Patricia F. Maness

EDUCATION

B.A., 1970, University of Texas at Austin

M.S., 1972, University of Texas at Houston (with Dr. Joan Suit)

Ph.D., 1975, University of Texas at Houston (with Dr. Antonio Orengo)

Postdoctoral Training, 1976-78, Rockefeller University (with Dr. Gerald M. Edelman)

 

ACADEMIC APPOINTMENTS

1992-present: Professor, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, School of Medicine

            Member: UNC Neuroscience Research Center, Conte Center for Schizophrenia Research, UNC Neurological Disorders Research Center

1986-1992: Associate Professor, Department of Biochemistry, University of North Carolina at Chapel Hill, School of Medicine

1980-1986: Assistant Professor, Department of Biochemistry, University of North Carolina at Chapel Hill, School of Medicine

1978-1980: Assistant Professor, Rockefeller University

 

UNIVERSITY AFFILIATIONS

Member, UNC Neuroscience Center

Member, UNC Neurobiology Curriculum

Member, UNC Neurological Disease Research Center

Member, UNC Curriculum in Toxicology

 

RESEARCH INTERESTS

Development of the vertebrate nervous system

Axon guidance and cortical neuron migration

Function of neural cell adhesion molecules

Signal transduction in neural differentiation

 

HONORS, AWARDS, EDITORIAL SERVICE

NIH Special Emphasis Panel, MDCN-2, 2002

NIH Study Section Full Member, Neurology C, 1988-1992

NIH Study Section-MCDN-6, 1999

Distinguished Investigator Award, National Alliance for Research on Schizophrenia and Depression (NARSAD), 1999

NIH Research Career Development Award, 1988-1992

Jefferson-Pilot Award in Academic Research, 1984

NIEHS/EPA Workshop. Growth and Differentiation, 1997

RIKEN review; Brain Research Institute, Tokyo, Japan, 2003

Associate Editor, Developmental Neuroscience, 1994-96

Editor, Journal of Neuroscience Research, "Oncogenes and Development", 1989

Special Reviewer for NSF Center Awards, 1989

The Anna Fuller Fund Postdoctoral Fellowship, 1976-1978

Rosalie B. Hite Predoctoral Fellowship, 1971-1975

Sigma Xi Award for Dissertation Research, University of Texas, 1975

 

PROFESSIONAL SOCIETIES

Society for Neuroscience

American Society for Cell Biology

Federation of American Societies for Experimental Biology

Sigma Xi

Society of Biological Psychiatry

 

TRAINING AND CORE GRANT PARTICIPATION

NIMH-UNC Silvio Conte Center for Schizophrenia Research

UNC Mental Health Research Center

UNC Curriculum in Toxicology

UNC Neurobiology Curriculum

 

GRADUATE STUDENTS SUPERVISED

Barcey T. Levy, Ph.D., 1985, Associate Professor University of Iowa

Carol G. Shores, Ph.D., 1988, Assistant Professor of Medicine, UNC-Chapel Hill

Wayne T. Matten, Ph.D., 1990, NIH Staff Fellow

Michael E. Cox, Ph.D., 1991, Research Assistant Professor University of Virginia

Michael lgnelzi, DDS., Ph.D., 1992, Associate Professor, University of Illinois

Jacqueline S. Biscardi, Ph.D., 1993, Research Associate, University of Virginia

Danette R. Miller, Ph.D., 1994, Research Associate, University of Colorado

Stephan G. Klinz, Ph.D., 1995, Scientist, Regeneron, Inc.

Hilary E. Beggs, Ph.D., 1996, Postdoctoral Fellow, UCSF

Wendy Morse Pruitt, Ph.D., 1999, Postdoctoral Fellow, UNC-CH

Ralf S. Schmid, Ph.D., 2000, Postdoctoral Fellow, University of Texas at Dallas

Tobias Gotschik, 2006 Visiting scholar, University of Bonn

Lilian Enriquez-Barreto, 2006 Visiting scholar, University Miguel Hernandez, Alicante, Spain

Amanda Gates Wright, current

            Ari Halberstadt, current

 

POSTDOCTORAL FELLOWS SUPERVISED

Laurie K. Sorge, Ph.D.

Daniel W. Fults, M.D.

Muriel Aubry, Ph.D.

Christine A. Ingraham, Ph.D.

Alison Hill, Ph.D.

Daryl Warder, M.D., Ph.D.

Dan J. Bare, Ph.D.

John R. Simon, Ph.D.

