 Experimental Neuroimaging Laboratory |
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Publications |
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Peer-Reviewed Publications
2013 Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Fonseca, RS, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V
Chronic rapamycin
restores brain vascular integrity and
function through NO synthase activation and
improves memory in symptomatic mice modeling
Alzheimer’s disease
J Cereb Blood Flow Metab, 2013; (in press).
Li
G, Shih YY,
Kiel JW, De La
Garza BH, Du F, Duong TQ
MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension Exp Eye Res, 2013; (in press).
Shih YY, Chen YY, Lai HY, Kao YC, Shyu BC, Duong TQ Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex Neuroimage, 2013; 73:113-120.
Huang S, Du F, Shih YY, Shen Q, Gonzalez-Lima F, Duong TQ Methylene blue potentiates stimulus-evoked fMRI responses and cerebral oxygen consumption during normoxia and hypoxia Neuroimage, 2013; 72:237-242.
Shih YY, Wang L, De La Garza BH, Li G, Cull G, Kiel JW, Duong TQ Quantitative retinal and choroidal blood flow during light, dark adaptation, and flicker light stimulation in rats using fluorescent microspheres Curr Eye Res, 2013; 38(2):292-8.
Chen CC, Shih YY,
Chang C
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI Neurobiol Dis, 2013; 49:99-106.
2012 Shih YY, Li G, Muir ER, De La Garza BH, Kiel JW, Duong TQ
Pharmacological MRI of
the retina: blood flow and BOLD responses
during nitroprusside infusion
Magn Reson Med, 2012; 68(4):1273-8.
De La Garza BH, Muir ER, Shih YY, Duong TQ
3D magnetic resonance microscopy of the ex
vivo retina
Magn Reson Med, 2012; 67(4):1154-8.
Li
G, De La Garza BH, Shih YY,
Muir ER, Duong TQ
Layer-specific blood flow MRI of retinitis pigmentosa in RCS rats Exp Eye Res, 2012;101:90-6.
De La Garza BH, Li
G, Shih YY, Duong TQ
Layer-specific manganese-enhanced MRI of the retina in light and dark adaptation Invest Ophthalmol Vis Sci, 2012; 53(8):4352-8.
Lai HY, Liao LD, Lin CT, Chen YY, Hsu JH,
Chen HF, Tsang S, Chang JY, Shih YY
Liao LD, Lin CT, Shih YY, Lai HY, Wang PH,
Duong TQ, Chang JY, Chen YY, Li ML
Shih YY, Muir ER, Li G, De La Garza BH,
Duong TQ
High resolution 3D microangiography of the
rat ocular circulation
Radiology,
Liao LD, Lin CT, Shih YY, Duong TQ, Lai HY, Wang PH, Wu R, Tsang S, Chang JY, Li ML, Chen YY
Transcranial imaging of functional cerebral
hemodynamic changes in single blood vessels
using in vivo photoacoustic microscopy
J Cereb Blood Flow
Metab,
2012;32(6):938-51.
Feature article
Shih YY, Chiang YC, Shyu BC, Jaw FS, Duong
TQ,
Chang C
Endogenous opioid-dopamine
neurotransmission underlie negative
CBV
fMRI signals
Exp Neurol,
2012; 234(2):382-8.
Chao WH, Lin SH, Shih YY, Chen YY, Lo YC,
Lin SH, Tsang S, Wu R, Jaw FS
Correction of inhomogeneous magnetic
resonance images using multiscale retinex
for segmentation accuracy improvement
Biomed Signal Proces,
2012; 7(2):129–40
Hsu YC, Shih YY, Chang CF, Huang GS
A rare case of coiling of the brachial artery: a description of the sonographic features
J Med Ultrason,
2012; 39(1):21-4.
Rogers W, Shih YY, De La Garza BH, Harrison
JM, Roby J, Duong TQ
A Low Cost Color Visual Stimulator for fMRI
J Neurosci Meth,
2012; 204:379–82.
2011
Shih YY, Hsu YH, Duong TQ, Lin SS, Chow KP,
Chang C
Longitudinal study of tumor-associated
macrophages during tumor expansion using MRI
NMR Biomed,
2011; 24(10): 1353–60.
Lai HY, Chen YY,
Lin SH,
Lo YC,
Tsang S,
Chen SY,
Zhao WT,
Chao WH,
Chang YC, Wu R, Shih YY, Tsai ST, Jaw FS
Automatic spike sorting for extracellular
electrophysiological recording using
unsupervised single linkage clustering based
on grey relational analysis
J Neural Eng,
2011; 8(3):036003.
