Booth, R.G. and Neumeyer, J.L. Chapter 20: Drugs used to treat neuromuscular disorders: Antiparkinsonian and Spasmolytic Agents. In Foye's Principals of Medicinal Chemistry 5th Edition (Lemke et al.,eds) Williams and Wilkins, Baltimore; pp. 480-497 (2002).

Booth, R.G. and Neumeyer, J.L. Psychotherapeutic Drugs: Chapter 17: Antipsychotic and Anxiolytic Agents. In Foye's Principals of Medicinal Chemistry 5th Edition (Lemke et al.,eds) Williams and Wilkins, Baltimore; pp. 408-434 (2002)

Booth,R.G., Moniri, N.H., Bakker, R.A., Choksi, N.Y., Timmerman, H., and Leurs, R. A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H1 receptors. Journal of Pharmacology and Experimental Therapeutics 302: 1-9 (2002)

Mottola, D., Kilts, J., Lewis, M., Smith, H., Walker, Q.D., Jones, S., Booth, R.G., Hyslop, D., Piercey, M., Wightman, M., Lawler, C., Nichols, D.E., and Mailman, R.B. Functional selectivity of dihydrexidine: I. Selective activation of post-synaptic dopamine D2 receptors linked to adenylate cyclase. Journal of Pharmacology and Experimental Therapeutics 301:1166-1178 (2002)

Moniri, N.H., Wyrick, S.D., and Booth, R.G. New rigid diarylaminopropanes are histamine H1 ligands that stimulate brain dopamine synthesis. Society for Neuroscience Abstracts 27:191 (2001)

Booth, R.G., Choksi, N.Y., Nix, W.B., Leurs, R. A novel phenylaminotetralin radioligand reveals a sub-population of histamine H1 receptors. Society for Neuroscience Abstracts 26:1065 (2000).

Booth, R.G. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents. In Foye’s Principals of Medicinal Chemistry 5th Edition. Williams and Wilkins, Baltimore (2000).

Booth, R.G. Drugs used to treat neuromuscular disorders: Antiparkinsonian and Spasmolytic Agents. In Foye’s Principals of Medicinal Chemistry 5th Edition. Williams and Wilkins, Baltimore (2000).

Choksi, N.Y., Nix, William B., Wyrick, S.D., and Booth, R.G. A novel phenylaminotetralin recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain. Brain Research 852:151-160 (2000).

Booth, R.G., Owens, C.E., Brown, R.L., Bucholtz, E.C., Lawler, C.P., and Wyrick, S.D. Putative s3 sites in mammalian brain have histamine H1 receptor properties: Evidence from ligand binding and distribution studies with the novel H1 radioligand [3H]-(-)-trans-1-phenyl-3-aminotetralin (PAT). Brain Research 837:95-105 (1999).

Bucholtz, E.C., Brown., R.L., Tropsha, A., Booth, R.G, and Wyrick, S.D. Synthesis, Evaluation and Comparative Molecular Field Analysis of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for Histamine H1 Receptors. Journal of Medicinal Chemsitry.42:3041-3054(1999)

Bucholtz, E.C., Brown, R.L., Tropsha, A., Booth, R.G., and Wyrick, S.D. Design, Synthesis, Evaluation, and Comparative Molecular Field Analysis of Ligands for the [3H]-(–)-trans-H2-PAT Binding Site. American Chemical Society Abstracts 217:151 (1999).

Choksi, N.Y., Nix, W.B., and Wyrick, S.D., and Booth, R.G. Phenylaminotetralins activate histamine H1 receptors to stimulate dopamine synthesis in vivo in rat brain. Camerino Symposium: Receptor Chemistry Towards the Third Millennium 12: 128 (1999).

Booth, R.G., Choksi, N.Y., Nix, W.B., and Wyrick, S.D. Histamine H1 receptors mediate stimulation of dopamine synthesis by phenylaminotetralins in vivo. Society for Neuroscience Abstracts 25:172 (1999).

Booth, R.G., Brown, R.L., Bucholtz, E.C., Choksi, N.Y., Owens, C.E., and Wyrick, S.D. Phenylaminotetralins: A new class of histamine H1-type ligands that affect catecholamine synthesis and release in vitro and in vivo. Society for Neuroscience Abstracts 24:1838 (1998).

