Avram Gold
Professor

Education
Harvard Univ., Cambridge, MA B.A. 1963 Chemistry
Harvard Univ., Cambridge, MA  Ph.D. 1969  Chemistry
Harvard School of Public Health, Boston, MA M.S.  1973  Air Pollution
Massachusetts Inst. Tech., Cambridge, MA Post-Doc 1969-70 Chemistry
Harvard Univ., Cambridge, MA 

 

 Post-Doc 1970-72 Chemistry
Professional Experience
1972-73 EPA Fellowship, towards MS in Air Pollution, Harvard School of Public Health
1973-79 Research Associate, Harvard School of Public Health, Boston, MA.
1979-82 Assistant Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina-Chapel Hill.
1982-86 Associate Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina-Chapel Hill.
1986- Professor, Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina-Chapel Hill.

Representative Publications
E. Bill, E.L. Bominaar, X.Q. Ding, A.X. Trautwein, H. Winkler, D. Mandon, R. Weiss, A. Gold, K. Jayaraj, and G.E. Toney, "Oxoferryl Porphyrin Cation Radicals in Model Systems: Evidence for Variable Metal-Radical Spin Coupling", in: Applications of the Mossbauer Effect, Vol. IV, Proc. of the Int. Conf. on the Application of the Mossbauer Effect, Budapest, Hungary, Sept. 4-8, D.L. Nagy, K. Lazar, Z. Kajcsos, eds.; J.C. Baltzer, pp 2343-2348, (1990).

S. Nesnow, G. Milo, P. Kurian, R. Sangaiah and A. Gold, "Induction of Anchorage-Independent Growth in Human Diploid Fibroblasts by the Cyclopenta-Polycyclic Aromatic Hydrocarbon, Benz(l)acenathylene", Mutation Res. 224, 221 (1990).

R. Sangaiah, A. Gold, "1,3,5-Tri-O-Acetyl-2-Deoxy-a ,b -D-Erythro-Pentose From 2-Deoxy-D-Erythro-Pentose", Nucleosides and Nucleotides 9, 907 (1990).

R. Sangaiah, A. Gold, K.O. Newcomb and L.M. Ball, "Synthesis and Biological Activity of Bay Region Metabolites of a Cyclopenta-fused Polymer Aromatic Hydrocarbon: Benz[j]aceanthrylene", J. Med. Chem. 34, 546 (1991).

L.M. Ball, S.H. Warren, R. Sangaiah and A. Gold, "Bacterial Mutagenicity of Two Cyclopenta-fused Isomers of Benzpyrene", Mutation Res. 260, 271 (1991).

R. Sangaiah and A. Gold, "Cyclopenta[cd]pyrene and Monomethyl Isomers", J. Org. Chem. 56, 6717 (1991).

S. Nesnow, J. Lasley, S. Curti, J. Ross, G. Nelson, R. Sangaiah and A. Gold, "Morphological Transforming Activity and DNA Adduct Formation by Benz[j]aceanthrylene and its Metabolities in C3H10T1/2C18 Cells", Cancer Res. 51, 6163 (1991).

R. Sangaiah, A. Gold, L.M. Ball, D.L. Matthews and G.E. Toney, "Synthesis and Resolution of Putative Diastereomeric N2-deoxyguanosine and N6-deoxyadenosine Adducts of Biologically Active Cyclopenta PAH", Tetrahedron Lett. 33, 3487 (1992).

D. Mandon, J. Fischer, R. Weiss, K. Jayaraj, R.N. Austin, A. Gold, P.S. White, O. Brigaud, P. Battioni and D. Mansuy, "b -Pyrrole Halogenated Porphyrins. Molecular Structures of 2,3,7,8,112,13,17,18-Octabromo-5,10,15,20-tetramesityl-porphyrin, Nickel(II)[2,3,7,8,12,13,17,18-octobromo-5,10,15,20-tetramesitylporphyrin] and Nickel(II)[2,3,7,8,12,13,- 17,18-octabromo-5,10,15,20-tetra(pentafluorophenyl)porphyrin]", Inorg. Chem. 31, 2044 (1992).