Shih
YY, De La Garza BH, Muir ER, Rogers WE,
Harrison, JM, Kiel JW, Duong TQ
Lamina-specific fMRI responses to visual
stimulation of the rat retina
Invest Ophthalmol Vis
Sci,
2011; 52(8):5303-10.
Shih
YY, Wey HY, De La Garza BH, Duong TQ
Striatal and cortical BOLD, blood flow,
blood volume, oxygen consumption, and
glucose consumption changes in noxious
forepaw electrical stimulation
J Cereb Blood Flow
Metab,
2011; 31(3):832-41.
Feature article
De La Garza BH, Muir ER, Li G, Shih YY,
Duong TQ
BOLD fMRI of Visual Stimulation in the Rat
Retina at 11.7 Tesla
NMR Biomed,
2011; 24(2):188-93.
2010
Chen
YY,
Shih
YY,
Chien
CN,
Siow
TY,
Jaw
FS
MicroPET imaging of noxious thermal stimuli
in the conscious rat brain
Somatosens Mot Res,
2010; 27(3):69-81.
Liao LD, Li ML, Lai HY, Shih YY, Lo YC,
Tsang S, Chao CP, Lin CY, Jaw FS, Chen YY
Imaging brain hemodynamic changes during rat
forepaw electrical stimulation using
functional photoacoustic microscopy
Neuroimage,
2010; 52(2):562-70.
Hsu YC, Shih YY, Gao GW, Huang GS
Intramuscular Schwannoma arising from the
Psoas muscle presenting with femoral nerve
neuropathy
South Med J,
2010; 103(5):477-9.
Hsu YC, Pan RY, Shih YY, Huang GS
Superior-capsular elongation and its
significance in atraumatic posteroinferior
multidirectional shoulder instability in MR
arthrography
Acta Radiol,
2010; 51(3):302-8.
Hsu YC, Shih YY, Gao HW, Huang GS
Subcutaneous lipoma compressing the common
peroneal nerve and causing palsy:
sonographic diagnosis
J Clin Ultrasound,
2010; 38(2):97-9.
Huang GS, Lee HS, Chou MC, Shih YY, Tsai PH,
Lin MH, Lin CY, Lee CH, Chung HW
Quantitative MR T2 measurement of articular
cartilage to assess the treatment effect of
intra-articular hyaluronic acid injection on
experimental osteoarthritis induced by ACLX
Osteoarthritis Cartilage,
2010;18(1):54-60.
2009
Shih
YY,
Chen
CC,
Shyu
BC,
Lin
ZJ,
Chiang
YC,
Jaw
FS,
Chen
YY,
Chang
C
A new scenario for negative functional
magnetic resonance imaging
signals: endogenous neurotransmision
J Neurosci,
2009; 29(10):3036-44.
see also “This Week in The Journal” in the J Neurosci, 2009; 29(10):i
and
Research Highlight
in the
Nat Rev Neurosci,
2009; 10(5):316.
Chen
YY,
Shih
YY,
Chien
CN,
Chou
TW,
Lee
TW,
Fu
YK,
Kuo
TS,
Jaw
FS
MicroPET study of brain activation during
electrical and mechanical stimulation of the
rat tail
Nucl Med Commun,
2009; 30(3):188-193.
Highlight of the issue
Chao WH, Chen YY, Lin
SH, Shih YY,
Tsang
S
Automatic segmentation of magnetic resonance
images using a decision tree with spatial
information
Comput Med Imaging Graph,
2009; 33(2):111-21.
2008
Chao
WH,
Chen
YY,
Cho
CW,
Lin
SH,
Shih
YY,
and Tsang
S
Improving segmentation accuracy for magnetic
resonance imaging using a boosted decision
tree
J Neurosci Meth,
2008; 175(2):206-17.
Shih YY, Chang C, Chen JC, Jaw FS
BOLD fMRI mapping of brain responses to
nociceptive stimuli in rats under ketamine
anesthesia
Med Eng Phys,
2008; 30(8):953-8.
Shih YY, Chiang YC, Chen JC,
Huang
CH,
Chen YY, Liu RS, Chang C, Jaw FS,
Brain nociceptive imaging in rats using
18f-fluorodeoxyglucose small-animal positron
emission tomography
Neuroscience,
2008; 155(4):1221-6.
Shih YY, Chen YY, Chen CC, Chen JC, Chang C,
Jaw FS
Whole brain fMRI mapping of acute
nociceptive responses induced by formalin in
rats using atlas registration based event
related analysis
J Neurosci Res,
2008; 86(8):1801-11.
