Welcome to the Kesimer Laboratory at UNC
Our laboratory located at Cystic Fibrosis and Pulmonary Research Center. One of the main focuses of our work is the characterization of the large mucin gene products (Mr 2-3 million) and the complexes they make (Mr 10-100 million) essential for the formation of the mucus gels vital for epithelial protection and function. our current work is focused around the human lung where there are many hypersecretory human diseases including asthma, cystic fibrosis, and chronic bronchitis in which these glycoconjugates are centrally implicated. My proteomic interest includes designing and implementing novel mass spectral methods for identifying proteins and glycoproteins in mucus gels where conventional proteomic methods do not work. Many of the molecules are heavily modified and thus MS methods for characterizing post-translational modifications are vital in this work.