Fabienne Denhez, Ph.D.

Ron D. Graff, Ph.D.

James Fiordalisi, Ph.D.

Terri Worley, Ph.D.

Leila K. Needham, Ph.D. (1997-2001)

Vishram Kedar, Ph.D. (1998-2001)

Anitha Panicker, Ph.D. (2000-2004)

Simone Diestel, PhD Visiting Postdoctoral Scholar, University of Bonn (2005)

Mona Buhusi, MD, Ph.D. (2001-2007)

Galina P. Demyanenko, Ph.D., postdoctoral fellow (1998-2001); Research Professor (current) 

Neeta Pillai-Nair, PhD (2003-2006) 

Leann Hinkle Brennaman, PhD (2004-current)

Monika Heiz, PhD (2005-current)

 

 

PUBLICATIONS:  

 

1.        Maness, P.F.: Analysis of Oxidoreductases and DNA Polymerase Activities in Membrane Fractions Obtained from Escherichia coli o1a1, 1971, M.S. Thesis.

 

2.         Maness, P.F.: Pyrimidine Nucleoside Monophosphate Kinase from Rat Liver: Purification and Mechanism of Activation by Thioredoxin and Other Sulfhydryl Reducing Agents, 1975, Ph.D. thesis.

 

3.         Maness P, Orengo A: A Pyrimidine Nucleoside Monophosphate Kinase from Rat Liver, Biochemistry 14:1484-1489,1975.

 

4.         Maness P, Orengo A: Activation of Rat Liver Pyrimidine Nucleoside Monophosphate Kinase, Biochim Bioghys Acta 429:182-190,1976.

 

5.         Maness P, Orengo A: Differences between Pyrimidine Nucleoside Monophosphate Kinase from Rat Novikoff Ascites Hepatoma and Rat Liver, Cancer Research 36:2312­2316, 1976.

 

6.         Maness PF, Orengo A: Serum Complement Levels in Patients with Digestive Tract Carcinomas and Other Neoplastic Diseases, Oncology 34:87-89, 1977.

 

7.         Maness PF, Orengo A: Pyrimidine Nucleoside Monophosphate Kinase Activities in Synchronized HeLa Cells, Cancer Biochem Biophys 2:151-153, 1978.

 

8.         Orengo A, Maness P: Pyrimidine Nucleoside Monophosphate Kinase from Rat Liver and Rat Novikoff Ascites Hepatoma (E.C. 2.7.4.14) In: Methods in Enzymology, Vol.  L1, pp. 321-331, Academic Press, New York, NY, 1978.

 

9.         Maness PF, Edelman GM: Inactivation and Chemical Alteration of Mating Factor a by Cells and Spheroplasts, Proc Natl Acad Sci USA 75:1304-1308, 1978.

 

10.       McClain DA, Maness PF, Edelman GM: Assay for Early Cytoplasmic Effects of the src Gene Product of Rous Sarcoma Virus, Proc Natl Acad Sci USA 75:2750-2754, 1978.

 

11.       Maness PF, Engeser H, Greenberg ME, O'Farrell M, Gall WE, Edelman GM: Characterization of the Protein Kinase Activity of the src Gene Product of Avian Sarcoma Virus, Proc Natl Acad Sci USA 76:5028-5032, 1979.

 

12.       Maness PF, Engeser H, Greenberg ME, O'Farrell M, Gall WE, Edelman GM: Activities of the src Gene Product of Avian Sarcoma Virus, Cold Spring Harbor Symp Quant Biol XLIV, 949-958, 1979.

 

13.       Maness PF: Actin Structure in Fibroblasts: Its Possible Role in Transformation and Tumorigenesis, Cell and Muscle Motilily 1:335-373, 1981.

 

14.       Maness F, Walsh RC Jr: Dihydrocytochalasin B Induces the Actin Transformation and Inhibits Initiation of DNA Synthesis in 3T3 Cells, Cell 30:253-262, 1982.

 

15.       Maness PF, Levy BT: Highly Purified pp60src Induces the Actin Transformation in Microinjected Cells and Phosphorylates Selected Cytoskeletal Proteins in vitro, Molecular and Cellular Biology 3:102-112, 1983.

 

16.       Maness PF, Perry ME, Levy BT: P1, P4 Di(adenosine 5')tetraphosphate Inhibits Phosphorylation of Immunoglobulin G by Rous Sarcoma Virus pp60src, J. Biol. Chem. 258:4055-4058,1983.

