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Louise M. Ball
Professor


Current Position   Professional Organizations
Research Interests   Selected Grants
Education   Other Funded Research (as Co-Investigator)
Professional Experience   Selected Publications



Current Position

Professor and Director, Environmental Health Sciences Program, Department of Environmental Sciences and Engineering, School of Public Health, CB #7431, Rosenau Hall, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431 (1999 - date).


Research Interests

Metabolism and disposition of xenobiotics in vivo and in vitro: isolation, identification, characterisation and quantitation of radioactive and unlabelled metabolites and DNA adducts. Enzymology of mixed-function-oxidase-dependent reactions. Toxicology of food additives, contaminants and environmental pollutants. Genotoxicity, mutagenicity and DNA binding of polycyclic aromatic hydrocarbons and nitrosubstituted arenes, and of water disinfection products.


Education

St. Mary's Hospital Medical School, University of London, England, Ph.D., Biochemistry, 1976
University of Bristol, England, B.Sc. (Hons), Biochemistry, 1972


Professional Experience

1993-1999 Associate Professor and Director, Environmental Health Sciences Program, Department of Environmental Sciences and Engineering, School of Public Health, CB #7400, Rosenau Hall, University of North Carolina, Chapel Hill, NC 27599-7400

1986-1993 Assistant Professor, Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27514.

1984-1986 Research Associate, Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27514.

1981-1984 National Research Council Resident Research Associate, Genetic Bioassay Branch, Genetic Toxicology Division, Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, U.S.A.

1981 Research Assistant Professor, Laboratory of Environmental Pharmacology and Toxicology, Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, U.S.A.

1979-1980 NIH Visiting Associate, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U.S.A.

1976-1979 NIH Visiting Fellow, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U.S.A.


Professional Organizations

The Biochemical Society (London), 1973 - date
North Carolina Chapter, Society of Toxicology, 1979 - date
Genotoxicity and Environmental Mutagen Society, 1983 - date
International Society for the Study of Xenobiotics, 1985 - date
Environmental Mutagens Society, 1986 - date
Sigma Xi, UNC Chapter, 1987 - date
American Chemical Society, 1997 - date


Selected Grants

National Institutes of Health RO1, ES05732, Metabolic Activation of Genotoxic Environmental NitroPAH, direct costs $ 276 811, 09/30/92 to 09/29/95.

U.S. Environmental Protection Agency, R825346, Heme Adducts From NitroPAH: Characterization and Mechanisms of Formation, total costs $ 390 896, 11/18/96-11/17/99.

U.S. Environmental Protection Agency, R825957, Metabolic Fate of Halogenated Disinfection By-Products in vivo, and Relation to Biological Activity, total costs $ 460 848, 01/23/98-01/22/02.

U.S. Environmental Protection Agency Co-operative Agreement, Co-operative Training Agreement between the Department of Environmental Sciences and Engineering-UNC and US EPA National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC, 04/28/98 to 04/27/04.

NIH/NIEHS, 5P42-ES05948 Superfund Basic Research Program, Environmental Exposure and Effect of Hazardous Chemicals (Chemistry Core), $ 190 377 (annual direct costs), 04/01/01-03/31/06.
The overall aims are to investigate fate, movement and mechanisms of biological activity of hazardous chemicals, principally Superfund-related chlorinated hydrocarbons in the environment. The Chemistry Core laboratory supplies standards, synthesizes labeled compounds and act as a resource in the development of analytical procedures for measuring protein and DNA adducts as markers for exposure.

U.S. Environmental Protection Agency, CT8247101,NHEERL-DESE Cooperative Training in Environmental Sciences Research, $ 202 918 (annual costs), 09/10/01-09/09/06.
The purpose of this project is to continue a cooperative training program in environmental and environmental health sciences between the National Health and Environmental Effects Research Laboratory, U.S. EPA, and the Department of Environmental Sciences and Engineering, UNC-Chapel Hill.



Other Funded Research (as Co-Investigator)

U.S. Environmental Protection Agency Co-operative Agreement CR-811817, Mechanisms of Metabolism and Activation of Cyclopenta-PAH and Derivatives, 10/1/1984 to 9/30/1987.

NC Water Resources Research Institute and American Water Works Association Research Foundation (70090), Identification of Mutagenic By-Products from Aquatic Humic Chlorination, 01/01/88 to 12/31/88.

U.S. Environmental Protection Agency Co-operative Agreement CR#814900, Identification of Mutagenic By-Products from Chloramination of Aquatic Humic Substances, 05/01/88 to 09/30/90.

National Institutes of Health RO1 CA47965, Pathways of Activation and DNA Adducts of Cyclopenta PAH, 07/01/88 to 06/30/91.

NC Water Resources Research Institute, Assessment of Treatability of Lake Jordan, 06/01/89 to 08/31/91.

U.S. Environmental Protection Agency Co-operative Agreement, Co-operative agreement between the Department of Environmental Sciences and Engineering-UNC and US EPA Health Effects Research Laboratory, Research Triangle Park, NC, 09/01/91 to 08/30/94.