Bucholtz, E.C., Wyrick, S.D., Owens, C.E., and Booth, R.G. 1-Phenyl-3-dimethylaminotetralins (PATs): Effect of stereochemistry on binding and function at brain histamine receptors. Medicinal Chemistry Research 8:322-332 (1998).

Bucholtz, E.C., Wyrick, S.D., Brown, R.L., Booth, R.G. Design of phenylaminotetralins selective for proposed histamine H1 receptor subtypes in mammalian forebrain. Society for Neuroscience Abstracts 23:2036 (1997).

Choksi, N.Y., Kodavanti, P.R.S., Tilson, H.A., and Booth, R.G. Effects of Polychlorinated Biphenyls (PCBs) on Brain Tyrosine Hydroxylase Activity and Dopamine Synthesis in Rats. Fundamentals of Applied Toxicology 39:76-80 (1997)

Nickell, W. Ward, H.E., and Booth, R.G. Antianxiety agents. In Burger’s Medicinal Chemistry and Drug Discovery, 5th Edition, Volume 5 (Manfred E. Wolff, ed.) John Wiley and Sons, New York, 153-194 (1997).

Choksi, N.Y., Wyrick, S.D., and Booth, R.G. Phenylaminotetralins modulate dopamine synthesis in rat nucleus accumbens in vivo by a presynaptic H1-type receptor. Society for Neuroscience Abstracts 23:2036 (1997).

Choksi, N.Y., Hussain, A., and Booth, R.G. 2-Phenylaminoadenosine stimulates dopamine synthesis in rat forebrain in vitro and in vivo via adenosine A2 receptors. Brain Research 761:151-155 (1997).

Booth, R.G. Feighner, J.P. and Boyer, W.F. Selective Serotonin Re-Uptake Inhibitors. American Journal of Pharmaceutical Education 61: 113 (1997).

Bucholtz, E.C., Owens, C.E., Wyrick, S.D., Mailman, R.B., Kula, N.S., Baldessarini, R.J.and Booth, R. G., Development of a selective antagonist for the 3H-trans-H2-PAT binding site. Society for Neuroscience Abstracts 22:2007 (1996).

Owens, C.E., Mailman, R.B., Wyrick, S.D., and Booth, R. G. Putative s3 sites in mammalian brain have histamine H1 properties. Society for Neuroscience Abstracts 22:2006 (1996).

Choksi, N.Y., Wyrick, S.D., and Booth, R.G. Modulation of brain dopamine synthesis in vivo by a putative s3 agonist via a G-protein receptor mechanism. Society for Neuroscience Abstracts 22:2006 (1996).

Blake, B.L., Wyrick, S.D., and Booth, R. G. Molecular mechanisms of novel sigma ligands as potential neurotoxicants. Society for Neuroscience Abstracts 22:1914 (1996).

Booth, R.G. and Neumeyer, J.L. Pesticides. In Principles of Medicinal Chemistry 4th. Edition (William O. Foye, ed.) Lea Febiger, Philadelphia, 908-926 (1995).

Wyrick, S.D., Booth, R.G., Myers, A.M., Owens, C.E., Bucholtz, E.C., Hooper, P.C., Kula, N.S., Baldessarini, R.J., and Mailman, R.B. 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and related derivatives as ligands for the neuromodulatory s3 receptor: Further structure-activity relationships. Journal of Medicinal Chemistry 38:3857-3864 (1995).

Booth, R.G., and Neumeyer, J.L. Neuroleptics and anxiolytic agents. In Principles of Medicinal Chemistry 4th. Edition (William O. Foye, ed.) Lea Febiger, Philadelphia, 199-231 (1995).

Owens, C.E., Bucholtz, E.C., Hooper, P.C., Myers, A.M., Kula, N.S., Baldessarini, R.J, Mailman, R.B., Wyrick, S.D., and Booth, R. G. Structure-activity relationships for phenylaminotetralins at [3H]-PAT-labeled s3 receptors in rodent brain. Society for Neuroscience Abstracts 21:1610 (1995).

Booth, R.G., and Neumeyer, J.L. Drugs used to treat neuromuscular disorders. In Principles of Medicinal Chemistry 4th. Edition (William O. Foye, ed.) Lea Febiger, Philadelphia, 232-246 (1995).

Bucholtz, E.C., Owens, C.E., Hooper, P.C., Wyrick, S.D., Booth, R. G., Mailman, R.B., Kula, N.S., and Baldessarini, R.J. Structure requirements for s3 receptor binding and function. Society for Neuroscience Abstracts 21:1610 (1995).

