The Hutchison Lab's collection of HIV-1 Reverse Transcriptase Mutants
 

 

                  95       100       105       110       115       120       125       130       135       140       145       150
                  |         |         |         |         |         |         |         |         |         |         |         |
wild-type         P H P A G L K K K K S V T V L D V G D A Y F S V P L D E D F R K Y T A F T I P S I N N E T P G I R Y Q Y N V L P 
sequence

Conservative      A   A P A I R R     A I P   M N   A E G F   A I   V E D E   K R F P G Y P L S G V   D D P T   M K F E F D L V
Substitutions             T               A                               N       A A S   S V T             A               I I
                                          S                                         S     A   A                                  

Non-              E N L V E F Q E N T L Q R G P V E F H V S L L D L F A G Y L W L D D L L I K H Y E H K G R R V N I N L D T A P L
Conservative      L L   E L Q I M T       V E G Y G   V     C   T H W G A   V     N V E C V T L R   K I A I L E F S C   N   T R
Substitutions       A           Q           A Q G R   Y     V   F R A Y V   I     H   V A E R R N   I H   K   R   Q D   C   F Q
                                              W             Q   C N T V     S     Q         F   C                   V   V   N T
                                                                    N       Q     L         N                       L   L     F
                                                                                                                    Q   Q     N



                         155       160       165       170       175       180       185       190       195       200    
                          |         |         |         |         |         |         |         |         |         |      
wild-type         Q G W K G S P A I F Q S S M T K I L E P F R K Q N P D I V I Y Q Y M D D L Y V G S D L E I G Q H R T K I E
sequence

Conservative        A F     A S T M Y E     I S R L V D A Y K R E   A E V   M F E F I E E V F I A A E I D L   E R   A   V D
Substitutions                 T S V         V     M     S               L   L       L N N M   L   P N V             S   M
                                            L     V                                 V             T                 P

Non-              P R G I E L R L R C P R C K I T S F V H C S T K K L H T D F H P N K V A F C A R F Y F K T V R Y T I N K V
Conservative      H V C E R       K L L C I T     T S   L I T Q P T R V R F T S R C   G H W   G E Y V   G K W L N I K I R G                                  
Substitutions     R N L           F A I N R F     F Q   R L G N R S   A F   S   H D   Y G S         G   V R R H P S R   Q A
                      Q           N   H     N     N N     Q   I L           N   K H     Y N         A           Q       F
                                                                                  S                                     N




                  48    57    60    73    87     232       283         289   331   365   376           383  
                  |     |     |     |     |       |         |           |     |     |     |             |    
wild-type         S . . N T P V . . K . . F W . . Y E L . . L R G T K A L . . K . . K . . T T E S I V I W 
sequence

Conservative      A     Q     I                   F       

Non-                    A           L     K K         A     K     K     K     A     A     K       K K K K     
Conservative            L           Q     D                             D                         
Substitutions                       



                 398   401               410   414   439   458   542
                  |     |                 |     |     |     |     |
wild-type         W . . W W T E Y W Q A T W . . K . . T . . V . . I
sequence

Conservative 

Non-              K     K K     K K       K     K     K     K     K
Conservative            D                 
Substitutions                       

 
 
Last updated 8/9/00

 

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