U.S. Environmental Protection Agency Co-operative Agreement, Co-operative agreement CR#820076 between the Department of Epidemiology-UNC and US EPA Health Effects Research Laboratory, Research Triangle Park, NC, 01/01/94 to 06/30/97.

National Institutes of Health RO1 ES06692, K-ras Activation and Adduct Formation by Cyclopenta PAH, direct costs $ 973 570, 08/01/94 to 07/31/98.

US EPA, Cooperative agreement CR#822673, What can epidemiology tell us about strategies for combining risk assessments for the individual constituents of a carcinogenic complex mixture (I. Herz-Piccioto, P.I.), 5% time and effort, total costs $ 315 954, 10/01/94-09/30/98.

CDC/NIOSH, U60-CCU415922, Evaluating animal-based predictions using epidemiology (I. Hertz-
Picciotto, P.I.), 15% time and effort, 09/30/98-09/29/01.

NIOSH, R01 OH07598 Nylander-French (PI), Dermal Exposure to 1,6-Hexamethylene Diisocyanate, 15% time and effort, 08/01/03 - 07/31/06. The major goal of this project is to develop measures of exposure to 1,6-hexamethylene diisocyanate applicable in the workplace.

 

Selected Publications

Kronberg, L., Christman, R.F., Singh, R. and Ball, L.M.: Identification of oxidized and reduced forms of the strong bacterial mutagen (Z)-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (MX) in extracts of chlorine-treated water. Environ. Sci. Technol., 25, 99-104, 1991.

Ball, L.M., Rafter, J.J., Gustafsson, J.-., Gustafsson, B.-E., Kohan, M.J. and Lewtas, J.: Formation Of Mutagenic Urinary Metabolites From 1-Nitropyrene In Germ-Free And Conventional Rats: Role of the Gut Flora, Carcinogenesis, 12, 1-5, 1991.

Lucas, S.V., Lee, K.W., Melton, C.W., Petersen, B.A., Lewtas, J., King, L.C. and Ball, L.M.: A Technique for Controllable Vapor-Phase Deposition of 1-Nitro[14C]pyrene and Other Polycyclic Aromatic Hydrocarbons onto Envi- ronmental Particulate Matter. Aerosol Sci. Technol., 14, 210-223, 1991.

Sangaiah, R., Gold, A., Newcomb, K.O. and Ball, L.M.: Synthesis and Biological Activity of Metabolites of Benz[j]aceanthrylene, a Novel Polycyclic Aromatic Hydrocarbon. J. Med. Chem., 34, 546-549, 1991.

Ball, L.M., Warren, S.H., Sangaiah, R. and Gold, A.: Bacterial Mutagenicity of Two Cyclopentafused Isomers of Benzpyrene. Mutat. Res. 260, 271-279, 1991.

Sangaiah, R., Gold, A., Ball, L.M., Matthews, D.L. and Toney, G.E.: Synthesis and Resolution of Putative Diastereomeric N2-Deoxyguanosine and N6-Deoxyadenosine Adducts of Biologically Active CyclopentaPAH. Tetrahedron Lett., 33, 5487-5490, 1992.

Kanniganti, R., Johnson, J.D., Ball, L.M and Charles, M.J.: Identification of Compounds in Mutagenic Extracts of Aqueous Monochloraminated Fulvic Acid. Environ. Sci. Technol., 26, 1998-2004, 1992.

Cozzie, D.A., Kanniganti, R., Charles, M.J., Johnson, J.D. and Ball, L.M.: Formation and characterization from reaction of the alternative disinfectant monochloramine with model aqueous solutions of fulvic acid. Environ. Molecular Mutag., 21, 237-246, 1993.

Holloway, T.C. and Ball, L.M.: Synthesis and mutagenicity of a series of nitrated carbazoles and hydroxycarbazoles. Mutagenesis, 8, 321-327, 1993.

Newcomb, K.O., Sangaiah, R., Gold, A. and Ball, L.M.: Activation and metabolism of benz[j]aceanthrylene-9,10-dihydrodiol, the precursor to bay-region metabolism of the genotoxic cyclopenta-PAH benz[j]aceanthrylene. Mutation Res., 287, 181-190, 1993.

Nesnow, S., Beck, S., Ball, L.M., Sangaiah, R. and Gold, A.: Morphological transformation of C3H10T1/2CL8 cells by cyclopenta-fused derivatives of benzo[a]pyrene and benzo[e]pyrene. Cancer Lett., 74, 25-30, 1994.

Massey, I.J., Aitken, M.D., Ball, L.M. and Heck, P.E.: Mutagenicity screening of reaction products from the enzyme catalyzed oxidation of phenolic pollutants. Environ. Toxicol. Chem., 13, 1743-1752, 1994.

Vermeulen, H.L., Sangaiah, R., Ball, L.M. and Gold, A.: Synthesis of mixed halogenated trihalomethanes labelled with the stable isotopes 2H or 13C. J. Labelled Compds Radiopharm., 36, 835-843, 1995.

