Research Fellow, Dept. of Chemistry, Tohoku University 1977-1978
Research Assoc., Dept. of Physiological Chemistry, U. of Wisconsin 1978-1981
Research Assoc., Laboratory of Genetics, U. of Wisconsin 1981-1983
Assistant Scientist, Laboratory of Genetics, U. of Wisconsin 1983-1986
Associate Scientist, Laboratory of Genetics, U. of Wisconsin 1986-1988
Associate Professor, Dept. of Pathology, U. of North Carolina 1988-1996
Professor, Dept. of Pathology, U. of North Carolina 1996-present
Adjunct Professor, Dept. of Nutrition, U. of North Carolina 1999-present
Selected Peer-Reviewed Publications
· Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Sigmund, C.D., Heistad, D.D., Faraci, F.M., and Lentz, S.R. Endothelial dysfunction and elevation of S-Adenosylhomocysteine in cystathionine b-synthase-deficient mice, Circ. Res.88:1203-1209 (2001).
· Knouff, C., Malloy, S., Wilder, J., Altenburg, M.K., and Maeda, N. Doubling
expression of the LDL receptor by truncation of the 3' UTR sequence
ameliorates type III hyperlipoproteinemia in
mice expressing the human apoE2 isoform, J. Biol. Chem. 276:3856-3862 (2001).
· Hodgin, J.B., Krege, J.H., Reddick,
R.L., Korach, K.S., Smithies, O., and
Maeda, N. Estrogen receptor α is a major mediator of the atheroprotective effect of 17b-estradiol
in Apoe-/- mice, J. Clin.
Invest. 107:333-340 (2001).
· Knowles, J.W., Esposito,
G., Mao, L., Hagaman, J.R., Fox, J.E.,
Smithies, O., Rockman, H.A., and Maeda, N.
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient
mice. J. Clin.
Invest. 107:975-984 (2001).
· Goy, M.F., Oliver,
P.M., Purdy, K.E., Knowles, J.W., Fox, J.E., Mohler,
P.J., Qian, X., Smithies, O., and Maeda,
N. Evidence for a novel natriuretic peptide
receptor that prefers brain natriuretic
peptide over atrial natriuretic
peptide. Biochemical J. 379-387 (2001).
· Fitzky, B.U., Moebius,
F.F., Asaoka, H., Waage-Baudet,
H., Xu, L., Xu,
G., Maeda, N., Kluckman, K., Hiller, S.,
Yu, H., Batta, A.K., Shefer,
S., Chen, T., Salen, G., Sulik, K., Simoni,
R.D., Ness, G.C., Glossmann, H., Patel,
S.B., and Tint, G.S. 7-Dehydrocholesterol-dependent
proteolysis of HMG-CoA reductase
suppresses sterol biosynthesis in a mouse model of Smith-Semli-Opitz/RSH syndrome. J. Clin.
Invest. 108:905-915 (2001).
· Gilmore RC, Baker Jr. J,
Dempsey S, Marchan R, Corprew
Jr. RNL, Byrd G, Maeda N, Smithies O,
· Hodgin, JB, Knowles, JW, Kim,
H-S, Smithies, O, and Maeda, N. Interactions between endothelial nitric
oxide synthase and sex hormones in vascular
protection in mice. J. Clin.
Invest. 109:541-548 (2002).
· Hatada, S., Seed, J.R., Barker, C., Hajduk, S.L., Black, S., and Maeda, N. No
trypanosome lytic activity in the sera of
mice producing human haptoglobin-related
protein. Mol. & Biochem.Parasitology 119:291-294 (2002).
· Wu, J.-H., Hagaman, J., Kim, S., Reddick,
R.L., and Maeda, N. Aortic constriction exacerbates atherosclerosis and
induces cardiac dysfunction in mice lacking apolipoprotein
E. Arterioscler Thromb Vasc Biol.
22:469-475 (2002).
· Takizawa,
S., Aratani, Y.,
· Nakata, Y., and Maeda, N. Vulnerable
Atherosclerotic Plaque Morphology in Apolipoprotein
E-Deficient Mice Unable to Make Ascorbic Acid. Circulation 105:1485-1490 (2002).
· Kim, H.-S., Lee, G., John, S.W.M.,
Maeda, N., and Smithies, O. Molecular phenotyping
for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration. Proc. Natl. Acad. Sci.
USA 99:4602-4607 (2002).
· Knowles, JW, Erickson, L,
Guy, V, Sigel, C, Wilder, JC, and Maeda, N. Common Variations in Noncoding Regions of the Human Natriuretic Peptide Receptor A Gene Have
Quantitative Effects. J. Hum. Genet.,
112:62-70 (2003).
·
· Ellmers, LJ, Knowles, JW, Kim,
H-S, Smithies, O, Maeda, N, and
· Aratani, A, Kura,
F, Watanabe, H, Akagawa, H, Takano, Y,
Suzuki, K, Dinauer, MC, Maeda, N, and
Koyama, H. Critical Role of Myeloperoxidase
and Nicotinamide Adenine Dinucleotide Phosphate – Oxidase
in High-Burden Systemic Infection of Mice with Candida albicans. J. Infect. Dis. 185:1833-1837 (2002).
· Garg, R, Oliver, PM, Maeda,
N, and Pandey, KN. Genomic structure,
organization, and promoter region analysis of murine guanylyl cyclase/atrial natriuretic peptide receptor-A gene. Gene 291:123-133 (2002).
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· Hodgin, JB, and Maeda, N. Minireview: Estrogen and Mouse Models of
Atherosclerosis. Endocrinology 143:4495-4501 (2002).
· Xiao, H, Heeringa, P., Hu, P., Liu, Z., Zhao,
M., Aratani, Y., Maeda, N.,
Falk, R.J., and Jennette, J.C. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase
cause glomerulonephritis and vasculitis in mice. J. Clin.
Invest. 110:955-963 (2002).
· Swardson-Oliver, C.J.,
· Aratani, Y., Kura, F., Watanabe, H., Akagawa,
H., Takano, Y., Suzuki, K., Dinauer, M.C.,
Maeda, N., and Koyama, H. Relative contributions of myeloperoxidase
and NADPH-oxidase to the early host defense
against pulmonary infections with Candida albicans
and Aspergillus fumigatus, Medical Mycology 40:557-563 (2002).
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