.

Kirkpatrick, D. and Solomon, F. Suppression of Cold-Sensitive Mutations in Alpha-Tubulin by Over-expression. Yeast Genetics and Molecular Biology Meeting, San Francisco, California, May 23-27, 1991.

Preston, R. A., Kirkpatrick, D. and Jones, E. W. Characterization of PEP3, an Essential Gene Required for Vacuole Biogenesis. Yeast Cell Biology Meeting, Cold Spring Harbor, 1987.

Teaching History:

Spring, 1991:
Teaching Assistant: Molecular Biology for Undergraduates
Taught by: Dr. Uttam RajBhandary and Dr. Alan Grossman

Fall, 1988:
Teaching Assistant: Introductory Undergraduate Lab
Taught by: Dr. Brent Cochran and Dr. Paul Matsudaira

Awards:

Outstanding Undergraduate Research Award
Carnegie - Mellon University, May 1987

Professional Activities:

1988 - Present: Genetics Society of America
1994: Full member, Sigma Xi
1987: Associate member, Sigma Xi

Contact Information:
Address: As Above
Telephone: (919) 962-1445
Email: dtkirkpa@email.unc.edu
Web: http://www.unc.edu/~dtkirkpa