Lee CY, Shih YY, Jaw FS
How to
extract
the
spatial
correlation
of
auditory
cortical
evoked
potentials
on
multiple
scalp
electrodes
in
tinnitus
patients
Biomed Eng Appl Basis Comm,
2008; 20(5):297-302.
Chen CM, Shih YY, Siow TY, Chiang YC, Chang
C, Jaw FS
Antinociceptive effect of morphine in α-chloralose
and isoflurane anesthetized rats using BOLD
fMRI
Biomed Eng Appl Basis Comm,
2008; 20:39–46.
2007
Chao WH, Cho CW, Shih YY, Chen YY, Chang C
Correction of inhomogeneous MR images using
multiscale retinex
Int J Image Process,
2007; 1:1–16.
Shih YY, Chen YY, Chen JC, Chang C, Jaw FS
ISPMER: integrated system for combined PET,
MRI, and electrophysiological recording in
somatosensory studies in rats
Nucl Instrum Meth A,
2007; 580(2):938-943.
Shih YY, Chen YY, Hsieh WY, Huang YY, Chang
C, Chen JC, Lin CI, Wang SJ, Jaw FS
Dynamic mapping of amphetamine stimulated
response in the rat brain using BOLD and
IRON techniques
Biomed Eng Appl Basis Comm,
2007; 19:157–63.
2005
Shih YY, Chen JC, Liu RS
Development of wavelet de-noising technique
for PET images
Comput Med Imaging
Graph,
2005; 29(4):297-304.
Conference Abstracts/Proceedings
2013 Kao YC, Lai HY, Kao C, Shih YY A modified photothrombotic stroke model using implantable optic fiber: in-bore stroke induction for probing peri-infarct spreading
depolarization
Proc. Intl. Soc. Mag. Reson. Med.,
Salt Lake City,
USA, 2013
(oral)
Younce JR, Lai HY, Shih YY Deep brain stimulation at the internal globus pallidus produces fMRI response in the motor cortex
Proc. Intl. Soc. Mag. Reson. Med.,
Salt Lake City,
USA, 2013
(oral)
Lai HY, Younce JR, Kao YC, Yuan H, Shih YY Deep brain stimulation at the subthalamic nucleus produces fMRI response in the motor cortex Proc. Intl. Soc. Mag. Reson. Med., Salt Lake City, USA, 2013
Lai HY, Younce JR, Kao YC, Shih YY Deep brain stimulation fMRI with a home-made two-channel tungsten microwire electrode Proc. Intl. Soc. Mag. Reson. Med., Salt Lake City, USA, 2013
Kao YC, Lai HY, Younce JR, Shih YY Deep brain stimulation fMRI in mice Proc. Intl. Soc. Mag. Reson. Med., Salt Lake City, USA, 2013
Shih YY, De La Garza BH, Huang S, Li G, Wang L, Duong TQ Quantitative cerebral and retinal blood flow using continuous arterial spin labeling MRI and fluorescent microsphere Proc. Intl. Soc. Mag. Reson. Med., Salt Lake City, USA, 2013
Lin W, Shih YY Brain functional connectivity from bench to bedside Brain 2013 - XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function, Shanghai, China, 2013
(abstract
from symposium chairman)
Lai HY, Younce JR, Kao YC, Shih YY Deep brain stimulation at the subthalamic nucleus and the internal globus pallidus produces fMRI response in the motor cortex Brain 2013 - XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function, Shanghai, China, 2013
(oral)
Kao YC, Lai HY, Lin W, Shih YY Real time spreading depolarization in hyperacute phase of stroke using perfusion MRI Brain 2013 - XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function, Shanghai, China, 2013
Shih YY, Huang S, Chen YY, Lai HY, Du F, Kao YC, Hui ES, Duong TQ Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw electrical stimulation under isoflurane anesthesia Brain 2013 - XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function, Shanghai, China, 2013
2012
Shih YY, Tiwari YV, Rogers W, Duong TQ
Deep brain stimulation fMRI of the rat ventral
posterior medial thalamus
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
(oral)
Shih YY, Huang S, Du F, Duong TQ
Striatal fMRI of focal ischemic rat brain
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
Shih YY, Li G, De La Garza BH, Wang L, Duong TQ
Cross validation of retinal and choroidal blood
flow using arterial spin labeling MRI and
fluorescent microsphere
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
De La Garza BH, Li G, Shih YY, Duong TQ
Layer-specific manganese-enhanced MRI of the
