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Mycobacterial
Genetics and Pathogenesis
The
UNIVERSITY of NORTH CAROLINA at CHAPEL HILL
Welcome to the
Braunstein lab webpage at UNC Chapel Hill. Our research focuses on
understanding the role protein secretion plays in the pathogenesis of Mycobacterium
tuberculosis. M. tuberculosis is the bacterium that causes
the disease tuberculosis. Currently, there are two million deaths per year
due to tuberculosis, and this disease has been deemed a Global Health
Emergency by the World Health Organization. In fact, more people are
dying today from this disease than at any other time in history. The
goal of this laboratory is to increase our understanding of the physiology
and pathogenesis of mycobacteria, which will enable the development of new
drugs and improved vaccines to combat tuberculosis.
Our laboratory is in the Microbiology
and Immunology Department in the UNC School of Medicine. We are
also affiliated with the
Interdisciplinary Biomedical Sciences (IBMS) Program, the
Curriculum in
Genetics and Molecular Biology, and the Center for Infectious Diseases (CFID).
M. tuberculosis is an intracellular pathogen. The fluorescent
image above shows M. tuberculosis (green rods) in murine bone
marrow-derived macrophages (larger red cells).
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