D. Mandon, R. Weiss, K. Jayaraj, A. Gold, J. Terner, E. Bill and A.X. Trautwein, "Models for Peroxidase Compound I: Generation and Spectroscopic Characterization of New Oxoferryl Porphyrin p Cation Radical Species", Inorg. Chem. 31, 4404 (1992).

E. Bill, X.-Q. Ding, E.L. Bominaar, CH. Butzlaff, A.X. Trautwein, D. Mandon R. Weiss and A. Gold, "Modulations of Exchange Coupling in Oxoferrylporphyrin Cation Radical Complexes Detected by Mössbauer and EPR Measurements", Hyperfine Interact. 71, 1299 (1992).

K.O. Newcomb, R. Sangaiah, A. Gold and L.M. Ball, "Activation and Metabolism of Benz[j]aceanthrylene-9,10-dihydrodiol, the Precursor to Bay-Region Metabolism of the Genotoxic Cyclopenta-PAH Benz[j]aceanthrylene", Mutation Res. 287, 181 (1993).

P. Ochsenbein, D. Mandon, J. Fischer, R. Weiss, R. Austin, K. Jayaraj, A. Gold, J. Terner, E. Bill, M. Müther and A.X. Trautwein, "Oxoferryl Cation Radical of b -Pyrrole Octachlorinated Tetramesitylporphyrin: Electronic and Structural Properties," Angew. Chem., Int. Ed. Engl. 32, 1437 (1993).

S. Nesnow, A. Gold, R. Sangaiah and T.J. Slaga, "Mouse Skin Tumor-initiating Activity of Benz[j]aceanthrylene in Senkar Mice", Cancer Lett. 73, 73 (1993).

S. Nesnow, S. Beck, L.M. Ball, R. Sangaiah and A. Gold, "Morphological transformation of C3H10T1/2CL8 Cells by Cyclopenta-fused Derivatives of Benzo[a]pyrene and Benzo[e]pyrene", Cancer Lett. 74, 25 (1993).]

P. Ochsenbein, K. Ayougou, D. Mandon, J. Fischer, R. Weiss, R.N. Austin, K. Jayaraj, A. Gold, J. Terner and J. Fajer, "Conformational Effects on the Redox Potentials Tetraarylporphyrins Halogenated at the b -Pyrrole Positions", Angew. Chem. Int. Ed. Engl. 33, 348 (1994).

S. Nesnow, J.A. Ross, G. Nelson, K. Wilson, B.C. Roop, A.J. Jeffers, A.J. Galati, G.D. Stoner, R. Sangaiah, A. Gold and M.J. Mass, "Cyclopenta[cd]pyrene-induced Tumorigenicity, Ki-ras Codon 12 Mutations, and DNA Adducts in Strain A/J/ Mouse Lung", Carcinogenesis 15, 601 (1994).

A. Gold, K. Brust, K. Jayaraj, R. Sangaiah, L.M. Ball, A.X. Trautwein, E. Bill and J. Terner, "Oxidation of Polycyclic Aromatic Hydrocarbons by an Oxoferryl Porphyrin p -Cation Radical", Polycyclic Aromatic Compounds 7, 27 (1994).

M. Müther, E. Bill, A.X. Trautwein, D. Mandon, R. Weiss, A. Gold, K. Jayaraj and R.M. Austin, "Spin Coupling in Distorted High-Valent Fe(IV)-Porphyrin Radical Complexes", Hyperfine Interact. 91, 803 (1994).

N. Scheller, R. Sangaiah, A. Ranasinghe, V. Amarnath, A. Gold and J.A. Swenberg, "Synthesis of [4,5,6,9-13C4]-2-Amino-6-Oxopurine, a Reagent for the Production of Internal Standards of Guanine DNA Adducts", Chem. Res. Toxicol., 8, 333 (1995).

H.L. Vermeulen, R. Sangaiah, L.M. Ball and A. Gold, "Synthesis of Mixed Halogenated Trihalomethanes Labelled with the Stable Isotopes 2H or 13C", J. Label. Cpds. and Radiopharm. 36, 835-843 (1995).