Wyrick, S.D, and Booth, R.G. Progress in sigma receptor research. Drugs of the Future 20:1033-1044 (1995).

Choksi, N.Y., Waller, C.L., and Booth, R.G. Neurotoxic and neuroprotective effects of polychlorinated biphenyls and adenosine ligands in rat brain. Society for Neuroscience Abstracts 21:1518 (1995).

Wyrick, S.D., Myers, A.M., Booth, R.G., Kula, N.S., Baldessarini, R.J., and Mailman, R.B. Synthesis of [N-C3H3]-trans-(1R,3S)-(–)-1-phenyl-3-N,N-dimethylamino-1,2,3,4-tetrahydro-naphthalene (H2-PAT). Journal of Labeled Compounds and Radiopharmaceuticals 34: 131-134 (1994).

Booth, R.G., and Wyrick, S.D. Development of phenylaminotetralin ligands for a novel sigma (s3) receptor in brain. Medicinal Chemistry Research 4:225-237 (1994).

Booth, R.G., Baldessarini, R.J., Owens, C.E., and Marsh, E. Actions of 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain. Brain Research 662:283-288 (1994).

Lawler, C.P., Watts, V.J., Booth, R.G., Southerland, S.B., and Mailman, R.B. Discrete functional selectivity of drugs: OPC-14597, a selective antagonist for postsynaptic dopamine D2 receptors. Society for Neuroscience Abstracts 20:525 (1994).

Myers, A.M., Charifson, P.S., Owens, C.E., Kula, N.S., Baldessarini, R.J., McPhail, A.T., Booth, R.G., and Wyrick, S.D. Conformational analyses, pharmacophore identification, and comparative, molecular field analyses of ligands for the neuromodulatory s3 receptor. Journal of Medicinal Chemistry 37:4109-4117 (1994).

Myers, A.M., Wyrick, S.D., Booth, R.G., Owens, C.E., Kula, N.S., Baldessarini, R.J., and Mailman, R.B. Phenylaminotetralins as ligands for a novel sigma-like receptor. American Chemical Society Abstracts 207: 168 (1994)

Myers, A.M., Wyrick, S.D., Booth, R.G., Owens, C.E., Choksie, N., and Hussain, A. Phenylaminotetralins as sigma ligands. American Chemical Society Abstracts, North Carolina Section 108: (1994).

Owens, C.E., Myers, A.M., Lawler, C.P., Wyrick, S.D., Mailman, R.B., Baldessarini, R.J., and Booth, R. G. Pharmacology of PAT-s3 receptors in rodent brain. North Carolina Society for Neuroscience Abstracts 7:39 (1994).

Choksi, N.Y., Hussain, A., Owens, C.E., Myers, A.M., Harvey, R.D., Baldessarini, R.J., Wyrick, S.D., and Booth, R.G. Adenosine A2 and PAT-s3 agonists affect adenylyl cyclase activity and dopamine synthesis in rat brain. North Carolina Society for Neuroscience Abstracts 7:41 (1994).

Choksi, N.Y., Hussain, A., Owens, C.E., Myers, A.M., Harvey, R.D., Wyrick, S.D., Baldessarini, R.J., and Booth, R.G. Stimulation of brain cAMP and dopamine synthesis by adenosine A2 and s3 agonists. Society for Neuroscience Abstracts 20:748 (1994).

Owens, C.E., Myers, A.M., Lawler, C.P., Mailman, R.B., Baldessarini, R.J., Wyrick, S.D., and Booth, R. G. Characterization and distribution of brain s3 receptors labeled by [3H]-(–)-trans-H2-PAT. Society for Neuroscience Abstracts 20:748 (1994).

Owens, C.E., Myers, A.M., Kula, N.S., Baldessarini, R.J., Lawler, C.P., Mailman, R.B., Wyrick, S.D., and Booth, R.G. Phenylaminotetralins as ligands for a novel receptor with sigma-like neuromodulatory activity. Society for Neuroscience Abstracts 19: 421 (1993).

Booth, R.G., Wyrick, S.D., Baldessarini, R.J., Kula, N.S., Myers, A.M., and Mailman, R.B. A new sigma-like receptor recognized by novel phenylaminotetralins: Ligand binding and functional studies Molecular Pharmacology 44: 1232-1239 (1993).

