Nobuyo Maeda

Research and Professional Experience

Research Fellow, Dept. of Chemistry, Tohoku University 1977-1978

Research Assoc., Dept. of Physiological Chemistry, U. of Wisconsin 1978-1981

Research Assoc., Laboratory of Genetics, U. of Wisconsin 1981-1983

Assistant Scientist, Laboratory of Genetics, U. of Wisconsin 1983-1986

Associate Scientist, Laboratory of Genetics, U. of Wisconsin 1986-1988

Associate Professor, Dept. of Pathology, U. of North Carolina 1988-1996

Professor, Dept. of Pathology, U. of North Carolina 1996-present

Adjunct Professor, Dept. of Nutrition, U. of North Carolina 1999-present

Selected Peer-Reviewed Publications

·        Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Sigmund, C.D., Heistad, D.D., Faraci, F.M., and Lentz, S.R. Endothelial dysfunction and elevation of S-Adenosylhomocysteine in cystathionine b-synthase-deficient mice, Circ. Res.88:1203-1209 (2001).

·         Knouff, C., Malloy, S., Wilder, J., Altenburg, M.K., and Maeda, N. Doubling expression of the LDL receptor by truncation of the 3' UTR sequence ameliorates type III hyperlipoproteinemia in mice expressing the human apoE2 isoform, J. Biol. Chem. 276:3856-3862 (2001).

·        Hodgin, J.B., Krege, J.H., Reddick, R.L., Korach, K.S., Smithies, O., and Maeda, N. Estrogen receptor α is a major mediator of the atheroprotective effect of 17b-estradiol in Apoe-/- mice, J. Clin. Invest. 107:333-340 (2001).

·        Knowles, J.W., Esposito, G., Mao, L., Hagaman, J.R., Fox, J.E., Smithies, O., Rockman, H.A., and Maeda, N. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J. Clin. Invest. 107:975-984 (2001).

·        Goy, M.F., Oliver, P.M., Purdy, K.E., Knowles, J.W., Fox, J.E., Mohler, P.J., Qian, X., Smithies, O., and Maeda, N. Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. Biochemical J. 379-387 (2001).

·      Fitzky, B.U., Moebius, F.F., Asaoka, H., Waage-Baudet, H., Xu, L., Xu, G., Maeda, N., Kluckman, K., Hiller, S., Yu, H., Batta, A.K., Shefer, S., Chen, T., Salen, G., Sulik, K., Simoni, R.D., Ness, G.C., Glossmann, H., Patel, S.B., and Tint, G.S.  7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Semli-Opitz/RSH syndrome. J. Clin. Invest. 108:905-915 (2001).

·        Gilmore RC, Baker Jr. J, Dempsey S, Marchan R, Corprew Jr. RNL, Byrd G, Maeda N, Smithies O, Bukoski RD, Harewood KR and Chatterjee PK. Using PAC nested deletions to order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus. Gene 275:65-72 (2001).

·        Hodgin, JB, Knowles, JW, Kim, H-S, Smithies, O, and Maeda, N. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J. Clin. Invest. 109:541-548 (2002).

·         Hatada, S., Seed, J.R., Barker, C., Hajduk, S.L., Black, S., and Maeda, N. No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein. Mol. & Biochem.Parasitology 119:291-294 (2002).

·        Wu, J.-H., Hagaman, J., Kim, S., Reddick, R.L., and Maeda, N. Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E. Arterioscler Thromb Vasc Biol. 22:469-475 (2002).

·      Takizawa, S., Aratani, Y., Fukuyama, N., Maeda, N., Hirabayashi, H., Koyama, H., Shinohara, Y., and Nakazawa, H. Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain. J. of Cerebral Blood Flow & Metabolism 22:50-54 (2002).

·     Nakata, Y., and Maeda, N. Vulnerable Atherosclerotic Plaque Morphology in Apolipoprotein E-Deficient Mice Unable to Make Ascorbic Acid. Circulation 105:1485-1490 (2002).


·     Kim, H.-S., Lee, G., John, S.W.M., Maeda, N., and Smithies, O. Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration. Proc. Natl. Acad. Sci. USA 99:4602-4607 (2002).

·        Knowles, JW, Erickson, L, Guy, V, Sigel, C, Wilder, JC, and Maeda, N. Common Variations in Noncoding Regions of the Human Natriuretic Peptide Receptor A Gene Have Quantitative Effects. J. Hum. Genet., 112:62-70 (2003).

·        Lyons, MA, Maeda, N, and Brown, AJ. Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. Biochimica et Biophysica Acta 1581 (2002) 119-126, (2002).

·        Ellmers, LJ, Knowles, JW, Kim, H-S, Smithies, O, Maeda, N, and Cameron, VA. Ventricular expression of natriuretic peptides in Npr1-/- mice with cardiac hypertrophy and fibrosis. Am. J. Physiol. Heart circ. Physiol. 283:H707-H714 (2002).

·        Aratani, A, Kura, F, Watanabe, H, Akagawa, H, Takano, Y, Suzuki, K, Dinauer, MC, Maeda, N, and Koyama, H. Critical Role of Myeloperoxidase and Nicotinamide Adenine Dinucleotide Phosphate – Oxidase in High-Burden Systemic Infection of Mice with Candida albicans. J. Infect. Dis. 185:1833-1837 (2002).

·        Garg, R, Oliver, PM, Maeda, N, and Pandey, KN. Genomic structure, organization, and promoter region analysis of murine guanylyl cyclase/atrial natriuretic peptide receptor-A gene. Gene 291:123-133 (2002).


·        Hinsdale, ME, Sullivan, PM, Mezdour , H, and Maeda, N. ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice. J. Lipid Res. 43:1520-1528 (2002).

·        Hodgin, JB, and Maeda, N. Minireview: Estrogen and Mouse Models of Atherosclerosis. Endocrinology 143:4495-4501 (2002).

·        Xiao, H, Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R.J., and Jennette, J.C. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 110:955-963 (2002).

·        Swardson-Oliver, C.J., Dawson, T.C., Burnett, R.C., Peiper, S.C., Maeda, N., and Avery, A.C. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion. Blood 99:2677-2684 (2002).

·        Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Suzuki, K., Dinauer, M.C., Maeda, N., and Koyama, H. Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus, Medical Mycology 40:557-563 (2002).

·        Adams, MR, Golden, DL, Register, TC, Anthony, MS, Hodgin, JB, Maeda, N, and Williams, JK. The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha, Arterioscler. Thromb. Vasc. Biol. 22(11):1859-64 (2002).

·        Hammond, LE, Gallagher, PA, Wang, S, Hiller, S., Kluckman, KD, Posey-Marcos, EL, Maeda, N, and Coleman, RA.   Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition, Mol. Cell. Biol. 22(23):8204-14 (2002).


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