Publications

Huai, Q., Kim, H.Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J., & Ke, H. (2002) Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes, Proc. Natl. Acad. Sci., USA, in press.

Zhang, W., Ke, H., & Colman, R. W. (2002) Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis, Mol. Pharmacol ., 62, 62514-62520.

Dym, O., Xenarios, I., Ke, H., & Colicelli, J. (2002) Molecular docking of competitive phosphodiesterase inhibitors, Mol. Pharmacol., 61, 20-25.

Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H. (2001) Crystal structures of ACC synthase and evidence for divergent evolution of vitamin B6-dependent enzymes, J. Biol. Chem., 276 , 38210-38216.

Huai, Q., Colandene, J. D., Topal, M. D., & Ke, H. (2001) Structure of NaeI-DNA complex reveals dual-mode DNA recognition and complete dimer rearrangement, Nat. Struct. Biol., 8 , 665-669.

Zhang, W., Ke, H., Tretiakova, A. P., Jameson, B., & Colman, R. W. (2001) Identification of overlapping but distinct cAMP and cGMP binding sites of cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B, Protein. Sci., 10, 1481-1489.

Fox, D. S., Cruz, C., Sia, R. A. L., Ke, H., Cox, G. M., Cardenas, M. E., & Heitman, J. (2001) Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococus neoformans, Mol. Microbiol., 39, 835-849.

Huai, Q., Colandene, J. D., Chen, Y., Luo, F., Zhao, Y., Topal, M. D., & Ke, H. (2000) Crystal structure of NaeI an evolutionary bridge between DNA endonuclease and topoisomerase, EMBO J., 19, 3110-3118.

Xu, R.X., Hassell, A. M., Vanderwall, D., Lambert, M. H., Holmes, W. D., Luther, M. A., Rocque, W. J., Milburn, M. V., Zhao, Y., Ke, H., & Nolte, R. T. (2000) Atomic structure of PDE4: Insight into phosphodiesterase mechanism and specificity, Science, 288, 1822-1825.

Zhao, Y., Chen, Y., Schukowski, M., Fischer, G., & Ke, H. (1997) Cyclophilin A complexed with a fragment of HIV-1 Gag protein: insight into HIV-1 infectious activity, Structure, 5, 139-146.