Wyrick, S.D., Booth, R.G., Myers, A.M., Owens, C.E., Kula, N.S., Baldessarini, R.J, Mailman, R.B., Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. Journal of Medicinal Chemistry 36: 2542-2551 (1993).

Owens, C.E., Myers, A.M., Kula, N.S., Lawler, C.P., Mailman, R.B., Baldessarini, R.J., Wyrick, S.D., and Booth, R.G. Sigma-type neuromodulatory activity and binding of novel phenylaminotetralins. North Carolina Society for Neuroscience Abstracts 6:19 (1993).

Booth, R.G. Tyler, V.E., Robbers, J.E., and Speedie, M.K. Pharmacognosy and Pharmacobiotechnology, 10th Edition. Lea and Febiger (Malvern, PA) 1993.

Wyrick, S.D., Booth, R.G., Myers, A.M., Kula, N.S., and Baldessarini, R.J. Synthesis of [N-C3H3]-racemic-trans-1-phenyl-3-dimethylamino-6-chloro-7-hydroxy-1,2,3,4-tetrahydronaphthalene (PAT-6). Journal of Labeled Compounds and Radiopharmaceuticals 31:871-874 (1992).

Teicher, M.H., Gallitano, A.L., Gelbard, H.A., Evans, H.K., Marsh, E.R., Booth, R.G., and Baldessarini, R.J. Dopamine D1 autoreceptor function: Possible expression in developing rat prefrontal cortex and striatum. Developmental Brain Research 63: 229-235 (1992).

Myers, A.M., Wyrick, S.D., Booth, R.G., Mailman, R.B., Kula, N.S., and Baldessarini, R.J. Phenylaminotetralin analogs active at the sigma receptor. North Carolina Society for Neuroscience Abstracts 5: 9 (1992).

Wyrick, S.D., Booth, R.G., Myers, A.M., Kula, N.S., Baldessarini, R.J., and Mailman, R.B. Phenylaminotetralins as novel sigma receptor ligands. American Chemical Society Abstracts 204: 22 (1992)

Booth, R.G. Hlavica, P. and Damani, L.A., eds. N-Oxidation of Drugs – Biochemistry, Pharmacology, and Toxicology. American Journal of Pharmaceutical Education 56: 221 (1992).

Booth, R.G., Kula, N.S., Myers, A.M., Wyrick, S.D., and Baldessarini, R.J. Novel Phenylaminotetralins as possible agonists at sigma-type neuromodulatory receptors. Society for Neuroscience Abstracts 18: 23 (1992).

Booth, R.G. and Baldessarini, R.J. (+)-Benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue. Brain Research 557: 349-352 (1991).

Booth, R.G., Baldessarini, R.J, and Campbell, A. Inhibition of dopamine synthesis in rat striatal minces: Evidence of autoreceptor supersensitivity to S(+) but not to R(–)-N-n-propylnorapomorphine after repeated pretreatment with fluphenazine. Biochemical Pharmacology 41: 2040-2043 (1991).

Baldessarini, R.J., Campbell, A., Booth, R.G., and Neumeyer, J.L. S(+)-Aporphines as potential limbic-selective antipsychotic agents. Schizophrenia Research 4: 311-312 (1991).

Mottola, D.M., Cook, L.L., Jones, S.R., Booth, R.G., Nichols, D.E., and Mailman, R.B. Dihydrexidine, a selective dopamine receptor agonist that may discriminate postsynaptic D2 receptors. Society for Neuroscience Abstracts 17: 818 (1991).

Teicher, M.H., Gallitano, A.L., Gelbard, H.A., Evans, H.K., Marsh, E.R., Booth, R.G., and Baldessarini, R.J. Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum. Proc. Neurosci Symposium (1991).

Booth, R.G. and Baldessarini, R.J. (+)-Benzomorphan sigma ligands stimulate striatal dopamine synthesis. Society for Neuroscience Abstracts 17: 361 (1991).

Teicher, M.H., Gallitano, A.L., Gelbard, H.A., Evans, H.K., Marsh, E.R., Booth, R.G., and Baldessarini, R.J. Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum. Society for Neuroscience Abstracts 17: 363 (1991).

Rollema, H., Booth, R.G., Caldera, P., Johnson, E.A., Lampen, P., Youngster, S.K., Trevor, A.J., Naiman, N., and Castagnoli, N. In vivo intracerebral microdialysis studies in rats of MPP+ analogs and related charged species. Journal of Medicinal Chemistry 33: 2221-2230 (1990).