retina associated with light and dark
adaptation at 11.7T
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
(oral)
Hsu YH, Chen CC, Shih YY, Chang C
Distinguishing the involvement of dopamine D2 and D3 receptors in
striatal vasoconstriction: two segregated
mechanisms to one end
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
(oral)
Hsu YH, Chen CC, Shih YY, Chang C
Coupling of long projecting vasoactive
dopaminergic afferents to striatal
vasoconstriction
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
Li G, Shih YY, De La Garza BH, Kiel JW, Duong TQ
Assessment of cerebral autoregulation by inducing
acute hypertension in rats
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
Li G, Shih YY, De La Garza BH, Kiel JW, Duong TQ
Retinal and choroidal blood flow autoregulation in
rats at 11.7T
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
Huang S, Du F, Shih YY, Shen Q, Lin AL, Yang SH,
Duong TQ
Methylene Blue (a Metabolic Enhancer) Increases
Basal CBF, and Hypercapnic and Functional
fMRI Responses
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
Huang S, Shen Q, Du F, Shih YY, Duong TQ
Evaluation of vascular and functional recovery in
focal ischemic rats using functional MRI
Proc. Intl. Soc. Mag. Reson. Med., Melbourne, Australia, 2012
2011
Shih YY, Chen YY, Lai HY, Duong TQ
Ultra high resolution functional MRI and
electrophysiology of the rat primary
somatosensory cortex
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
(oral)
Shih YY, Li G, De La Garza BH, Muir ER, Duong TQ
High resolution ∆R2, ∆R2*,
and vessel density MRI of the rat ocular
circulation
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
(oral)
Shih YY, Huang S, Duong TQ
Optimizing negative fMRI response in the rat
striatum under isoflurane anesthesia
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Shih YY, Huang S, Du F, Duong TQ
Negative fMRI response in the striatum: a marker
for striatal functional integrity in
ischemic rat brain
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Shih YY, Wey HY, Du F, Huang S, Shen Q, Karkar KM,
Duong TQ
Resting state fMRI of acute focal ischemic rat
brain
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Shih YY, Muir ER, Li G, De La Garza BH, Duong TQ
Ultra high resolution 3D microangiography of the
rat ocular circulation at 11.7 T
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Shih YY, De La Garza BH, Muir ER, Li G, Duong TQ
Layer-specific fMRI of visual stimulation in the
rat retina: responses to different
stimulation luminance, frequency, and color
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Shih YY, Li G, Duong TQ
Pharmacological MRI of the retina: blood flow and
BOLD uncoupling during nitroprusside
infusion
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
Li G, Shih YY, De La Garza BH, Muir ER, Duong TQ
Layer-specific blood flow MRI of retinal
degeneration at 11.7T
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
De La Garza BH, Cardenas D, Shih YY, Duong TQ
Manganese-enhanced MRI of bilateral retinas in
rat: flickering white light versus dark
Proc. Intl. Soc. Mag. Reson. Med., Montreal, Canada, 2011
2010
Shih YY, De La Garza BH, Wey HY, Duong TQ
18F-FDG microPET responses to the noxious forepaw
stimulation
World Molecular Imaging Congress, Kyoto, Japen, 2010
Shih YY, Chiang YC, Hsu YH, Jaw FS, Chen JC, Shyu
BC, Duong TQ, Chang C
Endogenous opioid-dopamine neurotransmission
evokes sustained negative CBV-weighted fMRI
responses
Proc. Intl. Soc. Mag. Reson. Med., Stockholm, Sweden, 2010
(oral)
Shih YY, De La Garza BH, Lavery WJ, Muir ER, Duong
TQ
Layer-Specific fMRI of photic stimulation in the
rat retina at 11.7 T
Proc. Intl. Soc. Mag. Reson. Med., Stockholm, Sweden, 2010
Shih YY, Wey HY, Shen Q, Duong TQ
Sustained negative BOLD, CBF, CBV, and CMRO2 fMRI
responses to the noxious stimuli in the rat
