37 HIV-1 RT structures
 

PDB #	Res.	RT chains	Mutation	Complexed with RT	Date	Lab	Reference
3hvt	2.9	p66/p51		NNI nevirapine	7/94	Steitz	PNAS 91, 7242 (1994)
1hvu	4.75	p66/p51		Pseudoknot RNA	6/98	Steitz	EMBO 17, 4535 (1998)
1har	2.2	fingers-palm			10/94	Unge	Structure 2, 953 (1994)
1eet *				MSC204	2/00	Unge
1hmv	3.2	p66/p51		unliganded	12/94	Harrison	PNAS 92, 1222 (1995)
1rtd	3.2	p66/p51		dsDNA & dNTP	8/98	Harrison	Science 282, 1669 (1998)
1hni	2.8	p66/p51		NNI a-APA	2/95	Arnold	Structure 3, 365 (1995)
1hnv	3.0	p66/p51		NNI 8-Cl TIBO	3/95	Arnold	Nat Str Biol 2, 407 (1995)
1dlo	2.7	p66/p51		unliganded	4/96	Arnold	Structure 4, 853 (1996)
1tvr	3.0	p66/p51		NNI 9-Cl TIBO	4/96	Arnold	JMB 264, 1085 (1996)
1uwb	3.2	p66/p51	Y181C, C280S	NNI 8-Cl TIBO	11/96	Arnold	JMB 264, 1085 (1996)
2hmi	2.8	p66/p51		dsDNA & antibody	4/98	Arnold	JMB 284, 1095 (1998)
1bqm	3.1	p66/p51		HBY 097	8/98	Arnold	JMB 284, 313 (1998)
1bqn	3.3	p66/p51	Y188L, C280S	HBY 097	8/98	Arnold	JMB 284, 313 (1998)
1qe1	2.85	p66/p51			7/99	Arnold	PNAS 96, 10027 (1999)
1c9r	3.5	p66/p51	M184I	DNA & antibody	8/99	Arnold	PNAS 96, 10027 (1999)
1vrt	2.2	p66/p51		NNI nevirapine	4/95	Stammers	Nat Str Biol 2, 293 (1995)
1vru	2.4	p66/p51		NNI	4/95	Stammers	Nat Str Biol 2, 293 (1995)
1rth	2.2	p66/p51		NNI	5/95	Stammers	Nat Str Biol 2, 293 (1995)
1rti	3.0	p66/p51		NNI	5/95	Stammers	Nat Str Biol 2, 293 (1995)
1rtj	2.35	p66/p51		unliganded	5/95	Stammers	Nat Str Biol 2, 303 (1995)
1rev	2.6	p66/p51		NNI 9-Cl TIBO	9/95	Stammers	Structure 3, 915 (1995)
1rt1	2.55	p66/p51		NNI MKC-442	3/96	Stammers	J Med Chem 39, 1589 (1996)
1rt2	2.55	p66/p51		NNI TNK-651	3/96	Stammers	J Med Chem 39, 1589 (1996)
1klm	2.65	p66/p51		NNI U-90152	3/97	Stammers	PNAS 94, 3984 (1997)
1rt3	3.0	p66/p51	D67N, K70R, T215F, K219Q		6/98	Stammers	PNAS 95, 9518 (1998)
1rt4	2.9				7/98	Stammers	Biochem 37, 14394 (1998)
1rt5	2.9				7/98	Stammers	Biochem 37, 14394 (1998)
1rt6	2.8				7/98	Stammers	Biochem 37, 14394 (1998)
1rt7	3.0				7/98	Stammers	Biochem 37, 14394 (1998)
1c0t	2.7	p66/p51			7/99	Stammers	J Med Chem 42, 3845 (1999)
1c0u	2.52	p66/p51			7/99	Stammers	J Med Chem 42, 3845 (1999)
1c1b	2.5	p66/p51			7/99	Stammers	J Med Chem 42, 4500 (1999)
1c1c	2.5	p66/p51			7/99	Stammers	J Med Chem 42, 4500 (1999)
1dtq	2.8	p66/p51			1/00	Stammers	JBC 275, 5633 (2000)
1dtt	3.0	p66/p51			1/00	Stammers	JBC 275, 5633 (2000)
1ep4 *				S-1153	3/00	Stammers

* structure on hold
 
 

5 MMLV RT structures
 

PDB #	Res.	Subdomains	Complexed with RT	Date	Lab	Reference
1mml	1.8	fingers-palm		7/95	Georgiadis	Structure 3, 879 (1995)
1qai	2.3	fingers-palm	DNA	3/99	Georgiadis	JMB 296, 613 (2000)
1qaj	2.3	fingers-palm	DNA	3/99	Georgiadis	JMB 296, 613 (2000)
1d0e	3.0	fingers-palm	DNA	9/99	Georgiadis	JMB 296, 613 (2000)
1d1u	2.3	fingers-palm	DNA	9/99	Georgiadis	JMB 296, 613 (2000)

 
 
 

Missing residues in HIV-1 Reverse Transcriptase crystal structures
 

		66 kd subunit (chain A)				51 kd subunit (chain B)
structure	1st residue	Missing residues	Last residue		1st residue	Missing residues	Last residue
1bqm	1		558		1		430
1bqn	1		558		1		430
1c0t	4	28-44, 49-53, 63-72, 131-143	539		6	88-95, 191-232	428
1c0u	1		539		6	88-92, 216-231	440
1c1b	1	66-69, 89-90	543		5	89-92, 218-230	436
1c1c	1	67-68	539		5	89-92, 216-231	440
1c9r	1		558		1		430
1dlo	1		556		1	219-230	427
1dtq	4	444-454	539		5	214-230, 357-361	428
1dtt	1	140-141	543		5	89-91, 218-230	432
1har	1	64-70, 91-103	216
1hmv	1	64-74, 134-140	554		5	66-70, 212-234	427
1hni	1		558		1		427
1hnv	1		558		1		427
1hvu	1		554		5	212-234	427
1klm	2		539		6	89-95, 216-231	433
1qe1	1		556		1	219-230	427
1rev	4	444-454	539		2	216-230	428
1rt1	1		539		6	89-92, 216-231	440
1rt2	1		543		6	90-94, 212-231	432
1rt3	2	136-139, 444-454	537		5	88-93, 215-230, 358-361	428
1rt4	1	137-141	542		5	88-92, 213-232	433
1rt5	1	137-141	542		6	88-92, 217-232	432
1rt6	1		539		6	89-92, 216-232	440
1rt7	4		539		6	89-92, 216-231	440
1rtd	1		554		3	218-230	429
1rth	1		543		3	88-90, 218-230	438
1rti	1		543		5	88-94, 218-230	437
1rtj	1		543		2	218-230	440
1tvr	1		558		1		427
1uwb	1		558		1		427
1vrt	4	444-454	539		5	89-91, 216-230, 357-361	428
1vru	3	444-454	539		4	218-230, 357-358	428
2hmi	1		558		1		430
3hvt	2		556		2	226-249, 359-363	428

Last updated July 30, 2000