Anticoagulated Parturient with Klippel-Feil Syndrome for Urgent Cesarean Section

 

Ravindra V. Prasad, MD                                                                                                      Chapel Hill, North Carolina

 

Objectives

After preparing for and discussing this case, the PBLD learner will be able to:

1.        Summarize the anesthetic implications of Klippel-Feil Syndrome

2.        Manage neuraxial anesthesia for anticoagulated patients

3.        Use the ASA difficult airway algorithm

Case Discussion

MS is a 33 year old, 5’3” 75kg woman with Klippel-Feil Syndrome, gravida 2, para 1 at 32 weeks gestation. She has a history of DVT, with PE after her caesarean-section two years ago and takes Lovenox for DVT prophylaxis. Her medical history is otherwise unremarkable. She presents to the labor and delivery suite for preoperative evaluation for scheduled c-section at 38 weeks gestation.

 

What is Klippel-Feil Syndrome? Are there any anesthetic implications?

How does Lovenox work? Are there any anesthetic implications?

Do you need additional information (history, physical, labs, diagnostic studies)?

What is your preferred anesthetic technique for this patient?

 

 

At 37 weeks gestation, MS presents to the labor and delivery suite in labor. Fetal heart rate tracing shows late decelerations and decreased beat-to-beat variability. The obstetrician requests anesthesia for urgent caesarean section. Airway exam reveals a Mallampati Class II oropharyngeal view, slightly decreased neck range of motion, and thyromental distance of 3 finger breadths.

 

Do you need additional information?

What anesthetic technique will you choose?

What, if any, additional equipment do you require be available before proceeding?

 

 

Fetal status has deteriorated; the obstetricians are preparing for emergency c-section. You elect to proceed with a general anesthetic. The patient is positioned with left uterine displacement and preoxygenated. After rapid sequence induction with sodium thiopental and succinylcholine, with cricoid pressure applied, direct laryngoscopy with a Macintosh 3 blade reveals only a Grade IV view. There is no improvement in visualization despite repositioning the patient and changing blades. A blind attempt is unsuccessful (esophageal). You try to mask ventilate, but are having difficulty as the patient starts to desaturate.

 

What do you do next?

Should you try to intubate?

How can you improve your mask airway?

 

 

You call for help while attempting to mask ventilate. You are still unable to ventilate after placing oro- and naso- pharyngeal airways. Your colleague attempts laryngoscopy with a Miller blade but cannot identify the vocal cords or epiglottis. The patient continues to desaturate.

 

What do you do next?

Should you allow the obstetricians to begin surgery?

 

 

You tell the obstetricians to proceed with surgery while you continue to manage the airway. You and your colleague are unable to place either a size 3 or 4 LMA. You place a Combitube and appear to have only minimal chest rise. However, the patient continues to desaturate and is now hypotensive and having frequent multifocal ventricular beats.

 

What do you do next?

 

Reading List

Burns AM. Dorje P. Lawes EG. Nielsen MS. Anaesthetic management of caesarean section for a mother with pre-eclampsia, the Klippel-Feil syndrome and congenital hydrocephalus. British Journal of Anaesthesia. 61(3):350-4, 1988 Sep.

 

Dresner MR. Maclean AR. Anaesthesia for caesarean section in a patient with Klippel-Feil syndrome. The use of a microspinal catheter. Anaesthesia. 50(9):807-9, 1995 Sep.

 

Pizzutillo, PD. Woods M. Nicholson, L. MacEwen GD. Risk Factors in Klippel-Feil Syndrome. Spine. 19(18): 2110-2116.

 

American Society of Anesthesiologists Task Force on Management of the Difficult Airway. Practice Guidelines for Management of the Difficult Airway. Anesthesiology, 78:597-602, 1993

http://www.asahq.org/Practice/Diff_Airway/difficult.html

 

Benumof JL. Management of the difficult adult airway. Anesthesiology. 75: 1087-1110, 1991.

 

Anonymous. Neuraxial Anesthesia and Anticoagulation, Consensus Statements. American Society of Regional Anesthesia Consensus Conference, Chicago, Illinois, May 2-3, 1998. http://www.asra.com/consensus/index.shtml

 

Horlocker TT. Wedel DJ. Neuraxial block and low-molecular-weight heparin: balancing perioperative analgesia and thromboprophylaxis. Regional Anesthesia & Pain Medicine. 23(6 Suppl 2):164-77, 1998 Nov-Dec.