Hutchison Lab Reverse Transcriptase Web Page

RT mutant ticker (displays %wt RT activity for each mutant)

Research Projects:

Project Personnel:


Hutchison lab links (RT related):

Representative HIV-1 publications:

Wrobel, J.A., Conrad, M.J., Bloedon, E., Swanstrom, R., and Hutchison, C.A. III  (2000).  Analysis of HIV type 1 reverse transcriptase:  Comparing sequences of viral isolates with mutational data.  AIDS Research and Human Retroviruses 16, 2049-2054.  [PubMed]

Wrobel, J.A., Chao, S.-F., Conrad, M.J., Merker, J.D., Swanstrom, R., Pielak, G.J.,  and Hutchison, C.A. III  (1998).  A genetic approach for identifying critical residues in the fingers and palm subdomains of HIV-1 reverse transcriptase.  Proc. Natl. Acad. Sci. USA 95, 638-645. [PubMed]

Chao, S.-F., Chan, V.L., Juranka, P., Kaplan, A.H., Swanstrom, R., and Hutchison, C.A. III (1995).  Mutational sensitivity patterns define critical residues in the HIV-1 reverse transcriptase palm domain.  Nucl. Acids Res. 12, 803-810.  [PubMed]

Loeb, D.D., Swanstrom, R., Everitt, L., Manchester, M., Stamper, S.E., and Hutchison, C.A. III  (1989).  Complete mutagenesis of the HIV-1 protease.  Nature 340, 397-400.  [PubMed]

Loeb, D.D., Hutchison, C.A. III, Edgell, M.H., Farmerie, W.G., and Swanstrom, R.  (1989).  Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases.  Journal of Virology 63, 111-121.  [PubMed]

Farmerie, W.G., Loeb, D.D., Casavant, N.C., Hutchison, C.A. III, Edgell, M.H., and Swanstrom, R. (1987).  Expression and processing of the AIDS virus reverse transcriptase in E. coli.  Science 236, 305-308. [PubMed]

Other useful links:
HIV-1 Reverse Transcriptase: H-bond between S191 & H198 critical for protein stability


Click here to view more interactive Reverse Transcriptase images

Maintained by John Wrobel.