 

17.       Levy BT, Sorge LK, Drum CC, Maness PF: Differential Inhibition by P1, P4-Di(adenosine­-5')-tetraphosphate of Protein Kinase Activities of Cellular and Viral pp60src, Molecular and Celllar Biology 3:1718-1723,1983.

 

18.       Levy BT, Sorge LK, Meymandi A, Maness PF: pp60c-src Kinase is in Embryonic Tissues of Chick and Human, Developmental Biology 104:9-17, 1984.

 

19.       Sorge LK, Levy BT, Gilmer TM, Maness PF: pp60c-src in Embryonic Tissues: Immunocytochemical Localization in Developing Retina, Cancer Cells, 1:117-122,1984.

 

20.       Maness PF: Ap4A Differentially Inhibits the Tyrosine-specific Protein Kinase of Rous sarcoma virus (pp60v-src) and its Normal Cellular Homolog from Embryonic Tissues, Hoppe-Seyler's Z. Physiol. Chem. 365:597-611, 1984.

 

21.       Sorge LK, Levy BT, Maness PF: pp60c-src is Developmentally Expressed in the Neural Retina, Cell 36:249-257, 1984.

 

22.       Sorge LK, Van Eldik L, Maness PF:  A Calmodulin-dependent Protein Kinase in Rous Sarcoma Virus-Transformed Rat cells and Normal Liver, Biochim. Biophys. Acta 844:174­-181, 1985.

 

23.       Fults DW, Lauder J, Maness PF: pp60c-src is Localized in Processes of Developing Cerebellar Neurons, Mol. Cell. Biol. 5:27-32, 1985.

 

24.       Sorge JP, Sorge LK, Maness PF: pp60c-src is Expressed in Human Fetal and Adult Brain, Am. J. Pathol. 119:151-157, 1985.

 

25.       Maness PF, Fults DW: Immunocytochemical Mapping of pp60c-src in the Developing Nervous System, Cancer Cells 3:425-432, 1985.

 

26.       Maness, PF: pp60c-src Encoded by the Proto-Oncogene c-src is a Product of Sensory Neurons, J. Neuroscience Res. 16:127-139, 1986.

 

27.       Maness PF, Sorge LS, Fults DW: An Early Developmental Phase of pp60c-src Expression in the Neural Ectoderm, Developmental Biology 117:83-89, 1986.

 

28.       Shores CG, Cox ME, Maness PF: A Tyrosine Kinase Related to pp60c-src Associated with Membranes of Electrophorus electricus Electric Organ, J. Biol. Chem. 262:9477­9485,1987.

 

29.       Hillsgrove D, Shores CG, Parker JC, Maness PF: The Band 3 Tyrosine Kinase in the Avian Erythrocyte Plasma Membrane is Immunologically Related to pp60c-src, Am. J. Physiol. 253:286-295, 1987.

 

30.       Matten WT and Maness PM.  Vmax Activation of pp60c-src Tyrosine Kinase from Neuroblastoma Neuro-2A, Biochem. J. 248:691-696, 1987.

 

31.       Maness PF, Aubry M, Frame L, Pfenninger KH: The c-src Gene Product in Developing Brain is Enriched in Nerve Growth Cone Membranes, Proc. Nat. Acad. Sci. 85:5001-5005, 1988.

 

32.       Aubry MA, and Maness PF.  Developmental Regulation of Protein Tyrosine Phosphorylation in Rat Brain, J. Neuroscience Res. 21:473-379, 1988.

 

33.       Ingraham, CA, Cox ME, Ward DC, Fults DW, and Maness PF.  Regulation of c-src and other Protooncogenes in Differentiating Neuronal Cells, Mol. Chem. Neuropathol. 10:1-14, 1989.

 

34.       Shores, CG, Maness PF.  Tyrosine Phosphorylated Proteins Accumulate in Junctional Regions of the Developing Chick Neural Retina, J. Neuroscience Res. 24:59-66, 1989.

 

35.       Fults, D, Maness, PF, Nakamura Y, and White, R. The N-ras Oncogene is Activated in Human Medulloblastoma Cell Line, Brain Research 503:281-287,1989.

 

36.       Maness PF.  Protein Tyrosine Phosphorylation in the Retinotectal Projection, Adv. Exp. Med. Biol. 265:117-126,1990.

 

37.       Maness PF and Matten WT.  Tyrosine Phosphorylation of Membrane-associated Tubulin in Nerve Growth Cones Enriched in pp60c-src, Ciba Foundation Symposium 150:57-88, 1989.