striatum at 11.7T
Proc. Intl. Soc. Mag. Reson. Med., Stockholm, Sweden, 2010
Wey HY, Du F, Lin AL, Shih YY, Madi M, Fox PT,
Gupte P, Duong TQ
Indirect 17O MRI using T1ρ at 11.7 T
Proc. Intl. Soc. Mag. Reson. Med., Stockholm, Sweden, 2010
Shih CM, Lin CY, Chen CY, Chou TW, Lin SS, Chou
CH, Shih YY, Chen JH, Chang C
Simultaneous Characterization of the Tumor
Vascular Permeability, Vessel Size and
Density By Using First-Pass Function/
Structure MR Imaging
Proc. Intl. Soc. Mag. Reson. Med., Stockholm, Sweden, 2010
2009
Chen CC, Shih YY, Mo KC, Yao NW, Lin ZJ, Huang CH,
Shyu BC, Chang C
Brain 2009 - XXIVth International Symposium on Cerebral Blood Flow, Metabolism and Function, Chicago, USA, 2009
Journal of Cerebral Blood Flow & Metabolism, 2009, 29, S607–S608
2008
Shih YY, Huang CH, Chiang YC, Chen CC, Chen YY,
Jaw FS, Shyu BC, Chang C
Vasoconstriction in the caudate-putamen following
nociceptive stimuli: role of dopamine D2
receptor
World Molecular Imaging Congress, Nice, France, 2008
Chiang YC, Shih YY, Shyu BC, Huang CH, Chen CC,
Chen YY, Jaw FS, Chang C
Vasoconstriction in the caudate-putamen following
nociceptive stimuli: role of opioid receptor
World Molecular Imaging Congress, Nice, France, 2008
Shih YY,
Chen YY, Chen CC, Shyu BC, Siow TY, Lin ZJ,
Chen JC, Jaw FS, Chang C
Proc. Intl. Soc. Mag. Reson. Med., Toronto, Canada, 2008
Wong WC, Shih YY, Chiang YC, Huang CH, Chang C,
Jaw FS
Quantitative mechanical stimulator for fMRI and
microPET studies
Proc. Intl. Soc. Mag. Reson. Med., Toronto, Canada, 2008
2007
Shih YY, Chiang YC, Chen JC, Chang C, Liu RS, Jaw
FS
Imaging brain glucose metabolism of hindpaw
tactile stimulation in rats
Joint Molecular Imaging Conference 2007, Rhode Island, USA, 2007.
Chen YY, Chien CN, Shih YY, Jaw FS
MicroPET study of brain activation during
electrical and mechanical stimulation of the
rat tail
Joint Molecular Imaging Conference 2007 Rhode Island, USA, 2007.
Chiang YC, Shih YY, Chen JC, Liu RS, Jaw FS
Expression of formalin-induced nociceptive
responses and pain-inhibited mechanism in
rat brain using FDG-microPET
Joint Molecular Imaging Conference 2007 Rhode Island, USA, 2007.
Shih YY, Chiang YC, Chen JC, Chang C, Jaw FS
Brain nociceptive imaging in rats using FDG-micorPET
Annual Meeting of the Society of Nuclear Medicine, Washington DC, USA, 2007.
2006
Shih YY, Chang C, Chen JC, Jaw FS
Brain processing of nociceptive stimuli under
ketamine anesthesia
International Symposium on Biomedical Engineering, Taipei, Taiwan, 2006.
(oral)
Chen CM, Shih YY, Chang C, Jaw FS
Brainmapping of morphine stimulated response in
isoflurane anesthetized rats using BOLD fMRI
International Symposium on Biomedical Engineering, Taipei, Taiwan, 2006.
(oral)
Shih YY, Chen YY, Chen MY, Chang C, Chen JC, Chen
JM, Lung Y, Wang CD, Chang WH, Lin CI, Wang
SJ, Jaw FS
Dynamic mapping of amphetamine stimulated response
by a novel USPIO MR contrast agent
Annual Meeting of the Society for Molecular Imaging, Hawaii, USA, 2006.
Shih YY, Chen YY, Chen JM, Lung Y, Chen JY, Chang
C, Chen JC, Jaw FS
Exploring nociceptive response by BOLD fMRI in α-chloralose
anesthetized rats
Annual International Conference of the IEEE Engineering in Medicine and
Biology Society, New York, USA,
2006.
(oral)
Shih YY, Chen YY, Lung Y, Chen JM, Chen JY, Chen
JC, Chang C, Jaw FS
ISPMER: an integrated system on PET, MRI and
electrophysiological recording for
stereotaxic coordinate somatosensory study
in rats
Imaging 2006, Stockholm, Sweden, 2006. (oral)
2004
Shih YY, Chen JC, Liu RS
Development of wavelet de-noising technique for
PET Images
International Workshop on Medical Image Analysis, Nanjing, China, 2004.
(oral)
2003
Shih YY, Chen JC, Liu RS
Wavelet de-noising on PET images
Proceedings of the 16th Annual Meeting of the Society of Nuclear Medicine,
Taipei, Taiwan,
2003.
(oral)
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