Booth, R.G., Baldessarini, R. J., Kula, N.S., Zong, R., Gao, Y., and Neumeyer, J.L. Presynaptic inhibition of dopamine synthesis in rat striatal tissue by enantiomeric mono- and dihydroxyaporphines. Molecular Pharmacology 38: 92-101 (1990).

Booth, R.G. and Baldessarini, R.J. Presynaptic regulation of dopamine synthesis in rat striatal tissue by dopamine, adenosine, and sigma receptors. Frontiers in Molecular Neuroscience 1: 6 (1990).

Booth, R.G. and Baldessarini, R.J. Receptor-mediated presynaptic regulation of dopamine synthesis in rat striatal tissue. Society for Neuroscience Abstracts 16: 81 (1990).

Booth, R.G., and Baldessarini, R.J. Adenosine A2 stimulation of tyrosine hydroxylase activity in rat striatal minces is reversed by dopamine D2 autoreceptor activation. European Journal of Pharmacology 185: 217-221 (1990).

Booth, R.G., Baldessarini, R.J., Neumeyer, J.L., and Kula, N.S. Presynaptic inhibition of dopamine synthesis in rat striatum by enantiomeric mono- and dihydroxyaporphine compounds. New England Society of Pharmacologists Abstracts 19: 6 (1990).

Booth, R.G., Baldessarini, R.J., Kula, N., and Neumeyer, J.L. Stereochemical effects of mono- and dihydroxyaporphines on presynaptic inhibition of tyrosine hydroxylase in vitro. Annals of New York Academy of Science 604: 592-595 (1990).

Johnson, E.A., Wu, E.Y., Rollema, H., Booth, R.G., Trevor, A.J., and Castagnoli, N. MPP+ Analogs: In vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake. European Journal of Pharmacology 166: 65-74 (1989).

Booth, R.G., Castagnoli, N., and Rollema, H. Intracerebral microdialysis neurotoxicity studies of quinoline and isoquinoline derivatives related to MPTP/MPP+. Neuroscience Letters 100: 306-312 (1989).

Booth, R.G., Trevor, A.J., Singer, T.P., and Castagnoli, N. Studies on semi-rigid tricyclic analogs of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Journal of Medicinal Chemistry 32: 473-477 (1989).

Booth, R.G., Kula, N.S., Neumeyer, J.L., and Baldessarini, R.J. Inhibition of tyrosine hydroxylase activity by enantiomeric aporphines in rat striatal minces. Society for Neuroscience Abstracts 15: 170 (1989).

Castagnoli, N., Trevor, A.J., Singer, T.P., Sparatore, A., Leung, L., Shinka, T., Wu., E.Y., and Booth, R.G. Metabolic studies on the nigrostriatal toxin MPTP. In Progress in Catecholamine Research, Alan R. Liss, Inc., New York, 93-100 (1988).

Sirawaraporn, W., Sertsrivanich, R., Booth, R.G., Hansch, C., Neal, R.A., and Santi, D.V. Inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines. Molecular Biochemical Parasitology 31: 79-86 (1988).

Rollema, H., Booth, R.G., and Castagnoli, N. In vivo dopaminergic neurotoxicity of the 2-b-methyl-carbolinium ion, a potential endogenous MPP+ analog. European Journal of Pharmacology 153: 131-134 (1988).

Booth, R.G., Singer, T.P., Trevor, A.T., and Castagnoli, N. MAO substrate properties of tricyclic MPTP analogs. Molecular Basis of the Action of Drugs and Toxic Substances 3: 1 (1987).

Booth, R.G., Trevor, A.T., Singer, T.P., and Castagnoli, N. Synthesis and pharmacological activity of rigid MPTP analogs. American Chemical Society Abstracts 194: 89 (1987).

Booth, R.G., Selassie, C.D., Hansch, C., and Santi, D.V. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. Journal of Medicinal Chemistry 30: 1218-1224 (1987).

Ramsay, R.R., McKeown, K.A., Johnson, E.A., Booth, R.G., and Singer, T.P. Inhibition of NADH oxidation by pyridine derivatives. Biochemical and Biophysical Research Communications 146: 53-60 (1987).

Booth, R.G., Castagnoli, N., and Trevor, A.T. Studies on tricyclic analogs of the nigrostriatal toxin MPTP relating to Parkinson's disease. Japanese-United States Congress of Pharmaceutical Sciences 1: 12 (1987).