 

38.       Ingraham CA and Maness PF.  Tyrosine Phosphorylated Proteins Decrease During Differentiation of Neuronal and Glial Cells, Developmental Neuroscience 12:272-285, 1990.

 

39.       Maften WT, Aubrv M, West J, and Maness PF.  Tubulin is Phosphorylated on Tyrosine in pp60c-src - Enriched Nerve Growth Cones, J. Cell Biol 111:1959-1970, 1990.

 

40.       Cox ME and Maness PF.  Neurite Extension and Protein Tyrosine Phosphorylation Elicited By Inducible Expression of the v-src Oncogene in a PC12 Cell Line, Exp. Cell Res 195:423­431, 1991.

 

41.       Biscardi JS, Shores CG, and Maness PF.  Elevated Protein Tyrosine Phosphorylation In The Optic Tract Of The Chick Embryo, Curr. Eye Res. 10:1121-1128, 1991.

 

42.       Atashi JR, Klinz SG, Ingraham CA, Matten WT, Schachner M, Maness PF.  Neural Cell Involves L1 Adhesion Molecules Modulate Tyrosine Phosphorylation of Tubulin in Nerve Growth Cone Membranes, Neuron 8:831-842, 1992.

 

43.       Ingraham CA, Cooke MP, Chuang Y-N, Perlmutter RM, and Maness PF.  Cell Type and Developmental Regulation of the Fyn Proto-oncogene in Neural Retina, Oncogene, 7:95-100, 1992.

 

44.       lgnelzi MA, Padilla SS, Warder DE, and Maness PF.  Altered Expression of pp60c-src Induced by Peripheral Nerve Injury, J. Comp. Neurol. 315:171-177, 1992.

 

45.       Maness PF.  Book review, Molecular Biology of Cancer Genes, M. Sluyser, ed., American Scientist 80:194, 1992.

 

46.       Maness PF and Cox ME.  Protein Tyrosine Kinases in Nervous System Development, Seminars in Cell Biology 3:117-126, 1992.

 

47.       Maness PF.  Nonreceptor Protein Tyrosine Kinases Associated with Neuronal Development, Dev. Neuroscience 14:257-270, 1992.

 

48.       Klinz SG and Maness PF.  Tyrosine Kinase pp60c-src in Nerve Growth Cones and Developing Brain: Topographical and Functional Analysis.  Neuroprotocols 1:224-231, 1992.

 

49.       Maness PF.  Book review of The Nerve Growth Cone, PC Letourneau, SB Kater, and E. Macagno, eds. in American Scientist, 80:608-609, 1992.

 

50.       Cox ME and Maness PF.  Tyrosine Phosphorylation of a-Tubulin is an Early Response to NGF and pp60v-src in PC12 Cells.  J. Mol.  Neuroscience 4:1-7, 1993.

 

51.       Biscardi JS, Cooper NGF, and Maness PF.  Phosphotyrosine-modified Proteins are Localized in Müller Cells of the Chick Neural Retina.  Exp. Eye Res. 56:281-289, 1993.

 

52.       Miller DR, Lee GM, and Maness PF.  Increased Neurite Outgrowth Induced by Inhibition of Protein Tyrosine Kinase Activity in PC12 Pheochromocytoma Cells.  J. Neurochem. 60:2134­-2144,1993.

 

53.       Bare DJ, Wilkie MB, Lauder JM, and Maness PF. p59fyn In Rat Brain is Localized in Developing Axonal Tracts and Subpopulations of Adult Neurons and Glia.  Oncogene 8:1429-1436, 1993.

 

54.       Ignelzi MA, Miller DR, Soriano P, and Maness PF.  Impaired Neurite Outgrowth of Src­minus Neurons on the Cell Adhesion Molecule L1.  Neuron 12:873-884, 1994.

 

55.       Beggs HE, Soriano P, and Maness PF.  Inhibition of NCAM-dependent Neurite Outgrowth in Fyn-minus Neurons.  J. Cell Biol. 127:825-833, 1994.

 

56.       Shock LP, Bare DJ, Klinz SG, and Maness PF.  Protein Tyrosine Phosphatases Expressed in Developing Brain and Retinal Mueller Glia.  Mol. Brain Res. 28:110-116, 1995.

 

57.       Klinz SG, Schachner M, and Maness PF.  L1 and NCAM Antibodies Trigger Protein Phosphatase Activity in Growth Cone-enriched Membranes.  J. Neurochem. 65:84-95, 1995.