Ball, L.M., Stocking, L.M., Kohan, M.J., Warren, S.H. and Lewtas, J.: Metabolic Activation of the Genotoxic Environmental Contaminants 2- and 3-Nitrofluoranthene in variants of Salmonella typhimurium. Mutagenesis, 10, 497-504, 1995.

Watanabe, T., Kohan, M.J., Walsh, D., Ball, L.M., DeMarini, D.M. and Lewtas, J.: Mutagenicity of nitrodibenzopyranones in the Salmonella plate-incorporation and microsuspension assays. Mutat. Res., 345, 1-9, 1995.

Rosser, P.F., Ramachandran, P., Sangaiah, R., Austin, R.N., Gold, A. and Ball, L.M.: Role of O-acetyltransferase in activation of oxidised metabolites of the genotoxic environmental pollutant 1-nitropyrene. Mutation Res., 369, 209-220, 1996.

Sangaiah, R., Christova-Gueorguieva, N.I., Ranasinghe, A., Tretyakova, N.Y., Gold, A., Ball, L.M. and Swenberg, J.A.: Synthesis of perdeuterated analogues of the epoxide metabolites of butadiene: 1,2-epoxybut-3-ene-d6 and 1,2,3,4-diepoxybutane-d6. J. Labelled Compds Radiopharm., 39, 731-739, 1997.

Gold, A., Jayaraj, K., Ball, L.M. and Brust, K.: Oxidation of polyaromatic hydrocarbons by an oxoferryl porphyrin p-cation radical. J. Molec. Catal. A: Chemical, 125:23-32, 1997.

Hertz-Picciotto, I., Korte, J., Schulz, M., Chiangm T.-C. and Ball, L.M.: Comment: Carbon black risk assessment comparison is flawed. Reg. Toxicol. Pharm., 26:338-339, 1997.

Prusiewicz, C.M., Sangaiah, R., Gold, A and Ball, L.M.: Synthesis of 3'-phosphate adducts of cyclopenta[cd]pyrene with deoxyguanosine via 3'-H-phosphonate intermediates.  Polycyc. Arom. Cmpds, 17:11-20, 1999.

Korte, J.E., Hertz-Picciotto, I., Schulz, M.R., Ball, L.M. and Duell, E.J.:  The contribution of benzene to smoking-induced leukemia.  Environ. Health Perspect., 108:333-339, 2000.

Jayaraj, K., Gold, A., Ball, L.M. and White, P.S.: N-Porphyrinylamino and -amido compounds by addition of an amino or amido nitrogen to a porphyrin meso position.  Inorg. Chem., 39:3652-3664, 2000.

DeMarini D.M., Shelton M.L., Kohan M.J., Hudgens E.E., Kleindienst T.E., Ball L.M., Walsh D., deBoer J.G., Lewis-Bevan L., Rabinowitz, J.R., Claxton L.D. and Lewtas J: Mutagenicity in Lung of Big Blue® Mice and Induction of Tandem Base Substitutions in Salmonella by the Air Pollutant Peroxyacetyl Nitrate (PAN): Predicted Formation of Intrastrand Crosslinks.  Mutat. Res., 457:41-55, 2000.

Schulz, M.R., Herz-Picciotto, I., Todd, L. and Ball, L.M.: Reconciling animal and human data in a cancer risk assessment of acrylonitrile.  Scand. J. Work Env Health, 27:14-20, 2001.

Schulz, M.R., Hertz-Picciotto, I., van Wijngaarden, E., Hernandez, J.C., Ball, L.M.: Dose-response relation between acrylamide and pancreatic cancer (letter). Occup. Environ. Medicine, 58:609, 2001.

Jayaraj, K., Gold, A., Sangaiah, R., Georgieva, N., Koc, H., Klapper, D.G., Ball, L.M., Reddy, A.P. and Swenberg, J.A.: Synthesis and characterization of peptides containing a cyclic valine adduct of diepoxybutane, a possible biomarker of human exposure to butadiene. Chem. Res. Toxicol., 16(5):637-643, 2003.

Gold, A., Nam, T.-G., Jayaraj, K., Sangaiah, R., Klapper, D.G., Ball, L.M., French, J.E., and Nylander-French, L.A.: Synthesis of S-Aryl-D,L-Cysteines and incorporation into keratin sequences. Organic Preparations and Procedures Int., 35(4): 375-381, 2003.

Powley, M.W., Jayaraj, K., Gold, A., Ball, L.M., and Swenberg, J.A.: 1,N2-propanodeoxyguanosine adducts of the 1,3-butadiene metabolite, hydroxymethylvinyl ketone. Chem. Res. Toxicol., 16: 1448-1454, 2003.

Casteel, M.J., Jayaraj, K., Gold, A., Ball, L.M., and Sobsey, M.D. Photoinactivation of Hepatitis A Virus by Synthetic Porphyrins. Photochem. Photobiol., in press, 2004.

Lin, P.-H., Sangaiah, R., Ranasinghe, A., Ball, L.M., Swenberg, J.A. and Gold, A. Synthesis of Chlorinated and Non-chlorinated Biphenyl-2,3- and 3,4-catechols and their [2H3]-isotopomers. Organic Biomolec. Chem., in press, 2004.