K. Jayaraj, A. Gold, R.N. Austin, D. Mandon, R. Weiss, J. Terner, E. Bill, M. Müther and A.X. Trautwein, "Compound I and II Analogues of a Chlorin", J. Am. Chem. Soc. 117, 9079 (1995).

K. Jayaraj, J. Terner, A. Gold, D.A. Roberts, R.N. Austin, D. Mandon, R. Weiss, E. Bill, M. Müther and A.X. Trautwein, "Influence of meso Substituents on Electronic States of Oxoferryl Porphyrin p -Cation Radicals", Inorg. Chem. 35, 1632-1640 (1996).

P.F. Rosser, P. Ramachandran, R. Sangaiah, R.N. Austin, A. Gold and L.M. Ball, "Role of O-Acetyltransferase in Activation of Oxidized Metabolites of the Genotoxic Environmental Pollutant of 1-Nitropyrene", Mutation Research 369, 209 (1996).

A. Gold, R. Sangaiah, C.J. Inhof, J. Zhang and L.M. Ball, "Metabolic Fate of the Environmental Mutagen 3-Nitrofluoranthene in the Rat", Polycyclic Aromatic Compounds, Polycyclic Aromatic Compounds 10, 19 (1996).

R. Weiss, D. Mandon, T. Wolter, A.X. Trautwein, M. Müther, E. Bill, A.Gold, K. Jayaraj and J. Terner, "Delocalization over the Heme and Axial Ligands of One of the Two Oxidizing Equivalents Stored Above the Ferric State in the Peroxidase and Catalase Compound-I Intermediates: Indirect Participation of the Proximal Axial Ligand of Iron in the Oxidation Reactions Catalyzed by Heme-Based Peroxidases and Catalases?" J. Biol. Inorg. Chem. 1, 377 (1996).

K. Ayougou, D. Mandon, J. Fischer, R. Weiss, M. Müther, E. Bill, V. Schünemann, A.X. Trautwein, J. Terner, K. Jayaraj, R.N. Austin and A. Gold, "Molecular Structure of the Chloroiron(III) Derivative of the Meso-Unsubstituted, Pyrrole b -Substituted (2,7,12,17-Tetramethyl-3,8,13,18-Tetramesityl)porphyrin and the Weak Ferromagnetic Exchange Interaction in the Corresponding A1u Oxoiron(IV) Porphyrin -Cation Radical Complex", Chem. Eur. 2, 1159-1163 (1996).

R. Sangaiah, N.I. Christova-Gueorguieva, A. Ranasinghe, N. Yu. Tretyakova, A. Gold, L.M. Ball and J.A. Swenberg, "Synthesis of Perdeuterated Analogues of the Epoxide Metabolites of Butadiene: 1,2-Epoxybut-3-ene-d6 and 1,2,3,4-Diepoxybutane-d6", J. Label. Compds. Radiopharm. XXXIX, 731-739 (1997).

A. Gold, K.. Jayaraj, L.M. Ball and K. Brust, "Oxidation of Polycyclic Aromatic Hydrocarbons by an Oxoferryl Porphyrin -Cation Radical", J. Mol. Catal. A: Chem., 125, 23-32 (1997).

K. Jayaraj, A. Gold, R.N. Austin, L.M. Ball, J. Terner, D. Mandon, R. Weiss, J. Fischer, A. DeCian, E. Bill, M. Müther, V. Schünemann, and A.X. Trautwein, "Compound I and Compound II Analogues from a Porpholactones", Inorg. Chem. 36, 4555-4566 (1997).

N. Tretyakova, R. Sangaiah, T.-Y. Yen, A. Gold and J.A. Swenberg, "Adenine Adducts with Diepoxybutane. Isolation and Analysis in Exposed Calf Thymus DNA", Chem. Res. Toxicol. 10, 1171-1179 (1997).

R. Jones, K. Jayaraj, A. Gold and M.L. Kirk, "Ground and Excited State Spectroscopic Probes of [TMP +Fe(IV)=O]+: The First Magnetic Circular Dichroism Study of a Model Peroxidase Compound I Intermediate", Inorg. Chem. 37, 2842-2843 (1998).