 

58.       Maness PF, Beggs HE, Klinz SG, and Morse WR.  Selective Neural Cell Adhesion Molecule Signaling by src Family Tyrosine Kinases and Phosphatases.  Perspectives on Developmental Neurobiology 4:159-181, 1996.

 

59.       Biscardi JS, Denhez F, Buehler GF, Chesnutt DA, Baragona SC, O'Bryan J, Fults DW, and Maness PF.  Rek, A Gene Expressed In Retina and Brain, Encodes a Novel Receptor Tyrosine Kinase of the Axl/Tyro 3 Family.  J. Biol. Chem. 271:29049-29059, 1996.

 

60.       Beggs HE, Baragona SC, Hemperly JJ, and Maness PF.  NCAM 140 Selectively Interacts with the Nonreceptor Tyrosine Kinases p59fyn and p125fak.  J. Biol. Chem. 272:8310-8319, 1997.

 

61.       Sadler TW, Rogers M, Slavkin H, Lauder J, Maness PF, Linney E, Sulik K, and Mirkes P.  NIEHS/EPA Workshops.  Growth and differentiation factors.  Reproductive Toxicology 11: 331-7, 1997.

 

62.       Weiss ER, Maness PF, and Lauder JM.  Why do neurotransmitters act like growth factors?  Perspectives on Developmental Biology 4:137-145, 1998.

 

63.       Simon JR, Graff RD, and Maness PF.  Microtubule Dynamics in a Cytosolic Extract of Fetal Rat Brain.  J. Neurocytology 27:119-126, 1998.

 

64.       Morse WR, Whitesides III JG, LaMantia AS, and Maness PF.  pp60c-src and p59fyn modulate axon guidance in the developing mouse olfactory pathway.  J. Neurobiology 36:53-63, 1998.

 

65.       Fiordalisi JJ and Maness PF.  Rek, an Axl/Tyro 3-related receptor-class tyrosine kinase, is expressed in Müller glia and differentiating neural subpopulations in the avian retina.  Exp. Eye Res. 68:  201-210, 1999.

 

66.       Schmid RS, Graff RD, Schaller MD, Chen S, Schachner M, Hemperly JJ and Maness PF.  NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells.  J. Neurobiology 38: 542-558, 1999.

 

67.       Demyanenko GP, Tsai AY, and Maness PF.  Abnormalities in Neuronal Process Extension, Hippocampal Development, and the Ventricular System of L1 Knockout Mice. J. Neuroscience 19: 4907-4920, 1999.

 

68.       Schmid RS, Pruitt WM, and Maness PF. A MAP kinase signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis. J. Neuroscience 20: 4177-4188, 2000.

 

69.       Bliss T, Errington ME, Fransen E, Godfraind J-M, Kauer J, Kooy F, Maness P, and Furley AJ. Long term potentiation in mice without L1-CAM.

 Current Biology 10: 1607-1610, 2001.

 

70.       Demyanenko GP, Shibata Y, and Maness PF. Altered distribution of dopaminergic neurons in the brain of L1 null mice, Developmental Brain Research 126: 21-30, 2001.

 

71.       Needham LK, Thelen K, Schmid R-S, and Maness PF. Cytoplasmic domain mutations of the L1 cell adhesion molelcule reduce L1-ankyrin interactions. 

Journal of  Neuroscience 21: 1490-1500, 2001.

 

72.       Schmid RS and Maness PF.  Cell recognition molecular and disorders of neurodevelopment.  Handbook on Brain and Behavior in Human Development, pp. 199-218, Kluwer Academic Publishers, 2001.

 

73.       Liu RY, Schmid R-S, Snider W, and Maness PF.  NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion     molecule.  Molecular Cellular Neuroscience 20: 2-12, 2002.

 

74.       Thelen, K, Kedar, V, Panicker A, Schmid, RS, Midkiff, BR, and Maness, PF.  L1 potentiates integrin-dependent migration  to extracellular matrix        through endocytosis. Journal of Neuroscience  22: 4918-4931, 2002.

Recommended

F1000 Factor 3.0

Selected by | Genevieve Rougon
Evaluated 10 Sep 2002

 

75.       Grove M, Demyanenko G, Zipfel PA, Echarri A, Quiroz ME, Rodriquiz RM, Playford M, Martensen SA, Robinson MR, Wetsel WC, Maness PF,    and Pendergast AM. Abi2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis and deficits in learning and            memory.  Molecular and Cellular Biology 24, 10905-10922, 2004.

