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Research Associate Professor |
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Laboratory for Molecular Modeling |
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Beard Hall, CB #7360 |
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Chapel Hill, NC 27599-7360 |
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Phone: (919) 966-3459 |
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Fax: (919) 966-0204 |
P r o f e s s i o n a l S k i l l s
Chem/o/informatics.
Development of Novel Theoretical and Computational Methods for Drug Discovery and Design.
Quantitative Structure-Activity Relationships Analysis.
Molecular Modeling.
Computational Chemistry.
Development of Algorithms and Computer Software.
P R O F E S S I O N A L E X P E R I E N C E
University of North Carolina at Chapel Hill October 1999 to present
Chapel Hill, NC, USA
Scientific activities:
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development of novel molecular descriptors and their applications in QSAR studies; |
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development of theoretical and computational methods for drug discovery and design and applications of these methods to chemical databases; |
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development of algorithms and software for QSAR and molecular diversity studies. |
Orleans University (Visit) January, 1998 to March 1999
Orleans, France
Work responsibilities included:
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development of 3D QSAR models of Acetylcholinesterase inhibitors; |
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applications of neural networks and other statistical methods to problems of molecular diversity; |
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computer network administration; |
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software development. |
Martin Luther University (Three months visit) June to October, 1997
Halle, Germany
Work responsibilities included:
molecular modeling of m- and d-opioid ligand receptor interactions.
Martin Luther University (Visit sponsored by DAAD) August to November, 1996
Halle, Germany
Work responsibilities included:
theoretical conformational analysis of m- and d-selective deltorphine analogues and Leu-enkephalin.
Latvian Institute of Organic Synthesis February, 1987 to October, 1999
Riga, Latvia
Work responsibilities included:
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theoretical conformational analysis of biologically active compounds and their analogues (deoxyguanosine analogues, analogues of enkephalin, sialic acid and its analogues, etc.); |
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development of algorithms and programs for conformational analysis. |
Design Office of Mechanization and Automation June, 1982 to February, 1987
Riga, Latvia
Work responsibilities included:
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problem definition, and development of algorithms and programs for lathes and milling machines with numerical control; |
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putting the developed software into operation in instrument-making plants. |
E d u c a t i o n
Latvian State University 1975 to 1980
Riga, Latvia
Faculty of Physics and Mathematics.
Specialized in Theoretical Physics.
Research activities in Nuclear Physics.
Latvian Institute of Organic Synthesis December 15, 1994
Riga, Latvia
Doctor’s degree in Chemistry (Dr. chem.)
(Resolution of Habilitation and Promotion Council of the Institute of Inorganic Chemistry of Latvian Academy of Sciences)
The title of thesis: “Conformational Aspects of Biological Activity of Deoxyguanozine Acyclic Analogs and Cyclic Analogs of Enkephalin.”