Experimental Neuroimaging Laboratory
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Welcome
 

The Experimental Neuroimaging Laboratory (Shih lab) is associated with the Department of Neurology and the Biomedical Research Imaging Center (BRIC) at the  University of North Carolina, Chapel Hill.

   

Mission:
Our lab focuses on developing and applying innovative magnetic resonance imaging (MRI) technologies to study neural circuitry and neurovascular coupling of the brain.

 

Current Projects:
1) Mapping optogenetic interrogation of neural circuitry using multimodal fMRI.

2) Dissecting neural and astrocytic contribution to fMRI signals using pharmacogenetic (DREADD) approach.

3) Identifying circuit mechanisms of deep brain stimulation therapy in Parkinson's disease.

4) Imaging cortical spreading depolarizations (CSDs) and the impact of tPA on CSDs in stroke.

  

Lab Position Openings:

We are currently seeking two highly motivated Postdoctoral Research Associates interested in mapping neural circuit function in normal and diseased animal models. Experience in 1) MRI, 2) electrophysiology, 3) optogenetics, or 4) rodent brain surgeries is desirable. We are also recruiting potential PhD students (admission through UNC BBSP or BME program). Please contact Dr. Ian Shih (shihy@unc.edu) for more information.

  

Lab Location:

     9.4 Tesla MRI facility: SB221 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27599

     Electrophysiology lab: SB231 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27599

     Electronic lab: 5223 Marsico Hall, 125 Mason Farm Rd, Chapel Hill, NC 27599

     Office: 3104 Bioinformatics Building, 130 Mason Farm Rd, CB#7513, Chapel Hill, NC 27599

 

  



News:

2014

  • A total of 8 peer-reviewed articles from our team were published  in 2014. Thanks all for the hard work!   

  • Shih lab receives a 4-year grant from American Heart Association (Scientist Development Grant Award).

  • Shih lab receives a one year grant from NCTraCS.

  • Dan receives a 2-year NIH NRSA (F31) Training Grant. Congrats!

  • Shih lab receives a 2-year grant from NARSAD (Brain & Behavior Research Foundation Young Investigator Award).

  • Esteban receives a 3-year Integrative Vascular Biology Training Grant (NIH T32). Congrats!

  • Manasmita receives a 3-year Cross-Disciplinary Fellowship from the Human Frontier Science Program. Congrats!

  • Shih lab receives funding from SeeCure Pharmaceutical, LLC.

  • Shih lab receives funding from University Research Council.

  • Manasmita receives stipend award to participate a NIH-funded Multi-modal Neuroimaging Training Program (MNTP) at the University of Pittsburgh and Carnegie Mellon University.

 

  • Jill is taking a faculty position at the Taipei Medical University starting December 1st. We all wish you the best of luck and will really miss you here at Chapel Hill!

     

    Jill's Farewell

  • The Shih lab submitted two abstracts to ISMRM Annual Meeting 2014 and they both received the Summa Cum Laude Merit Award. Congrats Heather and Jill!

  • Heather's abstract is selected for power poster presentation (oral+poster) in the 22nd ISMRM annual meeting. She also receives ISMRM Educational Stipend Award and BRIC Travel Support for her trip to Milan, Italy.

 

  • Charles Zhou (PhD rotation student) joins the Shih lab in November 2014.

  • Dr. Maggie Broadwater (Postdoctoral Research Associate) joins the Shih lab in October 2014 (primary mentor: Dr. Donita Robinson). 

  • Dr. Yuhui Li (Postdoctoral Research Associate) joins the Shih lab in September 2014 (primary mentor: Dr. Flavio Frohlich). 

  • Jessica Bullins (PhD rotation student) joins the Shih lab in March 2014.

  • Lindsay Walton (PhD student) joins the Shih lab in March 2014 (primary mentor: Dr. Mark Wightman).

 

2013

 

2013 Winter Gathering

  • A total of 6 peer-reviewed articles from our team were published  in 2013. Thanks all for the hard work!  

  • Dan's abstract is highlighted as the Leading Abstract Award in the 3rd World Parkinson Congress.

  • John is taking a position in the Neurology residency program at the Washington University in St. Louis. Congrats Dr. Younce!

  • Jill wins the Best Basic Science Research Award in the UNC BRIC Research Day. Congrats!

  • Hsinyi, Jill, and Ian receive Young Investigator Travel Awards from International Society for Cerebral Blood Flow and Metabolism.

  • Hsinyi's abstract is selected for oral presentation in the XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function. 

  • Congrats to Jill, John and Hsinyi on receiving Educational Stipend Award, and Heather on receiving New Entrant Stipend Award from ISMRM.  

  • Congrats to John on receiving the ISMRM Summa Cum Laude Merit Award, and Jill and Hsinyi on receiving Magna Cum Laude Merit Awards, representing top 3% and 15% of the work, respectively. Congrats! 

  • Jill's and John's abstracts are selected for oral presentation in the 21st ISMRM annual meeting.   

John's Farewell

  • Dr. Hui Li (Visiting Scholar) joins the Shih lab in November 2013. 

  • Dr. Ting He (Postdoctoral Research Associate) joins the Shih lab in November 2013 (primary mentor: Dr. Juan Song).

  • Esteban Oyarzabal (PhD student) joins the Shih lab in September 2013.

  • Dr. Manasmita Das (Postdoctoral Research Associate) joins the Shih lab in July 2013.  

 

 

ISMRM 2013 @ Salt Lake City

  • Shaili Jha (PhD rotation student) joins the Shih lab in March 2013. 

  • Gunhyo Choi (Visiting Scholar) joins the Shih lab in March 2013. 

  • Dan Albaugh (PhD student) joins the Shih lab in January 2013. 

 

2013 Spring Gathering

2012

  • A total of 12 peer-reviewed articles from our team were published  in 2012. Thanks all for the hard work! 

  • Dr. Maoxuan Lin (Visiting Scholar) joins the Shih lab in November 2012. 

  • Dr. Wenjing Li (Visiting Scholar) joins the Shih lab in September 2012. 

  • Dong Chen (Undergraduate research volunteer) joins the Shih lab in September 2012. 

  • Chris Kao (Undergraduate research volunteer) joins the Shih lab in September 2012. 

  • John Younce (Medical student) joins the Shih lab in July 2012. 

  • Heather Decot (PhD student) joins the Shih lab in June 2012 (primary mentor: Dr. Garret Stuber). 

  • Dr. Hsinyi Lai (Postdoctoral Research Associate) joins the Shih lab in April 2012. 

  • Dr. Jill Kao (Postdoctoral Research Associate) joins the Shih lab in March 2012. 

  • Our study entitled "Deep brain stimulation fMRI of the rat ventral posterior medial thalamus" has been awarded the Summa Cum Laude Merit Award in the 20th ISMRM annual meeting.