 

76.       Panicker, A. K., M. Buhusi, K. Thelen, & P.F. Maness.  Cellular signaling             mechanisms of neural cell adhesion molecules.

             Frontiers in Bioscience 7: 900-911, 2003.

 

77.    Otey, CA, Boukhelifa, M, and Maness, P. B35 Neuroblastoma Cells:  An Easily Transfected Culture Cell Model of CNS Neurons. Methods in Cell Biology 71: 287-304, 2003.

 

78.     Demyanenko, GP, and Maness, PF.  The L1 cell adhesion molecule is essential for topographic mapping of retinal axons. Journal of        Neuroscience 23: 530-538, 2003.

Must Read

F1000 Factor 6.0

Selected by | Christine Holt
Evaluated 18 May 2004

 

79.       Buhusi, M, Midkiff BR, Gates AM, Richter, M, Schachner M, and Maness PF.  Close Homolog of L1 (CHL1) is an enhancer of integrin-mediated cell migration.  Journal ­ of  Biological Chemistry 278: 25024-25031, 2003.

 

80.       Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J, and    Maness PF. Close Homolog of L1 (CHL1) Modulates Area-specific Neuronal Positioning and Dendrite Orientation in the Cerebral Cortex.  Neuron  44, 423-437, 2004. 

Must Read

F1000 Factor 4.8

Selected by | Vance Lemmon / Jeffrey Macklis
First evaluation 22 Nov 2004 | Latest evaluation 24 Nov 2004

 

81.     Pillai-Nair, N, Panicker, AP,  Rodriguiz, RM,  Miller, K, Demyanenko, GP, Huang, J,  Wetsel, WP, and Maness, PF.  NCAM-Secreting Transgenic             Mice Display Abnormalities in Interneurons and Behaviors Related to Schizophrenia.  Journal of Neuroscience 25, 4659-4671, 2005.

 

82.     Irintchev A, Koch M, Needham LK, Maness P, Schachner M. Impairment of  Sensorimotor Gating in Mice Deficient in Cell Adhesion Molecule L1 or its            Close Homologue, CHL1. Brain Research 1029, 131-134,  2004.

 

83.    Schmid RS, Kedar VP, Midkiff BR, and Maness PF. Adhesion Molecule L1 Stimulates Cell Migration through Vav2-Pak1 Signaling.

             Neuroreport  15, 2791-2794, 2004.

           

84.    Demyanenko, GP, Halberstadt, A, and Maness, PF.

            Neocortical Organization in Mice lacking cGMP-dependent Protein Kinase. Developmental Brain Research 160 (2005) 1-8.

 

85.    Diestel, S, Hinkle, CL, Schmitz, B, and Maness PF.  NCAM140 stimulates integrin-dependent cell migration and is regulated by NCAM140        ectodomain shedding.   Journal of Neurochemistry 95 (2005) 1777-1784.

 

86.   Hinkle, CL and Maness PF. Regulation of neural cell adhesion molecule function by ectodomain shedding.

            Recent Res. Devel. Mol. Cell. Biol. 6 (2006) 121-136.

 

87.  Panicker, AK, Buhusi M, Erickson A, and Maness PF. Endocytosis of β1 integrins is an early event in migration promoted by the cell adhesion          molecule L1.   Experimental Cell Research 312 (2006) 299-307.

 

88.  Hinkle, C.L., Diestel, S., Lieberman, J., and Maness, P.F.  Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM).      Journal of Neurobiology 66 (2006) 1378-1395.

 

89.  Sullivan, PF, Keefe RSE, Lange LA, Lange EM, Stroup TS, Lieberman J, and Maness PF. NCAM1 and Neurocognition in Schizophrenia.

            Biological Psychiatry 61 (2007) 902-910.

 

90.  Maness, PF and Schachner M.  Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and        neuronal migration. Nature Neuroscience  10 (2007) 19-26.

 

91.  Wright, AG, Demyanenko, GP, Powell A, Schachner M, Enriquez-Barreto, L, Polleux, F, and Maness PF.  Close Homolog of L1 is required for           guidance and targeting of thalamocortical axons. Submitted, 2006.

 

92.   Buhusi, M, Heiz, M, Thresher, R, and Maness, PF.  L1 Interaction with ankyrin is required for retinotopic axon mapping. Submitted, 2007.

 

93.   Heiz, M, Buhusi, M, and Maness, PF.  CHL1 binds ezrin-radixin-moesin proteins important for neuronal migration and axonal branching. Submitted,    2007.