Zhang Research Publication
Lab News
Research Interests
The last thirty years have witnessed exciting discoveries of diverse functions carried out by non-coding RNAs (ncRNAs), ranging from enzymatic catalysis to gene regulation. We are a young group of biophysicists and biochemists seeking to illuminate the structural dynamic properties of nucleic acids and ribonucleoprotein complexes that underlie the molecular basis for many vital RNA functions. In particular, by developing and applying state-of-the-art solution-state NMR methods, together with computational and biochemical approaches, we aim to visualize, with atomic resolution, the dynamic process of ribozyme catalysis, riboswitch-based gene regulation, microRNA biogenesis, and co-transcriptional RNA folding. The principles deduced from these studies will provide atomic basis for rationally manipulating RNA catalysis and folding and de novo design of small molecules to target specific RNA signals in cancer and human disease.